WWEDomain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis.
|SMART accession number:||SM00678|
|Interpro abstract (IPR018123):|
The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems. This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor [(PUBMED:16271883)]. It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins [(PUBMED:11343911)].
|GO function:||zinc ion binding (GO:0008270)|
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- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
- Literature (relevant references for this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
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