Affiliation: Northwestern University
- T-cell response dynamics in animal models of multiple sclerosis: implications for immunotherapiesBettina Schreiner
Northwestern University Medical School, Department of Microbiology Immunology and the Interdepartmental Immunobiology Center, 303 E Chicago Avenue Chicago, IL 60611, USA
Expert Rev Clin Immunol 3:57-72. 2007..Here, we review the current knowledge of the mechanisms of induction and progression of EAE and MS and the immunotherapies that have resulted from studies of the EAE model...
- Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitisStephen D Miller
Department of Microbiology, Northwestern University Medical School, Chicago, IL 60611, USA
Ann N Y Acad Sci 1103:179-91. 2007..In contrast, CNS-resident CD11b(+)CD11c(-)CD45(low) microglia purified from the inflamed CNS were found to be largely incapable of activating either naïve or effector T cells...
- PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAEBettina Schreiner
Department of Microbiology Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Eur J Immunol 38:2706-17. 2008..In contrast, blockade of B7-DC has less pronounced regulatory effects. Overall, the results demonstrate that B7-H1 expressed by CNS myeloid APC negatively regulates T-cell activation during acute relapsing EAE...
- CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAESamantha L Bailey
Department of Microbiology Immunology and the Interdepartmental Immunobiology Center, Northwestern University Medical School, Chicago, Illinois 60611, USA
Nat Immunol 8:172-80. 2007..Our findings indicate a critical function for CNS mDCs in driving relapses in relapsing EAE...