<s>
Gene	B-Application
Relationships	I-Application
Across	I-Application
Implicated	I-Application
Loci	I-Application
(	O
GRAIL	O
)	O
is	O
a	O
free	O
web	O
application	O
developed	O
by	O
Soumya	O
Raychaudhuri	O
at	O
the	O
Broad	O
Institute	O
with	O
the	O
goal	O
of	O
determining	O
the	O
relationships	O
among	O
genes	O
in	O
different	O
disease	O
associated	O
loci	O
through	O
statistical	O
analysis	O
.	O
</s>
<s>
When	O
single-nucleotide	O
polymorphisms	O
(	O
SNPs	O
)	O
are	O
identified	O
through	O
a	O
genome-wide	O
association	O
study	O
(	O
GWAS	O
)	O
as	O
being	O
possibly	O
linked	O
to	O
a	O
human	O
disease	O
,	O
GRAIL	O
works	O
by	O
comparing	O
those	O
with	O
SNPs	O
already	O
identified	O
in	O
the	O
scientific	O
literature	O
as	O
being	O
tied	O
to	O
the	O
disease	O
(	O
using	O
a	O
text-mining	B-Algorithm
algorithm	O
going	O
through	O
PubMed	B-Library
abstracts	O
)	O
,	O
and	O
determines	O
the	O
degree	O
of	O
functional	O
connectivity	O
among	O
the	O
associated	O
genes	O
.	O
</s>
