IndoleGard contains BioResponse DIM, a unique formulation containing pure diindolylmethane, an indole. Indoles are plant compounds with health promoting properties, found in cruciferous vegetables such as broccoli, cabbage, cauliflower and Brussels sprouts. Diindolylmethane, or DIM, has been shown to help regulate and promote a more efficient metabolism of estrogen, by supporting the body in metabolizing estrogen into more of the protective 2-hydroxyestrone rather than the proliferative 16-hydroxyestrone. BioResponse DIM is a stable bioavailable form of DIM, made possible through a proprietary delivery system. The formula is co-solubilized with phosphatidylcholine, and microencapsulated in starch particles.
Patented BioResponse DIM is ten times more potent than indole-3-carbinole (I3C). I3C is highly unstable and has no biologic activity until it is converted to DIM. Conversion of I3C takes place in the stomach and requires an appropriately acidic environment. In contrast to I3C, DIM is highly stable, requires no conversion in the stomach, and is the most active cruciferous phytonutrient in promoting beneficial estrogen metabolism. DIM is often preferred by clinicians over I3C.