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Associate ProfessorOffice: R730Phone: (601) 984-1656Lab: R725; Phone: (601) 984-1684Fax: (601) 984-1655E-mail: email@example.com
I am interested in the role of the epidermal growth factor receptor family in development of cutaneous innervation. I demonstrated that lack of EGFR results in a disorganized pattern of cutaneous innervation, along with a hyperinnervation phenotype. This phenotype is likely a target-derived effect, as revealed by examining the innervation in wild type and mutant skin grafts on nude mice and skin-targeted dominant negative EGFR skin. Microarray analysis of EGFR null and wild type skin suggested that alteration of extracellular matrix molecules such as laminin 5, nidogen, and gelsolin may mediate the EGFR’s effect on sensory nerves of the skin.
We are testing the importance of these matrix molecules for axon outgrowth and branching, using tissue culture model. For this experiment, the dorsal root ganglion cells are cultured on extracellular matrix derived from EGFR wild type and mutant keratinocytes. In addition, I am also interested in studying the effect of the hair cell polarity and the gobal polarity of the inner ear on the development of vestibular connectivity pattern to the vestibular nuclear complex and the cerebellum. I am employing a variety of techniques, such as immunocytochemistry and tract tracing.
Lamprey 3D Figure 1
A three-dimensional interactive model in which a complete labyrinth of the lamprey is shown; the two ciliated chambers and the semicircular duct system. The model is in Quick Time movie format and can be opened by Quick Time player 7, and can be manipulated in 3 dimensions by dragging with the computer mouse.
Lamprey 3D Figure 2
A three-dimensional interactive model of the labyrinth in lamprey in which the semicircular duct system is only shown after digital subtraction of the ciliated chambers. The model is in Quick Time movie format and can be opened by Quick Time player 7, and can be manipulated in 3 dimensions by dragging with the computer mouse.
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Jackson, MS 39216
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