February 2016 - New Publication
Inverted light-sheet microscope for imaging mouse development
Strnad and coworkers developed a new microscope to image mouse embryos from zygote to blastocyst and software for complete tracking and reconstruction of lineage trees to investigate cell fate decisions.
March 2016 - New Publication
ARHGEF17 as novel player in the spindle assembly checkpoint
Isokane and coworkers identified ARHGEF17 to be an essential player in the spindle assembly checkpoint, responsible to target Mps1 to kinetochores.
In the link below from the iBioseminar website, watch Jan Ellenberg explaining how to perform high throughput content imaging screening with an update on the recent technologies developed in our lab and EMBL.
Our group is an international interdisciplinary team drawing its members from biology, physics, chemistry, computer science, and engineering. The overarching theme of the lab is to understand the molecular mechanism of the nuclear division cycle in a comprehensive manner in the physiological context of the intact living cell. To achieve this we develop and use a braod range of fluorescence-based imaging technologies to assay the functions of the involved molecular machinery non-invasively, automate imaging to address all its molecular components and computationally process image data to extract biochemical and biophysical parameters in order to generate mechanistic understanding and predictive models. Our biological questions are currently focused on three areas.