Affiliation: University of California
- Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in miceNaveen Gupta
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 179:1855-63. 2007..In conclusion, treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice...
- Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytesAnna Krasnodembskaya
Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012..Thus intravenous MSC increased survival from gram-negative peritoneal sepsis, in part by a monocyte-dependent increase in bacterial phagocytosis...
- Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37Anna Krasnodembskaya
The Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Stem Cells 28:2229-38. 2010..Human bone marrow-derived MSCs possess direct antimicrobial activity, which is mediated in part by the secretion of human cathelicidin hCAP-18/ LL-37...
- Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injuryXiao Su
Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 297:L1-5. 2009..In summary, BAL RAGE is an indicator of ALI, and it may be useful in distinguishing direct from indirect models of ALI as well as assessing the response to specific therapies...
- Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lungJae W Lee
Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:16357-62. 2009..In summary, treatment with allogeneic human MSCs or the conditioned medium restores normal fluid balance in an ex vivo perfused human lung injured by E. coli endotoxin...
- Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and ratsXiao Su
Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
Am J Respir Cell Mol Biol 37:186-92. 2007..These results indicate that activation of alpha7 nAChR may provide a new therapeutic pathway for the treatment of acute lung injury...
- Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injuryJoyce S Lee
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA
Anat Rec (Hoboken) 294:165-72. 2011..This model should be useful to investigators studying ALI who want to simulate the clinical setting in which more than one insult often leads to greater clinical lung injury...
- Potential application of mesenchymal stem cells in acute lung injuryJae Woo Lee
University of California, Anesthesiology, 505 Parnassus Avenue, Box 0648, San Francisco, CA 94143 0648, USA
Expert Opin Biol Ther 9:1259-70. 2009..The review concludes with a discussion of future research directions required for potential clinical trials...
- Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in miceVladimir B Serikov
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Anat Rec (Hoboken) 290:1033-45. 2007..These data confirm that bone marrow-derived cultured mesenchymal cells can participate in the recovery of the injured airway epithelium after naphthalene-induced injury with minimal long-term engraftment...
- Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanismBoris V Popov
Children s Hospital Oakland Research Institute, Oakland, CA, USA
Tissue Eng 13:2441-50. 2007..We conclude that A-549 cells can trigger epithelial differentiation of MSCs by a paracrine mechanism that may include activation of beta-catenin signaling...
- Sepsis and stretch: synergistic effects on alveolar epithelial cell death?Naveen Gupta
Crit Care Med 34:1846-7. 2006