1. The worst STD known to mankind. It's a devastating combo of gonnorrhea, syphillis, herpes, and HIV/AIDS brought to the U.S. by an Irish immigrant who visited the Red Light district in Amsterdam.
2. Term used to describe a bitch thats so nasty that you're not even sure exactly what diseases she might have, so you just use a mix of all of the worst kinds. Usually, you don't want to touch this bitch
"Did you hear that Donkey Dan died from gonnasyphiherpelaids? Yeah, he got it from this dude from Ireland."
"Damn, that girl's a slut. I bet she's got gonnasyphiherpelaids. Can't you smell it?"