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CAPLUS COPYRIGHT 2013 ACS
||Process for the preparation of 5-(2-ethyl-dihydro-1h-inden-2-yl)-1h-imidazole and salts thereof
||Lusis, Viesturs; Muceniece, Dzintra; Reine, Inese; Zandersons, Armands
||Grindeks JSC, Latvia
||PCT Int. Appl., 15 pp. CODEN: PIXXD2
The invention provides an improved, highly efficient method for prepg. 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole (I), and its salts, in particular its pharmaceutically acceptable salts. Compd. I·HCl was prepd. via formylation of 4-iodo-1-tritylimidazole; the resulting 1-tritylimidazole-4-carboxaldehyde underwent condensation with phthalide to give 2-(1-trityl-1H-imidazol-4-yl)indan-1,3-dione, which underwent ethylation to give 2-ethyl-2-(1-trityl-1H-imidazol-4-yl)indan-1,3-dione, which underwent hydrolysis to give 2-ethyl-2-(1H-imidazol-4-yl)indan-1,3-dione, which underwent redn. to give I·HCl.
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