- Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formationAndrew D Beggs
Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS Genet 9:e1003488. 2013....
- Whole-genome methylation analysis of benign and malignant colorectal tumoursAndrew D Beggs
Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, UK
J Pathol 229:697-704. 2013..The finding that GRASP, which encodes the general receptor for phosphoinositide 1-associated scaffold protein, was differentially methylated in colorectal cancer is interesting. This may be a potential biomarker for colorectal cancer...
- Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CINAndrew D Beggs
University of Oxford, Oxford, UK
Oncotarget 3:1348-55. 2012..015). For Ku70, further studies are required to investigate the potential relationship of non-homologous end joining with chromosomal instability. Loss of ATM expression might serve as a biomarker of poor prognosis in colorectal cancer...