Thursday, March 6, 2014
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Humanized bone marrow,
liver and thymus (huBLT) mouse model of Kaposi's sarcoma-associated herpes
virus (KSHV) infection
The huBLT mouse model could
be used to study pathogenesis and transmission of KSHV. The model was
previously generated using nonobese diabetic (NOD) severe combined
immunodeficiency (SCID) mice that lacked IL-2 receptor g-chain
(Cd132) and showed
susceptibility to viruses that infect humans. In the huBLT mouse, oral or
intravaginal inoculation of KSHV established latent and lytic infection in
human B cells and macrophages in the spleen and latent infection in human
macrophages in the skin. Next steps include using the model to determine the
transmission route after KSHV exposure and how it can lead to persistent
Published online March 6, 2014
status not applicable
Wang, L-X. et al. Proc.
Natl. Acad. Sci. USA; published online
Feb. 10, 2014;
Contact: Charles Wood University of Nebraska, Lincoln, Neb.
Contact: Qingsheng Li, same affiliation as above
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