University of Pennsylvania / School of Medicine / Beers Lab / Research Projects
Biosynthetic pathways for expression of SP-C
: The cellular metabolism of surfactant protein C with emphasis on the intracellular trafficking of SP-C [See Figure 1
- SP-C Mutations and Conformational Lung Disease. Using SP-C as a model bitopic transmembrane protein, we are characterizing the mechanisms underlying the development of cellular dysfunction and apoptosis in vitro leading to the development of conformational lung disease and pulmonary fibrosis in vivo. [See Figure 2, Figure 3, Figure 4, and Figure 5]
- Developmental Expression of SP-C : Expression and synthetic processing of surfactant protein C in human fetal lung [See Figure 6]
- Host Defense Roles of Surfactant : The role of surfactant in local host defense and pathogenesis of Pneumocystis carinii lung infection [See Figure 7, Figure 8, and Figure 9]
- The role of pulmonary collectins (surfactant proteins A and D) in the modulation of inflammation and injury.