- Alan E. OestreichAffiliated withCincinnati Children's Hospital Medical Center
Osteodysplasias are well‐defined abnormalities of bone growth, typically genetic in origin. They may be systematic, affecting one aspect of skeletal development, typically in proportion to growth potential of each site, or else “aleatoric,” affecting sites of an aspect of bone development in a chance distribution, with a higher likelihood of occurrence at sites of greater normal growth. [I have borrowed the term aleatoric from modern music composition in which chance plays a role ( 1)] The aspect of growth may be slowed, disordered, or accelerated. The aspect involved is most often exclusively enchondral in nature or membranous in nature, with only secondary changes in the other. Most, but not all, dysplasias result in short stature (dwarfism). Kindred disorders include dysostoses, in which individual aspects of growth are affected, and sequences, in which an abnormal aspect of development causes a chain of consequent effects on bo ...
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- Encyclopedia of Diagnostic Imaging
- pp 1420-1423
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- Springer Berlin Heidelberg
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- Springer-Verlag Berlin Heidelberg New York
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