Aliases for SLC6A11 Gene
External Ids for SLC6A11 Gene
Previous GeneCards Identifiers for SLC6A11 Gene
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters, such as SLC6A11 (Borden et al., 1994 [PubMed 7874447]).[supplied by OMIM, Nov 2010]
GeneCards Summary for SLC6A11 Gene
SLC6A11 (Solute Carrier Family 6 (Neurotransmitter Transporter), Member 11) is a Protein Coding gene. Diseases associated with SLC6A11 include tricuspid valve stenosis and pulmonary valve insufficiency. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neurotransmitter:sodium symporter activity and gamma-aminobutyric acid:sodium symporter activity. An important paralog of this gene is SLC6A4.
UniProtKB/Swiss-Prot for SLC6A11 Gene
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals
GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters have been identified and localized to neurons and glia.