<s>
APOPT	B-Application
(	O
for	O
Advanced	O
Process	O
OPTimizer	O
)	O
is	O
a	O
software	O
package	O
for	O
solving	O
large-scale	O
optimization	O
problems	O
of	O
any	O
of	O
these	O
forms	O
:	O
</s>
<s>
Applications	O
of	O
the	O
APOPT	B-Application
include	O
chemical	O
reactors	O
,	O
</s>
<s>
Standard	O
benchmarks	O
such	O
as	O
CUTEr	B-Application
and	O
SBML	O
curated	O
models	O
are	O
used	O
to	O
test	O
the	O
performance	O
of	O
APOPT	B-Application
relative	O
to	O
solvers	O
BPOPT	O
,	O
IPOPT	B-Algorithm
,	O
SNOPT	B-Application
,	O
and	O
MINOS	O
.	O
</s>
<s>
A	O
combination	O
of	O
APOPT	B-Application
(	O
Active	O
Set	O
SQP	O
)	O
and	O
BPOPT	O
(	O
Interior	O
Point	O
Method	O
)	O
performed	O
the	O
best	O
on	O
494	O
benchmark	O
problems	O
for	O
solution	O
speed	O
and	O
total	O
fraction	O
of	O
problems	O
solved	O
.	O
</s>
