Dore, Maria Pina and Pedroni, Antonietta and Peltonen, Leena and Enattah, Nabil Satri and Tadeu, Vincenza and Delitala, Giuseppe and Cavalli-Sforza, Luca and Obinu, Domenica Anna (2008) Prevalence of lactase persistence and the performance of a new non invasive genetic test in adult patients. Digestive and Liver Disease, Vol. 40 (Suppl. 1), S63. ISSN 1590-8658. Article.
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Lactose malabsorption is a common problem in humans. Although not in all subjects lactose intake might cause diarrhea, abdominal pain, and flatulence limiting consumption of dairy products. The underlying mechanism of production of enzymes metabolizing lactose is genetically regulated. Persistent lactase activity was observed in populations that consumed milk products into adulthood. Genome polymorphisms are associated with persistence of lactase expression. The breath hydrogen test (BHT) is currently used to measure lactose nonabsorption, however false results can occur. Aim: To evaluate the prevalence of lactase persistence and the performance of a new non invasive genetic test based on the presence of C/T-13910 single nucleotide polymorphism.
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