<s>
Amyloid-related	B-Algorithm
imaging	I-Algorithm
abnormalities	I-Algorithm
(	O
ARIA	O
)	O
are	O
abnormal	O
differences	O
seen	O
in	O
magnetic	B-Algorithm
resonance	I-Algorithm
imaging	I-Algorithm
of	I-Algorithm
the	I-Algorithm
brain	I-Algorithm
in	O
patients	O
with	O
Alzheimer	O
's	O
disease	O
.	O
</s>
<s>
There	O
are	O
two	O
types	O
of	O
ARIA	O
:	O
ARIA-E	B-Algorithm
and	O
ARIA-H	B-Algorithm
.	O
</s>
<s>
ARIA-E	B-Algorithm
refers	O
to	O
cerebral	O
edema	O
,	O
involving	O
the	O
breakdown	O
of	O
the	O
tight	O
endothelial	O
junctions	O
of	O
the	O
blood-brain	O
barrier	O
and	O
subsequent	O
accumulation	O
of	O
fluid	O
.	O
</s>
<s>
In	O
a	O
double-blind	O
trial	O
of	O
the	O
humanised	O
monoclonal	O
antibody	O
solanezumab	O
(	O
n	O
=	O
2042	O
)	O
,	O
sixteen	O
patients	O
(	O
11	O
taking	O
the	O
drug	O
,	O
5	O
taking	O
a	O
placebo	O
)	O
,	O
or	O
0.78	O
%	O
developed	O
ARIA-E	B-Algorithm
.	O
A	O
further	O
7	O
patients	O
developed	O
ARIA-E	B-Algorithm
during	O
an	O
open-label	O
extension	O
of	O
the	O
trial	O
.	O
</s>
<s>
The	O
effect	O
of	O
ARIA-E	B-Algorithm
depends	O
on	O
the	O
severity	O
and	O
location	O
of	O
the	O
edema	O
.	O
</s>
<s>
ARIA-H	B-Algorithm
refers	O
to	O
cerebral	B-Algorithm
microhaemorrhages	I-Algorithm
(	O
mH	O
)	O
,	O
small	O
haemorrhages	O
on	O
the	O
brain	O
,	O
often	O
accompanied	O
by	O
hemosiderosis	O
.	O
</s>
<s>
+	O
ARIA	O
MRI	B-Algorithm
Classification	O
Criteria	O
ADUHELM	O
-	O
aducanumab	O
injection	O
,	O
solution	O
Drug	O
label	O
information	O
from	O
DailyMed	O
.	O
</s>
