This is a simple consequence of the one reality of life, namely death. The total mortality of the population is always 100%, as we all eventually die. Therefore the prevalence of a particular disease (which brings us closer to death) does not depend exclusively on factors (genetic or environmental) that cause the disease. It also depends on other diseases or lethal factors which might beat them to the punch.Here is Christakis on the Anthroposphere:
In previous centuries for example, death during childbirth, tuberculosis, death in war, famine etc. were more prevalent. Thus, they took a larger part of the 100% pie. Degenerative diseases were thus correspondingly less important, because irrespective of genes or environments affecting them, we used to die of other causes.
NICHOLAS A. CHRISTAKIS
Physician and social scientist, Harvard
The global population stood at one million at 10,000 BC, 50 million at 1,000 BC, and 310 million in 1,000 AD. It stood at about one billion in 1800, 1.65 billion in 1900, and 6.0 billion in 2000. Analysis of these macro-historical trends in human population usually focuses on this population growth and on the "demographic transition" underlying it.
During the first stage of the demographic transition, life—as Hobbes rightly suggested—was nasty, brutish, and short. There was a balance between birth rates and death rates, and both were very high (30-50 per thousand people per year). The human population grew less than 0.05% annually, with a doubling time of over 1,000 years. This state of affairs was true of all human populations everywhere until the late 18th century.
Then, during the second stage, the death rate began to decline—first in northwestern Europe, but then spreading over the next 100 years to the south and east. The decline in the death rate was due initially to improvements in food supply and in public health, both of which reduced mortality, particularly in childhood. As a consequence, there was a population explosion.
During the third stage, birth rates dropped for the first time in human history. The prior decline in childhood mortality probably prompted parents to realize they did not need as many children; and increasing urbanization, increasing female literacy, and (eventually) contraceptive technology also played a part.
Finally, during the fourth stage—in which the developed world presently finds itself—there is renewed stability. Birth and death rates are again in balance, but now both are relatively low. Causes of mortality have shifted from the pre-Modern pattern dominated by infectious diseases, perinatal diseases, and nutritional diseases, to one dominated by chronic diseases, mental illnesses, and behavioral conditions.
This broad story, however, conceals as much as it reveals. There are other demographic developments worldwide beyond the increasing overall size of the population, developments that are still unfolding and that matter much more. Changes in four aspects of population structure are key: (1) sex ratio, (2) age structure, (3) kinship systems, and (4) income distribution.
Sex ratios are becoming increasingly unbalanced in many parts of the world, especially in China and India (which account for 37% of the global population). The normal sex ratio at birth is roughly 106 males for every 100 females, but it may presently be as high as 120 for young people in China, or as high as 111 in India. This shift, much discussed, may arise from preferential abortion or the neglect of baby girls relative to boys. Gender imbalance may also have other determinants, such as large-scale migration of one or the other sex in search of work. This shift has numerous implications. For example, given the historical role of females as caregivers to elderly parents, a shortage of woman to fill this role will induce large-scale social adjustments. Moreover, an excess of low-status men unable to find wives results in an easy (and large) pool of recruits for extremism and violence.
This shift in gender ratios may have other, less heralded implications, however. Some of our own work has suggested that this shift may actually shorten men’s lives, reversing some of the historic progress we have made. Across a range of species, skewed sex ratios result in intensified competition for sexual partners and this induces stress for the supernumerary sex. In humans, it seems, a 5% excess of males at the time of sexual maturity shortens the survival of men by about three months in late life, which is a very substantial loss.
On the other hand, the population worldwide is getting older, especially in the developed world. Globally, the UN estimates that the proportion of people aged 60 and over will double between 2000 and 2050, from 10% to 21%, and the proportion of children will drop from 30% to 21%. This change also has numerous implications, including on the "dependency ratio," meaning that fewer young people are available to provide for the medical and economic needs of the elderly. Much less heralded, however, is the fact that war is a young person’s activity, and it is entirely likely that, as populations age, they may become less aggressive.
The changing nature of kinship networks, such as the growth in blended families—whether due to changing divorce patterns in the developed world or AIDS killing off parents in Africa—has implications for the network of obligations and entitlements within families. Changing kinship systems in modern American society (with complex mixtures of remarried and cohabiting couples, half-siblings, step-siblings, and so on) are having profound implications for caregiving, retirement, and bequests. Who cares for Grandma? Who gets her money when she dies?
Finally, it is not just the balance between males and females, or young and old, that is changing, but also the balance between rich and poor. Income inequality is reaching historic heights throughout the world. The top 1% of the people in the world receives 57% of the income. Income inequality in the US is presently at its highest recorded levels, exceeding even the Roaring Twenties. And while economic development in China has proceeded with astonishing rapidity, income is not evenly distributed; the prospects for conflict in that country as a result seem very high in the coming decades.
Lacking any real predators, a key feature of the human environment is other humans. In our rush to focus on threats such as global warming and environmental degradation, we should not overlook this fact. It is well to look around at who, and not just what, surrounds us. Population structure will change everything. Our health, wealth, and peace depend on it.