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|United States Patent||7,193,007|
|Cheng , et al.||March 20, 2007|
The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are convertible between soluble and insoluble in the solent depending on an environmental condition, and n>1. The composition forms a gel under environmental conditions in which B is insoluble, through formation of B aggregates. Block copolymers comprising polyethylene glycol (PEG) and poly(N-iso-propylacrylamide) (PNIPAAm) having a liquid form at ambient temperature under aqueous conditions and a gel form at body temperature are disclosed. Copolymer compositions according to the invention can be used to form in situ implants useful in slow-release formulations of biologically active molecules ##STR00001##
|Inventors:||Cheng; Yu-Ling (Mississauga, CA), Lin; Hai-Hui (Loveland, OH)|
|Filed:||March 15, 2001|
|PCT Filed:||March 15, 2001|
|371(c)(1),(2),(4) Date:||June 09, 2003|
|PCT Pub. No.:||WO01/68768|
|PCT Pub. Date:||September 20, 2001|
|Application Number||Filing Date||Patent Number||Issue Date|
|Current U.S. Class:||524/504 ; 424/486; 523/105; 524/505; 524/916|
|Current International Class:||C08F 290/04 (20060101); C08L 53/00 (20060101)|
|Field of Search:||524/504,505,916 523/105 424/486|
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