RL19 What Do We Gain with Placebo Treated Patients in First-in-Human Studies?
*Bob Parker, Amgen
In many first in human (FIH) studies, participants are randomly allocated to active drug or placebo (PL) at each dose level, often in a 2:1 or 3:1 ratio. Results in PL participants for the different dose levels are combined to have an overall PL group. In Oncology studies, however, usually all patients receive active drug. Why, then, do most FIH studies have PL treated participants, while some FIH studies do not? Besides blinding (which is not unimportant) what specifically is gained from having PL patients in an FIH study? How does this help interpret the results – particularly of potential safety signals? Would it be possible to use the subject as their own control for all studies – especially for those studies involving patients, rather than healthy volunteers? This roundtable will discuss some hypothetical results to help see what value PL participants have for FIH studies.
April 30 - May 22, 2013
Invited Abstract Submission Open
June 4, 2013
Online Registration Opens
August 9 - August 23, 2013
Invited Abstract Editing
August 23, 2013
Short Course materials due from Instructors
August 26, 2013
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC