The Pancreas Clinical Research and Epidemiology program supports patient-oriented clinical research and epidemiology research in diseases of the exocrine pancreas—excluding cystic fibrosis, which covered in another program. The program supports small clinical studies focused on research that is innovative and of potential high impact and should lead to full-scale clinical trials (Phase III clinical trials), which are typically multi-center and involve several hundred patients randomized to two or more treatments, one of which is usually a placebo. The aim of such trials is to provide evidence for support of, or a change in, health policy or standard of care. Studied treatments may include pharmacologic, nonpharmacologic, and behavioral interventions for disease prevention, prophylaxis, diagnosis, or therapy. The program’s research portfolio includes clinical and epidemiological studies aimed to increase our knowledge of the risk factors; means of detection and diagnosis; natural history and prognosis; and prevention and treatment of pancreatitis, both acute and chronic.