Little is known about the issue of drug use by travellers. This Thematic paper seeks to increase the interest in this topic both in terms of research and of developing adequate responses to problems related to drugs and travel. The paper aims to shed some light on this topic by investigating the following five questions: What is the profile of those who travel and use drugs? Which destinations have been associated with drug use among travellers? What is the prevalence of drug use among travellers? What are the risks associated with using drugs while travelling? What is the potential for prevention interventions?