Our research group, including the Schroeder Laboratory and affiliates, has hubs at the Nathan Kline Institute and Columbia University Medical Center in Gotham City (NYC), edged by the George Washington Bridge. We investigate the neuronal mechanisms of cognition and behavior. Specifically, our research program aims to define the neuronal circuits, cellular mechanisms and oscillatory dynamics of sensory processing, related cognitive processes such as attention, and motor influences on sensory processing and perception ("active sensing"). Our research paradigms range from simple sensory encoding and discrimination to perception of language and music. We pursue an active, direct integration of monkey and human studies, made possible by recent advances in electrode, computing and brain imaging technologies, as well as in anatomical circuit and cell structure investigation techniques. There is constant exchange between empirical and computational modeling investigations.
The results of the monkey and human studies are directly interrelated by using comparable neural measurements and focusing on homologous brain operations. Most of our current work in humans involves direct recordings using implanted subdural electrode arrays in surgical epilepsy patients. Monkeys are studied in greater depth and resolution, using techniques that can directly and precisely define the neurophysiological and anatomical mechanisms underlying effects noted in humans. These techniques include single cell and cell ensemble electrophysiology, pharmacological manipulations, and anatomical tract tracing. Electrophysiological studies are conducted using both acutely and chronically positioned multielectrode arrays. We maintain active collaborations with a number of allied research groups that study language and music, computational neuroscience, and neuroanatomy.
Our current topics of interest