In the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally, transcription elongation is incomplete with non-processive polymerases disengaging from the proviral DNA template prematurely (reviewed in Karn 1999). The mechanism of Tat-mediated elongation is described below.
|GO Biological Process||transcription elongation from RNA polymerase II promoter (0006368)|
|Human immunodeficiency virus infectious disease||526||[HIV infection]|
|15049426||Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages||Curr HIV Res||2003|
|10550206||Tackling Tat||J Mol Biol||1999|