- Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cellsMichael Bodd
Centre for Immune Regulation and Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway
Hum Immunol 73:376-81. 2012..The differential ability of DQ8 and DQ9 to harness a negatively charged anchor at P9 may result in fewer potential gluten epitopes in DQ9 patients. Our data further indicate that DQ9 is a susceptibility factor for celiac disease...
- HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22M Bodd
Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
Mucosal Immunol 3:594-601. 2010..We conclude that gluten-reactive T cells produce IL-21 and IFN-γ, but not IL-17. Their production of IL-21 suggests a role for this cytokine in the pathogenesis of celiac disease...