<s>
Discovering	B-Operating_System
Dengue	I-Operating_System
Drugs	I-Operating_System
–	I-Operating_System
Together	I-Operating_System
(	O
DDDT	O
)	O
was	O
a	O
World	B-Operating_System
Community	I-Operating_System
Grid	I-Operating_System
project	O
launched	O
in	O
2007	O
sponsored	O
by	O
scientists	O
at	O
the	O
University	O
of	O
Texas	O
Medical	O
Branch	O
at	O
Galveston	O
and	O
the	O
University	O
of	O
Chicago	O
.	O
</s>
<s>
Like	O
all	O
World	B-Operating_System
Community	I-Operating_System
Grid	I-Operating_System
projects	O
,	O
Discovering	B-Operating_System
Dengue	I-Operating_System
Drugs	I-Operating_System
–	I-Operating_System
Together	I-Operating_System
used	O
a	O
computational	B-Architecture
grid	I-Architecture
made	O
up	O
of	O
thousands	O
of	O
client	B-Protocol
computers	I-Protocol
belonging	O
to	O
independent	O
volunteers	B-Operating_System
,	O
in	O
conjunction	O
with	O
servers	O
that	O
distribute	O
portions	O
of	O
the	O
work	O
to	O
the	O
clients	O
.	O
</s>
<s>
The	O
first	O
phase	O
of	O
the	O
project	O
launched	O
on	O
August	O
21	O
,	O
2007	O
and	O
used	O
AutoDock	B-Application
2007	O
(	O
the	O
same	O
software	O
used	O
for	O
FightAIDS	B-Operating_System
@Home	I-Operating_System
)	O
to	O
test	O
how	O
well	O
antiviral	O
drug	O
candidates	O
are	O
predicted	O
to	O
bind	O
to	O
the	O
target	O
virus	O
's	O
proteases	O
.	O
</s>
<s>
Processing	O
resumed	O
in	O
January	O
2009	O
,	O
with	O
the	O
server	B-Application
function	O
transferred	O
from	O
the	O
University	O
of	O
Texas	O
Medical	O
Branch	O
in	O
Galveston	O
to	O
the	O
Texas	O
Advanced	O
Computing	O
Center	O
in	O
Austin	O
.	O
</s>
<s>
The	O
second	O
phase	O
of	O
the	O
project	O
was	O
designed	O
to	O
reduce	O
the	O
number	O
of	O
false	O
positive	O
predictions	O
made	O
during	O
Phase	O
1	O
,	O
using	O
the	O
CHARMM	B-Application
software	O
package	O
to	O
predict	O
how	O
tightly	O
small	O
drug-like	O
molecules	O
bind	O
to	O
the	O
different	O
flavivirus	O
proteases	O
.	O
</s>
