ChemAxon’s Reaction Library provides a full spectrum of organic chemical reactions used in synthetic routes from recent chemical literature. It incorporates both experimental and in-silico transformation rules to help chemists explore chemical space. Reactor provides a wizard-like interface to generate products without minimal manual interference. However, users are also provided with full control over the reaction rules, and they are able to implement their own reactions easily. The presentation will highlight chemical features as well as design and application of our diverse reaction collection in Reactor.