<s>
ESyPred3D	B-Application
is	O
an	O
automated	O
homology	O
modeling	O
program	O
.	O
</s>
<s>
The	O
final	O
three-dimensional	O
structure	O
is	O
built	O
using	O
the	O
modeling	O
package	O
MODELLER	B-Application
.	O
</s>
<s>
To	O
perform	O
homology	O
modeling	O
,	O
the	O
ESyPred3D	B-Application
program	O
first	O
searches	O
for	O
a	O
template	O
(	O
a	O
similar	O
sequence	O
of	O
known	O
structure	O
)	O
,	O
before	O
aligning	O
the	O
query	O
and	O
template	O
sequences	O
.	O
</s>
<s>
EsyPred3D	B-Application
then	O
build	O
the	O
3D	O
models	O
using	O
the	O
alignment	O
and	O
the	O
template	O
structure	O
,	O
before	O
assessing	O
the	O
final	O
3D	O
model	O
.	O
</s>
<s>
The	O
consensus	O
method	O
uses	O
a	O
neural	B-Architecture
network	I-Architecture
to	O
find	O
the	O
best	O
aligned	O
residues	O
and	O
analyzing	O
all	O
possible	O
combinations	O
using	O
a	O
dead	O
end	O
elimination	O
algorithm	O
.	O
</s>
<s>
The	O
final	O
3D	O
model	O
is	O
built	O
from	O
the	O
target-template	O
alignment	O
and	O
the	O
3D	O
structure	O
of	O
the	O
template	O
using	O
MODELLER	B-Application
.	O
</s>
<s>
MODELLER	B-Application
is	O
also	O
used	O
to	O
build	O
the	O
missing	O
loops	O
.	O
</s>
