Affiliation: University of Oslo
- Plasmacytoid dendritic cells are scarcely represented in the human gut mucosa and are not recruited to the celiac lesionM Raki
Centre for Immune Regulation and Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway
Mucosal Immunol 6:985-92. 2013..IFN-λ, a type III IFN important in intestinal antiviral defense, was produced mainly by APCs, but its expression was not increased in the celiac lesion...
- The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac diseaseM Raki
Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Norway
Clin Exp Immunol 142:333-40. 2005..In conclusion, atorvastatin has specific effects on isolated gluten-reactive T cells and dendritic cells, but does not shut down the gluten-induced production of proinflammatory cytokines in intestinal biopsies...
- A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cellsMelinda Raki
Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
Gastroenterology 131:428-38. 2006..The aim of this study was to identify the antigen-presenting cells that are responsible for the activation of gluten-reactive T cells in the celiac lesion...
- Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patientsMelinda Raki
Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
Proc Natl Acad Sci U S A 104:2831-6. 2007..Most of the cells had a memory phenotype, but many other phenotypic markers showed a heterogeneous pattern. Tetramer staining of gluten-specific T cells has the potential to be used for diagnosis of celiac disease...
- Surface expression of transglutaminase 2 by dendritic cells and its potential role for uptake and presentation of gluten peptides to T cellsM Raki
Institute of Immunology, The Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
Scand J Immunol 65:213-20. 2007..However, we were unable to obtain evidence for a role of surface TG2 in the loading and subsequent generation of deamidated gluten peptides in these cells...
- Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesionA C R Beitnes
Centre for Immune Regulation, Institute of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Scand J Immunol 74:186-94. 2011....
- HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22M Bodd
Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
Mucosal Immunol 3:594-601. 2010..We conclude that gluten-reactive T cells produce IL-21 and IFN-γ, but not IL-17. Their production of IL-21 suggests a role for this cytokine in the pathogenesis of celiac disease...