The Obesity, Pregnancy, and Intrauterine Environment program supports basic and clinical research to understand the impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of both mother and offspring. The program supports observational and interventional clinical studies on the adverse effects of obesity and gestational/type 2 diabetes during pregnancy on mothers and their offspring. Interventional studies may involve, but are not limited to, diet (including food components/dietary supplements), physical activity programs, medications, or bariatric surgery that aim to mitigate or prevent adverse effects of over-nutrition during and after pregnancy/delivery in both the mothers and their offspring. The program also supports basic and clinical research investigating the mechanisms by which the intrauterine environment alters metabolic responses in offspring. A particular focus is on the role of the pathophysiological consequences of obesity and/or diabetes on the offspring. The long-term goal of this program is to identify molecular targets that could be therapeutically altered in order to prevent or ameliorate the increasing incidence and deleterious effects of obesity and type 2 diabetes.