<s>
The	O
program	O
UCSF	O
DOCK	B-Application
was	O
created	O
in	O
the	O
1980s	O
by	O
Irwin	O
"	O
Tack	O
"	O
Kuntz	O
's	O
Group	O
,	O
and	O
was	O
the	O
first	O
docking	O
program	O
.	O
</s>
<s>
DOCK	B-Application
uses	O
geometric	O
algorithms	O
to	O
predict	O
the	O
binding	O
modes	O
of	O
small	O
molecules	O
.	O
</s>
<s>
Case	O
,	O
and	O
Robert	O
C.Rizzo	O
are	O
codevelopers	O
of	O
DOCK	B-Application
.	O
</s>
<s>
Two	O
versions	O
of	O
the	O
docking	O
program	O
are	O
actively	O
developed	O
:	O
DOCK	B-Application
6	O
and	O
DOCK	B-Application
3	O
.	O
</s>
<s>
Ligand	O
sampling	O
methods	O
used	O
by	O
the	O
program	O
DOCK	B-Application
include	O
.	O
</s>
<s>
A	O
molecular	O
dynamics	O
engine	O
was	O
implemented	O
into	O
DOCK	B-Application
v6	O
by	O
David	O
A	O
.	O
</s>
<s>
Case	O
's	O
Group	O
in	O
the	O
scoring	O
function	O
AMBER	B-Device
score	O
.	O
</s>
