Univariate analyses of prognostic factors for overall survival revealed that 9 of 13 evaluated factors had a statistically significant prognostic effect, including sex, serum AFP concentration, preexisting or iatrogenic tumor rupture, types of hepatic resection, intraoperative blood loss, perioperative blood replacement, microscopic tumor involvement of resection margin, tumor size, and cancer stage (Table 5). On multivariate analyses, only cancer stage (risk ratio [RR], 1.514; 95% CI, 1.371-1.673; P<.001), sex (RR, 1.184; 95% CI, 1.014-1.383; P = .03), perioperative blood replacement (RR, 1.135; 95% CI, 1.06-1.215, P<.001), and tumor size (RR, 1.031; 95% CI, 1.005-1.058; P = .03) were independent predictors of overall survival. When the same clinicopathologic factors were analyzed for their effect on disease-free survival, 8 factors (sex, serum AFP concentration, preexisting or iatrogenic tumor rupture, intraoperative blood loss, perioperative blood transfusion, microscopic tumor involvement of resection margin, tumor size, and cancer stage) were statistically significant factors in the univariate analysis (Table 6). Multivariate analyses showed 5 variables to be statistically significant predictive factors for disease-free survival, including cancer stage (RR, 1.406; 95% CI, 1.271-1.556; P<.001), serum AFP concentration (RR, 1.327; 95% CI, 1.07-1.645; P = .009), sex (RR, 1.228; 95% CI, 1.063-1.418; P = .005), perioperative blood replacement (RR, 1.083; 95% CI, 1.0-1.172; P = .04), and tumor size (RR, 1.032; 95% CI, 1.0-1.058; P = .01). After adjustment of survival data by the identified prognostic factors using the Cox hazard ratio, there were no significant differences in overall survival (P = .79) and disease-free survival (P = .74) between the FNAC and non-FNAC groups.