About the Lab/Branch
The Genetics of Development and Disease Branch (GDDB) seeks to understand the function of diverse signaling pathways, mediated by genes, proteins and lipids, that determine how cell behavior is governed. When these pathways are disturbed, human diseases can result. Our work is aimed at identifying the altered pathways in human disease in order to rationally develop new therapeutic approaches. Our scope includes processes affecting diabetes, metabolism, obesity, cancer, and neurodegenerative diseases.