Tue Mar 28 08:50:07 EST 1995
In article <3kuifv$368 at netnews.upenn.edu>, David Peritt <Peritt_d at a1.mscf.upenn.edu> says:
>In article <3kqfnn$s0o at decaxp.harvard.edu> derek chan,
>chan4 at fas.harvard.edu writes:
>I must redeem myself. I believe there are Th2 and Th1 tendencies in CD4
>T cells. I just do not believe it is so cut and dry as the murine
>leishmaniaisis data suggests. We work in human T cells and find a
>rainbow of T cells producing tons of gINF and no IL-4 all the way to tons
>of IL-4 and low gIFN. But 95% of the cells are in between. and If you
>look broader at IL4,5,6,10 etc... you see that when IL4 is high IL5 or 10
>may not be and vice versa. does this mean we have Th3 or th6 cells.
>NOOOOOOO. What we have are independently regulated cytokine genes. Our
>lab has shown for instance that gIFN is increased by IL-12
>administration. Therefore even a Th2 looking cell will make tons of gIFN
>if IL-12 is added. In that same paper we show that IL-12 added at the
>time of first priming actually stabally increases IFN production-for the
>life of the cell.
>So, what I am saying is the following. Don't be too dogmatic with this
>Th1 vs 2 thing. Th0 is used to explain these intermediates but it is
>much messier. I have begun to present my clonal data in linear form
>assigning the clones a gINF/IL4 ratio of production. Therefore a Th1
>like cell will be a 600 and a Th2 a .3. You get the picture.
>The beauty of the immune system is not the perfectness but the slop.
>Slop allows the immune system to recognize and adapt so well. Dogma is
>good to get us started and thanks to tim Mossman for that but it is time
>to dive into the slop. Pleasant swimming.
COULD I POSSIBLY GET A REFERENCE FOR THIS IL12 STUFF PLEASE.
THANKS IN ADVANCE
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