Schizophrenia is a debilitating disease that effects approximately 1% of the population with the onset of the disease occurring usually in the mid 20's and persisting in many cases for the lifetime of the patient. Researchers have hypothesised that schizophrenia is due to excessive limbic dopaminergic function within the brain (Jaber et al 1996). Antipsychotic drugs may be defined as medications that alleviate delusions, hallucinations and some aspects of formal thought disorder that occur in a variety of illnesses, most notably schizophrenia. The mechanism of action of these drugs has focused on their interaction with the central nervous system (CNS) neurotransmitter dopamine (DA). However recent work strongly implicates the neurotransmitter serotonin (5HT) as a further target of action (Schmidt et a1 1995). Antipsychotic drugs are further loosely classified into typical or atypical, initially based on animal model tests. Nowadays it is on their reduced liability to produce extrapyramidal side effects (EPS) (Waddington and O'Callaghan 1997), and this has lead to hypotheses in terms of limbic selectivity and 5HTz/D2 ratios.