J B Meigs
Affiliation: Harvard University
- Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring StudyJ B Meigs
General Internal Medicine Unit, Massachusetts General Hospital, Boston 02114, USA
Diabetes 46:1594-600. 1997..Insulin resistance (reflected by hyperinsulinemia) alone did not appear to underlie all features of the insulin resistance syndrome...
- Metabolic risk factors worsen continuously across the spectrum of nondiabetic glucose tolerance. The Framingham Offspring StudyJ B Meigs
Massachusetts General Hospital, Harvard Medical School, Boston University School of Public Health, 02114, USA
Ann Intern Med 128:524-33. 1998..Categorical definitions for glucose intolerance imply that risk thresholds exist, but metabolic risk for type 2 diabetes mellitus or cardiovascular disease may increase continuously as glucose intolerance increases...
- Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring StudyJ B Meigs
General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Institute for Prevention of Cardiovascular Disease, Boston 02114, USA
JAMA 283:221-8. 2000..Hyperinsulinemia associated with glucose intolerance may increase risk directly, or its effect could be mediated through impaired hemostatic function...
- Association of diabetes-related emotional distress with diabetes treatment in primary care patients with Type 2 diabetesL M Delahanty
MGH Diabetes Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Diabet Med 24:48-54. 2007..To characterize the determinants of diabetes-related emotional distress by treatment modality (diet only, oral medication only, or insulin)...
- Parental transmission of type 2 diabetes: the Framingham Offspring StudyJ B Meigs
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Diabetes 49:2201-7. 2000..Given equivalent risk ratios for type 2 diabetes, fathers may transmit unique paternal genetic factors of similar strength to maternal environmental factors...
- Insulin resistance influences the association of adiponectin levels with diabetes incidence in two population-based cohorts: the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 study and the Framingham Offspring StudyM F Hivert
Department of Medicine, Harvard Medical School, Boston, MA, USA
Diabetologia 54:1019-24. 2011..We tested the hypothesis that the association of adiponectin levels with incident type 2 diabetes differs between insulin-resistant and insulin-sensitive individuals...
- Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association ResourceC T Liu
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Diabetologia 55:2970-84. 2012..We tested the transferability of 18 single-nucleotide polymorphisms (SNPs) associated with glycaemic traits identified in European ancestry (EuA) populations in 5,984 non-diabetic AfAs...
- Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolismG A Walford
Center for Human Genetic Research, Simches Research Building CPZN 5 250, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
Diabetologia 55:331-9. 2012..We hypothesised that a subset of these variants may have different effects on the transition from normal fasting glucose (NFG) to impaired fasting glucose (IFG) than on that from IFG to diabetes...
- Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart StudyS Demissie
Boston University School of Public Health, Department of Biostatistics, Boston, MA, USA
Aging Cell 5:325-30. 2006....
- Correlates of health-related quality of life in type 2 diabetesD J Wexler
Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
Diabetologia 49:1489-97. 2006..We assessed the impact of medical comorbidities, depression, and treatment intensity on quality of life in a large primary care cohort of patients with type 2 diabetes...
- Invited commentary: insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factorsJ B Meigs
General Internal Medicine Unit, Massachusetts General Hospital, Boston 02114 2698, USA
Am J Epidemiol 152:908-11; discussion 912. 2000....
- TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart StudyE S Stolerman
Simches Research Building CPZN 5 250, Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA
Diabetologia 52:614-20. 2009..We reproduced the association of diabetes-associated variants with proinsulin/insulin ratios, and also examined the association of a TCF7L2 haplotype with obesity in the Framingham Heart Study (FHS)...
- The clinical application of genetic testing in type 2 diabetes: a patient and physician surveyR W Grant
Division of General Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Diabetologia 52:2299-305. 2009..Little is known about current physician and patient views regarding type 2 diabetes genetic testing. We hypothesised that physician and patient views would differ regarding the impact of genetic testing on motivation and adherence...
- A genotype risk score predicts type 2 diabetes from young adulthood: the CARDIA studyJ L Vassy
General Medicine Division, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
Diabetologia 55:2604-12. 2012..We hypothesised that a genotype score predicts incident type 2 diabetes from young adulthood and improves diabetes prediction models based on clinical risk factors alone...
- Cardiovascular disease prevention practices by U.S. Physicians for patients with diabetesJ B Meigs
General Medicine Division, Massachusetts General Hospital, Medical Services, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
J Gen Intern Med 15:220-8. 2000..Current evidence suggests that wider implementation of these recommendations can be expected to reduce the burden of cardiovascular disease in patients with diabetes...
- Management of the metabolic syndromeR W Grant
General Medicine Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Panminerva Med 47:219-28. 2005..Currently, the standard of care includes active identification and aggressive management of traditional cardiovascular risk factors with an emphasis on healthy lifestyle changes to reduce weight and increase physical fitness...
- Epidemiology of cardiovascular complications in type 2 diabetes mellitusJ B Meigs
General Medicine Division, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA 02114, USA
Acta Diabetol 40:S358-61. 2003..There are several potential explanations for this apparent paradox, including the roles of the metabolic syndrome and post-load hyperglycaemia in the association of type 2 diabetes and CVD...
- Circulating IL-18 and the risk of type 2 diabetes in womenM F Hivert
Massachusetts General Hospital, Boston, USA
Diabetologia 52:2101-8. 2009..The pathophysiology of type 2 diabetes involves pro-inflammatory pathways. We tested the hypothesis that IL-18 predicts future diabetes cases...