Simian Virus 40 (SV 40) and the murine polyoma viruses belong to the polyomaviridae family and are the simplest of double- stranded DNA viruses. SV 40 was discovered in the early 1960s as a frequent contamitant of the rhesus macaque kidney cell cultures which were used to grow poliomyelitis vaccines. SV 40 was found in hamster tumors and has been studied extensively as a model of tumor-causing viruses. But SV 40 is genarally not considered as a human pathogen, but it was recently shown that SV 40 DNA is present in tumors of people. Although many people were vaccinated with the contaminated vaccines, no SV-40-related tumors have ever been reported . Viruses enter a cell by binding to their specific receptor on a surface of a host cell. The Major Histocompatibility Complex (MHC) class I molecules are the specific receptor for SV 40 .
The main issue of this presentation is the stucture of the SV 40 capsid: the building blocks the virial particle is made off and how the subunits and the capsid are hold together. Some scripts will need some time until they are displayed on the screen. Please have patience and do not press further buttons until the image appears.
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the complete Viron 1sva.mmol (whole capsid ~70MB)
1sva.5fold giving 1 unique pentamer (5-fold-coordinated)
1sva.23fold giving 1 unique hexamer (6-fold-coordinated)
1sva.unique giving a set of chains that display all possible protein
Development of the template used to construct this presentation was supported
by a grant
from the Division of Undergraduate Education of the National Science Foundation.
When released, the template will be available as part of the Protein
Thanks to Len Norkin for further information about SV 40.
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