|Publication number||US6610100 B2|
|Application number||US 09/829,449|
|Publication date||26 Aug 2003|
|Filing date||10 Apr 2001|
|Priority date||10 Sep 1998|
|Also published as||US6290728, US6953481, US7101402, US7347867, US20010053932, US20030105514, US20030195458, US20050004505, US20060041218|
|Publication number||09829449, 829449, US 6610100 B2, US 6610100B2, US-B2-6610100, US6610100 B2, US6610100B2|
|Inventors||David Y. Phelps, Greg R. Furnish, Todd A. Hall|
|Original Assignee||Percardia, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (207), Non-Patent Citations (13), Referenced by (51), Classifications (36), Legal Events (8)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This is a continuation of U.S. application Ser. No. 09/369,048, filed Aug. 4, 1999, now U.S. Pat. No. 6,290,728 which claims the benefits of priority of U.S. Provisional Application No. 60/099,767, filed Sep. 10, 1998, and of U.S. Provisional Application No. 60/104,397, filed Oct. 15, 1998, all of which are incorporated herein by reference.
The present invention relates to an apparatus for bypassing a blocked blood vessel segment, and, more particularly, to a conduit or stent positioned between the coronary artery or other blocked vessel and a chamber of the heart, such as the left ventricle of the heart, to bypass a blocked segment of the coronary artery or other blood vessel.
Coronary artery disease is a major problem in the U.S. and throughout the world. Coronary arteries as well as other blood vessels frequently become clogged with plaque, which at the very least impairs the efficiency of the heart's pumping action, and can lead to heart attack and death. In some cases, these arteries can be unblocked through noninvasive techniques such as balloon angioplasty. In more difficult cases, a bypass of the blocked vessel is necessary.
In a bypass operation, one or more venous segments are inserted between the aorta and the coronary artery. The inserted venous segments or transplants act as a bypass of the blocked portion of the coronary artery and thus provide for a free or unobstructed flow of blood to the heart. More than 500,000 bypass procedures are performed in the U.S. every year.
Such coronary artery bypass surgery, however, is a very intrusive procedure that is expensive, time-consuming and traumatic to the patient. The operation requires an incision through the patient's sternum (sternotomy), and that the patient be placed on a bypass pump so that the heart can be operated on while not beating. A vein graft is harvested from the patient's leg, another highly invasive procedure, and a delicate surgical procedure is required to piece the bypass graft to the coronary artery (anastomosis). Hospital stays subsequent to the surgery and convalescence are prolonged.
As mentioned above, another conventional treatment is percutaneous transluminal coronary angioplasty (PTCA) or other types of angioplasty. However, such vascular treatments are not always indicated due to the type or location of the blockage, or due to the risk of emboli.
Thus, there is a need for an improved bypass system which is less traumatic to the patient.
The preferred embodiments of the present invention address the need in the previous technology by providing a bypass system that avoids the sternotomy and other intrusive procedures normally associated with coronary bypass surgery. These embodiments also free the surgeon from the multiple anastomoses necessary in the current process.
The preferred device provides a shunt for diverting blood directly from a chamber in the heart, such as the left ventricle, to the coronary artery, distal to the blockage, therefore bypassing the blocked portion of the vessel. The shunt comprises a stent or conduit adapted to be positioned in the heart wall or myocardium between the left ventricle and the coronary artery that allows for the direct passage of blood therethrough. As used herein, the terms “stent” and “conduit” are interchangeable, and refer to a device that allows for the passage of blood therethrough. The terms “myocardium” and “heart wall” are also used interchangeably. In addition, although the left ventricle is referred to throughout the description, it should be understood that the conduit described herein can be used to provide a passageway for the flow of blood from any heart chamber, not only the left ventricle.
The stent device is delivered either externally or internally through the coronary artery to a position distal to the blockage. At that position, the coronary artery, the myocardium and the wall of the left ventricle are pierced to provide a channel completely through from the coronary artery to the left ventricle of the heart. The stent is then positioned in the channel to provide a permanent passage for blood to flow between the left ventricle of the heart and the coronary artery, distal to the blockage. The stent is sized so that one open end is positioned within the coronary artery, while the other open end is positioned in the left ventricle. The hollow lumen of the stent provides a passage for the flow of blood.
The stent can be self-expandable or expanded by means of a balloon or similar device, and can be provided with various means to anchor it in position within the myocardium, such as expandable legs, hooks, barbs, collars, suture holes and the like. The stent can be formed from a plurality of rings, which can be connected to provide stability. The stent can include a valve in its interior, and can also be used to deliver drugs or other pharmaceutical compounds directly into the myocardium and the coronary circulation.
FIG. 1A is a cross-sectional view of a human heart, aorta and coronary artery.
FIG. 1B is a side view of one embodiment of an expandable stent and the balloon catheter used for stent delivery.
FIG. 2 is a side view of the stent of FIG. 1B mounted on the distal end of the catheter for delivery into the myocardium, with the coronary artery and myocardium shown cut-away.
FIG. 3 is a side view of the distal end of the stent/catheter assembly of FIG. 1B positioned in the myocardium, with the coronary artery and myocardium shown cut-away.
FIG. 4 is a cross-sectional side view of the stent of FIG. 1B positioned within the myocardium after removal of the catheter used for delivery.
FIG. 5 is a side view of another embodiment of the stent and the catheter used for stent delivery.
FIG. 6 is a cross-sectional side view of the catheter and puncture device used to introduce the self-expanding stent of FIG. 5 into the myocardium.
FIG. 7 is a cross-sectional side view of the stent/catheter assembly of FIG. 5 positioned in the myocardium.
FIG. 8 is a side view of the self-expanding stent of FIG. 5 positioned within the myocardium after removal of the catheter and puncture device, with the coronary artery and myocardium shown cut-away.
FIG. 9 is a perspective view of another embodiment of the stent having expandable legs, showing the stent mounted on the distal end of the introducer catheter.
FIG. 10 is a perspective view of the stent of FIG. 9, showing the distal end of the introducer catheter pushed forward to allow the legs of the stent to expand.
FIG. 11 is a perspective view of the stent of FIG. 9, showing the legs of the stent in an expanded position.
FIG. 12 is a side view of another embodiment of the stent positioned within the myocardium, with the coronary artery and myocardium shown cut-away.
FIG. 13 is a side view of a biodegradable stent positioned within the myocardium, with the coronary artery and myocardium shown cut-away.
FIG. 14 is a side view of a catheter and puncture device used to introduce a bulkhead stent into the myocardium, with the coronary artery and myocardium shown cut-away.
FIG. 15 is a side view of the stent/catheter assembly of FIG. 14 positioned in the myocardium, with the coronary artery and myocardium shown cutaway.
FIGS. 16-19 are progressive side views of the stent/catheter assembly of FIG. 14, showing the bulkhead stent being deployed into the myocardium.
FIGS. 20 and 21 are enlarged views of FIGS. 18 and 19, respectively, showing the bulkhead stent being deployed into the myocardium.
FIG. 22 is a perspective view of a ring of a bulkhead stent in a loaded configuration
FIG. 23 is a perspective view of a ring of a bulkhead stent in an inserted configuration.
FIG. 24 is a perspective view of a bulkhead stent within a delivery catheter, showing the rings of the bulkhead stent being inserted.
FIG. 25 is a perspective view of a bulkhead stent, with the rings of the stent in loaded and inserted configurations.
FIG. 26 is a perspective view of an inserter device used to insert a bulkhead stent.
FIG. 27A is a schematic, cross-sectional view of the human heart, showing a catheter used to form a channel through the myocardium and into the left ventricle inserted into the coronary artery.
FIG. 27B is an enlarged view of the distal end of the catheter and the channel through the myocardium in FIG. 27A.
FIG. 28 is a schematic, cross-sectional view of a stent delivery catheter positioned inside the channel formed in the myocardium.
FIG. 29 is a schematic, partial cross-sectional view of a self-expanding spring stent being positioned in the channel formed in the myocardium.
FIG. 30 is a schematic, partial cross-sectional view of the self-expanding stent deployed within the myocardium.
FIG. 31 is a perspective view of another embodiment of a stent having retention members which maintain the position of the stent.
As is well known, the coronary artery branches off the aorta and is positioned along the external surface of the heart wall. The anatomy of the human heart is illustrated in FIG. 1A. Oxygenated blood flows from the heart PH to the aorta AO, on to the rest of the body, some of the blood flowing into the coronary artery CA. In some individuals, plaque builds up within the coronary artery CA, blocking the free flow of blood and causing complications ranging from mild angina to heart attack and death.
In order to restore the flow of oxygenated blood through the coronary artery, one embodiment of the present invention provides for the shunting of blood directly from the heart to a site in the coronary artery that is distal to the blockage. A channel is formed through the wall of the coronary artery and the myocardium and into the left ventricle of the heart that lies beneath the coronary artery. A stent or conduit is positioned in the passage to keep it open, and allow for the flow of oxygenated blood directly from the heart into the coronary artery. Again, it should be understood that while the insertion of the conduit in the myocardium between the left ventricle and the coronary artery is described in detail below, this is merely exemplary and use of the conduit between other chambers of the heart and the coronary artery, and between blood vessels is also contemplated.
The principles of the present invention are not limited to left ventricular conduits, and include conduits for communicating bodily fluids from any space within a patient to another space within a patient, including any mammal. Furthermore, such fluid communication through the conduits is not limited to any particular direction of flow and can be antegrade or retrograde with respect to the normal flow of fluid. Moreover, the conduits may communicate between a bodily space and a vessel or from one vessel to another vessel (such as an artery to a vein or vice versa). Moreover, the conduits can reside in a single bodily space so as to communicate fluids from one portion of the space to another. For example, the conduits can be used to achieve a bypass within a single vessel, such as communicating blood from a proximal portion of an occluded coronary artery to a more distal portion of that same coronary artery.
In addition, the conduits and related methods can preferably traverse various intermediate destinations and are not limited to any particular flow sequence. For example, in one preferred embodiment of the present invention, the conduit communicates from the left ventricle, through the myocardium, into the pericardial space, and then into the coronary artery. However, other preferred embodiments are disclosed, including direct transmyocardial communication from a left ventricle, through the myocardium and into the coronary artery. Thus, as emphasized above, the term “transmyocardial” should not be narrowly construed in connection with the preferred fluid communication conduits, and other non-myocardial and even noncardiac fluid communication are preferred as well. With respect to the walls of the heart (and more specifically the term “heart wall”), the preferred conduits and related methods are capable of fluid communication through all such walls including, without limitation, the pericardium, epicardium, myocardium, endocardium, septum, etc.
The bypass which is achieved with certain preferred embodiments and related methods is not limited to a complete bypass of bodily fluid flow, but can also include a partial bypass which advantageously supplements the normal bodily blood flow. Moreover, the occlusions which are bypassed may be of a partial or complete nature, and therefore the terminology “bypass” or “occlusion” should not be construed to be limited to a complete bypass or a complete occlusion but can include partial bypass and partial occlusion as described.
The preferred conduits and related methods disclosed herein can also provide complete passages or partial passages through bodily tissues. In this regard, the conduits can comprise stents, shunts, or the like, and therefore provide a passageway or opening for bodily fluid such as blood. Moreover, the conduits are not necessarily stented or lined with a device but can comprise mere tunnels or openings formed in the tissues of the patient.
The conduits of the present invention preferably comprise both integral or one-piece conduits as well as plural sections joined together to form a continuous conduit. The present conduits can be deployed in a variety of methods consistent with sound medical practice including vascular or surgical deliveries, including minimally invasive techniques. For example, various preferred embodiments of delivery rods and associated methods may be used. In one embodiment, the delivery rod is solid and trocar-like. It may be rigid or semi-rigid and capable of penetrating the tissues of the patient and thereby form the conduit, in whole or in part, for purposes of fluid communication. In other preferred embodiments, the delivery rods may be hollow so as to form the conduits themselves (e.g., the conduits are preferably self-implanting or self-inserting) or have a conduit mounted thereon (e.g., the delivery rod is preferably withdrawn leaving the conduit installed). Thus, the preferred conduit device and method for installation is preferably determined by appropriate patient indications in accordance with sound medical practices.
In some individuals, aortic insufficiency or peripheral venous insufficiency occurs. Aortic insufficiency is the leakage of blood through the aortic valve, resulting in a backflow of blood into the left ventricle. The heart compensates for the backflow of blood by pumping harder, resulting in hypertrophy (thickening of the heart muscle) and dilation of the left ventricle wall. Left untreated, heart failure can result. In venous insufficiency, the heart valves are unable to prevent the backflow of blood. This too can result in heart failure. Accordingly, one embodiment of the invention provides for the use of a conduit placed within the heart wall to improve the flow of oxygenated blood through the body.
A first embodiment of the present invention is illustrated in FIG. 1B. This embodiment is a balloon-expanded stent 10. The stent 10 is introduced as described below, using a high-pressure balloon catheter 12 to deploy the stent 10 once it is properly positioned in the myocardium MYO (FIG. 2). When the stent 10 is positioned inside the myocardial wall MYO, the balloon 14 is inflated to expand the stent 10 and open the conduit from the left ventricle LV into the coronary artery CA. The stent 10 can include attachment mechanisms not limited to hooks, barbs, flanges, large collars, suture holes and/or other means to ensure a seal is created between the coronary artery CA and the wall of the myocardium MYO and to prevent the threat of stent 10 migration. When the attachment of the stent 10 is completed, the remaining catheter assembly 12 is removed, leaving the stent 10 in place. Upon deflating the balloon 14, the stent 10 will remain open. Because of the shape of this stent 10, a dumbbell shaped balloon 14 is preferably used to ensure proper expansion, as described below.
FIGS. 1B through 4 illustrate the introduction of the balloon-expanded stent 10 into the myocardial wall MYO. FIG. 1B illustrates the stent 10 mounted over the balloon 14 on the distal end of the stent introducer catheter 12. FIG. 2 illustrates the stent introducer catheter 12 following the path created by a puncture wire 16 extending past the distal end of the introducer catheter 12, and used to access the left ventricle LV through the coronary artery CA and myocardium MYO. Further details regarding conduits and conduit delivery systems are described in copending patent applications entitled DELIVERY METHODS FOR LEFT VENTRICULAR CONDUIT, U.S. patent application Ser. No. 09/368,868, LEFT VENTRICULAR CONDUIT WITH BLOOD VESSEL GRAFT, U.S. patent application Ser. No. 09/369,061, VALVE DESIGNS FOR LEFT VENTRICULAR CONDUIT, U.S. patent application Ser. No. 09/368,393, LEFT VENTRICULAR CONDUITS TO CORONARY ARTERIES AND METHODS FOR CORONARY BYPASS, U.S. patent application Ser. No. 09/369,039, and BLOOD FLOW CONDUIT DELIVERY SYSTEM AND METHOD OF USE, U.S. patent application Ser. No. 09/368,644, all filed on Aug. 4, 1999, and U.S. Pat. Nos. 5,429,144 and 5,662,124, the disclosures of which are all hereby incorporated by reference in their entirety.
FIG. 3 illustrates the non-expanded stent 10 positioned inside the myocardial wall MYO prior to inflation of the balloon 14. FIG. 4 illustrates an expanded stent 10 in position, with the introducer catheter 12 removed. Because of the way the attachment mechanisms 18 expand on this stent 10, a dumbbell shaped balloon 14 is preferably used to flare out the ends of the stent 10. These flared edges 18 maintain the stent 10 in its proper position in the heart wall MYO and provide a seal between the coronary artery CA and the outer heart wall MYO.
The second embodiment of the stent or conduit incorporates a self-expanding stent 20, illustrated in FIGS. 5-8. The stent 20, having a retaining sheath 26 to hold it in a non-expanded configuration, is introduced into the wall of the myocardium MYO as follows. The stent delivery catheter 22 is advanced over a puncture mechanism 24 and into the wall of the myocardium MYO as described above. When the stent 20 is properly seated in the myocardial wall MYO, its retaining sheath 26 is withdrawn, allowing the stent 20 to expand and open a conduit from the ventricle LV to the coronary artery CA. This stent 20 also includes attachment mechanisms not limited to hooks, barbs, flanges, large collars, suture holes and/or other means to ensure a seal is created between the artery CA and the wall of the myocardium MYO, and to prevent the threat of stent 20 migration. When the positioning is completed, the remaining catheter assembly 22 is removed, leaving the stent 20 in place.
The self-expanding stent 20 mounted on the distal end of the stent introducer catheter 22 is illustrated in FIG. 5. FIG. 6 illustrates the stent introducer 22 following the path created by a puncture wire 24 used to form the passage between the coronary artery CA and the left ventricle LV. FIG. 7 illustrates a non-expanded stent 20 located in position on the stent introducer catheter 22 with the introducer catheter 22 in position in the heart wall MYO. FIG. 8 illustrates the self-expanding stent 20 in position, with the introducing catheter 22 removed. Flared edges 28 on the stent 20 maintain its proper position in the heart wall MYO and provide a seal between the coronary vessel CA and outer surface of the heart MYO.
For the stent designs described above, additional anchoring methods may be desired to maintain the stent's proper position and/or create a leak-free seal in the coronary artery. Suitable attachment mechanisms include a set of barbs located on the stent body or flares and a collar on the coronary side to help seal and prevent blood from exiting the gap between the vessel and outer heart wall. The stent can also be anchored in place by applying sutures. The stent can include holes at either end to facilitate the placement of these anchoring sutures. A suture gun can be used to apply multiple sutures at the same time. In addition, the stents can be lined, if desired, with materials such as polymers, for example polytetrafluoroethylene (PTFE), silicone or GORTEX, to provide for the ease of blood flow therethrough.
A third embodiment of the stent design, illustrated in FIGS. 9-11, incorporates attachment flanges or “legs” 30 that expand after introduction into the myocardium to hold the stent 34 in place. The puncture instrument 32 and stent 34 are mated together and are advanced into the myocardial wall as a single unit. The puncture instrument's distal end 36 is shaped in a “nose-cone” configuration, which is responsible for containing the legs 30 of the stent 34 while it is being introduced into the wall of the myocardium. When the stent 34 is in the proper position in the myocardial wall, the nose cone 36 is pushed forward, releasing the attachment legs 30 of the stent 34. The internal diameter (ID) of the stent 34 is large enough to allow the nose cone 36 to pass back through. The stent 34 is then released from the catheter 38 and the catheter 38 is removed.
FIG. 9 illustrates the stent 34 mounted on the introducer catheter 38. The expanding legs 30 of the stent 34 are held in place by the nose cone 36 on the distal end of the catheter 38 that acts as a dilator. The catheter assembly 38 is advanced over a puncture wire if desired, into proper position in the myocardium, and the nose cone 36 is pushed forward allowing the legs 30 to expand as shown in FIG. 10. The nosecone/puncture assembly 32, 36 is then withdrawn through the lumen of the stent 34. When the nose-cone/puncture assembly 32, 36 is removed, the stent 34 can be pushed off the introducer catheter 38 and remains in the myocardium in the position shown in FIG. 11. FIG. 11 also illustrates a sealing collar 44 that may be used in the interface between the coronary artery and the outer wall of the heart to prevent hemorrhaging around the stent 34 and to hold the stent 34 in place. Sutures can be used to ensure that the stent is maintained in its proper position and prevent migration.
FIG. 12 illustrates a further embodiment of the present invention, a “bulkhead” stent 50. This stent 50 consists of a plurality of rings, which are placed in the myocardium MYO. The rings 50 form a passage through which blood flows from a chamber in the heart, such as the left ventricle LV, directly into the coronary artery CA. The stent 50 is preferably formed of biocompatible material such as a metal or polymer. A gun or other suitable device can be used to implant the stent 50 in the myocardium MYO.
If desired, the separate units or rings of the stent 50 can be connected via a wire, suture thread, or similar means. The wire is threaded through the holes 51 located in each ring. Connecting the rings of the stent 50 in this manner serves to make the stent 50 more stable and to prevent the migration of the individual units. If desired, a valve (not shown) can be incorporated into the stent 50 to help prevent the backflow of blood into the left ventricle LV. Additional details regarding valve designs are disclosed in the above referenced copending applications entitled LEFT VENTRICULAR CONDUIT WITH BLOOD VESSEL GRAFT, U.S. patent application Ser. No. 09/369,061, VALVE DESIGNS FOR LEFT VENTRICULAR CONDUIT, U.S. patent application Ser. No. 09/368,393 and LEFT VENTRICULAR CONDUITS TO CORONARY ARTERIES AND METHODS FOR CORONARY BYPASS, U.S. patent application Ser. No. 09/369,039, filed on Aug. 4, 1999, all of which are incorporated by reference in their entirety.
If desired, the stent or conduit of the present invention can be formed of biodegradable or bioabsorbable materials and/or used to deliver drugs directly into the myocardium and the coronary circulation. Such a stent 52 is illustrated in FIG. 13. The biodegradable stent 52 can extend only partially through the myocardium MYO as illustrated in FIG. 13, but can also extend entirely through from the left ventricle LV to the coronary artery CA. Once positioned in the myocardium MYO, the stent 52 degrades, dissolves or is absorbed over time to release drugs, genes, angiogenesis or growth factors, or other pharmaceutical compounds directly into the heart muscle MYO and the coronary artery CA, as shown by the arrows in FIG. 13. Bioabsorbable materials include, but are not limited to, polymers of the linear aliphatic polyester and glycolide families, such as polylactide and polyglycolide. Further details are described in the above-referenced application entitled LEFT VENTRICULAR CONDUITS TO CORONARY ARTERIES AND METHODS FOR CORONARY BYPASS, U.S. patent application Ser. No. 09/369,039, filed on Aug. 4, 1999.
Turning now to FIGS. 14-26, there is illustrated in greater detail one preferred method and apparatus for providing a bulkhead stent 50, as shown in FIG. 12, into the myocardium MYO. As shown in FIG. 14, a stent delivery catheter 60 is advanced over a puncture wire 62 and into the wall of the myocardium MYO as described above. The stent delivery catheter 60 follows the path created by the puncture wire 62 used to form the passage between the coronary artery CA and the left ventricle LV. FIG. 15 illustrates a bulkhead stent 50 still located in position inside the stent delivery catheter 60 with the catheter 60 in position in the heart wall MYO.
FIGS. 16-19 show one embodiment for deploying the bulkhead stent 50 into the myocardium MYO. As the delivery catheter 60 is retracted proximally from the myocardium MYO, the rings comprising the bulkhead stent 50 are deployed into the myocardium MYO. FIGS. 20 and 21 are enlarged views of FIGS. 18 and 19, showing the rings of the bulkhead stent 50 positioned within the myocardium MYO to form the passageway therethrough.
FIGS. 22-25 illustrate more particularly the structure and deployment of the rings comprising the bulkhead stent 50. As shown in FIG. 24, the bulkhead stent comprises a plurality of rings 64 that are initially loaded into the delivery catheter 60. While inside the lumen of the catheter 60, each ring 64 has a loaded configuration 64A, shown in FIGS. 22 and 25. After ejectment from the catheter 60, the ring 64 assumes an inserted configuration 64B, shown in FIGS. 23 and 25. Preferably, the inserted configuration of ring 64B includes a plurality of flanges 66 around the circumference of each ring 64, thereby providing a securement mechanism to anchor each ring 64 to the myocardium MYO. Each ring 64 transforms from its loaded configuration 64A to its inserted configuration 64B by virtue of being released from the catheter 60. Specifically, the catheter 60 acts as a restraint on each ring 64 to keep it in its loaded configuration 64A. Then, once the ring 64 is released from the catheter 60, the flanges 66 provided along the circumference of each ring 64 are allowed to extend outward to provide the securement mechanism.
FIG. 26 illustrates an inserter device or handle 68 that may be used in deploying the bulkhead stent 50 into the myocardium. The inserter handle 68 preferably comprises a gun 70 with a trigger 72, and a wire 74 extending from a nozzle 76. The rings 64 (not shown) of the bulkhead stent 50 are preferably loaded onto the wire 74, and may be deployed into the myocardium preferably one at a time by pressing the trigger 72.
FIGS. 27-30 illustrate another embodiment of the present invention. Here, a self-expanding spring or screw stent 140 is delivered into the myocardium MYO. As illustrated in FIG. 27A, a channel 142 through the wall of the myocardium MYO is first created, as described above, using a device 144 delivered through the aorta AO and coronary artery CA. The channel 142 travels from the coronary artery CA through the myocardium MYO and into the left ventricle LV as shown in FIG. 27B. The distal end of the stent delivery catheter 146 bearing the stent 140 is then positioned within the channel 142, as shown in FIG. 28. Preferably, the position of the distal end of the delivery catheter 146 is checked radiographically, to ensure proper positioning. Next, as illustrated in FIG. 29, the self-expanding spring stent 140 is delivered into the channel 142 wall of the myocardium MYO. The stent 140 is cut such that it does not extend past the myocardium MYO and into either the left ventricle LV or the coronary artery CA. Again, the proper positioning and length of the stent 140 is preferably checked radiographically and any necessary adjustments made before the delivery catheter 146 is removed, as shown in FIG. 30.
FIG. 31 illustrates another embodiment of the stent 200 having retention members 202. The hollow stent body 204 is held in place in the heart wall by one or more retention members 202 which are deployed after the stent 200 is properly positioned, as described above. FIG. 31 shows the retention members 202 in their deployed position. A flange 206 acts to seal the opening in the coronary artery, while the retention members 202 reside in the myocardium, helping to anchor the stent 200 in place.
It should be appreciated that the stents described above, and particularly the bulkhead stent, are useful in other applications in addition to stenting the myocardium. For example, these stents may also serve as other types of coronary stents, arterial or venous stents, as well as billiary and esophageal stents.
The present vascular shunt provides significant improvements in the present treatment of blockages in the coronary artery. Although the invention has been described in its preferred embodiments in connection with the particular figures, it is not intended that this description should be limited in any way.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US4503568||25 Nov 1981||12 Mar 1985||New England Deaconess Hospital||Small diameter vascular bypass and method|
|US4733665||7 Nov 1985||29 Mar 1988||Expandable Grafts Partnership||Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft|
|US4769029||19 Jun 1987||6 Sep 1988||Patel Jayendrakumar I||Prosthetic graft for arterial system repair|
|US4995857||7 Apr 1989||26 Feb 1991||Arnold John R||Left ventricular assist device and method for temporary and permanent procedures|
|US5035702||18 Jun 1990||30 Jul 1991||Taheri Syde A||Method and apparatus for providing an anastomosis|
|US5135467||7 Dec 1989||4 Aug 1992||Medtronic, Inc.||Implantable system and method for coronary perfusions assistance|
|US5193546||15 May 1991||16 Mar 1993||Alexander Shaknovich||Coronary intravascular ultrasound imaging method and apparatus|
|US5258008||29 Jul 1992||2 Nov 1993||Wilk Peter J||Surgical stapling device and associated method|
|US5287861||30 Oct 1992||22 Feb 1994||Wilk Peter J||Coronary artery by-pass method and associated catheter|
|US5330486||25 Nov 1992||19 Jul 1994||Wilk Peter J||Laparoscopic or endoscopic anastomosis technique and associated instruments|
|US5344426||15 Apr 1993||6 Sep 1994||Advanced Cardiovascular Systems, Inc.||Method and system for stent delivery|
|US5385541||24 Apr 1992||31 Jan 1995||Loma Linda University Medical Center||Cerebrospinal fluid shunt capable of minimal invasive revision|
|US5409019||3 Nov 1993||25 Apr 1995||Wilk; Peter J.||Coronary artery by-pass method|
|US5423851||6 Mar 1994||13 Jun 1995||Samuels; Shaun L. W.||Method and apparatus for affixing an endoluminal device to the walls of tubular structures within the body|
|US5429144||5 Apr 1994||4 Jul 1995||Wilk; Peter J.||Coronary artery by-pass method|
|US5443497||22 Nov 1993||22 Aug 1995||The Johns Hopkins University||Percutaneous prosthetic by-pass graft and method of use|
|US5456712||18 Oct 1993||10 Oct 1995||Maginot; Thomas J.||Graft and stent assembly|
|US5456714||3 Jul 1992||10 Oct 1995||Owen; Earl R.||Tubular surgical implant having a locking ring and flange|
|US5470320||10 Apr 1992||28 Nov 1995||Tiefenbrun; Jonathan||Method and related device for obtaining access to a hollow organ|
|US5527337||22 Feb 1994||18 Jun 1996||Duke University||Bioabsorbable stent and method of making the same|
|US5554119||27 Jan 1994||10 Sep 1996||Scimed||Drug delivery catheter with manifold|
|US5578075||1 Jun 1995||26 Nov 1996||Michael Peck Dayton||Minimally invasive bioactivated endoprosthesis for vessel repair|
|US5593434||7 Jun 1995||14 Jan 1997||Advanced Cardiovascular Systems, Inc.||Stent capable of attachment within a body lumen|
|US5609626||22 Jun 1994||11 Mar 1997||Baxter International Inc.||Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts|
|US5618299||8 Aug 1995||8 Apr 1997||Advanced Cardiovascular Systems, Inc.||Ratcheting stent|
|US5655548||16 Sep 1996||12 Aug 1997||Circulation, Inc.||Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion|
|US5662124||19 Jun 1996||2 Sep 1997||Wilk Patent Development Corp.||Coronary artery by-pass method|
|US5755682||13 Aug 1996||26 May 1998||Heartstent Corporation||Method and apparatus for performing coronary artery bypass surgery|
|US5758663||5 Apr 1996||2 Jun 1998||Wilk; Peter J.||Coronary artery by-pass method|
|US5797933||16 Jul 1996||25 Aug 1998||Heartport, Inc.||Coronary shunt and method of use|
|US5810836||7 Nov 1996||22 Sep 1998||Myocardial Stents, Inc.||Device and method for trans myocardial revascularization (TMR)|
|US5824038||26 Dec 1995||20 Oct 1998||Wall; W. Henry||Angioplasty stent|
|US5824071||12 Feb 1997||20 Oct 1998||Circulation, Inc.||Apparatus for treatment of ischemic heart disease by providing transvenous myocardial perfusion|
|US5830222||11 Oct 1996||3 Nov 1998||Transvascular, Inc.||Device, system and method for intersititial transvascular intervention|
|US5843163||6 Jun 1996||1 Dec 1998||Wall; William H.||Expandable stent having radioactive treatment means|
|US5851232||15 Mar 1997||22 Dec 1998||Lois; William A.||Venous stent|
|US5855597||7 May 1997||5 Jan 1999||Iowa-India Investments Co. Limited||Stent valve and stent graft for percutaneous surgery|
|US5865723||29 Dec 1995||2 Feb 1999||Ramus Medical Technologies||Method and apparatus for forming vascular prostheses|
|US5876419||15 Oct 1997||2 Mar 1999||Navius Corporation||Stent and method for making a stent|
|US5878751||20 Oct 1997||9 Mar 1999||Myocardial Stents, Inc.||Method for trans myocardial revascularization (TMR)|
|US5908028||11 Jul 1997||1 Jun 1999||Wilk Patent Development Corp.||Coronary artery by-pass method|
|US5908029||15 Aug 1997||1 Jun 1999||Heartstent Corporation||Coronary artery bypass with reverse flow|
|US5935119||6 Aug 1997||10 Aug 1999||United States Surgical Corporation||Perfusion structure|
|US5935161||11 Apr 1997||10 Aug 1999||C. R. Bard, Inc.||Non-migrating vascular prosthesis and minimally invasive placement system therefor|
|US5935162||16 Mar 1998||10 Aug 1999||Medtronic, Inc.||Wire-tubular hybrid stent|
|US5944019||25 Jun 1997||31 Aug 1999||Heartstent Corporation||Closed chest coronary bypass|
|US5961548||18 Nov 1997||5 Oct 1999||Shmulewitz; Ascher||Bifurcated two-part graft and methods of implantation|
|US5968093||28 Oct 1997||19 Oct 1999||Biotronik Mess-And Therapiegerate Gmbh & Co.||Stent|
|US5971993||16 Dec 1998||26 Oct 1999||Myocardial Stents, Inc.||System for delivery of a trans myocardial device to a heart wall|
|US5976159||8 Feb 1996||2 Nov 1999||Heartport, Inc.||Surgical clips and methods for tissue approximation|
|US5976169||30 Nov 1998||2 Nov 1999||Cardiovasc, Inc.||Stent with silver coating and method|
|US5976181||22 Sep 1997||2 Nov 1999||Ave Connaught||Balloon mounted stent and method therefor|
|US5976182||15 Jun 1998||2 Nov 1999||Advanced Cardiovascular Systems, Inc.||Balloon-expandable, crush-resistant locking stent and method of loading the same|
|US5976192||10 Dec 1996||2 Nov 1999||Baxter International Inc.||Method of forming an externally supported tape reinforced vascular graft|
|US5976650||7 Jun 1995||2 Nov 1999||W. L. Gore & Associates, Inc.||Method of securing a thin-wall intraluminal graft|
|US5979455||5 May 1998||9 Nov 1999||Maginot Vascular Systems||Method for directing blood flow in the body of a patient with a graft and stent assembly|
|US5980548||29 Oct 1997||9 Nov 1999||Kensey Nash Corporation||Transmyocardial revascularization system|
|US5980551||7 Feb 1997||9 Nov 1999||Endovasc Ltd., Inc.||Composition and method for making a biodegradable drug delivery stent|
|US5980552||4 Dec 1996||9 Nov 1999||Medinol Ltd.||Articulated stent|
|US5980553||7 Apr 1997||9 Nov 1999||Cordis Corporation||Axially flexible stent|
|US5980566||11 Apr 1998||9 Nov 1999||Alt; Eckhard||Vascular and endoluminal stents with iridium oxide coating|
|US5984955||11 Sep 1997||16 Nov 1999||Wisselink; Willem||System and method for endoluminal grafting of bifurcated or branched vessels|
|US5984956||6 Oct 1997||16 Nov 1999||Heartstent Corporation||Transmyocardial implant|
|US5984963||23 Apr 1996||16 Nov 1999||Medtronic Ave, Inc.||Endovascular stents|
|US5984965||28 Aug 1997||16 Nov 1999||Urosurge, Inc.||Anti-reflux reinforced stent|
|US5989207||3 Nov 1997||23 Nov 1999||Hughes; Boyd R.||Double swirl stent|
|US5989287||6 May 1998||23 Nov 1999||Av Healing Llc||Vascular graft assemblies and methods for implanting same|
|US5993481||29 Apr 1997||30 Nov 1999||Intervascular, Inc.||Modular bifurcated intraluminal grafts and methods for delivering and assembling same|
|US5993482||30 Jun 1997||30 Nov 1999||Endovascular Technologies, Inc.||Flat wire stent|
|US5997563||28 Sep 1998||7 Dec 1999||Medtronic, Inc.||Implantable stent having variable diameter|
|US5997573||29 Jul 1997||7 Dec 1999||Baxter International, Inc.||Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts|
|US6001123||28 May 1996||14 Dec 1999||Gore Enterprise Holdings Inc.||Folding self-expandable intravascular stent-graft|
|US6004261||13 Feb 1997||21 Dec 1999||C. R. Bard, Inc.||Formed-in-place endovascular stent and delivery system|
|US6004347||4 Dec 1996||21 Dec 1999||C. R. Bard, Inc.||Non-migrating vascular prosthesis and minimally invasive placement system therefor|
|US6004348||27 Apr 1998||21 Dec 1999||Impra, Inc.||Endoluminal encapsulated stent and methods of manufacture and endoluminal delivery|
|US6007544||16 Apr 1998||28 Dec 1999||Beth Israel Deaconess Medical Center||Catheter apparatus having an improved shape-memory alloy cuff and inflatable on-demand balloon for creating a bypass graft in-vivo|
|US6007575||6 Jun 1997||28 Dec 1999||Samuels; Shaun Laurence Wilkie||Inflatable intraluminal stent and method for affixing same within the human body|
|US6007576||6 Feb 1998||28 Dec 1999||Mcclellan; Scott B.||End to side anastomic implant|
|US6010530||18 Feb 1998||4 Jan 2000||Boston Scientific Technology, Inc.||Self-expanding endoluminal prosthesis|
|US6017365||20 May 1998||25 Jan 2000||Jomed Implantate Gmbh||Coronary stent|
|US6029672||20 Apr 1998||29 Feb 2000||Heartstent Corporation||Transmyocardial implant procedure and tools|
|US6045565||2 Nov 1998||4 Apr 2000||Scimed Life Systems, Inc.||Percutaneous myocardial revascularization growth factor mediums and method|
|US6053911||18 Mar 1997||25 Apr 2000||Thomas J. Fogarty||Transvascular TMR device and method|
|US6053924 *||29 Apr 1999||25 Apr 2000||Hussein; Hany||Device and method for trans myocardial revascularization|
|US6053942||18 Aug 1998||25 Apr 2000||Heartstent Corporation||Transmyocardial implant with coronary stent|
|US6067988||26 Dec 1996||30 May 2000||Eclipse Surgical Technologies, Inc.||Method for creation of drug delivery and/or stimulation pockets in myocardium|
|US6068638||27 Oct 1998||30 May 2000||Transvascular, Inc.||Device, system and method for interstitial transvascular intervention|
|US6071292||28 Jun 1997||6 Jun 2000||Transvascular, Inc.||Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures|
|US6076529||20 Apr 1998||20 Jun 2000||Heartstent Corporation||Transmyocardial implant with inserted vessel|
|US6080163||15 Jun 1998||27 Jun 2000||Myocardial Stents, Inc.||Device and method for trans myocardial revascularization (TMR)|
|US6093166||3 Apr 1998||25 Jul 2000||Heartstent, Llc||Coronary bypass implant|
|US6095997||4 Mar 1998||1 Aug 2000||Corvascular, Inc.||Intraluminal shunt and methods of use|
|US6102941||8 Feb 1999||15 Aug 2000||Heartstent Corporation||Transmyocardial implant with coronary ingrowth|
|US6106538||5 Apr 1999||22 Aug 2000||Shiber; Samuel||Method for forming an internal coronary bypass|
|US6110201||18 Feb 1999||29 Aug 2000||Venpro||Bifurcated biological pulmonary valved conduit|
|US6113630||13 Aug 1999||5 Sep 2000||Heartstent Corporation||Transmyocardial implant with minimized coronary insertion|
|US6113823||9 Jun 1998||5 Sep 2000||Heartstent Corporation||Pyrolytic carbon transmyocardial implant|
|US6117165||10 Jun 1998||12 Sep 2000||Becker; Gary J.||Expandable intraluminal endoprosthesis|
|US6123682||3 Apr 1998||26 Sep 2000||Heartstent Corporation||Closed chest coronary bypass|
|US6126649||10 Jun 1999||3 Oct 2000||Transvascular, Inc.||Steerable catheter with external guidewire as catheter tip deflector|
|US6139541||2 Sep 1998||31 Oct 2000||Heartstent Corporation||Guide for transmyocardial implant|
|US6152141||8 Dec 1997||28 Nov 2000||Heartport, Inc.||Method for delivery of therapeutic agents to the heart|
|US6159225||27 Oct 1998||12 Dec 2000||Transvascular, Inc.||Device for interstitial transvascular intervention and revascularization|
|US6162245||5 Jan 1999||19 Dec 2000||Iowa-India Investments Company Limited||Stent valve and stent graft|
|US6182668||13 May 1999||6 Feb 2001||Heartstent Corporation||Transmyocardial implant with induced tissue flap|
|US6186972||9 Dec 1998||13 Feb 2001||James A. Nelson||Methods and apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion|
|US6187034 *||13 Jan 1999||13 Feb 2001||John J. Frantzen||Segmented stent for flexible stent delivery system|
|US6190353||11 Oct 1996||20 Feb 2001||Transvascular, Inc.||Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures|
|US6193726||15 Jan 1999||27 Feb 2001||Heartstent Corporation||Insertion tool for transmyocardial implant|
|US6196230||10 Sep 1998||6 Mar 2001||Percardia, Inc.||Stent delivery system and method of use|
|US6197050||14 Sep 1998||6 Mar 2001||Heartstent Corporation||Transmyocardial implant with compliance collar|
|US6203556 *||5 Aug 1999||20 Mar 2001||Kensey Nash Corporation||Transmyocardial revascularization system and method of use|
|US6214041||20 Jan 1998||10 Apr 2001||Heartstent Corporation||Transmyocardial implant with septal perfusion|
|US6223752||27 Oct 1998||1 May 2001||Heartstent Corporation||Transmyocardial implant procedure|
|US6231587||11 Mar 1999||15 May 2001||Transvascular, Inc.||Devices for connecting anatomical conduits such as vascular structures|
|US6237607||4 Nov 1999||29 May 2001||Heartstent Corporation||Transmyocardial implant procedure|
|US6238406||1 Mar 2000||29 May 2001||Scimed Life Systems, Inc.||Percutaneous myocardial revascularization growth factor mediums and method|
|US6245102 *||21 Jul 1999||12 Jun 2001||Iowa-India Investments Company Ltd.||Stent, stent graft and stent valve|
|US6250305||20 Jan 1998||26 Jun 2001||Heartstent Corporation||Method for using a flexible transmyocardial implant|
|US6253768||4 Aug 1999||3 Jul 2001||Percardia, Inc.||Vascular graft bypass|
|US6254564||4 Aug 1999||3 Jul 2001||Percardia, Inc.||Left ventricular conduit with blood vessel graft|
|US6258119||15 Apr 1999||10 Jul 2001||Myocardial Stents, Inc.||Implant device for trans myocardial revascularization|
|US6261304||4 Aug 1999||17 Jul 2001||Percardia, Inc.||Delivery methods for left ventricular conduit|
|US6283951||25 Mar 1998||4 Sep 2001||Transvascular, Inc.||Systems and methods for delivering drugs to selected locations within the body|
|US6283983||10 Aug 1998||4 Sep 2001||Transvascular, Inc.||Percutaneous in-situ coronary bypass method and apparatus|
|US6287317||5 Apr 2000||11 Sep 2001||Transvascular, Inc.||Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures|
|US6290719||14 Jul 1998||18 Sep 2001||Sorin Biomedica Cardio S.P.A.||Element for anchoring an implant device in place|
|US6290728||4 Aug 1999||18 Sep 2001||Percardia, Inc.||Designs for left ventricular conduit|
|US6293955||8 Oct 1999||25 Sep 2001||Converge Medical, Inc.||Percutaneous bypass graft and securing system|
|US6302875||11 Apr 1997||16 Oct 2001||Transvascular, Inc.||Catheters and related devices for forming passageways between blood vessels or other anatomical structures|
|US6302892||4 Aug 1999||16 Oct 2001||Percardia, Inc.||Blood flow conduit delivery system and method of use|
|US6306125||21 Jun 1999||23 Oct 2001||Neovasys, Inc.||Angiogenic implant delivery system and method|
|US6330884||2 Jun 1998||18 Dec 2001||Transvascular, Inc.||Deformable scaffolding multicellular stent|
|US6350248||13 Apr 2000||26 Feb 2002||Heartstent Corporation||Expandable myocardial implant|
|US6361519||13 Apr 2000||26 Mar 2002||Heartstent Corporation||Mesh tip myocardial implant|
|US6363938 *||22 Dec 1998||2 Apr 2002||Angiotrax, Inc.||Methods and apparatus for perfusing tissue and/or stimulating revascularization and tissue growth|
|US6363939||18 May 1999||2 Apr 2002||Wilk Patent Development Corp.||Coronary artery by-pass method|
|US6375615||31 Mar 1999||23 Apr 2002||Transvascular, Inc.||Tissue penetrating catheters having integral imaging transducers and their methods of use|
|US6379319||27 Oct 1998||30 Apr 2002||Transvascular, Inc.||Systems and methods for directing and snaring guidewires|
|US6387119||2 Mar 2001||14 May 2002||Percardia, Inc.||Delivery methods for left ventricular conduit|
|US6406488||27 Aug 1998||18 Jun 2002||Heartstent Corporation||Healing transmyocardial implant|
|US6406491||4 May 1999||18 Jun 2002||Heartstent Corporation||Compliant transmyocardial implant|
|US6409697||4 May 1999||25 Jun 2002||Heartstent Corporation||Transmyocardial implant with forward flow bias|
|US6409751||14 Nov 2000||25 Jun 2002||Percardia, Inc.||Stent delivery system and method of use|
|US6423089||22 Apr 1999||23 Jul 2002||Atrium Medical Corporation||Vascular endoprosthesis and method|
|US6432126||30 Sep 1998||13 Aug 2002||C.R. Bard, Inc.||Flexible vascular inducing implants|
|US6432127||14 Nov 1997||13 Aug 2002||Transvascular, Inc.||Devices for forming and/or maintaining connections between adjacent anatomical conduits|
|US6432132||11 Jan 2000||13 Aug 2002||Orbus Medical Technologies Inc.||Expandable intraluminal endoprosthesis|
|US6447522||18 Jun 2001||10 Sep 2002||C. R. Bard, Inc.||Implant delivery system|
|US6447539||15 Sep 1997||10 Sep 2002||Transvascular, Inc.||Method and apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion|
|US6454760||26 Feb 2001||24 Sep 2002||Heartstent Corporation||Insertion tool for transmyocardial implant|
|US6454794||7 Jun 1999||24 Sep 2002||Heartstent Corporation||Coronary bypass implant|
|US6458323||19 Apr 1996||1 Oct 2002||Peter Boekstegers||Method and device for the vascular pressure-controlled selective perfusion of fluids through blood vessels|
|US20010004683||31 Jan 2001||21 Jun 2001||Gambale Richard A.||Vascular inducing implants|
|US20010004690||31 Jan 2001||21 Jun 2001||Gambale Richard A.||Vascular inducing implants|
|US20010004699||1 Feb 2001||21 Jun 2001||Ventrica, Inc.||Methods and devices for forming vascular anastomoses|
|US20010008969||1 Feb 2001||19 Jul 2001||Kensey Nash Corporation||Transmyocardial revascularization system and method of use|
|US20010012948||26 Feb 2001||9 Aug 2001||Heartstent Corporation||Insertion tool for transmyocardial implant|
|US20010014813||22 Dec 1998||16 Aug 2001||Vahid Saadat||Methods and apparatus for perfusing tissue and/or stimulating revascularization and tissue growth|
|US20010016700||4 May 1999||23 Aug 2001||Heartstent Corporation||Transmyocardial implant with flow reduction|
|US20010025643||11 Apr 2001||4 Oct 2001||Ventrica, Inc.||Methods and devices providing transmyocardial blood flow to the arterial vascular system of the heart|
|US20010027287||27 Feb 2001||4 Oct 2001||Trans Vascular, Inc.||Apparatus for providing coronary retroperfusion and/or left ventricular assist and methods of use|
|US20010034547||2 Mar 2001||25 Oct 2001||Percardia, Inc.||Delivery methods for left ventricular conduit|
|US20010037117||18 Jun 2001||1 Nov 2001||Gambale Richard A.||Implant delivery system|
|US20010037149||10 Apr 2001||1 Nov 2001||Percardia, Inc||Vascular graft bypass|
|US20010039426||18 Jul 2001||8 Nov 2001||Trans Vascular, Inc.||Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures|
|US20010039445||27 Jun 2001||8 Nov 2001||Percardia, Inc.||Stent delivery system and method of use|
|US20010041902||10 Sep 1999||15 Nov 2001||Michael J. Lynch||Anastomotic methods and devices for placing a target vessel in fluid communication with a source of blood|
|US20010047165||24 Jul 2001||29 Nov 2001||Transvascular, Inc.||Catheters and related devices for forming passageways between blood vessels or other anatomical structures|
|US20010053932||10 Apr 2001||20 Dec 2001||Percardia, Inc.,||Designs for left ventricular conduit|
|US20020002349||3 Apr 2001||3 Jan 2002||Transvascular, Inc.||Systems and methods for delivering drugs to selected locations within the body|
|US20020004662||10 Apr 2001||10 Jan 2002||Percardia, Inc.||Blood flow conduit delivery system and method of use|
|US20020004663||7 May 2001||10 Jan 2002||Ventrica, Inc.||Methods and devices for placing a conduit in fluid communication with a target vessel|
|US20020007138||10 Apr 2001||17 Jan 2002||Percardia, Inc.||Left ventricular conduit with blood vessel graft|
|US20020029079||24 Jul 2001||7 Mar 2002||Transvascular, Inc.||Devices for forming and/or maintaining connections between adjacent anatomical conduits|
|US20020032476||21 Nov 2001||14 Mar 2002||Gambale Richard A.||Flexible vascular inducing implants|
|US20020049486||30 Apr 2001||25 Apr 2002||Heartstent Corporation||Method and apparatus for performing coronary artery bypass surgery|
|US20020058897||20 Sep 2001||16 May 2002||Percardia, Inc.||Designs for left ventricular conduit|
|US20020062146||26 Nov 2001||23 May 2002||Joshua Makower||Methods and apparatus for transmyocardial direct coronary revascularization|
|US20020065478||9 Jan 2002||30 May 2002||Heartstent Corporation||Method and apparatus for revascularizing a coronary vessel with an implant having a tapered myocardial leg|
|US20020072699||15 Feb 2002||13 Jun 2002||Heartstent Corporation||Transmyocardial implant with improved flow|
|US20020077566||13 Oct 1998||20 Jun 2002||Gilbert S. Laroya||Placing a guide member into a heart chamber through a coronary vessel and delivering devices for placing the coronary vessel in communication with the heart chamber|
|US20020092535||5 Feb 2002||18 Jul 2002||Wilk Patent Development Corp.||Coronary artery by-pass method|
|US20020095111||8 Mar 2002||18 Jul 2002||Heartstent Corporation||Healing transmyocardial implant|
|US20020100484||8 Mar 2002||1 Aug 2002||Hall Todd A.||Delivery methods for left ventricular conduit|
|US20020111672||20 Aug 2001||15 Aug 2002||Transvascular, Inc.||Deformable scaffolding multicellular stent|
|US20020123698||30 Apr 2002||5 Sep 2002||Transvascular, Inc.||Systems and methods for directing and snaring guidewires|
|US20020144696||10 Sep 1999||10 Oct 2002||A. Adam Sharkawy||Conduits for use in placing a target vessel in fluid communication with a source of blood|
|US20020161424||13 Oct 1998||31 Oct 2002||Alan R. Rapacki||Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication|
|US20020165479||1 Jul 2002||7 Nov 2002||Percardia, Inc.||Left ventricular conduits to coronary arteries and methods for coronary bypass|
|US20020165606||4 Aug 1999||7 Nov 2002||Wolf Scott J.||Valve designs for left ventricular conduits|
|USD438618||25 Feb 2000||6 Mar 2001||Jan Otto Solem||Graft connector|
|EP0732088B1||14 Mar 1996||12 Apr 2000||Advanced Cardiovascular Systems, Inc.||Expandable stent forming projecting barbs|
|EP0824903B1||15 Aug 1997||14 Jan 2004||Medtronic Ave, Inc.||A profiled stent and method of manufacture|
|EP0876803B1||6 May 1998||19 Jul 2006||C.R. Bard, Inc.||TMR stent and delivery system|
|EP0903123A1||21 Sep 1998||24 Mar 1999||Cordis Corporation||Axially flexible stent|
|EP0904745A2||11 Sep 1998||31 Mar 1999||Arterial Vascular Engineering, Inc.||Endolumenal prosthesis and method of use in bifurcation regions of body lumens|
|EP0955017B1||22 Apr 1999||7 Jun 2006||Abbott Laboratories Vascular Enterprises Limited||Radially expandable stent|
|EP0955019B1||30 Apr 1999||26 Jan 2005||Vascutek Limited||Prosthetic tubular aortic conduit and method for manufacturing the same|
|EP0962194A3||28 May 1999||19 Apr 2000||Bard Connaught||Expandable stent having articulated connecting rods|
|EP1020166A1||12 Jan 1999||19 Jul 2000||Orbus Medical Technologies, Inc.||Expandable intraluminal endoprosthesis|
|EP1020870B1||19 Mar 1999||16 Mar 2005||Macronix International Co., Ltd.||Method and device for multi-level programming of a memory cell|
|EP1020878B1||18 Jan 2000||19 Nov 2003||Matsushita Electric Industrial Co., Ltd.||High electric resistance magnetic film|
|EP1027870B1||12 Jan 2000||30 Mar 2005||Orbus Medical Technologies, Inc.||Expandable intraluminal endoprosthesis|
|EP1097676A1||4 Nov 1999||9 May 2001||Transvascular, Inc.||Device for forming holes in tissue|
|EP1166721A3||11 Oct 1996||3 Dec 2003||Transvascular, Inc.||Apparatus for transvascular procedures|
|GB2316322B||Title not available|
|1||Anabtawi, M.D. et al., "Experimental evaluation of myocardial tunnelization as a method of myocardial revascularization," The Journal of Thoracic and Cardiovasular Surgery, Nov. 1969, vol. 58, No. 5, pp. 638-646.|
|2||Burch et al., "Surgical closure of coronary artery fistula emptying into left ventricle," American Heart Journal, Jan. 1980, vol. 99, No. 1, p. 133.|
|3||Gardner, M.D. et al., "An Experimental Anatomic Study of Indirect Myocardial Revascularization," Journal of Surgical Research, May 1971, vol. 11, No. 5, pp. 243-247.|
|4||Kuzela, M.D. et al., "Experimental evaluation fo direct transventricular revascularization," The Journal of Thoracic and Cardiovascular Surgery, Jun. 1969, vol. 57, No. 6, pp. 770-773.|
|5||Lary, M.D. et al., "Myocardial Revascularization Experiments Using the Epicardium," Archives of Surgery, Jan. 1969, vol. 98, No. 1, pp. 69-72.|
|6||Massimo, M.D. et al., "Myocardial Revascularization by a New Method of Carrying Blood Directly from the Left Ventricular Cavity into the Coronary Circulation," Journal of Thoracic Surgeons, Aug. 1997, vol. 34, No. 2, pp. 257-264.|
|7||Munro, M.D. et al., "The possibility of myocardial revascularization by creation of a left ventriculocoronary artery fistula," Journal of Thoracic and Cardiovascular Surgery, Jul. 1969, vol. 58, No. 1, pp. 25-32.|
|8||Palmaz et al., "Expandable Intrahepatic Portacaval Shunt Stents in Dogs with Chronic Portal Hypertension," AJR, 1986, vol. 147, pp. 1251-1254.|
|9||Palmaz et al., "Expandable Intrahepatic Portacaval Shunt Stents: Early Experience in the Dog," AJR, 1985, vol. 145, pp. 821-825.|
|10||Richter, M.D. et al., "Transjugular Intrahepatic Portacaval Stent Shunt: Preliminary Clinical Results," Radiology, 1990, vol. 174, No. 3, pp. 1027-1030.|
|11||Tweden et al., "Ventriculocoronary Artery Bypass (VCAB), a Novel Approach to Myocardial Revascularization," #2000-4653, Feb. 2000.|
|12||US 6,331,185, 12/2001, Gambale et al. (withdrawn)|
|13||Zemel, M.D. et al., "Percutaneous Transjugular Portosystemic Shunt," JAMA, 1991, vol. 266, No. 3, pp. 390-393.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US6953481 *||23 Jun 2004||11 Oct 2005||Percardia, Inc.||Designs for left ventricular conduit|
|US7658879||4 May 2006||9 Feb 2010||Medtronic, Inc.||Trajectory guide with angled or patterned guide lumens or height adjustment|
|US7660621||9 Feb 2010||Medtronic, Inc.||Medical device introducer|
|US7699854||4 May 2006||20 Apr 2010||Medtronic, Inc.||Trajectory guide with angled or patterned guide lumens or height adjustment|
|US7704222||30 Aug 2004||27 Apr 2010||Jenavalve Technology, Inc.||Methods and conduits for flowing blood from a heart chamber to a blood vessel|
|US7704260||6 Dec 2004||27 Apr 2010||Medtronic, Inc.||Low profile instrument immobilizer|
|US7736327||9 May 2008||15 Jun 2010||Jenavalve Technology, Inc.||Methods and conduits for flowing blood from a heart chamber to a blood vessel|
|US7744606 *||29 Jun 2010||Medtronic, Inc.||Multi-lumen instrument guide|
|US7803163||28 Oct 2005||28 Sep 2010||Medtronic, Inc.||Multiple instrument retaining assembly and methods therefor|
|US7815651||19 Oct 2010||Medtronic, Inc.||Device for immobilizing a primary instrument and method therefor|
|US7828809||26 Jun 2007||9 Nov 2010||Medtronic, Inc.||Device for immobilizing a primary instrument and method therefor|
|US7833231||25 Jun 2007||16 Nov 2010||Medtronic, Inc.||Device for immobilizing a primary instrument and method therefor|
|US7857820||26 Jun 2007||28 Dec 2010||Medtronic, Inc.||Sheath assembly for an access device and method therefor|
|US7867242||11 Jan 2011||Medtronic, Inc.||Instrument for guiding stage apparatus and method for using same|
|US7896889||1 Mar 2011||Medtronic, Inc.||Trajectory guide with angled or patterned lumens or height adjustment|
|US7981120||23 Apr 2007||19 Jul 2011||University Of South Florida||Trajectory guide with angled or patterned guide lumens or height adjustment|
|US8088060||15 Nov 2006||3 Jan 2012||Orbusneich Medical, Inc.||Progenitor endothelial cell capturing with a drug eluting implantable medical device|
|US8116850||9 Nov 2009||14 Feb 2012||Medtronic, Inc.||Organ access device and method|
|US8192445||17 Nov 2009||5 Jun 2012||Medtronic, Inc.||Trajectory guide with instrument immobilizer|
|US8216174||30 Apr 2010||10 Jul 2012||Jenavalve Technology, Inc.||Methods and conduits for flowing blood from a heart chamber to a blood vessel|
|US8328837||7 Dec 2005||11 Dec 2012||Xlumena, Inc.||Method and apparatus for performing needle guided interventions|
|US8357193||3 May 2010||22 Jan 2013||Xlumena, Inc.||Apparatus and method for deploying stent across adjacent tissue layers|
|US8425539 *||4 Oct 2007||23 Apr 2013||Xlumena, Inc.||Luminal structure anchoring devices and methods|
|US8454632||21 Apr 2009||4 Jun 2013||Xlumena, Inc.||Tissue anchor for securing tissue layers|
|US8597226||12 Jun 2012||3 Dec 2013||Jenavalve Technology, Inc.||Methods and conduits for flowing blood from a heart chamber to a blood vessel|
|US8617196||10 Dec 2012||31 Dec 2013||Xlumena, Inc.||Method and apparatus for performing needle guided interventions|
|US8777967||14 Dec 2006||15 Jul 2014||Xlumena, Inc.||Methods and devices for anchoring to tissue|
|US8784437||8 Jun 2006||22 Jul 2014||Xlumena, Inc.||Methods and devices for endosonography-guided fundoplexy|
|US8845656||7 Oct 2010||30 Sep 2014||Medtronic, Inc.||Device for immobilizing a primary instrument and method therefor|
|US8911452||7 Oct 2010||16 Dec 2014||Medtronic, Inc.||Device for immobilizing a primary instrument and method therefor|
|US9282968||22 Nov 2010||15 Mar 2016||Treus Medical, Inc.||Applicator for endoscopic treatment of biliary disease|
|US20030137008 *||10 Jan 2003||24 Jul 2003||Hidetoshi Nozaki||Solid state imaging device having a photodiode and a MOSFET and method of manufacturing the same|
|US20030212413 *||1 May 2003||13 Nov 2003||Percardia, Inc.||Blood flow conduit delivery system and method of use|
|US20030216801 *||17 May 2002||20 Nov 2003||Heartstent Corporation||Transmyocardial implant with natural vessel graft and method|
|US20040133969 *||10 Jan 2003||15 Jul 2004||Tyler Pipe Company, A Division Of Ransom Industries, Lp||Closet carrier system and method of assembly|
|US20050004505 *||23 Jun 2004||6 Jan 2005||Percardia, Inc.||Designs for left ventricular conduit|
|US20050101903 *||9 Nov 2004||12 May 2005||Percardia, Inc.||Interventional diagnostic catheter and a method for using a catheter to access artificial cardiac shunts|
|US20050288618 *||24 Jun 2004||29 Dec 2005||Scimed Life Systems, Inc.||Myocardial treatment apparatus and method|
|US20060112956 *||24 Oct 2003||1 Jun 2006||Michel Serpelloni||Use of branched malto-dextrins as granulation binders|
|US20060195119 *||4 May 2006||31 Aug 2006||Image-Guided Neurologics, Inc.||Trajectory guide with angled or patterned guide lumens or height adjustment|
|US20070255275 *||26 Jun 2007||1 Nov 2007||Mayo Foundation For Medical Education Research, Image-Guided Neurologics, Inc.||Sheath assembly for an access device and method therefor|
|US20080109069 *||7 Nov 2006||8 May 2008||Coleman James E||Blood perfusion graft|
|US20090143713 *||25 Nov 2008||4 Jun 2009||Jacques Van Dam||Biliary Shunts, Delivery Systems, Methods of Using the Same and Kits Therefor|
|US20090143759 *||25 Nov 2008||4 Jun 2009||Jacques Van Dam||Methods, Devices, Kits and Systems for Defunctionalizing the Cystic Duct|
|US20090143760 *||25 Nov 2008||4 Jun 2009||Jacques Van Dam||Methods, Devices, Kits and Systems for Defunctionalizing the Gallbladder|
|US20100016946 *||13 Sep 2007||21 Jan 2010||C.R. Bard, Inc||Single layer eptfe and discrete bioresorbable rings|
|US20110054381 *||1 Jun 2010||3 Mar 2011||Jacques Van Dam||Biliary shunts, delivery systems, and methods of using the same|
|US20110071350 *||24 Mar 2011||Jacques Van Dam||Applicator for endoscopic treatment of biliary disease|
|US20120130417 *||24 May 2012||Keke Lepulu||Apparatus and method for penetrating and enlarging adjacent tissue layers|
|WO2003049598A2 *||6 Dec 2002||19 Jun 2003||Biopsy Sciences, Llc||Bioabsorbable sealant|
|WO2003049598A3 *||6 Dec 2002||29 Apr 2004||Ahari Frederick||Bioabsorbable sealant|
|U.S. Classification||623/23.7, 604/8, 623/1.15|
|International Classification||A61F2/82, A61F2/94, A61F2/02, A61F11/00, A61B17/00, A61F2/00, A61B17/22|
|Cooperative Classification||Y10S623/903, A61F2/915, A61B17/3207, A61B2017/22077, A61F2/958, A61F2/82, A61F2002/91541, A61B2017/00252, A61F2/2493, A61F2250/0067, A61F2002/826, A61F2/91, A61F2/95, A61F2/94, A61F2230/006, A61F2220/0016, A61F2220/0008, A61F2230/005|
|European Classification||A61F2/95, A61F2/958, A61F2/91, A61F2/915, A61F2/24Y, A61F2/94, A61F2/82, A61B17/3207|
|6 Jan 2004||CC||Certificate of correction|
|3 Oct 2006||AS||Assignment|
Owner name: HORIZON TECHNOLOGY FUNDING COMPANY LLC, CONNECTICU
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PERCARDIA, INC.;REEL/FRAME:018375/0912
Effective date: 20060701
|14 Mar 2007||REMI||Maintenance fee reminder mailed|
|24 Aug 2007||SULP||Surcharge for late payment|
|24 Aug 2007||FPAY||Fee payment|
Year of fee payment: 4
|4 Apr 2011||REMI||Maintenance fee reminder mailed|
|26 Aug 2011||LAPS||Lapse for failure to pay maintenance fees|
|18 Oct 2011||FP||Expired due to failure to pay maintenance fee|
Effective date: 20110826