PolyPhen-2 (Polymorphism Phenotyping v2) is a tool which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. Please, use the form below to submit your query. Batch query allows submitting large number of SNPs in bulk. Please limit your queries by 150,000 amino acid residue substitutions or 5 million SNP chromosome coordinates.
08-Jul-2015: Please do not submit excessively large (e.g. whole proteome) batch queries without contacting PolyPhen-2 support first. Specifically, large batches of variants in species other than human are not allowed and will be terminated without warning.