Affiliation: University of Western Australia
- Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in miceThea Shavlakadze
M309, School of Anatomy and Human Biology, The University of Western Australia, Perth, Western Australia
Biogerontology 11:363-76. 2010..This delay is transient. Once inflammation occurs, myogenesis can proceed. The presence of well developed myotubes in old muscle autografts at 10 days confirms a very good inherent myogenic response of geriatric skeletal muscle...
- Of bears, frogs, meat, mice and men: complexity of factors affecting skeletal muscle mass and fatThea Shavlakadze
School of Anatomy and Human Biology, The University of Western Australia, 6009, Western Australia
Bioessays 28:994-1009. 2006....
- Targeted expression of insulin-like growth factor-I reduces early myofiber necrosis in dystrophic mdx miceThea Shavlakadze
School of Anatomy and Human Biology, University of Western Australia, Crawley, Perth, Western Australia 6009, Australia
Mol Ther 10:829-43. 2004..This mechanism of action can account for the long-term reduced severity of the dystropathology in mdx mice that overexpress mIGF-1 and provides promising opportunities for therapeutic strategies...
- Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophyThea Shavlakadze
School of Anatomy and Human Biology, The University of Western Australia, 35, Stirling Highway, Crawley, Perth, WA 6009, Australia
Neuromuscul Disord 15:139-46. 2005..It is proposed that the protective effect of mIGF-1 on denervated myofibres might be due to reduced protein breakdown...
- Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscleThea Shavlakadze
School of Anatomy and Human Biology, The University of Western Australia, Crawley, Perth, Western Australia 6009, Australia
Growth Horm IGF Res 15:4-18. 2005..Full understanding of these complex in vivo issues is essential, not only for skeletal muscle but for many other tissues, in order to effectively extend observations derived from transgenic studies into potential clinical situations...
- Rskalpha-actin/hIGF-1 transgenic mice with increased IGF-I in skeletal muscle and blood: impact on regeneration, denervation and muscular dystrophyT Shavlakadze
School of Anatomy and Human Biology, The University of Western Australia, Crawley, Perth
Growth Horm IGF Res 16:157-73. 2006..No beneficial effect of muscle specific over-expression of Rskalpha-actin/hIGF-I transgene was seen in these three experimental models...
- A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivoThea Shavlakadze
School of Anatomy and Human Biology, The University of Western Australia, Perth 6009, WA, Australia
J Cell Sci 123:960-71. 2010..These data demonstrate that elevated IGF-1 has a hypertrophic effect on skeletal muscle only in growth situations...
- Early regeneration of whole skeletal muscle grafts is unaffected by overexpression of IGF-1 in MLC/mIGF-1 transgenic miceThea Shavlakadze
School of Anatomy and Human Biology, University of Western Australia, Crawley, Western Australia 6009
J Histochem Cytochem 52:873-83. 2004..Skeletal muscle-specific overexpression of mIGF-1 does not appear to stimulate the early events associated with myogenesis during regeneration of whole muscle grafts...
- Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscleMiranda D Grounds
School of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia
Clin Exp Pharmacol Physiol 35:846-51. 2008....
- Silencing TNFalpha activity by using Remicade or Enbrel blocks inflammation in whole muscle grafts: an in vivo bioassay to assess the efficacy of anti-cytokine drugs in miceMiranda D Grounds
School of Anatomy and Human Biology, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009, Australia
Cell Tissue Res 320:509-15. 2005..This simple reproducible in vivo assay model in mice can be used to evaluate the efficacy of many novel anti-cytokine interventions designed to block inflammation...
- Quantification of ceroid and lipofuscin in skeletal muscleHatice Tohma
School of Biomedical, Biomolecular and Chemical Science, The University of Western Australia, Crawley, Western Australia
J Histochem Cytochem 59:769-79. 2011..After optimizing for these factors, the authors show that ceroid and lipofuscin can be measured reproducibly in the skeletal muscle of dystrophic mice (ceroid) and aged mice (lipofuscin)...
- Growing muscle has different sarcolemmal properties from adult muscle: a proposal with scientific and clinical implications: reasons to reassess skeletal muscle molecular dynamics, cellular responses and suitability of experimental models of muscle disordMiranda D Grounds
School of Anatomy and Human Biology, The University of Western Australia, Western Australia, Australia
Bioessays 33:458-68. 2011..The consequences of a dynamic, expanding sarcolemma during growth, compared with that of an adult myofibre of a fixed length, are discussed with respect to various aspects of muscle biology...
- Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx miceFelicity J Waters
School of Anatomy and Human Biology, University of Western Australia, Crawley, WA, Australia
Mol Cell Biochem 337:119-31. 2010..These results support the hypothesis that p53 plays some role in TNF-mediated necrosis of dystrophic muscle and present a potential new target for therapeutic interventions...
- Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscleRuth Jinfen Chai
School of Anatomy and Human Biology, The University of Western Australia, Perth, Western Australia, Australia
PLoS ONE 6:e28090. 2011..The challenge is to identify which components of the neuromuscular system are primarily responsible for the marked changes within the NMJ and muscle, in order to selectively target future interventions to reduce sarcopenia...
- A single 30 min treadmill exercise session is suitable for 'proof-of concept studies' in adult mdx mice: a comparison of the early consequences of two different treadmill protocolsHannah Radley-Crabb
School of Anatomy and Human Biology, The University of Western Australia, Crawley, Australia
Neuromuscul Disord 22:170-82. 2012..A more precise understanding of the changes in dystrophic muscle after exercise aims to identify biomarkers and new potential therapeutic drug targets for Duchenne Muscular Dystrophy...
- Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactionsPeter G Arthur
School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Australia
Curr Opin Clin Nutr Metab Care 11:408-16. 2008..Understanding these interactions in vivo will assist in identifying opportunities for more targeted therapies to reduce skeletal muscle wasting...
- Identification of muscle necrosis in the mdx mouse model of Duchenne muscular dystrophy using three-dimensional optical coherence tomographyBlake R Klyen
The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical Biomedical Engineering Laboratory, M018, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
J Biomed Opt 16:076013. 2011..These findings demonstrate the utility of 3D-OCT for the evaluation of small-animal skeletal muscle morphology and pathology, particularly for studies of mouse models of muscular dystrophy...
- Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx miceJonathan D Schertzer
Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
Am J Physiol Cell Physiol 294:C161-8. 2008..The results demonstrate that IGF-I can ameliorate fundamental aspects of E-C coupling failure in dystrophic muscle fibers and that these effects are important for the improvements in cellular function induced by this growth factor...