Aliases for KDM1B Gene
External Ids for KDM1B Gene
Previous HGNC Symbols for KDM1B Gene
Previous GeneCards Identifiers for KDM1B Gene
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
GeneCards Summary for KDM1B Gene
KDM1B (Lysine (K)-Specific Demethylase 1B) is a Protein Coding gene. Among its related pathways are Chromatin organization and RNA Polymerase I Promoter Opening. GO annotations related to this gene include oxidoreductase activity and histone demethylase activity (H3-dimethyl-K4 specific). An important paralog of this gene is PAOX.
UniProtKB/Swiss-Prot for KDM1B Gene
Histone demethylase that demethylates Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated Lys-4 of histone H3. Has no effect on tri-methylated Lys-4, mono-, di- or tri-methylated Lys-9, mono-, di- or tri-methylated Lys-27, mono-, di- or tri-methylated Lys-36 of histone H3, or on mono-, di- or tri-methylated Lys-20 of histone H4 (By similarity).