Zavattari, Patrizia and Esposito, Laura and Nutland, Sarah L. and Todd, John A. and Cucca, Francesco (2000) Transmission-ratio distortion at Xp11.4-p21.1 in type 1 diabetes. The American Journal of Human Genetics, Vol. 66 (1), p. 330-332. ISSN 0002-9297. Article.
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Naumova et al. (1998) reported a deviation from the expected Mendelian 1:1 ratio of grandpaternal/grandmaternal alleles at loci in Xp11.4-p21.1 in the children of 47 families not selected on the basis of the disease status of the children. The transmission-ratio distortion (TRD) was found only among male offspring and was manifested as a bias in favor of the inheritance of the alleles of the maternal grandfather. The critical region, containing the putative TRD locus, named “DMS1,” was mapped to an interval bounded by DXS538 and DXS7 and peaking at DXS1068. These observations might have an impact on the results of a study in which we have provided evidence of linkage to type 1 diabetes mellitus (MIM 222100), in the same region of chromosome X (Cucca et al. 1998). The possibility of TRD at chromosome Xp gives rise to the question of whether the diabetes-linkage results are indeed disease specific. The following evidence suggests that it is highly unlikely that the DMS1 locus is responsible for the chromosome Xp linkage to type 1 diabetes.
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