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Philadelphia Univer- sity of Pennsylvania. Addiction refers to a psychological and behavioral syndrome characterized by a continued craving for an opioid drug to achieve a psychic effect (psychological dependence) and associated aberrant drug-related behaviors, such as compulsive drug seeking, unsanc- tioned use or dose escalation, and use despite harm to self or others.20, 179, 181, 182 Nespor, M.
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