Affiliation: University of Queensland
- Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury--a pilot studyCatherine J Nikles
School of Medicine, The University of Queensland, Ipswich Campus, Building 12, Salisbury Rd, Ipswich 4305, Australia
Trials 15:54. 2014..Objectives were to determine the efficacy of CNS stimulants for children with TBI, and to calculate the sample size for a larger trial using the Conners' 3 Parent Rating Scales Score as the primary endpoint...
- Central nervous system stimulants for secondary attention deficit-hyperactivity disorder after paediatric traumatic brain injury: a rationale and protocol for single patient (n-of-1) multiple cross-over trialsHugh E J Senior
Discipline of General Practice, School of Medicine, The University of Queensland, 11 Salisbury Rd, Ipswich 4305, Australia
BMC Pediatr 13:89. 2013..There is conflicting evidence on whether treatment with stimulant therapy with medications such as methylphenidate or dexamphetamine will improve the attention and behavior of children with this condition...
- Using aggregated single patient (N-of-1) trials to determine the effectiveness of psychostimulants to reduce fatigue in advanced cancer patients: a rationale and protocolHugh Ej Senior
Discipline of General Practice, The University of Queensland, Brisbane, Queensland, Australia
BMC Palliat Care 12:17. 2013..The negative impact of fatigue on function (physical, mental, social and spiritual) and quality of life is substantial for many palliative patients as well as their families/carers...
- Prioritising drugs for single patient (n-of-1) trials in palliative careJ Nikles
Discipline of General Practice, The University of Queensland, Herston, Brisbane, Queensland, Australia
Palliat Med 23:623-34. 2009..Although not all the drugs used in palliative care are suitable, SPTs provide a potential alternative method of gathering evidence in palliative care...
- Long-term changes in management following n-of-1 trials of stimulants in attention-deficit/hyperactivity disorderC Jane Nikles
School of Medicine, University of Queensland, Queensland, Australia
Eur J Clin Pharmacol 63:985-9. 2007..Our objective was to evaluate the long-term impact of n-of-1 trials-within-patient randomised, double-blind, cross-over comparisons of stimulant versus placebo or stimulant-on ADHD management...
- An n-of-1 trial service in clinical practice: testing the effectiveness of stimulants for attention-deficit/hyperactivity disorderC Jane Nikles
The University of Queensland, Herston, Queensland 4006, Australia
Pediatrics 117:2040-6. 2006..We sought to describe the clinical use of n-of-1 trials for attention-deficit/hyperactivity disorder in publicly and privately funded family and specialized pediatric practice in Australia...
- Bias influencing maternal reports of child behaviour and emotional stateJ M Najman
School of Social Science, The University of Queensland, Australia
Soc Psychiatry Psychiatr Epidemiol 36:186-94. 2001..We examine two potential sources of bias that may influence reports of a child's behaviour/mental health. The first is the mental or emotional impairment of the respondent; the second concerns gender-related expectations of children...
- Mothers' mental illness and child behavior problems: cause-effect association or observation bias?J M Najman
Department of Anthropology and Sociology, University of Queensland, Australia
J Am Acad Child Adolesc Psychiatry 39:592-602. 2000..However, the validity of this finding is in doubt because the majority of these studies have relied on maternal reports as indicators of children's behavior...
- Using n-of-1 trials as a clinical tool to improve prescribingC Jane Nikles
Discipline of General Practice, University of Queensland Medical School, Herston, Queensland 4006, Australia
Br J Gen Pract 55:175-80. 2005..We have investigated the use of these, offered to doctors as individualised medication effectiveness tests (IMETs), as a tool to improve drug prescribing...
- Do individualized medication effectiveness tests (n-of-1 trials) change clinical decisions about which drugs to use for osteoarthritis and chronic pain?C Jane Nikles
Discipline of General Practice, The University of Queensland, Herston, Queensland, Australia
Am J Ther 12:92-7. 2005..Our results provide a new (individual) perspective on the well-known recommendation for paracetamol as first-line treatment for chronic pain and demonstrate that it is feasible to provide IMETs nationally by mail and telephone...
- The role of paracetamol in chronic pain: an evidence-based approachC Jane Nikles
Discipline of General Practice, The University of Queensland, Herston, Herston, Queensland 4006, Australia
Am J Ther 12:80-91. 2005..In patients with chronic pain, paracetamol can play an important role as an NSAID sparer, with resultant benefits in terms of reduced adverse effects and cost savings...