<s>
A	O
digital	B-Application
pill	I-Application
(	O
also	O
known	O
as	O
smart	O
pill	O
,	O
ingestible	O
sensor	O
)	O
is	O
a	O
pharmaceutical	O
dosage	O
form	O
that	O
contains	O
an	O
ingestible	O
sensor	O
inside	O
of	O
a	O
pill	O
.	O
</s>
<s>
The	O
first	O
digital	B-Application
pill	I-Application
to	O
be	O
approved	O
by	O
the	O
United	O
States	O
Food	O
and	O
Drug	O
Administration	O
(	O
FDA	O
)	O
,	O
a	O
version	O
of	O
aripiprazole	O
(	O
Abilify	O
)	O
manufactured	O
by	O
Otsuka	O
Pharmaceutical	O
,	O
was	O
approved	O
in	O
November	O
2017	O
.	O
</s>
<s>
This	O
digital	B-Application
pill	I-Application
's	O
sensor	O
,	O
developed	O
by	O
Proteus	O
Digital	O
Health	O
,	O
is	O
activated	O
by	O
acid	O
in	O
the	O
stomach	O
,	O
and	O
generates	O
an	O
electrical	O
signal	O
that	O
is	O
picked	O
up	O
by	O
a	O
patch	O
worn	O
on	O
the	O
ribcage	O
;	O
the	O
patch	O
in	O
turn	O
forwards	O
information	O
to	O
a	O
smartphone	B-Application
app	I-Application
.	O
</s>
<s>
The	O
drug	O
is	O
taken	O
by	O
people	O
with	O
schizophrenia	B-Application
.	O
</s>
<s>
People	O
with	O
the	O
condition	O
tend	O
to	O
have	O
problems	O
with	O
adherence	O
,	O
and	O
the	O
digital	B-Application
pill	I-Application
could	O
help	O
with	O
that	O
;	O
however	O
,	O
some	O
people	O
with	O
schizophrenia	B-Application
have	O
paranoia	B-Application
which	O
the	O
digital	B-Application
pill	I-Application
could	O
make	O
worse	O
.	O
</s>
<s>
A	O
video	O
from	O
the	O
Wall	O
Street	O
Journal	O
that	O
shows	O
an	O
overview	O
of	O
how	O
digital	B-Application
pills	I-Application
work	O
can	O
be	O
found	O
.	O
</s>
<s>
These	O
devices	O
are	O
powered	O
by	O
batteries	O
,	O
can	O
transmit	O
video	O
at	O
up	O
to	O
2.7	O
Mbit/s	O
,	O
and	O
are	O
less	O
invasive	O
than	O
other	O
traditional	O
endoscopic	B-Application
imaging	O
devices	O
.	O
</s>
<s>
Digital	B-Application
pills	I-Application
that	O
have	O
imaging	O
capabilities	O
are	O
used	O
in	O
endoscopy	B-Application
to	O
look	O
for	O
inflammation	O
and	O
lacerations	O
in	O
the	O
esophagus	O
.	O
</s>
<s>
The	O
pH	O
value	O
of	O
the	O
stomach	O
is	O
important	O
for	O
proper	O
digestion	O
and	O
is	O
something	O
that	O
can	O
be	O
detected	O
by	O
certain	O
types	O
of	O
digital	B-Application
pills	I-Application
.	O
</s>
<s>
Stomach	O
enzymes	O
and	O
electrolyte	O
production	O
are	O
also	O
able	O
to	O
be	O
detected	O
by	O
a	O
digital	B-Application
pill	I-Application
.	O
</s>
<s>
For	O
example	O
,	O
digital	B-Application
pills	I-Application
can	O
be	O
programmed	O
to	O
search	O
for	O
helicobacter	O
pylori	O
in	O
the	O
stomach	O
,	O
which	O
is	O
known	O
to	O
be	O
a	O
cause	O
of	O
ulcers	O
.	O
</s>
<s>
Most	O
digital	B-Application
pills	I-Application
use	O
silver-oxide	O
batteries	O
.	O
</s>
<s>
Most	O
digital	B-Application
pills	I-Application
rely	O
on	O
passive	O
locomotion	O
,	O
or	O
allowing	O
the	O
body	O
's	O
digestive	O
system	O
to	O
do	O
all	O
the	O
work	O
moving	O
the	O
pill	O
,	O
however	O
some	O
pills	O
do	O
utilise	O
active	O
locomotion	O
.	O
</s>
<s>
One	O
active	O
locomotion	O
method	O
is	O
to	O
include	O
a	O
small	O
magnet	O
in	O
the	O
digital	B-Application
pill	I-Application
that	O
can	O
then	O
be	O
activated	O
by	O
an	O
external	O
magnetic	O
field	O
,	O
which	O
can	O
then	O
move	O
the	O
pill	O
from	O
outside	O
the	O
body	O
.	O
</s>
<s>
It	O
is	O
possible	O
that	O
the	O
digital	B-Application
pill	I-Application
and	O
pacemakers	O
may	O
interfere	O
with	O
each	O
other	O
,	O
however	O
,	O
this	O
has	O
not	O
been	O
verified	O
.	O
</s>
