<s>
The	O
(	O
HIVE	B-Application
)	O
is	O
a	O
distributed	B-Operating_System
computing	I-Operating_System
environment	I-Operating_System
used	O
for	O
healthcare-IT	O
and	O
biological	O
research	O
,	O
including	O
analysis	O
of	O
Next	O
Generation	O
Sequencing	O
(	O
NGS	O
)	O
data	O
,	O
preclinical	O
,	O
clinical	O
and	O
post	O
market	O
data	O
,	O
adverse	O
events	O
,	O
metagenomic	O
data	O
,	O
etc	O
.	O
</s>
<s>
Currently	O
it	O
is	O
supported	O
and	O
continuously	O
developed	O
by	O
US	O
Food	O
and	O
Drug	O
Administration	O
(	O
government	O
domain	O
)	O
,	O
George	O
Washington	O
University	O
(	O
academic	O
domain	O
)	O
,	O
and	O
by	O
DNA-HIVE	O
,	O
WHISE-Global	O
and	O
Embleema	O
(	O
commercial	O
domain	O
)	O
.	O
</s>
<s>
HIVE	B-Application
currently	O
operates	O
fully	O
functionally	O
within	O
the	O
US	O
FDA	O
supporting	O
wide	O
variety	O
( +60	O
)	O
of	O
regulatory	O
research	O
and	O
regulatory	O
review	O
projects	O
as	O
well	O
as	O
for	O
supporting	O
MDEpiNet	O
medical	O
device	O
postmarket	O
registries	O
.	O
</s>
<s>
Academic	O
deployments	O
of	O
HIVE	B-Application
are	O
used	O
for	O
research	O
activities	O
and	O
publications	O
in	O
NGS	O
analytics	O
,	O
cancer	O
research	O
,	O
microbiome	O
research	O
and	O
in	O
educational	O
programs	O
for	O
students	O
at	O
GWU	O
.	O
</s>
<s>
Commercial	O
enterprises	O
use	O
HIVE	B-Application
for	O
oncology	O
,	O
microbiology	O
,	O
vaccine	O
manufacturing	O
,	O
gene	O
editing	O
,	O
healthcare-IT	O
,	O
harmonization	O
of	O
real-world	O
data	O
,	O
in	O
preclinical	O
research	O
and	O
clinical	O
studies	O
.	O
</s>
<s>
HIVE	B-Application
is	O
a	O
massively	O
parallel	O
distributed	B-Operating_System
computing	I-Operating_System
environment	I-Operating_System
where	O
the	O
distributed	O
storage	O
library	O
and	O
the	O
distributed	O
computational	O
powerhouse	O
are	O
linked	O
seamlessly	O
.	O
</s>
<s>
The	O
data	O
deposition	O
back-end	O
allows	O
automatic	O
uploads	O
and	O
downloads	O
of	O
external	O
datasets	O
into	O
HIVE	B-Application
data	O
repositories	O
.	O
</s>
<s>
Differentiating	O
HIVE	B-Application
from	O
other	O
object	O
oriented	O
databases	O
is	O
that	O
HIVE	B-Application
implements	O
a	O
set	O
of	O
unified	O
APIs	B-Application
to	O
search	O
,	O
view	O
,	O
and	O
manipulate	O
data	O
of	O
all	O
types	O
.	O
</s>
<s>
The	O
security	O
model	O
,	O
designed	O
for	O
sensitive	O
data	O
,	O
provides	O
comprehensive	O
control	O
and	O
auditing	O
functionality	O
in	O
compliance	O
with	O
HIVE	B-Application
's	O
designation	O
as	O
a	O
FISMA	O
Moderate	O
system	O
.	O
</s>
<s>
Data-retrieval	O
:	O
the	O
HIVE	B-Application
is	O
capable	O
of	O
retrieving	O
data	O
from	O
a	O
variety	O
of	O
sources	O
such	O
as	O
local	O
,	O
cloud-based	O
or	O
network	O
storage	O
,	O
sequencing	O
instruments	O
,	O
and	O
from	O
http	O
,	O
ftp	O
and	O
sftp	O
repositories	O
.	O
</s>
<s>
Additionally	O
,	O
HIVE	B-Application
implements	O
the	O
sophisticated	O
handshake	O
protocols	O
with	O
existing	O
large	O
scale	O
data	O
platforms	O
such	O
as	O
NIH/NCBI	O
to	O
download	O
large	O
amounts	O
of	O
reference	O
genomic	O
or	O
sequence	O
read	O
data	O
on	O
behalf	O
of	O
users	O
in	O
an	O
easy	O
and	O
accurate	O
manner	O
.	O
</s>
<s>
Data-warehousing	O
:	O
HIVE	B-Application
honeycomb	O
data	O
model	O
was	O
specifically	O
created	O
for	O
adopting	O
complex	O
hierarchy	O
of	O
scientific	O
datatypes	O
,	O
providing	O
a	O
platform	O
for	O
standardization	O
and	O
provenance	O
of	O
data	O
within	O
the	O
framework	O
of	O
object-oriented	O
data	O
models	O
.	O
</s>
<s>
By	O
using	O
an	O
integrated	O
data-engine	O
,	O
honeycomb	O
,	O
HIVE	B-Application
contributes	O
to	O
the	O
veracity	O
of	O
biomedical	O
computations	O
and	O
helps	O
ensure	O
reproducibility	O
,	O
and	O
harmonization	O
of	O
bio-computational	O
processes	O
.	O
</s>
<s>
Security	O
:	O
HIVE-honeycomb	O
employs	O
a	O
hierarchical	O
security	O
control	O
system	O
,	O
allowing	O
the	O
determination	O
of	O
access	O
privileges	O
in	O
an	O
acutely	O
granular	O
manner	O
without	O
overwhelming	O
the	O
security	O
subsystem	O
with	O
a	O
multiplicity	O
of	O
rules	O
.	O
</s>
<s>
Integration	O
:	O
HIVE	B-Application
provides	O
unified	O
Application	B-Application
Program	I-Application
Interface	I-Application
(	O
API	B-Application
)	O
to	O
search	O
,	O
edit	O
,	O
view	O
,	O
secure	O
,	O
share	O
and	O
manipulate	O
data	O
and	O
computations	O
of	O
all	O
types	O
.	O
</s>
<s>
As	O
an	O
Integrator	O
platform	O
HIVE	B-Application
provides	O
developers	O
means	O
to	O
develop	O
(	O
C/C	O
++	O
,	O
Python	O
,	O
Perl	O
,	O
JavaScript	O
,	O
R	O
)	O
and	O
integrate	O
existing	O
almost	O
any	O
open	O
source	O
or	O
commercial	O
tools	O
using	O
generic	O
adaptation	O
framework	O
to	O
integrate	O
command	O
line	O
tools	O
.	O
</s>
<s>
Additionally	O
session	O
controlled	O
web-API	O
provides	O
means	O
to	O
drive	O
HIVE	B-Application
to	O
perform	O
data	O
quality	O
control	O
and	O
complex	O
computations	O
on	O
behalf	O
of	O
remote	O
users	O
.	O
</s>
<s>
Currently	O
there	O
are	O
tens	O
of	O
big	O
data	O
analytics	O
tools	O
in	O
production	O
HIVE	B-Application
and	O
dozens	O
more	O
being	O
developed	O
;	O
these	O
include	O
but	O
are	O
not	O
limited	O
to	O
DNA-	O
,	O
RNA-	O
,	O
Transposon-	O
,	O
Chip-	O
,	O
Immune-sequencing	O
)	O
,	O
de	O
novo	O
assembly	O
,	O
population	O
genomics	O
metagenomic	O
sequencing	O
,	O
differential	O
profiling	O
,	O
statistical	O
,	O
classification	O
and	O
clusterization	O
utilities	O
to	O
study	O
bacteria	O
,	O
viruses	O
,	O
human	O
germline	O
and	O
somatic	O
profiles	O
,	O
quasispecies	O
,	O
infections	O
,	O
pathogens	O
.	O
</s>
<s>
Computations	O
:	O
Unlike	O
many	O
virtual	O
computing	O
environments	O
,	O
HIVE	B-Application
virtualizes	O
services	O
,	O
not	O
processes	O
:	O
it	O
provides	O
computations	O
as	O
a	O
service	O
by	O
introducing	O
agnostic	O
abstraction	O
layer	O
between	O
hardware	O
,	O
software	O
and	O
the	O
computational	O
tasks	O
requested	O
by	O
users	O
.	O
</s>
<s>
Visualization	O
:	O
HIVE	B-Application
provides	O
number	O
of	O
scientific	O
visualization	O
components	O
using	O
technologies	O
as	O
HTML5	O
,	O
SVG	O
,	O
D3JS	O
within	O
its	O
Data	O
Driven	O
Document	O
context	O
.	O
</s>
<s>
FDA	O
launched	O
HIVE	B-Application
Open	O
Source	O
as	O
a	O
platform	O
to	O
support	O
end	O
to	O
end	O
needs	O
for	O
NGS	O
analytics	O
.	O
</s>
<s>
HIVE	B-Application
biocompute	O
harmonization	O
platform	O
is	O
at	O
the	O
core	O
of	O
High-throughput	O
Sequencing	O
Computational	O
Standards	O
for	O
Regulatory	O
Sciences	O
(	O
HTS-CSRS	O
)	O
project	O
.	O
</s>
<s>
Hardware	O
architecture	O
:	O
At	O
the	O
core	O
of	O
HIVE	B-Application
there	O
exists	O
a	O
solid	O
backbone	O
hardware	O
made	O
of	O
few	O
redundant	O
critical	O
components	O
and	O
scalable	O
compute	O
and	O
storage	O
units	O
.	O
</s>
<s>
The	O
diagram	O
at	O
the	O
right	O
demonstrates	O
the	O
connectivity	O
and	O
components	O
assignations	O
for	O
such	O
HIVE	B-Application
cluster	O
.	O
</s>
<s>
switches	O
and	O
firewall	O
hardware	O
organize	O
the	O
secure	O
high	O
performance	O
network	O
environment	O
for	O
HIVE	B-Application
cloud	O
.	O
</s>
<s>
System	O
is	O
extremely	O
scalable	O
and	O
has	O
deployment	O
instances	O
ranging	O
from	O
a	O
single	O
HIVE	B-Application
in	O
a	O
box	O
appliance	O
to	O
massive	O
enterprise	O
level	O
systems	O
of	O
thousands	O
of	O
compute	O
units	O
.	O
</s>
<s>
Software	O
architecture	O
:	O
HIVE	B-Application
software	O
infrastructure	O
consists	O
of	O
layers	O
incrementally	O
providing	O
more	O
functionality	O
.	O
</s>
<s>
HIVE	B-Application
cloud	O
backbone	O
supports	O
distributed	O
storage	O
,	O
security	O
and	O
computing	O
environment	O
.	O
</s>
<s>
Low	O
level	O
libraries	O
provide	O
Application	B-Application
Programming	I-Application
Interface	I-Application
(	O
API	B-Application
)	O
for	O
developing	O
tools	O
and	O
utilities	O
.	O
</s>
<s>
Dr.	O
Vahan	O
Simonyan	O
and	O
Dr.	O
Raja	O
Mazumder	O
presented	O
at	O
the	O
NIH	O
Frontiers	O
in	O
Data	O
Science	O
about	O
HIVE	B-Application
acting	O
as	O
a	O
bridge	O
between	O
research	O
and	O
regulatory	O
analytics	O
.	O
</s>
<s>
HIVE	B-Application
was	O
additionally	O
discussed	O
in	O
FedScoop	O
.	O
</s>
<s>
Inside	O
the	O
HIVE	B-Application
,	O
the	O
FDA	O
's	O
Multi-Omics	O
Compute	O
Architecture	O
,	O
BioIT	O
World	O
.	O
</s>
