lymphomas of the gall bladder and extrahepatic bile ducts
Thursday 2 September 2010
Lymphomas of the gall bladder and extrahepatic bile ducts are exceedingly rare.
The most common primary lymphoma types were:
diffuse large B-cell lymphoma
extranodal marginal zone lymphoma
Some cases have features of lymphomatous polyposis with follicular lymphoma or mantle cell lymphoma, with disease limited to the mantle zones, so-called in situ mantle cell lymphoma.
Patients with diffuse large B-cell lymphoma and extranodal marginal zone lymphoma are older (mean age 75.8 y) than those with other subtypes (mean age 47 y) and more likely to have gallstones (60% vs. 12.5%).
Primary lymphomas of the gall bladder and extrahepatic bile ducts show a broad spectrum of disease types, but in many respects mirror the spectrum of primary lymphomas of the gastrointestinal tract.
Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications. Mani H, Climent F, Colomo L, Pittaluga S, Raffeld M, Jaffe ES. Am J Surg Pathol. 2010 Sep;34(9):1277-86. PMID: 20679881 (Free)