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|Title:||Challenges in human genetic diversity: demographic history and adaption|
|Authors:||Balaresque, Patricia L.|
Ballereau, Stéphane J.
Jobling, Mark A.
|Publisher:||Oxford University Press|
|Citation:||Human Molecular Genetics, 2007, 16 (Sp. Iss. 2), pp.R134-139|
|Abstract:||Modern human genetic diversity is the result of demographic history, and selective effects that have acted to adapt different populations to their environments. Broad patterns of global diversity are well explained by geography, based on an out-of-Africa model of early human evolution. Genome-wide searches for signals of selection, plus studies of specific candidate loci and candidate phenotypes, have identified genes that show population differences due to adaptation to pathogens, climate, diet, and possibly cognitive challenges. Some past adaptations are now maladaptive, and can lead to disease. However, the history of adaptation is complex, and adaptive explanations are often unsupported by hard evidence.|
|Rights:||This is the final published version of the paper published as Human Molecular Genetics, 2007, 16(Sp. Iss. 2), pp.R134-139. It is also available from http://hmg.oxfordjournals.org/cgi/content/abstract/16/R2/R134, doi: 10.1093/hmg/ddm242. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Appears in Collections:||Published Articles, Dept. of Genetics|
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