<s>
Biochemical	B-Application
and	I-Application
Organic	I-Application
Simulation	I-Application
System	I-Application
(	O
BOSS	O
)	O
is	O
a	O
general-purpose	O
molecular	O
modeling	O
program	O
that	O
performs	O
molecular	O
mechanics	O
calculations	O
,	O
Metropolis	B-Algorithm
Monte	I-Algorithm
Carlo	I-Algorithm
statistical	O
mechanics	O
simulations	O
,	O
and	O
semiempirical	O
Austin	O
Model	O
1	O
(	O
AM1	O
)	O
,	O
PM3	O
,	O
and	O
PDDG/PM3	O
quantum	O
mechanics	O
calculations	O
.	O
</s>
<s>
The	O
molecular	O
mechanics	O
calculations	O
cover	O
energy	O
minimizations	O
,	O
normal	O
mode	O
analysis	O
and	O
conformational	O
searching	O
with	O
the	O
Optimized	O
Potentials	O
for	O
Liquid	O
Simulations	O
(	O
OPLS	B-Algorithm
)	O
force	O
fields	O
.	O
</s>
