<s>
CellCognition	B-Algorithm
is	O
a	O
free	O
open-source	B-Application
computational	O
framework	O
for	O
quantitative	O
analysis	O
of	O
high-throughput	O
fluorescence	O
microscopy	O
(	O
time-lapse	O
)	O
images	O
in	O
the	O
field	O
of	O
bioimage	O
informatics	O
and	O
systems	O
microscopy	O
.	O
</s>
<s>
The	O
CellCognition	B-Algorithm
framework	O
uses	O
image	B-Algorithm
processing	I-Algorithm
,	O
computer	B-Application
vision	I-Application
and	O
machine	O
learning	O
techniques	O
for	O
single-cell	O
tracking	B-Operating_System
and	O
classification	O
of	O
cell	O
morphologies	O
.	O
</s>
<s>
CellCognition	B-Algorithm
uses	O
a	O
computational	O
pipeline	O
which	O
includes	O
image	B-Algorithm
segmentation	I-Algorithm
,	O
object	B-General_Concept
detection	I-General_Concept
,	O
feature	B-Algorithm
extraction	I-Algorithm
,	O
statistical	B-General_Concept
classification	I-General_Concept
,	O
tracking	B-Operating_System
of	O
individual	O
cells	O
over	O
time	O
,	O
detection	O
of	O
class-transition	O
motifs	O
(	O
e.g.	O
</s>
<s>
The	O
software	O
is	O
written	O
in	O
Python	B-Language
2.7	O
and	O
binaries	O
are	O
available	O
for	O
Windows	O
and	O
Mac	O
OS	O
X	O
.	O
</s>
<s>
CellCognition	B-Algorithm
(	O
Version	O
1.0.1	O
)	O
was	O
first	O
released	O
in	O
December	O
2009	O
by	O
scientists	O
from	O
the	O
Gerlich	O
Lab	O
and	O
the	O
Buhmann	O
group	O
at	O
the	O
Swiss	O
Federal	O
Institute	O
of	O
Technology	O
Zürich	O
and	O
the	O
Ellenberg	O
Lab	O
at	O
the	O
European	O
Molecular	O
Biology	O
Laboratory	O
Heidelberg	O
.	O
</s>
<s>
CellCognition	B-Algorithm
has	O
been	O
used	O
in	O
RNAi-based	O
screening	O
,	O
applied	O
in	O
basic	O
cell	O
cycle	O
study	O
,	O
and	O
extended	O
to	O
unsupervised	O
modeling	O
.	O
</s>
