Affiliation: University of Manchester
- Computational cluster validation in post-genomic data analysisJulia Handl
School of Chemistry, University of Manchester, Faraday Building, Sackville Street, PO Box 88, Manchester M60 1QD, UK
Bioinformatics 21:3201-12. 2005..Suitable computational cluster validation techniques are available in the general data-mining literature, but have been given only a fraction of the same attention in bioinformatics...
- Ant-based clustering and topographic mappingJ Handl
School of Chemistry, The University of Manchester, P O Box 88, Sackville Street, M60 1QD Manchester, UK
Artif Life 12:35-61. 2006..We provide evidence that the solutions generated by the ant algorithm are barely topology-preserving, and we explain in detail why results have--in spite of this--been misinterpreted (much more positively) in previous research...
- Multiobjective optimization in bioinformatics and computational biologyJulia Handl
School of Chemistry, The University of Manchester, Manchester, UK
IEEE/ACM Trans Comput Biol Bioinform 4:279-92. 2007....
- Artefacts and biases affecting the evaluation of scoring functions on decoy sets for protein structure predictionJulia Handl
Faculty of Life Sciences, University of Manchester, Manchester, UK
Bioinformatics 25:1271-9. 2009..We contribute to this ongoing discussion an empirical assessment of several decoy datasets commonly used in experimental studies...
- Streamlining the construction of large-scale dynamic models using generic kinetic equationsDelali A Adiamah
Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
Bioinformatics 26:1324-31. 2010..Furthermore, the integration of gene expression and protein levels into kinetic models is not straightforward...