Aliases for KDM8 Gene
External Ids for KDM8 Gene
Previous HGNC Symbols for KDM8 Gene
This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]
GeneCards Summary for KDM8 Gene
KDM8 (Lysine (K)-Specific Demethylase 8) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is HSPBAP1.
UniProtKB/Swiss-Prot for KDM8 Gene
Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated Lys-36 (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.