<s>
DelPhi	B-Application
is	O
a	O
scientific	O
application	O
which	O
calculates	O
electrostatic	O
potentials	O
in	O
and	O
around	O
macromolecules	O
and	O
the	O
corresponding	O
electrostatic	O
energies	O
.	O
</s>
<s>
It	O
incorporates	O
the	O
effects	O
of	O
ionic	O
strength	O
mediated	O
screening	O
by	O
evaluating	O
the	O
Poisson-Boltzmann	B-Algorithm
equation	I-Algorithm
at	O
a	O
finite	O
number	O
of	O
points	O
within	O
a	O
three-dimensional	O
grid	O
box	O
.	O
</s>
<s>
DelPhi	B-Application
is	O
commonly	O
used	O
in	O
protein	O
science	O
to	O
visualize	O
variations	O
in	O
electrostatics	O
along	O
a	O
protein	O
or	O
other	O
macromolecular	O
surface	O
and	O
to	O
calculate	O
the	O
electrostatic	O
components	O
of	O
various	O
energies	O
.	O
</s>
<s>
Analytical	O
solutions	O
of	O
the	O
corresponding	O
Poisson-Boltzmann	B-Algorithm
Equation	I-Algorithm
(	O
PBE	O
)	O
are	O
not	O
available	O
for	O
such	O
cases	O
and	O
the	O
distribution	O
of	O
the	O
potential	O
can	O
be	O
found	O
only	O
numerically	O
.	O
</s>
<s>
DelPhi	B-Application
,	O
developed	O
in	O
Professor	O
Barry	O
Honig	O
's	O
lab	O
in	O
1986	O
,	O
was	O
the	O
first	O
PBE	O
solver	O
used	O
by	O
many	O
researchers	O
.	O
</s>
<s>
The	O
widespread	O
popularity	O
of	O
DelPhi	B-Application
is	O
due	O
to	O
its	O
speed	O
,	O
accuracy	O
(	O
calculation	O
of	O
the	O
electrostatic	O
free	O
energy	O
is	O
only	O
slightly	O
dependent	O
on	O
the	O
resolution	O
of	O
the	O
grid	O
)	O
and	O
the	O
ability	O
to	O
handle	O
extremely	O
high	O
grid	O
dimensions	O
.	O
</s>
<s>
In	O
addition	O
to	O
the	O
typical	O
potential	O
map	O
,	O
DelPhi	B-Application
can	O
generate	O
and	O
output	O
the	O
calculated	O
distribution	O
of	O
either	O
the	O
dielectric	O
constant	O
or	O
ion	O
concentration	O
,	O
providing	O
the	O
biomedical	O
community	O
with	O
extra	O
tools	O
for	O
their	O
research	O
.	O
</s>
<s>
Pdb	O
files	O
are	O
typically	O
used	O
as	O
input	O
for	O
DelPhi	B-Application
calculations	O
.	O
</s>
<s>
Binary	O
Potential	O
files	O
as	O
output	O
from	O
DelPhi	B-Application
can	O
be	O
viewed	O
in	O
most	O
molecular	O
viewers	O
such	O
as	O
UCSF	B-Application
Chimera	I-Application
,	O
Jmol	B-Language
,	O
and	O
VMD	B-Application
,	O
and	O
can	O
either	O
be	O
mapped	O
onto	O
surfaces	O
or	O
visualized	O
at	O
a	O
fixed	O
cutoff	O
.	O
</s>
<s>
Delphi	B-Application
distribution	O
comes	O
as	O
a	O
sequential	O
as	O
well	O
as	O
parallelized	O
codes	O
,	O
runs	O
on	O
Linux	B-Application
,	O
Mac	B-Operating_System
OS	I-Operating_System
X	I-Operating_System
and	O
Microsoft	B-Application
Windows	I-Application
systems	O
and	O
the	O
source	O
code	O
is	O
available	O
in	O
Fortran	O
95	O
and	O
C++	B-Language
programming	I-Language
languages	I-Language
.	O
</s>
<s>
DELPHI	B-Application
is	O
also	O
implemented	O
into	O
an	O
accessible	O
web-server	O
.	O
</s>
<s>
DELPHI	B-Application
has	O
also	O
been	O
utilized	O
to	O
build	O
a	O
server	O
that	O
predicts	O
pKa	O
's	O
of	O
biological	O
macromolecules	O
such	O
as	O
proteins	O
,	O
RNAs	O
and	O
DNAs	O
which	O
can	O
be	O
accessed	O
via	O
web	O
.	O
</s>
<s>
DelPhi	B-Application
v.7	O
is	O
distributed	O
in	O
four	O
versions	O
:	O
</s>
<s>
LINUX	B-Application
version	O
,	O
compiled	O
under	O
Red	O
Hat	O
7.1	O
,	O
kernel	O
2.4.2	O
Operating	O
System	O
,	O
using	O
GNU	O
gfortran	O
compilers	O
,	O
</s>
<s>
PC	O
version	O
,	O
compiled	O
under	O
Windows	B-Application
Operating	I-Application
System	I-Application
,	O
using	O
Microsoft	O
Developer	O
Studio	O
C++	B-Language
and	O
Fortran	O
compilers	O
.	O
</s>
<s>
Each	O
distribution	O
contains	O
one	O
executable	O
(	O
named	O
delphi	B-Application
or	O
delphi.exe	O
)	O
,	O
the	O
source	O
codes	O
(	O
with	O
corresponding	O
makefile	O
when	O
needed	O
)	O
,	O
and	O
some	O
worked	O
examples	O
.	O
</s>
