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CAPLUS COPYRIGHT 2011 ACS
||Process for the synthesis of anti-neoplasia agent VNP40101M
||Lin, Xu; King, Ivan
||Nanotherapeutics, Inc., USA
||U.S., 10pp. CODEN: USXXAM
The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent. One particularly preferred method uses Me chloroformamide in a one-pot reaction at elevated temps. to provide VNP40101M in high yield.
View the full-text U.S. patent from USPTO.