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Silver-impregnated contact lens (CL) storage cases aim to reduce microbial contamination of storage cases during use, however there are limited data on their effectiveness. This study evaluated early anti-microbial activity of silver-impregnated CL cases and silver release characteristics in-vitro.
Three silver-impregnated CL storage cases Microblock, i-clean(R) and Nano-case(R) were evaluated. The test organisms included the ISO14729 panel and 2 clinical isolates, Delftia acidovorans and Stenotrophomonas maltophilia. Each well of the case was challenged with 2mL of the organism in phosphate buffered saline at 10(3), 10(4), 10(5) and 10(6) CFU/mL. Survivors were recovered following 6, 10 and 24h incubation at 25 degrees C. Inductively-coupled plasma mass spectrometry was used to quantify the release of silver from the cases for similar incubation conditions and for time points up to 28 days.
Significant differences in anti-microbial activity were observed between cases (p=0.001). Activity was only apparent after 24h. Microblock showed the highest activity against P. aeruginosa (2.4+/-0.5 log reduction at 10(6)), S. marcescens (3.3+/-0.9 log reduction), D. acidovorans (2.8+/-0.1 log reduction) and F. solani (0.5+/-0.2). i-clean(R) was most effective against S. aureus (5.4+/-1.1 log reduction), whereas Nano-case(R) showed the greatest activity against S. maltophilia (0.2+/-0.3 log reduction). Microblock was the only case to demonstrate the silver release over 28 days.
Current silver-impregnated CL storage cases show variation in their in vitro antimicrobial activity. Broadly, the Microblock case demonstrated robust activity against most Gram-negative bacteria, while the i-clean(R) case was more effective against S. aureus. Silver release data suggest different modes of action for different cases.
University of New South Wales, Brien Holden Vision Institute, School of Optometry and Vision Science, Sydney, Australia.
This article was published in the following journal.
Name: Investigative ophthalmology & visual science
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