Few modifiable risk factors have been implicated in the etiology of pancreatic cancer.
There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer.
Dr Bas Bueno–De–Mesquita and colleagues from the Netherlands investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer.
The research team conducted the study within the European Prospective Investigation into Nutrition and Cancer cohort, comprising male and female participants from 10 European countries.
Between 1992 and 2000, there were 477,312 participants without cancer who completed a dietary questionnaire, and were followed up to determine pancreatic cancer incidence.
Coffee and tea intake was calibrated with a 24-hour dietary recall.
|865 first incidences of pancreatic cancers were reported|
|Clinical Gastroenterology & Hepatology|
The researchers found that during a mean follow-up period of 12 years, 865 first incidences of pancreatic cancers were reported.
When divided into fourths, the team noted that neither total intake of coffee, decaffeinated coffee, nor tea were associated with risk of pancreatic cancer.
The team observed that moderately low intake of caffeinated coffee was associated with an increased risk of pancreatic cancer, compared with low intake.
However, no graded dose response was observed, and the association attenuated after restriction to histologically confirmed pancreatic cancers.
Dr Bueno–De–Mesquita's team concludes, "Based on an analysis of data from the European Prospective Investigation into Nutrition and Cancer cohort, total coffee, decaffeinated coffee, and tea consumption are not related to the risk of pancreatic cancer."