Background and interests
Dr. Pomper was born in Chicago, Illinois and attended college at the University of Illinois at Urbana-Champaign, majoring in biochemistry and chemistry. Also at Illinois, in the context of the Medical Scholars Program, he earned M.D. and Ph.D. degrees, the latter in organic chemistry. All of his postgraduate medical training was undertaken at the Johns Hopkins University School of Medicine, which included an internship in medicine (Osler Service), residencies in radiology and nuclear medicine, and a neuroradiology fellowship. He is currently an associate professor in the Neuroradiology Division of the Department of Radiology. His research interests involve molecular imaging, particularly of central nervous system processes and cancer.
Dr. Pomper is also the director of the Small Animal Imaging Resource Program (SAIRP) at Johns Hopkins and Deputy Director of the In Vivo Cellular and Molecular Imaging Center (ICMIC). Specific research projects in central nervous system imaging include (a) using magnetic resonance spectroscopy (MRS) to uncover brain metabolic correlates of AIDS dementia, (b) using positron emission tomography (PET) to study molecular (neurotransmitter) and cellular abnormalities in patients with AIDS dementia, and (c) the development of new radiopharmaceuticals for imaging nicotinic and glutamatergic neurotransmission. In oncology, advanced magnetic resonance imaging (MRI) techniques, such as sodium imaging, diffusion tensor imaging, and MRS are being used to study brain tumors. In addition, PET agents are being pursued to study prostate cancer, angiogenesis and to study the pharmacokinetics of chemotherapeutic agents in vivo.
From a clinical standpoint, his interests lie in central nervous system vasculitis and brain tumor imaging, serving as a member of the Johns Hopkins Vasculitis Center and of a consortium to develop New Approaches to Brain Tumor Therapy (NABTT). In collaboration with the Department of Neurosurgery, he is heading up a new initiative to develop an imaging center dedicated to the characterization of brain tumors.
Phone: 410 955-2789
FAX: 443 817-0990
Professor of radiology
Johns Hopkins University
1550 Orleans Street
Rm 492, CRB II
Baltimore, MD, 21231
Fu D, Tanhehco Y, Chen J, Foss CA, Fox JJ, Chong J-M, Fukayama M, Sgouros G, Kowalski J, Pomper MG, Ambinder RF. Bortezomib-induced enzyme-targeted radiotherapy in herpesvirus-associated tumors. Nat Med 2008; in press.
Terrovitis J, Kwok KF, Lautamaki R, Engles JM, Barth AS, Miake J, Leppo MK, Fox J, Seidel J, Pomper M, Wahl RL, Tsui B, Bengel F, Marban E, Abraham MR. Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by SPECT or PET. J Am Coll Cardiol 2008; in press.
Gabrielson KL, Mok GSP, Nimmagadda S, Bedja D, Pin S, Tsao A, Wang Y, Sooryakumar D, Yu SJ, Pomper MG, Tsui BMW. Detection of dose response in chronic doxorubicin mediated cell death with cardiac SPECT 99mTc annexin V imaging. Mol Imaging 2008; in press.
Zhang Y, Laterra J, Pomper MG. The hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia, in press. Pomper MG, Hammond H, Yu X, Ye Z, Foss CA, Lin DD, Fox JJ, Cheng L. Serial imaging of human embryonic stem cell engraftment and teratoma formation in live mouse models. Cell Res, in press.
Ma WW, Jimeno A, Kulesza P, Chan A, Zhang XF, Wheelhouse J, Jacene HA, Messersmith WA, Endres C, Forastiere AA, Gillison MK, Pomper MG, Hidalgo M. Early prediction of anti-epidermal growth factor receptor therapy with [18F]FDG-PET: a preclinical and clinical correlation. Cancer Ther, in press.
Barinka C, Byun Y, Dusich CL, Ray S, Chen Y, Castanares M, Kozikowski AP, Mease RC, Pomper MG, Lubkowski J. Interactions between Human Glutamate Carboxypeptidase II and Urea-based Inhibitors: Structural Characterization. J Med Chem, in press.
Chen Y, Foss CA, Byun Y, Nimmagadda S, Pullambhatla M, Fox JJ, Castanares SE, Babich JW, Mease RC, Pomper MG. Radiohalogenated PSMA-based ureas as imaging agents for prostate cancer. J Med Chem, in press.
Guilarte T, Hammoud DA, McGlothan JL, Caffo BS, Foss CA, Kozikowski AP, Pomper MG. Dysregulation of glutamate carboxypeptidase II in psychiatric disease. Schizophr Res 2008; 99:324-332.
Tipre DN, Fox JJ, Holt DP, Green G, Yu J, Pomper M, Dannals RF, Bengel FM. In vivo PET imaging of cardiac presynaptic sympathoneuronal mechanisms in the rat. J Nucl Med 2008; 49:1189-1195.
Wang AY, Foss CA, Mo X, Pomper MG, Yu MS. Collagen mimetic peptide’s binding specificity to collagen is driven by triple helical propensity. Biomacromolecules 2008; 9:1755-1763.
Chandran SS, Banerjee SR, Mease RC, Pomper MG, Denmeade SR. Formulation, characterization and in vitro toxicity of docetaxel loaded PSMA-targeted nanoparticles. Cancer Biol Ther 2008; 7:974-982.
Zhou J, Blakeley JO, Hua J, Kim M, Laterra JL, Pomper MG, van Zijl PCM. A practical data acquisition method for human brain amide proton transfer (APT) imaging. Magn Reson Med 2008; 60:842-849.
Banerjee SR, Foss CA, Castanares M, Mease RC, Byun Y, Fox JJ, Hilton J, Lupold S, Kozikowski AP, Pomper MG. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA). J Med Chem 2008; 51:4504-4517.
Song H, Shahverdi K, Huso DL, Wang Y, Fox JJ, Hobbs RF, Gimi B, Gabrielson KL, Pomper MG, Tsui BM, Bhujwalla Z, Reilly RT, Sgouros G. An immunotoleratnt HER-2/new transgenic mouse model of metastatic breast cancer. Clin Cancer Res 2008; 14:6116-6124.
Zhang Y, Bressler JP, Neal J, Laterra J, Pomper MG. ABCG2/BCRP Expression Modulates
D-Luciferin-based Bioluminescence Imaging. Cancer Res, in press.
Lee JS, Orita H, Gabrielson K, Alvey S, Hagemann RL, Kuhujda FP, Gabrielson EW, Pomper MG. Pharmacodynamic assessment of the fatty acid synthase inhibitor C-75 in an experimental model of lung cancer with FDG-PET. Pharm Res 2007; 24:1202-7.
Fu D-X, Tanhehco YC, Chen J, Foss CA, Fox J, Lemas V, Chong J-M, Ambinder RF, Pomper MG. Tumor imaging by induction of integrated viral gene expression. Clin Cancer Res 2007; 13:1453-1458.
Wang Y, Seidel J, Tsui BMW, Vaquero JJ, Pomper MG. Performance evaluation of the GE eXplore VISTA DR small animal PET scanner. J Nucl Med 2006; 47:1891-1900.
Zhou J, Neale JH, Pomper MG, Kozikowski AP. NAAG Peptidase inhibitors and their potential for diagnosis and therapy. Nat Rev Drug Discovery, 2005; 4:1015-26.
Hammoud DA, Endres CA, Chander AR, Guilarte TR, Wong DF, Sacktor NC, McArthur JC, Pomper MG. Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS. J Neurovirol, 2005; 11:346-355.
Guilarte TR, McGlothan JL, Foss CA, Zhou Z, Heston WD, Kozikowski AP, Pomper MG. Glutamate Carboxypeptidase II Levels in Rodent Brain using [125I]DCIT Quantitative Autoradiography. Neurosci Lett, 2005; 387:141-144.
Foss CA, Mease RC, Fan H, Wang Y, Ravert HT, Dannals RF, Olszewski RT, Heston WD, Kozikowski AP, Pomper MG. Radiolabeled small molecule ligands for prostate-specific membrane antigen: in vivo imaging in experimental models of prostate cancer. Clin Cancer Res 2005; 11:4022-4028.
Pomper MG, Phillips E, Fan H, McCarthy DJ, Keith RA, Gordon JC, Dannals RF, Musachio JL. Synthesis and biodistribution of radiolabeled a7 nicotinic acetylcholine receptor ligands. J Nucl Med, 2005; 46:326-334
Bettegowda C, Foss CA, Wang Y, Fox J, Zhou S, Kinzler K, Vogelstein B, Pomper MG. Imaging bacterial infection in live animals with radiolabeled FIAU. Proc Natl Acad Sci USA, 2005; 102:1145-51150.