<s>
BioNumerics	B-Application
is	O
a	O
bioinformatics	O
desktop	O
software	O
application	O
that	O
manages	O
microbiological	O
data	O
.	O
</s>
<s>
BioNumerics	B-Application
was	O
first	O
released	O
in	O
1998	O
.	O
</s>
<s>
PulseNet	O
,	O
a	O
network	O
run	O
by	O
the	O
Centers	O
for	O
Disease	O
Control	O
and	O
Prevention	O
(	O
CDC	O
)	O
,	O
uses	O
BioNumerics	B-Application
to	O
compare	O
pulsed	O
field	O
gel	O
electrophoresis	O
(	O
PFGE	O
)	O
patterns	O
and	O
whole	O
genome	O
sequences	O
from	O
different	O
bacterial	O
strains	O
.	O
</s>
<s>
CaliciNet	O
,	O
an	O
outbreak	O
surveillance	O
network	O
for	O
noroviruses	O
,	O
is	O
another	O
example	O
of	O
a	O
network	O
which	O
uses	O
BioNumerics	B-Application
to	O
submit	O
norovirus	O
sequences	O
and	O
basic	O
epidemiologic	O
information	O
to	O
a	O
central	O
database	O
.	O
</s>
<s>
The	O
basis	O
of	O
BioNumerics	B-Application
is	O
a	O
database	O
consisting	O
of	O
entries	O
.	O
</s>
<s>
In	O
BioNumerics	B-Application
,	O
experiments	O
are	O
divided	O
in	O
seven	O
classes	O
:	O
fingerprints	O
,	O
spectra	O
,	O
characters	O
,	O
sequences	O
,	O
sequence	O
read	O
sets	O
,	O
trend	O
data	O
and	O
matrices	O
.	O
</s>
<s>
Examples	O
of	O
BioNumerics	B-Application
applications	O
are	O
whole	O
genome	O
Multi	O
Locus	O
Sequence	O
Typing	O
(	O
wgMLST	O
)	O
,	O
whole	O
genome	O
Single	O
Nucleotide	O
Polymorphisms	O
(	O
wgSNP	O
)	O
,	O
genome	O
comparison	O
,	O
identification	O
based	O
on	O
MALDI-TOF	O
Mass	O
Spectrometry	O
,	O
PFGE	O
typing	O
,	O
Amplified	O
Fragment	O
Length	O
Polymorphism	O
(	O
AFLP	O
)	O
typing	O
,	O
sequence-based	O
typing	O
of	O
viruses	O
,	O
antibiotic	O
resistance	O
profiling	O
and	O
functional	O
genotyping	O
.	O
</s>
