|Perceived stress and biological risk: is the link stronger in Russians than in Taiwanese and Americans?|
|PMID: 23534869 Owner: NLM Status: MEDLINE|
|Allostatic load theory implies a relationship between exposure to psychological stress and multi-system physiological dysregulation. We used data from population-based samples of men and women in Russia (Moscow; n = 1800; age, mean 68.6 years), Taiwan (n = 1036; 65.6 years) and the United States (US; n = 1054; 58.0 years) -- which are likely to vary widely with respect to levels of stress exposure and biological markers -- to determine the magnitude of the association between perceived stress and physiological dysregulation. The measure of overall dysregulation was based on 15 markers including standard cardiovascular/metabolic risk factors as well as markers of inflammation and neuroendocrine activity. Subjective psychological stress was measured by the perceived stress scale. Only the Moscow sample demonstrated a positive association with overall dysregulation in both sexes. In the US, we found an association among women but not men. Among the Taiwanese, who report the lowest perceived stress, there was no association in women but an unexpected inverse relationship in men. The effects also varied across system-level subscores: the association with perceived stress was most consistent for standard cardiovascular/metabolic factors. Perceived stress was associated with inflammation and neuroendocrine activity in some samples. Although the evidence that perceived stress is the primary source of physiological dysregulation is generally modest, it was stronger in Russia where the level of perceived stress was particularly high. For Russia only, we had information about heart function based on a 24 h ambulatory electrocardiogram; perceived stress was consistently associated with heart rate dysregulation in Russian men and women.|
|Dana A Glei; Noreen Goldman; Vladimir M Shkolnikov; Dmitri Jdanov; Maria Shkolnikova; James W Vaupel; Maxine Weinstein|
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|Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2013-05-03|
|Title: Stress (Amsterdam, Netherlands) Volume: 16 ISSN: 1607-8888 ISO Abbreviation: Stress Publication Date: 2013 Jul|
|Created Date: 2013-06-17 Completed Date: 2014-01-21 Revised Date: 2014-07-02|
Medline Journal Info:
|Nlm Unique ID: 9617529 Medline TA: Stress Country: England|
|Languages: eng Pagination: 411-20 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Allostasis / physiology*
Asian Continental Ancestry Group / psychology*
Cardiovascular System / physiopathology
Creatinine / metabolism
European Continental Ancestry Group / psychology*
Hydrocortisone / blood
Inflammation / physiopathology
Moscow / epidemiology
Neurosecretory Systems / physiology
Perception / physiology*
Stress, Psychological / physiopathology*
Taiwan / epidemiology
United States / epidemiology
|1UL1RR025011/RR/NCRR NIH HHS; M01-RR00865/RR/NCRR NIH HHS; M01-RR023942/RR/NCRR NIH HHS; P01 AG020166/AG/NIA NIH HHS; P01 AG020166/AG/NIA NIH HHS; P01-AG020166/AG/NIA NIH HHS; R01 AG016661/AG/NIA NIH HHS; R01 AG016790/AG/NIA NIH HHS; R01 AG026786/AG/NIA NIH HHS; R01 AG16661/AG/NIA NIH HHS; R01 AG16790/AG/NIA NIH HHS; R01AG026786/AG/NIA NIH HHS; R01AG16661/AG/NIA NIH HHS; R01AG16790/AG/NIA NIH HHS; R24 HD047879/HD/NICHD NIH HHS; R24HD047879/HD/NICHD NIH HHS; UL1 TR000427/TR/NCATS NIH HHS|
|0/Biological Markers; AYI8EX34EU/Creatinine; WI4X0X7BPJ/Hydrocortisone|
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