<s>
In	O
statistics	O
,	O
the	O
closed	B-General_Concept
testing	I-General_Concept
procedure	I-General_Concept
is	O
a	O
general	O
method	O
for	O
performing	O
more	O
than	O
one	O
hypothesis	O
test	O
simultaneously	O
.	O
</s>
<s>
The	O
closed	B-General_Concept
testing	I-General_Concept
principle	I-General_Concept
allows	O
the	O
rejection	O
of	O
any	O
one	O
of	O
these	O
elementary	O
hypotheses	O
,	O
say	O
Hi	O
,	O
if	O
all	O
possible	O
intersection	O
hypotheses	O
involving	O
Hi	O
can	O
be	O
rejected	O
by	O
using	O
valid	O
local	O
level	O
α	O
tests	O
;	O
the	O
adjusted	O
p-value	O
is	O
the	O
largest	O
among	O
those	O
hypotheses	O
.	O
</s>
<s>
The	O
Holm	B-General_Concept
–	I-General_Concept
Bonferroni	I-General_Concept
method	I-General_Concept
is	O
a	O
special	O
case	O
of	O
a	O
closed	B-General_Concept
test	I-General_Concept
procedure	I-General_Concept
for	O
which	O
each	O
intersection	O
null	O
hypothesis	O
is	O
tested	O
using	O
the	O
simple	O
Bonferroni	B-General_Concept
test	I-General_Concept
.	O
</s>
<s>
Multiple	O
test	O
procedures	O
developed	O
using	O
the	O
graphical	O
approach	O
for	O
constructing	O
and	O
illustrating	O
multiple	O
test	O
procedures	O
are	O
a	O
subclass	O
of	O
closed	B-General_Concept
testing	I-General_Concept
procedures	I-General_Concept
.	O
</s>
