<s>
Dr.	B-Application
Mario	I-Application
Online	I-Application
Rx	I-Application
,	O
stylized	O
as	O
and	O
released	O
in	O
PAL	O
regions	O
as	O
Dr.	B-Application
Mario	I-Application
&	I-Application
Germ	I-Application
Buster	I-Application
,	O
is	O
a	O
puzzle	O
video	O
game	O
starring	O
Dr.	O
Mario	O
.	O
</s>
<s>
Dr.	B-Application
Mario	I-Application
Online	I-Application
Rx	I-Application
features	O
versions	O
of	O
the	O
Nintendo	B-Device
DS	I-Device
title	O
Brain	B-Application
Age	I-Application
2	I-Application
's	O
mini-games	O
called	O
Virus	O
Buster	O
and	O
Germ	O
Buster	O
,	O
which	O
uses	O
the	O
pointer	O
function	O
of	O
the	O
Wii	B-Device
Remote	I-Device
to	O
move	O
pills	O
,	O
and	O
allows	O
up	O
to	O
four	O
players	O
to	O
participate	O
cooperatively	O
.	O
</s>
<s>
The	O
title	O
supports	O
the	O
now	O
defunct	O
Nintendo	B-Application
Wi-Fi	I-Application
Connection	I-Application
service	O
,	O
which	O
allowed	O
players	O
to	O
compete	O
with	O
one	O
another	O
over	O
the	O
Internet	O
.	O
</s>
<s>
A	O
majority	O
of	O
features	O
from	O
previous	O
installments	O
,	O
such	O
as	O
the	O
virus	O
and	O
speed	O
levels	O
,	O
are	O
present	O
in	O
Dr.	B-Application
Mario	I-Application
Online	I-Application
Rx	I-Application
.	O
</s>
<s>
Players	O
played	O
online	O
against	O
another	O
with	O
only	O
one	O
copy	O
,	O
as	O
an	O
online-play	O
demo	O
could	O
be	O
sent	O
akin	O
to	O
DS	B-Device
Download	O
Play	O
.	O
</s>
<s>
Unlike	O
Dr.	B-Device
Mario	I-Device
64	I-Device
,	O
Online	O
Rx	O
lacks	O
the	O
ability	O
to	O
play	O
with	O
four	O
players	O
,	O
instead	O
only	O
allowing	O
up	O
to	O
2	O
players	O
in	O
Vs.	O
Mode	O
.	O
</s>
<s>
Several	O
features	O
in	O
this	O
game	O
previously	O
appeared	O
in	O
Dr.	B-Device
Mario	I-Device
64	I-Device
,	O
including	O
the	O
four	O
musical	O
tracks	O
:	O
"	O
Fever	O
"	O
,	O
"	O
Chill	O
"	O
,	O
"	O
Cube	O
"	O
,	O
and	O
"	O
Que	O
Que	O
"	O
(	O
the	O
latter	O
two	O
tracks	O
are	O
now	O
named	O
"	O
Cough	O
"	O
and	O
"	O
Sneeze	O
"	O
)	O
.	O
</s>
<s>
Flash	O
Mode	O
,	O
which	O
challenges	O
the	O
player(s )	O
to	O
clear	O
just	O
three	O
flashing	O
viruses	O
among	O
many	O
,	O
also	O
returns	O
from	O
Dr.	B-Device
Mario	I-Device
64	I-Device
.	O
</s>
<s>
Virus	O
Buster	O
,	O
previously	O
seen	O
as	O
a	O
mini-game	O
in	O
Brain	B-Application
Age	I-Application
2	I-Application
has	O
more	O
customization	O
than	O
the	O
original	O
.	O
</s>
<s>
Instead	O
of	O
being	O
controlled	O
directly	O
with	O
the	O
D-pad	B-Device
,	O
they	O
are	O
guided	O
with	O
the	O
Wii	B-Device
Remote	I-Device
pointer	O
.	O
</s>
<s>
IGN	O
gave	O
Dr.	B-Application
Mario	I-Application
Online	I-Application
Rx	I-Application
an	O
8.5/10	O
,	O
calling	O
the	O
main	O
game	O
"	O
timeless	O
"	O
and	O
the	O
new	O
Virus	O
Buster	O
mode	O
"	O
chaotically	O
awesome	O
"	O
.	O
</s>
<s>
In	O
contrast	O
,	O
GamesRadar	O
gave	O
it	O
6/10	O
,	O
calling	O
it	O
a	O
"	O
slightly	O
awkward	O
puzzler	O
"	O
that	O
"	O
just	O
is	O
n't	O
addictive	O
enough	O
to	O
make	O
you	O
care	O
"	O
and	O
likened	O
it	O
to	O
"	O
Puyo	B-Application
Puyo	I-Application
's	O
in-bred	O
cousin	O
"	O
.	O
</s>
