Working toward breast cancer chemopreventive strategies. See our projects.
The long term objective of the Schedin Lab research program is to develop breast cancer chemopreventive strategies that are targeted to specific windows of breast development. By understanding normal mammary gland development and homeostasis, it should possible to identify both mammary specific and life cycle specific chemopreventive strategies.
The focus of my lab is on characterizing extracellular matrix (ECM) proteins that mediate mammary epithelial cell death during key windows of normal mammary gland differentiation, such as adolescent mammary gland development, the estrous cycle, and the pregnancy/lactation/involution cycle. Major areas of investigation include adolescent mammary development, mammary epithelial cell-stromal interactions, tissue remodeling, mammary carcinogenesis, and chemoprevention in rodent models.