The automorphism group of the symmetric group $S_n$ is $S_n$ when $n$ is not $2$ or $6$, in which cases it is respectively $1$ and the semidirect product of $S_6$ with the (cyclic) group of order $2$. (For this famous outer automorphism, see for instance wikipedia or Baez's thoughts on the number $6$.)
On the other hand, $S_2$ is the automorphism group of $Z_3$, $Z_4$ and $Z_6$ (and only those groups among finite groups). Hence my question: is $S_6$ the automorphism group of a group? of a finite group?