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Anti-aging Research > Chrysin.
News & Research:
- Chrysin: Is It An Effective
Aromatase Inhibitor? - vrp.com - "Unfortunately,
there does not appear to be any effective natural inhibitor of aromatase"
Replenish Testosterone Naturally - Life Extension Magazine, 1/00 -
"chrysin and 10 other flavonoids were compared to an
aromatase-inhibiting drug (aminoglutethimide). The study tested the
aromatase-inhibiting effects of these natural flavonoids (such as genistein,
rutin, tea catechins, etc.) in human fat cell cultures. Chrysin was the most
potent aromatase-inhibitor, and was shown to be similar in potency and
effectiveness to the aromatase-inhibiting drug ... Chrysin, for example, is
a potent antioxidant that possesses vitamin-like effects in the body ...
Chrysin was shown to produce anti-anxiety effects comparable with diazepam,
but without sedation and muscle relaxation. In other words, chrysin produced
a relaxing effect in the brain, but with no impairment of motor activity ...
chrysin can reduce anxiety without inducing the common side-effects
associated with benzodiazepine drugs ... chrysin displayed potent
anti-anxiety effects in rats, but did not interfere with cognitive
performance ... chrysin selectively inhibits anxiety in the brain but,
unlike diazepam, does not induce the cognitive impairment ... Chrysin may
therefore offer libido-enhancing effects in the aging male by: Increasing
free testosterone, - Decreasing excess estrogen, - Producing a safe
Hormone Modulation Therapy - Life Extension Magazine, 11/99
Monthly Updates - Hair Loss Research, 10/01 -
"While finasteride (Propecia/Proscar) decreases
serum DHT, it also is thought to increase estrogen which suggests that men
over 35 may want to consider using it in conjunction with a systemic
aromatase inhibitor such as Chrysin/Piperine
Arimidex, or stinging nettle extract, to
maximize its hair growth effects and minimize potential side effects (that
are listed in the PDR) such as
Gynocaemastia (breast enlargement in
males), sexual side effects, and an increase in fat deposition. These
compounds have been reliably shown to increase testosterone and reduce
excess estrogen, resulting in a youthful hormone profile that optimizes
immune function and to some degree, body composition"
Suppresses IL-6-Induced Angiogenesis via Down-regulation of JAK1/STAT3 and
VEGF: An in Vitro and in Ovo Approach - J Agric Food Chem. 2010 May 5 -
"Chrysin may provide new therapeutic potential for
IL-6-induced pathological angiogenesis"
Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human
tumor cells via suppression of nuclear factor-kappaB - Cancer Lett. 2010
Feb 2 - "In the present study, we found that,
pretreatment with chrysin greatly sensitized various human cancer cells to
tumor necrosis factor-alpha (TNFalpha)-induced apoptosis"
Inhibition of aromatase activity by flavonoids - Arch Pharm Res. 1999
Flavonoid inhibition of aromatase enzyme activity in human preadipocytes
- J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8 -
"Chrysin, the most potent of the naturally-occurring
flavonoids, was similar in potency and effectiveness to AG, a pharmaceutical
aromatase inhibitor used clinically in cases of estrogen-dependent
Inhibition of human estrogen synthetase (aromatase) by flavones -
Science. 1984 Sep 7;225(4666):1032-4 -
"7,8-Benzoflavone and chrysin were potent
competitive inhibitors and induced spectral changes in the aromatase
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