<s>
Big	B-Application
Pharma	I-Application
is	O
a	O
simulation	O
game	O
developed	O
by	O
Twice	B-Application
Circled	I-Application
and	O
published	O
by	O
Positech	O
Games	O
where	O
the	O
player	O
builds	O
a	O
drug	O
factory	O
.	O
</s>
<s>
In	O
Big	B-Application
Pharma	I-Application
the	O
player	O
takes	O
the	O
role	O
as	O
the	O
manager	O
of	O
a	O
pharmaceutical	O
company	O
,	O
producing	O
medication	O
from	O
raw	O
materials	O
.	O
</s>
<s>
Most	O
of	O
the	O
positive	O
benefits	O
can	O
be	O
enhanced	O
to	O
more	O
desirable	O
effects	O
,	O
or	O
negative	O
side	O
effects	O
can	O
be	O
outright	O
removed	O
,	O
by	O
bringing	O
the	O
material	O
to	O
a	O
specific	O
concentration	O
range	O
and	O
applying	O
an	O
indicated	O
process	O
,	O
some	O
further	O
requiring	O
the	O
addition	O
of	O
a	O
catalyst	B-Device
material	O
which	O
itself	O
carries	O
positive	O
and	O
negative	O
effects	O
.	O
</s>
<s>
This	O
is	O
done	O
on	O
an	O
isometric	B-Application
view	O
of	O
building	O
plant	O
floorplan	O
,	O
with	O
various	O
ports	O
along	O
the	O
edges	O
that	O
can	O
be	O
used	O
to	O
bring	O
in	O
materials	O
or	O
ship	O
out	O
completed	O
drugs	O
.	O
</s>
<s>
Big	B-Application
Pharma	I-Application
has	O
a	O
score	O
of	O
72%	O
on	O
Metacritic	O
,	O
and	O
scored	O
an	O
8/10	O
from	O
IGN	O
Spain	O
.	O
</s>
