When haptoglobin capacity to buffer hemoglobin is overwhelmed, hemoglobin undergoes a rapid conversion to methemoglobin. Ferriheme is transferred directly from methemoglobin to hemopexin (Miller et al. 1996, Mauk and Mauk 2010).
|8855948||Role of hemopexin in protection of low-density lipoprotein against hemoglobin-induced oxidation||Biochemistry||1996|
|20430887||Metal ions and electrolytes regulate the dissociation of heme from human hemopexin at physiological pH||J Biol Chem||2010|