Prozac (fluoxetine) is an antidepressant affecting serotonin. It is unlike the older tricyclic types such as Elavil® (amitriptyline). It has not been shown to be effective in reducing migraine frequency. It is the earliest compound approved in the group known as serotonin reuptake inhibitors. Several newer compounds in the class include Paxil® (paroxetine HCI), Zoloft® (sertraline HCI), and Lexapro®.