<s>
The	O
commonly	O
used	O
dual-flashlight	B-Application
plot	I-Application
is	O
for	O
the	O
difference	O
between	O
two	O
groups	O
in	O
high-throughput	O
experiments	O
such	O
as	O
microarrays	O
and	O
high-throughput	O
screening	O
studies	O
,	O
in	O
which	O
we	O
plot	O
the	O
SSMD	B-General_Concept
versus	O
average	O
log	O
fold-change	O
on	O
the	O
y	O
-	O
and	O
x-axes	O
,	O
respectively	O
,	O
for	O
all	O
genes	O
or	O
compounds	O
(	O
such	O
as	O
siRNAs	O
or	O
small	O
molecules	O
)	O
investigated	O
in	O
an	O
experiment	O
.	O
</s>
<s>
As	O
a	O
whole	O
,	O
the	O
points	O
in	O
a	O
dual-flashlight	B-Application
plot	I-Application
look	O
like	O
the	O
beams	O
of	O
a	O
flashlight	O
with	O
two	O
heads	O
,	O
hence	O
the	O
name	O
dual-flashlight	B-Application
plot	I-Application
.	O
</s>
<s>
With	O
the	O
dual-flashlight	B-Application
plot	I-Application
,	O
we	O
can	O
see	O
how	O
the	O
genes	O
or	O
compounds	O
are	O
distributed	O
into	O
each	O
category	O
in	O
effect	B-Application
sizes	I-Application
,	O
as	O
shown	O
in	O
the	O
figure	O
.	O
</s>
<s>
The	O
dual-flashlight	B-Application
plot	I-Application
is	O
similar	O
to	O
the	O
volcano	B-Application
plot	I-Application
.	O
</s>
<s>
Hence	O
,	O
the	O
value	O
of	O
SMCV	B-General_Concept
is	O
comparable	O
whereas	O
the	O
value	O
of	O
p-value	B-General_Concept
or	O
q-value	O
is	O
not	O
comparable	O
in	O
experiments	O
with	O
different	O
sample	O
size	O
,	O
especially	O
when	O
many	O
investigated	O
genes	O
or	O
compounds	O
do	O
not	O
have	O
exactly	O
zero	O
effects	O
.	O
</s>
<s>
The	O
dual-flashlight	B-Application
plot	I-Application
bears	O
the	O
same	O
advantage	O
that	O
the	O
SMCV	B-General_Concept
has	O
,	O
as	O
compared	O
to	O
the	O
volcano	B-Application
plot	I-Application
.	O
</s>
