|Publication number||US4530691 A|
|Application number||US 06/560,880|
|Publication date||Jul 23, 1985|
|Filing date||Dec 13, 1983|
|Priority date||Dec 13, 1983|
|Also published as||EP0165290A1, WO1985002560A1|
|Publication number||06560880, 560880, US 4530691 A, US 4530691A, US-A-4530691, US4530691 A, US4530691A|
|Inventors||Richard I. Brown|
|Original Assignee||Baxter Travenol Laboratories, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (10), Referenced by (173), Classifications (7), Legal Events (4)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This invention relates to a centrifugal liquid processing apparatus, and more particularly, to an improved apparatus for centrifugal apheresis, such as plasmapheresis or plateletapheresis.
In recent years the separation of whole blood into therapeutic components, such as red blood cells, platelets and plasma, and collection of those components has increased significantly. The separation is generally achieved in a centrifuge and is referred to as centrifugal apheresis.
In centrifugal processing, whole blood is delivered to a processing chamber where the blood is centrifugally separated into therapeutic components. The processing chamber is commonly bowl-shaped, rigid and disposable.
Presently whole blood is taken from a donor at a donation site and is then transported in a sterile container to a central processing laboratory where it is processed for separation and collection of the therapeutic components.
The apparatus used at the processing laboratory for centrifugal apheresis is bulky, expensive and usually not conducive for use at the donation site. However, on-site processing is becoming more popular since the time, handling and storage between donation and processing can be minimized. Furthermore, therapeutic component yield can be increased if processing for separation and collection is performed during donation. For example, in on-site processing greater quantities of platelets can be collected because greater quantities of whole blood can be processed for platelets and returned to the donor. Since the volume of blood being processed may vary and the chamber volume may vary during component separation and processing, the processing bowls and the apparatus which cooperates with the bowls must be capable of handling the varying volumes.
In U.S. patent application, Ser. No. 560,946 filed on even date herewith and entitled "Flexible Disposable Centrifuge Chamber", there is disclosed a flexible, variable-volume, bowl-shaped chamber which can be used in on-site processing apparatus.
It is the object of this invention to provide an apparatus for on-site centrifugal apheresis which is constructed for use in systems where the volume of biological fluids processed is variable.
It is another object of this invention to provide an apparatus for on-site apheresis which is convenient to use and of a lower cost to manufacture.
These and other objects of this invention will become apparent from the following description and appended claims.
There is provided by this invention a centrifugal liquid processing apparatus for use in the onsite processing of whole blood into therapeutic constituents by centrifugal apheresis (e.g., plasmapheresis or plateletpheresis). The apparatus is particularly useful with a flexible, variable-volume, processing chamber and includes a chamber bowl or cover for receiving the processing chamber. A chamber-engaging mandrel is provided for engaging said chamber and causing the chamber to conform to the cover and for cooperation in controlling the volume of said chamber. The cover and mandrel are spun about a spin axis and the processing chamber spins therewith for separating the components. Fluid conduits are provided for connecting the chamber to the donor and to external sites for the collection of the therapeutic components.
The mandrel, cover and chamber cooperate to define a blood-collecting volume generally along the side walls of the chamber and a central plasma collecting volume at the base of the chamber. These volumes are substantially equal and remain equal as the total chamber volume changes.
Furthermore, the chamber is configured so that the surface area at which red blood cells will separate is greater than the surface area of the red blood cell/plasma interface. The result of the volume and surface area relationships is to maximize red blood cell (RBC) separation while minimizing platelet sedimentation back into the red blood cell bed or packed cell bed during RBC separation and collection.
FIG. 1 is a vertical, sectional view showing the basic elements of an on-site centrifugal apheresis apparatus, including a rotatable external housing and an internal chamber support system;
FIG. 2 is a vertical sectional view showing the housing in an open position and the processing chamber mounted on the mandrel;
FIG. 3 shows the chamber support system in the operative position; and
FIG. 4 shows the processing chamber being filled for separation.
Referring now to FIG. 1, an apparatus for centrifugal apheresis 10 generally is shown and includes a rotatable external assembly or housing 12 and a rotatable inner chamber support assembly 14 which carries the variable-volume chamber and movable mandrel.
The housing 12 is generally cylindrical in shape and includes top and bottom half sections 16 and 18 which are connected by hinge 20. The bottom section 18 is connected to a drive system 22, which spins the outer housing at a first predetermined speed about a spin axis A--A. Different types of drive systems are known in the art and can be employed. See U.S. Pat. Nos. 3,986,442 Khoja et al and Re. 29,738 Adams for exemplary drive systems.
The top section 16 carries the inner chamber support assembly 14, which is positioned within the outer housing 12 and aligned with the spin axis A--A for rotation with the outer housing 12. An inner assembly drive 23 is mounted to the top section 16 and supports the chamber and cooperating members via drive shaft 24. The inner assembly drive spins the inner assembly 14 in the same direction as the outer assembly 12, but at twice the rate.
If the rate of rotation for the outer housing is designated as one-omega (i.e., 1ω), then the rate of rotation for the inner assembly is two-omega (2ω) in the same direction. Use of the 1ω/2ω drive permits the entire apparatus to be connected to the stationary external blood sources and collection sites using conduits or stationary seals (i.e., non-rotating seals).
Systems which employ such drives and fluid connections are disclosed in the previously identified patents as well as U.S. Pat. Nos. 4,108,353 Brown; 4,109,852 Brown et al; and 4,109,855 Brown et al. Furthermore, mechanical and electrical control systems are known for maintaining the 1ω/2ω drive relationship. A control system designated by block diagram 26 is connected to both drives 22 and 23.
The inner assembly includes an inverted cup-shaped chamber support plate 28, which carries the chamber bowl or cover 30 and spring-biased chamber mandrel 32. A flexible, variable-volume, bowl-shaped chamber is positioned in the cover between the cover and mandrel, as best seen in FIGS. 2-4. A fluid conduit, which is sometimes referred to as an umbilicus 34, extends from the cover through the outer housing to a stationary external connection 36. The umbilicus can be either a single or multi-lumen tube. See, for example, U.S. Pat. Nos. 4,132,349Khoja et al and 4,389,207 Bacehowski et al.
The cover 30 is fixed to the chamber support plate 28 by a removable band 38 which releasably secures the cover to the support plate.
Both the outer and inner housings are substantially symmetric about the central spin axis A--A, and during operation, the chamber conforms to the shape of the mandrel and cover and assumes a generally axially symmetric shape.
Referring to FIG. 2, the processing chamber, which is a flexible, variable-volume, bowl-shaped member 40, is shown with a fluid communication port 42. This port is to be located on the spin axis A--A and is referred to as the low-gravity (low-G) port. In some systems a port is also located at the radially outermost point and is referred to as the high-G port. In a distended shape the chamber has a bladder-like shape that can be formed to the bowl-like shape.
In order to mount the chamber to the support assembly, the top section 16 of the outer housing is swung open about hinge 20 to an inverted horizontal position, the retainer band 38 is removed, and the chamber bowl cover is removed as shown in FIG. 2. Thereafter, a flexible, variable-volume chamber 40 is fitted to the mandrel 32 by rolling the chamber thereon. This chamber 40 has been fabricated from two heat-sealed and vacuum-formed polyvinylchloride sheets. The sealing flange 44 is shown engaging the support plate 28.
In a sense, the chamber is fitted to the mandrel as a glove is fitted to a hand. In this inverted position the mandrel is extended under a biasing action, but its movement is limited by the drive shaft. After the chamber is fitted to the mandrel, the bowl cover 30 is refitted and secured with the retainer band and the top section is returned to its closed position.
FIG. 3 shows the fully assembled inner assembly with the variable-volume chamber in place. More specifically, the internal drive 23 is supported by the outer housing top section 16. The drive shaft 24 is aligned with the spin axis A--A and extends downwardly from the drive 23 through the support plate 28.
The drive shaft 24 includes a support plate connecting pin 24a for establishing a driving connection with the support plate 28.
The support plate 28 includes a transverse top wall 28a which has a downwardly-extending bosslike stub 28b. The stub includes an aperture 28c through which the drive shaft 24 extends and defines a spring seat 28d. A drive pin connecting groove 28e is provided on the drive side of the stub 28b for driving connection with the pin 24a. The support plate also includes a peripheral side wall 28f that terminates in an outwardly-extending flange 28g. The flange 28g may include one-half of a high-G port opening 28h.
The bowl cover 30, which is secured to the support plate 28, includes a transverse bottom wall portion 30a, and an upwardly-extending and outwardly-tapering side wall portion 30b which terminates in flange 30c that cooperates with the support plate flange 28g for securing the bowl 30 to the plate 28.
A conduit-receiving aperture 30d extends through the bottom wall, is aligned with the spin axis A--A and the low-G port 42 passes therethrough. The flange also includes a high-G port opening 30e which can be aligned with port opening 28h to form a high-G outlet. The cover 30 has a slot 30f which extends through the side wall from the flange to the port.
The mandrel 32 is positioned inside the cover 30, is shaped to generally conform to the interior of the rotor and has a bottom wall 32a, tapering side wall 32b and skirt 32c. The bottom wall is provided with a retainer recess 32d.
A spring-biasing mechanism is provided for urging the mandrel 32 toward the bowl 30 and against the chamber 40. The biasing mechanism includes a coiled compression spring 46 that surrounds the drive shaft 24, and is held in position at the top end by the stub 28b and spring seat 28d and at the bottom end by post-like keeper 48.
The post 48 is an elongated, hollow, cylindrically-shaped member which seats in the mandrel recess 32d. The post includes a body portion 48a which fits within the spring 46 and an outwardly-extending flange or spring seat 48b on which the lower end of the spring rests. At the upper end, the post 48 has a top wall 48c with an aperture 48d through which the drive shaft 24 extends.
The drive shaft has at its lower end a retainer groove 24b which is positioned within the post 48 and a C-shaped retainer spring 24c which fits within the groove to retain the post 48 on the drive shaft and limits the extension of the spring 46.
Thus the biasing spring cooperates with the support plate stub 28b, post 48, drive shaft 24, pin 24a, and retainer 24c to urge the mandrel against the processing chamber 40 and toward the bowl 30. The maximum extension of the spring is controlled by the length of the drive shaft, between the pin 24a and retainer 24c, positioning of the retainer 24c, as shown in FIG. 2, mandrel engages the bowl 30 as shown in FIG. 3. The limit for compression of the spring 46 is defined by its solid height; abutment of the post 48 and the stub 28b; and/or engagement of the mandrel skirt 32d and support plate.
After assembly and installation of the chamber and closure of the housing, the biasing spring 46 urges the post 48 and, thus the mandrel, downwardly toward the bowl cover. The downward travel of the mandrel is limited by the restraint of the bowl and the engagement of the shaft retainer 24c and post 48. In the fully extended position, the mandrel expresses substantially all fluid from the chamber, and, as shown, the chamber is prepared for receiving whole blood and component separation.
In operation the centrifuge is started with drives 22 and 23, and whole blood drawn from the donor is delivered to the chamber via the umbilicus 34. The whole blood entering the chamber causes the chamber to expand and push against the mandrel 32. As the chamber fills, it conforms to the shape of the mandrel and cover and urges the mandrel toward a retracted position. As the mandrel retracts, the post 48 is pushed upwardly, which causes the spring 46 to compress until the chamber is fully expanded or until the spring reaches its fully compressed solid height where the post abuts the support plate stub.
During separation, therapeutic components may be selectively withdrawn from the chamber through the low-G port 42 (or other ports if provided), thus decreasing the chamber volume. As the chamber volume decreases, the mandrel advances toward the cover, thus maintaining a conforming force against the chamber. As the mandrel advances and retracts in response to volume changes, the rim edge 40a of the chamber rolls up and down.
The chamber is sufficiently flexible so as to permit adjustment in volume without fracturing or tearing. It will be noted that the chamber walls may fold back against themselves during this process. At the end of the procedure, the chamber is removed by opening the housing and interior casing and then sliding the chamber off the mandrel.
From the foregoing it will be seen that the apparatus disclosed herein provides an apparatus for centrifugal apheresis in which the volume of the processing chamber is variable.
The shape of the bowl 30 and mandrel 32 cooperates with the chamber 40 to define a red blood cell collection volume and a plasma collection volume. Referring to FIG. 4, the plasma collection volume 50 is a cylindrical, disc-like space between the bowl bottom wall 30a and the mandrel bottom wall 32a. The blood cell collection volume is the annularly-shaped space 52 defined by the bowl side wall 30b and the mandrel side wall 32b.
The blood cell collection volume 52 and plasma collection volume 50 are approximately equal as shown in the filled condition in FIG. 4. Furthermore, the volumes remain approximately equal to each other as the total volume of the chamber varies. In other words, throughout the range of chamber volumes from empty to full, the ratio of red blood cell or packed cell collection volume to plasma collection volume remains substantially constant at about 1:1.
Referring now to the packed cell collection volume 52, it is seen that during operation the red blood cells sediment toward or are driven toward the bowl wall 30b. This wall has a large surface area so as to maximize separation of the red blood cells.
The interface between the packed or red blood cell volume and plasma volume is a cylindrically-shaped surface, shown with dotted lines, which extends between the outer edge of the mandrel bottom wall 32a and the outer edge of the cover bottom wall 30a. During separation, a layer known as the "buffy layer" forms at that interface due to the separation of the platelets from the plasma. As shown, the interface surface area is smaller than the RBC sedimentation surface. The reason the interface surface area is smaller is to minimize platelet separation during RBC collection.
In the embodiment shown herein, the RBC sedimentation surface area is greater than the platelet interface surface area. Desirably, the ratio of RBC surface area to interface surface area is at least 2:1 and even as great as 4:1. These relationships are selected so as to maximize RBC separation while minimizing platelet from plasma separation and loss into the buffy layer during RBC separation. During RBC separation fluids in the red blood cell volume 52 are exposed to high-G forces, while fluids in the plasma volume 50 are exposed to low-G forces.
In operation, the chamber is filled with whole blood and then subjected to a first or hard spin to obtain RBC separation. During this spin, red blood cells sediment and move radially outwardly and into the volume 52 where the cells then sediment toward the outer wall. During this operation plasma and platelets are displaced inwardly toward the plasma volume 50.
Platelet-rich plasma collects in the volume 50 and is subjected to much lower G or separation forces since its radial distance from the spin axis is less than that for the RBC's. Hence platelet separation from the plasma is minimized.
In one example, the chamber is filled with about 500 milliliters of whole blood having a hematocrit of 40 (i.e., 40 volume percent red blood cells). After spinning and separation, about 250 milliliters of packed red blood cells, with a hematocrit of 80, is obtained in the volume 52 and about 250 milliliters of platelet-rich plasma is available in the plasma volume 50.
Collection of the RBC or platelet-rich plasma can be effected through the high or low-G ports as desired. Thereafter, in subsequent separations platelets can be separated from the plasma so as to permit separate collection of platelets and plateletfree plasma.
It will be appreciated that numerous changes and modifications can be made to the embodiment shown herein without departing from the spirit and scope of this invention.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3145713 *||Sep 12, 1963||Aug 25, 1964||Protein Foundation Inc||Method and apparatus for processing blood|
|US3244363 *||Mar 27, 1963||Apr 5, 1966||Hein George N||Centrifuge apparatus and bag therefor|
|US3858796 *||Nov 14, 1972||Jan 7, 1975||Stephan L Schwartz||Container for use in treatment of liquid|
|US3987961 *||Jan 23, 1975||Oct 26, 1976||Heraeus-Christ Gmbh||Centrifuge bag for treatment of biological liquids|
|US4109855 *||Oct 25, 1977||Aug 29, 1978||Baxter Travenol Laboratories, Inc.||Drive system for centrifugal processing apparatus|
|US4142670 *||Jan 27, 1978||Mar 6, 1979||Beckman Instruments, Inc.||Chylomicron rotor|
|US4151844 *||Nov 11, 1977||May 1, 1979||Baxter Travenol Laboratories, Inc.||Method and apparatus for separating whole blood into its components and for automatically collecting one component|
|US4413771 *||Sep 10, 1979||Nov 8, 1983||E. I. Du Pont De Nemours And Company||Method and apparatus for centrifugal separation|
|US4413772 *||Sep 29, 1980||Nov 8, 1983||E. I. Du Pont De Nemours And Company||Apparatus for centrifugal separation|
|US4413773 *||Sep 29, 1980||Nov 8, 1983||E. I. Du Pont De Nemours And Company||Method and apparatus for centrifugal separation|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4675117 *||Mar 20, 1985||Jun 23, 1987||Fresenius Ag||Method of separating blood and apparatus for carrying out the method|
|US4724317 *||Dec 5, 1985||Feb 9, 1988||Baxter Travenol Laboratories, Inc.||Optical data collection apparatus and method used with moving members|
|US4776964 *||Aug 24, 1984||Oct 11, 1988||William F. McLaughlin||Closed hemapheresis system and method|
|US4806252 *||Jan 30, 1987||Feb 21, 1989||Baxter International Inc.||Plasma collection set and method|
|US4828716 *||Apr 3, 1987||May 9, 1989||Andronic Devices, Ltd.||Apparatus and method for separating phases of blood|
|US4834890 *||Jan 30, 1987||May 30, 1989||Baxter International Inc.||Centrifugation pheresis system|
|US4851126 *||Nov 25, 1987||Jul 25, 1989||Baxter International Inc.||Apparatus and methods for generating platelet concentrate|
|US4889524 *||Sep 4, 1987||Dec 26, 1989||Haemonetics Corporation||Portable centrifuge apparatus|
|US4911833 *||Jun 6, 1988||Mar 27, 1990||William F. McLaughlin||Closed hemapheresis system and method|
|US4940543 *||Nov 30, 1988||Jul 10, 1990||Baxter International Inc.||Plasma collection set|
|US4981585 *||Jun 28, 1989||Jan 1, 1991||Norfolk Scientific, Inc.||Centrifuge system and fluid container therefor|
|US5053127 *||May 21, 1990||Oct 1, 1991||William F. McLaughlin||Continuous centrifugation system and method for directly deriving intermediate density material from a suspension|
|US5067939 *||Mar 21, 1990||Nov 26, 1991||Bird Machine Company||Conveyorless clarifier|
|US5076911 *||Mar 27, 1991||Dec 31, 1991||Baxter International Inc.||Centrifugation chamber having an interface detection surface|
|US5104526 *||May 26, 1989||Apr 14, 1992||Baxter International Inc.||Centrifugation system having an interface detection system|
|US5160310 *||Jul 29, 1991||Nov 3, 1992||Centritech Ab||Centrifugal separator|
|US5271852 *||May 1, 1992||Dec 21, 1993||E. I. Du Pont De Nemours And Company||Centrifugal methods using a phase-separation tube|
|US5282981 *||May 1, 1992||Feb 1, 1994||E. I. Du Pont De Nemours And Company||Flow restrictor-separation device|
|US5308506 *||Dec 31, 1992||May 3, 1994||Mcewen James A||Apparatus and method for separating a sample of blood|
|US5316666 *||Aug 19, 1993||May 31, 1994||Baxter International Inc.||Blood processing systems with improved data transfer between stationary and rotating elements|
|US5316667 *||Aug 19, 1993||May 31, 1994||Baxter International Inc.||Time based interface detection systems for blood processing apparatus|
|US5322620 *||Aug 21, 1991||Jun 21, 1994||Baxter International Inc.||Centrifugation system having an interface detection surface|
|US5360542 *||Nov 2, 1993||Nov 1, 1994||Baxter International Inc.||Centrifuge with separable bowl and spool elements providing access to the separation chamber|
|US5362291 *||Feb 9, 1994||Nov 8, 1994||Baxter International Inc.||Centrifugal processing system with direct access drawer|
|US5370802 *||Oct 22, 1992||Dec 6, 1994||Baxter International Inc.||Enhanced yield platelet collection systems and methods|
|US5419835 *||Oct 13, 1993||May 30, 1995||E. I. Du Pont De Nemours And Company||Flow restrictor-separation device|
|US5427695 *||Jul 26, 1993||Jun 27, 1995||Baxter International Inc.||Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate|
|US5462716 *||Nov 10, 1992||Oct 31, 1995||Holm; Niels E.||Container for receiving and separating a fluid, preferably blood plasma, into its ingredients|
|US5480378 *||Aug 24, 1994||Jan 2, 1996||Weis-Fogh; Ulla||Apparatus for preparing a concentrate of coagulation factors from a blood sample|
|US5494578 *||Feb 22, 1994||Feb 27, 1996||Baxter International Inc.||Centrifugation pheresis system|
|US5529691 *||Nov 8, 1994||Jun 25, 1996||Baxter International Inc.||Enhanced yield platelet collection systems and method|
|US5549834 *||May 30, 1995||Aug 27, 1996||Baxter International Inc.||Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes|
|US5551942 *||Dec 22, 1993||Sep 3, 1996||Baxter International Inc.||Centrifuge with pivot-out, easy-load processing chamber|
|US5573678 *||Jun 7, 1995||Nov 12, 1996||Baxter International Inc.||Blood processing systems and methods for collecting mono nuclear cells|
|US5603845 *||Apr 12, 1995||Feb 18, 1997||E. R. Squibb & Sons, Inc.||Liquid separation apparatus and method|
|US5628915 *||Jun 7, 1995||May 13, 1997||Baxter International Inc.||Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions|
|US5632893 *||Jun 7, 1995||May 27, 1997||Baxter Internatinoal Inc.||Enhanced yield blood processing systems with angled interface control surface|
|US5641414 *||Jun 7, 1995||Jun 24, 1997||Baxter International Inc.||Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields|
|US5651766 *||Jun 7, 1995||Jul 29, 1997||Transfusion Technologies Corporation||Blood collection and separation system|
|US5656163 *||Nov 1, 1993||Aug 12, 1997||Baxter International Inc.||Chamber for use in a rotating field to separate blood components|
|US5658533 *||Jun 6, 1995||Aug 19, 1997||E.R. Squibb & Sons, Inc.||Container for receiving and separating a fluid into its ingredients|
|US5674458 *||Jun 6, 1995||Oct 7, 1997||E. R. Squibb & Sons, Inc.||Container for receiving and separating a fluid into its ingredients|
|US5690602 *||Aug 30, 1996||Nov 25, 1997||Baxter International Inc.||Centrifuge with pivot-out, easy-load processing chamber|
|US5690835 *||Sep 24, 1996||Nov 25, 1997||Baxter International Inc.||Systems and methods for on line collection of cellular blood components that assure donor comfort|
|US5693232 *||Jan 29, 1996||Dec 2, 1997||Baxter International Inc.||Method for collecting a blood component concentration|
|US5728060 *||Jun 13, 1996||Mar 17, 1998||Transfusion Technologies Corporation||Blood collection and separation system|
|US5733253 *||Oct 13, 1994||Mar 31, 1998||Transfusion Technologies Corporation||Fluid separation system|
|US5733446 *||Dec 2, 1994||Mar 31, 1998||Bristol-Myers Squibb Company||Centrifuge with annular filter|
|US5738784 *||Dec 1, 1995||Apr 14, 1998||E.R. Squibb & Sons, Inc.||Device for separating a blood component from blood or plasma|
|US5741428 *||Oct 31, 1996||Apr 21, 1998||E.R. Squibb & Sons, Inc.||Rapid centrifugal process for preparing fibrin monomer solution|
|US5746979 *||Jun 6, 1995||May 5, 1998||F. R, Squibb & Sons, Inc.||Method for receiving and separating a fluid into its ingredients|
|US5750039 *||Nov 8, 1996||May 12, 1998||Baxter International Inc.||Blood processing systems and methods for collecting mono nuclear cells|
|US5776336 *||Oct 31, 1996||Jul 7, 1998||Bristol-Myers Squibb Company||Annular filter assembly|
|US5779660 *||Jun 13, 1996||Jul 14, 1998||Transfusion Technologies Corporation||Blood collection and separation process|
|US5792344 *||Oct 31, 1996||Aug 11, 1998||Bristol-Myers Squibb Company||Liquid separation container for a centrifugal separator|
|US5792372 *||Dec 27, 1996||Aug 11, 1998||Baxter International, Inc.||Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma|
|US5795489 *||Nov 8, 1996||Aug 18, 1998||Bristol-Myers Squibb Company||Centrifugal filtration method|
|US5804079 *||Sep 24, 1996||Sep 8, 1998||Baxter International Inc.||Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes|
|US5807492 *||Nov 26, 1997||Sep 15, 1998||Baxter International Inc.||Blood processing systems and methods for collecting mono nuclear cell|
|US5824230 *||Nov 7, 1996||Oct 20, 1998||E.R. Squibb & Sons, Inc.||Method and device for separating a component such as fibrin I from blood plasma|
|US5830352 *||Dec 1, 1995||Nov 3, 1998||Bristol-Myers Squibb Company||Centrifuge reagent delivery system|
|US5849203 *||Oct 3, 1997||Dec 15, 1998||Baxter International Inc.||Methods of accumulating separated blood components in a rotating chamber for collection|
|US5853382 *||Jun 13, 1996||Dec 29, 1998||Transfusion Technologies Corporation||Blood collection and separation process|
|US5858253 *||Oct 31, 1996||Jan 12, 1999||Bristol-Myers Squibb Company||Blood separation process|
|US5885239 *||Feb 12, 1997||Mar 23, 1999||Transfusion Technologies Corporation||Method for collecting red blood cells|
|US5924972 *||Mar 24, 1998||Jul 20, 1999||Turvaville; L. Jackson||Portable D.C. powered centrifuge|
|US5935432 *||Nov 6, 1997||Aug 10, 1999||Bristol-Myers Squibb Company||Centrifuge reagent delivery system|
|US5958253 *||Nov 6, 1997||Sep 28, 1999||Bristol-Myers Squibb Company||Centrifuge reagent delivery method|
|US5961842 *||Jul 1, 1997||Oct 5, 1999||Baxter International Inc.||Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit|
|US5980760 *||Jul 1, 1997||Nov 9, 1999||Baxter International Inc.||System and methods for harvesting mononuclear cells by recirculation of packed red blood cells|
|US5993370 *||Nov 25, 1997||Nov 30, 1999||Baxter International Inc.||Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma|
|US6007472 *||Feb 17, 1998||Dec 28, 1999||Schill Enterprises, Inc.||Variable volume cell saver bowl|
|US6007509 *||Apr 9, 1997||Dec 28, 1999||Transfusion Technologies Corp.||Blood collection and separation system|
|US6007725 *||Nov 21, 1997||Dec 28, 1999||Baxter International Inc.||Systems and methods for on line collection of cellular blood components that assure donor comfort|
|US6019742 *||Feb 12, 1997||Feb 1, 2000||Transfusion Technologies Corporation||Method for liquid separation|
|US6027657 *||Jul 1, 1997||Feb 22, 2000||Baxter International Inc.||Systems and methods for collecting diluted mononuclear cells|
|US6039711 *||Nov 20, 1998||Mar 21, 2000||Transfusion Technologies Corporation||System for liquid separation|
|US6071421 *||Nov 25, 1997||Jun 6, 2000||Baxter International Inc.||Systems and methods for obtaining a platelet suspension having a reduced number of leukocytes|
|US6071423 *||Dec 29, 1998||Jun 6, 2000||Baxter International Inc.||Methods of collecting a blood plasma constituent|
|US6074335 *||Feb 12, 1997||Jun 13, 2000||Transfusion Technologies Corporation||Rotor with elastic diaphragm defining a liquid separating chamber of varying volume|
|US6102883 *||Nov 4, 1997||Aug 15, 2000||Transfusion Technologies Corporation||Blood collection and separation process|
|US6228017||May 14, 1997||May 8, 2001||Baxter International Inc.||Compact enhanced yield blood processing systems|
|US6261217 *||Apr 14, 1998||Jul 17, 2001||Sanguistech Aktiebolag||Separation set having plate-like separation container with annular pinch valve for blood component preparation|
|US6296602||Mar 17, 1999||Oct 2, 2001||Transfusion Technologies Corporation||Method for collecting platelets and other blood components from whole blood|
|US6315706 *||Feb 17, 1997||Nov 13, 2001||Gambro, Inc.||Method for separating cells, especially platelets, and bag assembly therefor|
|US6379322||Feb 20, 1998||Apr 30, 2002||Transfusion Technologies Corporation||Blood collection and separation system|
|US6511411||Sep 13, 2000||Jan 28, 2003||Baxter International Inc.||Compact enhanced yield blood processing systems|
|US6558307||Jul 30, 2001||May 6, 2003||Haemonetics Corporation||Method for collecting platelets and other blood components from whole blood|
|US6582349||Sep 26, 2000||Jun 24, 2003||Baxter International Inc.||Blood processing system|
|US6602179 *||Jun 12, 2000||Aug 5, 2003||Haemonetics Corporation||Rotor with elastic diaphragm defining a liquid separating chamber of varying volume|
|US6632191 *||Mar 17, 1999||Oct 14, 2003||Haemonetics Corporation||System and method for separating blood components|
|US6641552||Feb 1, 2000||Nov 4, 2003||Haemonetics Corporation||Blood collection and separation system|
|US6656105||Nov 30, 2001||Dec 2, 2003||Gambro, Inc.||Centrifuge for processing blood and blood components in ring-type blood processing bags|
|US6689042||Jan 22, 2002||Feb 10, 2004||Gambro, Inc.||Centrifuge and container system for treatment of blood and blood components|
|US6740239||Nov 30, 2001||May 25, 2004||Gambro, Inc.||Method and apparatus for processing blood and blood components|
|US6780333||May 16, 2000||Aug 24, 2004||Baxter International Inc.||Centrifugation pheresis method|
|US6855102||Oct 15, 2001||Feb 15, 2005||Gambro Inc||Method for separating cells, especially platelets, and bag assembly therefor|
|US6899666||Jan 7, 2003||May 31, 2005||Baxter International Inc.||Blood processing systems and methods|
|US6982038||Jan 10, 2003||Jan 3, 2006||Medtronic, Inc.||Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma|
|US7060018 *||Sep 11, 2003||Jun 13, 2006||Cobe Cardiovascular, Inc.||Centrifuge apparatus for processing blood|
|US7097774||Jul 24, 2003||Aug 29, 2006||Gambro Inc||Method for processing a blood product with a bag set having a multi-way connector|
|US7186230||Feb 27, 2003||Mar 6, 2007||Therakos, Inc||Method and apparatus for the continuous separation of biological fluids into components|
|US7211037||Sep 3, 2003||May 1, 2007||Therakos, Inc.||Apparatus for the continuous separation of biological fluids into components and method of using same|
|US7235041||Aug 1, 2006||Jun 26, 2007||Gambro Bct, Inc.||Centrifuge for processing a blood product with a bag set having a processing bag|
|US7252758||Nov 10, 2005||Aug 7, 2007||Medtronic, Inc.||Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma|
|US7279107||Apr 16, 2003||Oct 9, 2007||Gambro, Inc.||Blood component processing system, apparatus, and method|
|US7306555||Sep 8, 2006||Dec 11, 2007||Medtronic, Inc.||Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma|
|US7311849||Jul 23, 2004||Dec 25, 2007||Sorin Group Italia S.R.L.||Control device for the separate collection of blood components in output from a blood centrifugation cell|
|US7332125||Jun 16, 2003||Feb 19, 2008||Haemonetics Corporation||System and method for processing blood|
|US7407472||Mar 14, 2005||Aug 5, 2008||Sorin Group Usa, Inc.||Centrifuge apparatus for processing blood|
|US7452322||Jan 9, 2003||Nov 18, 2008||Haemonetics Corporation||Rotor with elastic diaphragm for liquid-separation system|
|US7479123||Sep 3, 2003||Jan 20, 2009||Therakos, Inc.||Method for collecting a desired blood component and performing a photopheresis treatment|
|US7497944||Mar 27, 2007||Mar 3, 2009||Caridianbct, Inc.||Blood component processing system, apparatus, and method|
|US7503889||Apr 19, 2006||Mar 17, 2009||Dennis Briggs||Apparatus for the continuous separation of biological fluids into components and method of using same|
|US7708889||Jan 26, 2009||May 4, 2010||Caridianbct, Inc.||Blood component processing system method|
|US7850634||Dec 19, 2006||Dec 14, 2010||Therakos, Inc.||Method for collecting a desired blood component and performing a photopheresis treatment|
|US7867159||Jun 4, 2007||Jan 11, 2011||Arteriocyte Medical Systems, Inc.|
|US7914477||Apr 19, 2006||Mar 29, 2011||Therakos, Inc.||Apparatus for the continuous separation of biological fluids into components and method of using same|
|US7998052||Aug 16, 2011||Jacques Chammas||Rotor defining a fluid separation chamber of varying volume|
|US8317672||Nov 27, 2012||Kensey Nash Corporation||Centrifuge method and apparatus|
|US8394006||Apr 13, 2012||Mar 12, 2013||Kensey Nash Corporation||Centrifuge|
|US8454548||Jun 4, 2013||Haemonetics Corporation||System and method for plasma reduced platelet collection|
|US8469871||Aug 12, 2011||Jun 25, 2013||Kensey Nash Corporation||Centrifuge|
|US8485958||Aug 7, 2012||Jul 16, 2013||Kensey Nash Corporation||Systems and methods for separating constituents of biologic liquid mixtures|
|US8556794||Feb 15, 2012||Oct 15, 2013||Kensey Nash Corporation||Centrifuge|
|US8562501||Feb 18, 2013||Oct 22, 2013||Kensey Nash Corporation||Methods for separating constituents of biologic liquid mixtures|
|US8617042||Mar 18, 2013||Dec 31, 2013||Kensey Nash Corporation||Methods for separating constituents of biologic liquid mixtures|
|US8628489||Apr 14, 2008||Jan 14, 2014||Haemonetics Corporation||Three-line apheresis system and method|
|US8647289||Mar 31, 2011||Feb 11, 2014||Haemonetics Corporation||System and method for optimized apheresis draw and return|
|US8702637||Apr 14, 2008||Apr 22, 2014||Haemonetics Corporation||System and method for optimized apheresis draw and return|
|US8747291||Oct 18, 2013||Jun 10, 2014||Kensey Nash Corporation||Methods for separating constituents of biologic liquid mixtures|
|US8758211||Oct 11, 2013||Jun 24, 2014||Kensey Nash Corporation||Centrifuge|
|US8808217||May 2, 2013||Aug 19, 2014||Haemonetics Corporation||System and method for plasma reduced platelet collection|
|US8808978||Nov 15, 2010||Aug 19, 2014||Haemonetics Corporation||System and method for automated platelet wash|
|US8834402||Mar 12, 2009||Sep 16, 2014||Haemonetics Corporation||System and method for the re-anticoagulation of platelet rich plasma|
|US8870733||Feb 13, 2013||Oct 28, 2014||Kensey Nash Corporation||Centrifuge|
|US8974362||Jun 3, 2014||Mar 10, 2015||Kensey Nash Corporation||Centrifuge|
|US9079194||Jul 18, 2011||Jul 14, 2015||Terumo Bct, Inc.||Centrifuge for processing blood and blood components|
|US9095665||Dec 10, 2013||Aug 4, 2015||Haemonetics Corporation||Three-line apheresis system and method|
|US9114408||Jun 19, 2014||Aug 25, 2015||Kensey Nash Corporation||Centrifuge|
|US9238097||Jun 7, 2010||Jan 19, 2016||Therakos, Inc.||Method for collecting a desired blood component and performing a photopheresis treatment|
|US9248227||Aug 14, 2014||Feb 2, 2016||Haemonetics Corporation||System and method for the re-anticoagulation of platelet rich plasma|
|US9302042||Jun 20, 2013||Apr 5, 2016||Haemonetics Corporation||System and method for collecting platelets and anticipating plasma return|
|US20030102272 *||Jan 7, 2003||Jun 5, 2003||Baxter International Inc.||Blood processing systems and methods|
|US20030125182 *||Jan 9, 2003||Jul 3, 2003||Headley Thomas D.||Rotor with elastic diaphragm for liquid-separation system|
|US20030181305 *||Feb 27, 2003||Sep 25, 2003||Briggs Dennis A.||Method and apparatus for the continuous separation of biological fluids into components|
|US20030211927 *||Jun 16, 2003||Nov 13, 2003||Baxter International Inc.||Blood processing chamber counter-balanced with blood-free liquid|
|US20030232712 *||Jan 10, 2003||Dec 18, 2003||Dolecek Victor D.|
|US20040127840 *||Sep 3, 2003||Jul 1, 2004||Steve Gara||Blood separation apparatus and method of using the same|
|US20040127841 *||Sep 3, 2003||Jul 1, 2004||Dennis Briggs||Method for collecting a desired blood component and performing a photopheresis treatment|
|US20040147865 *||Jun 16, 2003||Jul 29, 2004||Cianci James P.||System and method for processing blood|
|US20050054508 *||Jul 23, 2004||Mar 10, 2005||Ivo Panzani||Control device for the separate collection of blood components in output from a blood centrifugation cell|
|US20050059540 *||Sep 11, 2003||Mar 17, 2005||Skinkle David W.||Apparatus for separating blood components|
|US20060021952 *||Mar 14, 2005||Feb 2, 2006||Skinkle David W||Apparatus for separating blood components|
|US20060124561 *||Nov 10, 2005||Jun 15, 2006||Medtronic, Inc.|
|US20060270542 *||Aug 1, 2006||Nov 30, 2006||Gambro, Inc.||Centrifuge for Processing Blood and Blood Components|
|US20070045201 *||Sep 8, 2006||Mar 1, 2007||Dolecek Victor D|
|US20070213191 *||Mar 7, 2006||Sep 13, 2007||Jacques Chammas||Rotor defining a fluid separation chamber of varying volume|
|US20070293385 *||Jun 4, 2007||Dec 20, 2007||Dolecek Victor D|
|US20090259162 *||Apr 14, 2008||Oct 15, 2009||Toshiyasu Ohashi||System and Method for Plasma Reduced Platelet Collection|
|US20090259163 *||Apr 14, 2008||Oct 15, 2009||Etienne Pages||Three-Line Apheresis System and Method|
|US20090259164 *||Apr 14, 2008||Oct 15, 2009||Etienne Pages||System and Method for Optimized Apheresis Draw and Return|
|US20090309308 *||Jun 15, 2009||Dec 17, 2009||Zymequest, Inc.||Rotating seals for cell processing systems|
|US20100234788 *||Mar 12, 2009||Sep 16, 2010||Haemonetics Corporation||System and Method for the Re-Anticoagulation of Platelet Rich Plasma|
|US20110237418 *||Sep 29, 2011||Jacques Chammas||Rotor defining a fluid separation chamber of varying volume|
|EP0794824A1 *||Dec 1, 1995||Sep 17, 1997||Bristol-Myers Squibb Company||Method and device for separating fibrin monomer from blood plasma|
|WO1988005332A1 *||Jan 12, 1988||Jul 28, 1988||Mclaughlin, William, F.||Continuous centrifugation system and method for directly deriving intermediate density material from a suspension|
|WO1988005690A1 *||Jan 29, 1988||Aug 11, 1988||Baxter Travenol Laboratories, Inc.||Plasma collection set and method|
|WO1988005691A1 *||Jan 29, 1988||Aug 11, 1988||Baxter Travenol Laboratories, Inc.||Centrifugation pheresis system|
|WO1996011747A2 *||Oct 10, 1995||Apr 25, 1996||Transfusion Technologies Corporation||Blood processing system|
|WO1996011747A3 *||Oct 10, 1995||Jul 11, 1996||Transfusion Technologies Corp||Blood processing system|
|WO2005025754A2 *||Sep 10, 2004||Mar 24, 2005||Cobe Cardiovascular, Inc.||Apparatus for separating blood components|
|WO2005025754A3 *||Sep 10, 2004||Jun 2, 2005||Cobe Cardiovascular Inc||Apparatus for separating blood components|
|U.S. Classification||494/45, 494/65|
|International Classification||B04B7/12, B04B5/00, B04B5/04|
|Nov 2, 1984||AS||Assignment|
Owner name: BAXTER TRAVENOL LABORATORIES INC. DEERFIELD ILLINO
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:BROWN, RICHARD I.;REEL/FRAME:004323/0932
Effective date: 19831208
|Dec 27, 1988||FPAY||Fee payment|
Year of fee payment: 4
|Jan 4, 1993||FPAY||Fee payment|
Year of fee payment: 8
|Jan 22, 1997||FPAY||Fee payment|
Year of fee payment: 12