Genomes and Genes
- Signaling through LRP1: Protection from atherosclerosis and beyondPhilippe Boucher
CNRS, UMR7175, Universite de Strasbourg, 74, route du Rhin, Illkirch F 67401, France
Biochem Pharmacol 81:1-5. 2011..Tissue-specific gene deletion studies also reveal an important contribution of LRP1 in vascular remodeling, foam cell biology, the central nervous system, and in the molecular mechanisms of atherosclerosis...
- The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cellsEstelle Woldt
CNRS, UMR 7213, University of Strasbourg, 67401 Illkirch, France
Nat Commun 3:1077. 2012..Targeting this signalling pathway may have clinical implications in the context of common complications of atherosclerosis, including coronary artery calcification and valvular sclerosis...
- LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signalingJerome Terrand
CNRS, UMR7175, Universite de Strasbourg, Illkirch, F 67401 France
J Biol Chem 284:381-8. 2009..These results establish LRP1 as a novel integrator of adipogenic differentiation and fat storage signals...