Sanderson, D.J. and Hindley, E. and Smeaton, E. and Denny, N. and Taylor, A. and Barkus, C. and Sprengel, R. and Seeburg, P.H. and Bannerman, D.M. (2011) 'Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory.', Learning & memory., 18 (3). pp. 181-190.
Deletion of the GluA1 AMPA receptor subunit impairs short-term spatial recognition memory. It has been suggested that short-term recognition depends upon memory caused by the recent presentation of a stimulus that is independent of contextual–retrieval processes. The aim of the present set of experiments was to test whether the role of GluA1 extends to nonspatial recognition memory. Wild-type and GluA1 knockout mice were tested on the standard object recognition task and a context-independent recognition task that required recency-dependent memory. In a first set of experiments it was found that GluA1 deletion failed to impair performance on either of the object recognition or recency-dependent tasks. However, GluA1 knockout mice displayed increased levels of exploration of the objects in both the sample and test phases compared to controls. In contrast, when the time that GluA1 knockout mice spent exploring the objects was yoked to control mice during the sample phase, it was found that GluA1 deletion now impaired performance on both the object recognition and the recency-dependent tasks. GluA1 deletion failed to impair performance on a context-dependent recognition task regardless of whether object exposure in knockout mice was yoked to controls or not. These results demonstrate that GluA1 is necessary for nonspatial as well as spatial recognition memory and plays an important role in recency-dependent memory processes.
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|Publisher Web site:||http://dx.doi.org/10.1101/lm.2083411|
|Record Created:||11 Oct 2012 11:20|
|Last Modified:||11 Oct 2012 14:20|
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