<s>
The	O
BioCompute	B-Application
Object	I-Application
(	O
BCO	O
)	O
Project	O
is	O
a	O
community-driven	O
initiative	O
to	O
build	O
a	O
framework	O
for	O
standardizing	O
and	O
sharing	O
computations	O
and	O
analyses	O
generated	O
from	O
High-throughput	O
sequencing	O
(	O
HTS	O
--	O
also	O
referred	O
to	O
as	O
next-generation	O
sequencing	O
or	O
massively	O
parallel	O
sequencing	O
)	O
.	O
</s>
<s>
Bioinformatic	O
pipelines	B-Operating_System
typically	O
use	O
multiple	O
pieces	O
of	O
software	O
,	O
each	O
of	O
which	O
typically	O
has	O
multiple	O
versions	O
available	O
,	O
multiple	O
input	O
parameters	O
,	O
multiple	O
outputs	O
,	O
and	O
possibly	O
platform-specific	O
configurations	O
.	O
</s>
<s>
The	O
BioCompute	O
Framework	O
provides	O
an	O
object	B-Application
oriented	I-Application
design	I-Application
from	O
which	O
a	O
BCO	O
that	O
contains	O
details	O
of	O
a	O
pipeline	B-Operating_System
and	O
how	O
it	O
was	O
used	O
can	O
be	O
constructed	O
,	O
digitally	O
signed	O
,	O
and	O
shared	O
.	O
</s>
<s>
As	O
a	O
standardization	O
for	O
genomic	O
data	O
,	O
BioCompute	B-Application
Objects	I-Application
are	O
mostly	O
useful	O
to	O
three	O
groups	O
of	O
users	O
:	O
1	O
)	O
academic	O
researchers	O
carrying	O
out	O
new	O
genetic	O
experiments	O
,	O
2	O
)	O
pharma/biotech	O
companies	O
that	O
wish	O
to	O
submit	O
work	O
to	O
the	O
FDA	O
for	O
regulatory	O
review	O
,	O
and	O
3	O
)	O
clinical	O
settings	O
(	O
hospitals	O
and	O
labs	O
)	O
that	O
offer	O
genetic	O
tests	O
and	O
personalized	O
medicine	O
.	O
</s>
<s>
The	O
BioCompute	B-Application
Object	I-Application
is	O
in	O
json	B-General_Concept
format	O
and	O
,	O
at	O
a	O
minimum	O
,	O
contains	O
all	O
the	O
software	O
versions	O
and	O
parameters	O
necessary	O
to	O
evaluate	O
or	O
verify	O
a	O
computational	O
pipeline	B-Operating_System
.	O
</s>
<s>
A	O
BioCompute	B-Application
Object	I-Application
can	O
be	O
integrated	O
with	O
HL7	O
FHIR	O
as	O
a	O
Provenance	O
Resource	O
.	O
</s>
<s>
The	O
BioCompute	B-Application
Object	I-Application
working	O
group	O
facilitates	O
a	O
means	O
for	O
different	O
stakeholders	O
to	O
provide	O
input	O
on	O
current	O
practices	O
on	O
the	O
BCO	O
.	O
</s>
<s>
The	O
simple	O
R	O
package	O
biocompute	O
can	O
create	O
,	O
validate	O
,	O
and	O
export	O
BioCompute	B-Application
Objects	I-Application
.	O
</s>
<s>
There	O
are	O
several	O
internally	O
developed	O
open	B-Application
source	I-Application
software	I-Application
packages	O
and	O
web	O
applications	O
that	O
implement	O
the	O
BioCompute	O
specification	O
,	O
three	O
of	O
which	O
have	O
been	O
deployed	O
in	O
a	O
publicly	O
accessible	O
AWS	O
EC2	O
cloud	O
.	O
</s>
<s>
These	O
include	O
an	O
instance	O
of	O
the	O
High-performance	B-Application
Integrated	I-Application
Virtual	I-Application
Environment	I-Application
,	O
the	O
(	O
a	O
form-based	O
web	O
application	O
that	O
can	O
create	O
and	O
edit	O
BioCompute	B-Application
Objects	I-Application
based	O
on	O
the	O
IEEE-2791-2020	O
standard	O
,	O
and	O
a	O
BioCompute	O
compliant	O
instance	O
of	O
Galaxy	O
.	O
</s>
