<s>
Angle-resolved	B-Algorithm
low-coherence	I-Algorithm
interferometry	I-Algorithm
(	O
a/LCI	O
)	O
is	O
an	O
emerging	O
biomedical	B-Application
imaging	I-Application
technology	O
which	O
uses	O
the	O
properties	O
of	O
scattered	O
light	O
to	O
measure	O
the	O
average	O
size	O
of	O
cell	O
structures	O
,	O
including	O
cell	O
nuclei	O
.	O
</s>
<s>
A/LCI	O
combines	O
low-coherence	O
interferometry	O
with	O
angle-resolved	O
scattering	O
to	O
solve	O
the	O
inverse	O
problem	O
of	O
determining	O
scatterer	O
geometry	O
based	O
on	O
far	B-Algorithm
field	I-Algorithm
diffraction	O
patterns	O
.	O
</s>
<s>
Similar	O
to	O
optical	O
coherence	O
domain	O
reflectometry	O
(	O
OCDR	O
)	O
and	O
optical	B-Application
coherence	I-Application
tomography	I-Application
(	O
OCT	O
)	O
,	O
a/LCI	O
uses	O
a	O
broadband	B-General_Concept
light	O
source	O
in	O
an	O
interferometry	O
scheme	O
in	O
order	O
to	O
achieve	O
optical	O
sectioning	O
with	O
a	O
depth	O
resolution	O
set	O
by	O
the	O
coherence	O
length	O
of	O
the	O
source	O
.	O
</s>
<s>
Angle-resolved	O
scattering	O
measurements	O
capture	O
light	O
as	O
a	O
function	O
of	O
the	O
scattering	O
angle	O
,	O
and	O
invert	O
the	O
angles	O
to	O
deduce	O
the	O
average	O
size	O
of	O
the	O
scattering	O
objects	O
via	O
a	O
computational	B-Algorithm
light	I-Algorithm
scattering	I-Algorithm
model	I-Algorithm
such	O
as	O
Mie	O
theory	O
,	O
which	O
predicts	O
angles	O
based	O
on	O
the	O
size	O
of	O
the	O
scattering	O
sphere	O
.	O
</s>
<s>
A	O
broadband	B-General_Concept
light	O
source	O
is	O
used	O
to	O
produce	O
a	O
spectrum	O
of	O
wavelengths	O
at	O
once	O
,	O
and	O
the	O
backscattered	O
light	O
is	O
collected	O
by	O
a	O
coherent	O
optical	B-Architecture
fiber	I-Architecture
in	O
the	O
return	O
path	O
to	O
capture	O
different	O
scattering	O
angles	O
simultaneously	O
.	O
</s>
<s>
Data	O
from	O
the	O
imaging	O
spectrometer	O
are	O
transferred	O
to	O
a	O
computer	O
via	O
universal	B-Protocol
serial	I-Protocol
bus	I-Protocol
interface	O
for	O
signal	O
processing	O
and	O
display	O
of	O
results	O
.	O
</s>
<s>
The	O
portable	O
system	O
uses	O
a	O
2ft	O
by	O
2ft	O
optical	O
breadboard	O
as	O
the	O
base	O
,	O
with	O
the	O
source	O
,	O
fiber	B-Architecture
optic	I-Architecture
components	O
,	O
lens	O
,	O
beamsplitter	O
,	O
and	O
imaging	O
spectrometer	O
mounted	O
to	O
the	O
breadboard	O
.	O
</s>
<s>
An	O
aluminum	O
cover	O
protects	O
the	O
optics	B-Algorithm
.	O
</s>
