In Reply.—We agree with Dr Finkelstein that measurements of urine reducing glucose concentration may provide different information than that indicated by the total amount of reducing sugar excreted in random specimens. Measurement of the volume of random urine specimens, however, has not been previously recommended in the management of clinical diabetes. Indeed, we are unaware of any published data indicating that measurement of the total amount of sugar excreted in random urine samples improves the value of the tests or the ability to manage diabetes.
It is suggested by Dr Finkelstein that, if knowledge of the total quantity of glucose in each of several random urine samples allowed any doubt about the appropriate management of a child with diabetes, the collection of urine for 24 hours to determine total glucose excretion would correct that difficulty. In an earlier report1 we found that the 24-hour excretion of glucose not