Treatment & Outcomes of Histoplasmosis
The mild pulmonary (lung) form of histoplasmosis will generally resolve within about a month without treatment.
Prescription antifungal medications are needed to treat severe cases of acute histoplasmosis, and all cases of chronic or disseminated disease. Itraconazole is one commonly used antifungal medication. Treatment may continue for 3 to 12 months, depending on the severity of the disease and the immune status of the person. Past infection can provide partial protection against severe disease if a person becomes re-infected later in life.
Centers for Disease Control and Prevention