Spiromide™ / Spiromide™ 40 mg
[Spironolactone + Furosemide]
Description / Properties
Spiromide is a combination of Spironolactone and Furosemide. Spironolactone is a potassium-sparing diuretic. Spironolactone is a synthetic 17-spirolactone steroid that is competititive antagonist of aldosterone. Spironolactone is used as an antihypertensive agent. It frequently is used to treat ascites associated with cirrhosis and also has been used as a diagnostic aid for primary hyperaldosteronism. Spironolactone is a poor agent for treating hypertension or generalized edema, although its effects can be additive with thiazide diuretics. It was approved by the FDA in 1960.
Furosemide is an antihypertensive agent. Furosemide is a prototype drug of Loop Diuretics. Loop diuretics have much greater diuretic effects than thiazides. Furosemide is a sulfonamide derivative. It has a carboxyl group with a sulfamoyl moiety in the meta position. A halide or phenoxy substitution is present at carbon 4, and a substituted amino group is present at carbon 2 or 3. Furosemide is characterized by high efficacy and rapid onset of action. It increases the urination and decrease the amount of water retained in the body.
Frusemide or Furosemide is primarily indicated in conditions like Congestive heart failure, Degradation of pancreatic enzyme suppliments, Edema, Heart failure, Hypertension, Long-term treatment of healed reflux oesophagitis, Oedema, Oliguria, Oliguria due to renal failure, Oliguria due to renal failure, Pulmonary edema, and can also be given in adjunctive therapy as an alternative drug of choice in Hypercalcaemia, Liver cirrhosis, Renal failure.
Furosemide is known to interact with other drugs like Amikacin (Sulphate), Arbekacin, Calcium Gluconate, Captopril, Cefaclor (Monohydrate), Cefazolin, Ceftizoxime (Na), Cephaloridine, Cephalothin (Na), Cephradine, Chloral Hydrate, Cisplatin, Clofibrate, Colestipol (HCl), Desonide, Diazoxide, Digoxin, Fludrocortisone (Acetate), Fluprednisolone, Flurbiprofen, Fluticasone Propionate, Gemfibrozil, Gentamicin (Sulphate), Hydrocortisone, Indomethacin, Ketoprofen, Lithium, Metformin (HCl), Metolazone, Milrinone (Lactate), Naproxen, Pancuronium (Br), Phenytoin (Na), Prednisolone and Prednisone, Probenecid, Sodium Bicarbonate, Streptomycin, Terbutaline, Tobramycin, Triclofos (Na), Tubocurarine (Cl).
These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Spiromide: 1-4 tablets daily in either single or divided doses
Spiromide 40: 1-2 tablets daily in either single or divided doses
Spiromide: each tablet contains: Furosemide 20mg + Spironolactone 50mg
Spiromide 40: each tablet contains: Furosemide 40mg + Spironolactone 50mg
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