|Function||type III secretion low calcium response chaperone LcrH/SycD|
|Domain Trusted Cutoff||104.80|
|Domain Noise Cutoff||89.40|
|Entry Date||Apr 19 2005 10:37AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Genes in this family are found in type III secretion operons. LcrH, from Yersinia is believed to have a regulatory function in the low-calcium response of the secretion system [1,2]. The same protein is also known as SycD (SYC = Specific Yop Chaperone) for its chaperone role . In Pseudomonas, where the homolog is known as PcrH, the chaperone role has been demonstrated and the regulatory role appears to be absent .
ScyD/LcrH contains three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array .|
RM PMID: 1705541
RT Analysis of the V antigen lcrGVH-yopBD operon of Yersinia pseudotuberculosis: evidence for a regulatory role of LcrH and LcrV.
RA Bergman T, Hakansson S, Forsberg A, Norlander L, Macellaro A, Backman A, Bolin I, Wolf-Watz H.
RL J Bacteriol. 1991 Mar;173(5):1607-16.
RM PMID: 11844757
RT YopD and LcrH regulate expression of Yersinia enterocolitica YopQ by a posttranscriptional mechanism and bind to yopQ RNA.
RA Anderson DM, Ramamurthi KS, Tam C, Schneewind O.
RL J Bacteriol. 2002 Mar;184(5):1287-95.
RM PMID: 9987117
RT Role of SycD, the chaperone of the Yersinia Yop translocators YopB and YopD.
RA Neyt C, Cornelis GR.
RL Mol Microbiol. 1999 Jan;31(1):143-56.
RM PMID: 14673772
RT PcrH of Pseudomonas aeruginosa is essential for secretion and assembly of the type III translocon.
RA Broms JE, Forslund AL, Forsberg A, Francis MS.
RL J Infect Dis. 2003 Dec 15;188(12):1909-21. Epub 2003 Dec 3.
RM PMID: 12799000
RT Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators.
RA Pallen MJ, Francis MS, Futterer K.
RL FEMS Microbiol Lett. 2003 Jun 6;223(1):53-60.|
|Genome Property||GenProp0052: type III secretion (HMM)|
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