- The enzyme from mammals accepts a range of hydroperoxy
icosatetraenoates producing one or several different hydroxy epoxy
- The human enzyme has highest activity with (12R)-HPETE producing
followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy-
11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8-
- The mouse enzyme has highest activity with (8S)-HPETE, producing
- The enzymes also have the activity of EC 188.8.131.52.