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STUDY: Isoenzymes of alkaline phosphatase - reference values in young people and effects of protein diet
JOURNAL: Experientia 1976;32(7):832-834
AUTHORS: Stepan J, Graubaum HJ, Meurer W, Wagenknecht C
ABSTRACT: In 260 normal students, 20-25 years old, the variation in the activities of serum alkaline phosphatase and its isoenzymes with sex, ABO blood groups, and protein intake were studied. The values are on the whole higher in males than in females. The activity of the intestinal isoenzyme was higher in subjects taking protein-rich diet than in those taking protein poor diet.
COMMENTARY: Many vegan-vegetarian critics of the blood group diet theory point to studies that indicate that a high protein diet (the type O diet profile, but a simplification) can cause increased loss of calcium.
This may be somewhat true for blood group A non-secretors (which have the lowest levels of intestinal alkaline phosphatase, an enzyme made by the intestine to split dietary fat and to help assimilate calcium) but it is not valid for blood groups O and B, who are known to have higher levels of this enzyme. In addition, the above study throws the 'across the board' notion that protein increases bone loss into a cocked hat, since the results of this study indicate that protein actually enhances the levels of alkaline phosphatase.
Once again we have proof that simplified notions of what is right-or-wrong for one person being applicable to all just doesn't work and is not supported by the scientific literature; proving that 'one man's food is someone else's poison.'
Type O individuals can look forward to healthier bones with the adoption of a higher protein diet.