The drug Motilium contains active ingridient Domperidone 10mg. It is ant-emitic, dopamine antagonist type of drug. The main purpose of Domperidone is to treat nausea and vomiting, also it can be used to treat fullness, abdominal fullness, bloating and discomfort.
The mechanism of this medicine is based on blocking certain dopamine receptors in brain chemoreceptor trigger zone (CTZ). It effectively blocks vomiting reflex and stop nausea.
Consult your doctor before using this medicine. Take greater concern in case of following:
Allergic reaction to Domperidone.
Pregnancy - there are no studies of Domperidone in pregnant women, but no birth defects have been detected in animal test.
Breast-feeding - domperidone passes into women milk, but there is no information of possible negative effects. Be sure to consult your doctor before taking domperidone.
Children - domperidone was not studied in children, but there is no specific information about possible harm.
Consult your doctor before taking this medicine if you have bowel problems, bleeding from stomach, liver disease.
Noraml dose of domperidone is 10mg 3-4 times a day, 20-30 min before meals or at bedtime. The dose can be increased to 20mg 3-4 times a day.
Possible side effects
Domperidone is not recommended for long term use.
Take not that Motilium contains lactose and may be not suitable for people with intolerance to lactose. Possible side effects of domperidone can include the following: diarrhoea, breast pain, stomach cramps, abnormal enlargement of breasts in men, abnormal movements legs, face, hands, neck and tongue, eg tremor, twitching, rigidity (extrapyramidal effects).
If you take to much symptoms of evrdose can incluse disorientation, drowsiness and extrapyramidal reactions. Anti-parkinson or anticholinergic may be helpful in these situations.
Drugs that can interact with domperidone 10mg are following:
• "azole" antifungals ( itraconazole, fluconazole, ketoconazole, miconazole)
• erythromycin antibiotics ( clarithromycin)
• MAO inhibitors (phenelzine)
• HIV protease inhibitors (, indinavir)
Consult your doctor to decide how you can combine those taking those drugs together with domperidone.
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