<s>
Chronux	B-Application
is	O
an	O
open-source	O
software	O
package	O
developed	O
for	O
the	O
loading	O
,	O
visualization	O
and	O
analysis	O
of	O
a	O
variety	O
of	O
modalities	O
/	O
formats	O
of	O
neurobiological	O
time	O
series	O
data	O
.	O
</s>
<s>
Usage	O
of	O
this	O
tool	O
enables	O
neuroscientists	O
to	O
perform	O
a	O
variety	O
of	O
analysis	O
on	O
multichannel	O
electrophysiological	O
data	O
such	O
as	O
LFP	O
(	O
local	O
field	O
potentials	O
)	O
,	O
EEG	B-Application
,	O
MEG	O
,	O
Neuronal	O
spike	O
times	O
and	O
also	O
on	O
spatiotemporal	O
data	O
such	O
as	O
FMRI	B-Algorithm
and	O
dynamic	O
optical	O
imaging	O
data	O
.	O
</s>
<s>
The	O
software	O
consists	O
of	O
a	O
set	O
of	O
MATLAB	B-Language
routines	O
interfaced	O
with	O
C	O
libraries	O
that	O
can	O
be	O
used	O
to	O
perform	O
the	O
tasks	O
that	O
constitute	O
a	O
typical	O
study	O
of	O
neurobiological	O
data	O
.	O
</s>
<s>
These	O
include	O
local	O
regression	O
and	O
smoothing	B-Application
,	O
spike	O
sorting	O
and	O
spectral	O
analysis	O
-	O
including	O
multitaper	O
spectral	O
analysis	O
,	O
a	O
powerful	O
nonparametric	B-General_Concept
method	O
to	O
estimate	O
power	O
spectrum	O
.	O
</s>
<s>
Chronux	B-Application
is	O
GNU	O
GPL	O
v2	O
licensed	O
(	O
and	O
MATLAB	B-Language
is	O
proprietary	O
)	O
.	O
</s>
<s>
The	O
most	O
recent	O
version	O
of	O
Chronux	B-Application
is	O
version	O
2.12	O
.	O
</s>
<s>
The	O
popularity	O
of	O
these	O
pedagogical	O
efforts	O
and	O
the	O
need	O
for	O
wider	O
dissemination	O
of	O
sophisticated	O
time-series	O
analysis	O
tools	O
in	O
the	O
wider	O
neuroscience	O
community	O
led	O
the	O
Mitra	O
Lab	O
at	O
Cold	O
Spring	O
Harbor	O
Laboratory	O
to	O
initiate	O
an	O
NIH	O
funded	O
effort	O
to	O
develop	O
software	O
tools	O
for	O
neural	O
data	O
analysis	O
in	O
the	O
form	O
of	O
the	O
Chronux	B-Application
package	O
.	O
</s>
<s>
Chronux	B-Application
welcome	O
contributions	O
from	O
interested	O
individuals	O
.	O
</s>
<s>
Chronux	B-Application
is	O
organized	O
into	O
a	O
number	O
of	O
distinct	O
toolboxes	O
.	O
</s>
<s>
In	O
addition	O
,	O
a	O
number	O
of	O
domain-specific	O
GUIs	O
are	O
part	O
of	O
the	O
Chronux	B-Application
package	O
and	O
more	O
are	O
envisaged	O
.	O
</s>
<s>
Much	O
of	O
Chronux	B-Application
is	O
written	O
in	O
MATLAB	B-Language
with	O
certain	O
intensive	O
computations	O
being	O
coded	O
in	O
C	O
with	O
a	O
MEX	O
interface	O
to	O
MATLAB	B-Language
.	O
</s>
<s>
Chronux	B-Application
provides	O
robust	O
estimates	O
of	O
the	O
confidence	O
intervals	O
on	O
computed	O
quantities	O
.	O
</s>
<s>
The	O
GUI	O
can	O
be	O
invoked	O
from	O
the	O
MATLAB	B-Language
prompt	O
by	O
typing	O
ndb	O
–	O
short	O
for	O
the	O
Neuro	O
Data	O
Browser	O
(	O
NDB	O
)	O
–	O
which	O
provides	O
a	O
standard	O
user	O
interface	O
for	O
loading	O
,	O
visualizing	O
and	O
analyzing	O
neurobiological	O
time	O
series	O
data	O
.	O
</s>
<s>
The	O
data	O
can	O
be	O
in	O
different	O
formats	O
such	O
as	O
EEG	B-Application
,	O
MEG	O
,	O
FMRI	B-Algorithm
etc	O
.	O
</s>
<s>
At	O
a	O
basic	O
level	O
,	O
the	O
GUI	O
enables	O
users	O
,	O
to	O
load	O
data	O
,	O
analyze	O
them	O
and	O
visualize	O
the	O
results	O
within	O
the	O
Browser	O
framework	O
without	O
a	O
need	O
to	O
write	O
separate	O
MATLAB	B-Language
codes	O
.	O
</s>
<s>
For	O
advanced	O
users	O
,	O
it	O
also	O
provides	O
a	O
command	B-Application
line	I-Application
interface	I-Application
,	O
so	O
that	O
data	O
can	O
be	O
directly	O
loaded	O
and	O
visualized	O
for	O
analysis	O
.	O
</s>
<s>
The	O
usage	O
of	O
XML	B-Protocol
based	O
plugin-architecture	O
allows	O
for	O
extending	O
support	O
to	O
other	O
modalities	O
and	O
formats	O
and	O
also	O
serves	O
to	O
integrate	O
any	O
other	O
MATLAB	B-Language
toolbox	O
with	O
minimal	O
changes	O
in	O
the	O
plugin	B-Application
XML	B-Protocol
.	O
</s>
<s>
The	O
M2HTML	O
documentation	O
is	O
an	O
archive	O
of	O
online	O
help	O
for	O
all	O
MATLAB	B-Language
routines	O
incorporated	O
in	O
Chronux	B-Application
.	O
</s>
