S E Artandi
Affiliation: Harvard University
- A critical role for telomeres in suppressing and facilitating carcinogenesisS E Artandi
Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Curr Opin Genet Dev 10:39-46. 2000..Recent data suggest that the severe chromosomal instability of telomere crisis promotes secondary genetic changes that facilitate carcinogenesis. Reactivation of telomerase stabilizes telomere ends and allows continued tumor growth...
- Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in miceS E Artandi
Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nature 406:641-5. 2000..Our data suggest a model in which telomere dysfunction brought about by continual epithelial renewal during life generates the massive ploidy changes associated with the development of epithelial cancers...
- Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiationK K Wong
Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Nat Genet 26:85-8. 2000..Our findings establish a intimate relationship between functionally intact telomeres and the genomic, cellular and organismal response to ionizing radiation...
- p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesisL Chin
Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 97:527-38. 1999....