Paige Maas, B.A., Predoctoral Fellow, Biostatistics Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI)
Title: Using Risk Models to Inform Cancer Prevention Efforts
Risk models have been developed for many cancers and thoroughly validated in independent studies. This talk discusses ways to use these risk models to guide patient decision-making and to target public health interventions, accounting for the fact that not all risk factors can be modified to reduce risk. The ideas will be illustrated with a breast cancer risk model, however approaches to targeted prevention apply generally to many cancers.
Mitchell Machiela, Sc.D., Postdoctoral Fellow, Laboratory of Translational Genomics, DCEG, NCI
Topic: Detection of large clonal mosaic events in existing genome-wide association study data
Human genetic mosaicism is the presence of two or more genetically distinct populations of cells in an individual that developed from a single zygote. Genotype data from GWAS can provide observations on the frequency, location, and distribution of detectible human mosaic abnormalities as well as indicate evidence for associations with age, gender, ancestry, and cancer risk. The detected distribution of mosaic abnormalities provide further support for age-related genomic senescence and suggest an even larger spectrum of somatic events than current studies have detected.
Arash Etemadi, M.D., M.P.H., Ph.D., Postdoctoral Fellow, Nutritional Epidemiology Branch, DCEG, NCI
Title: Cancer Susceptibility: From Carcinogens to Precursors and Stem Cells
This talk will summarize some of the recent approaches to esophageal cancer research. It shows how an integrated approach starting from carcinogen exposure and metabolism to early precursor lesions can improve our understanding of cancer causation and early detection. It also highlights the value of successful collaborations and a global approach to solving health problems.
Thursday, November 7, 2013
10:30 to 11:30 AM Shady Grove Room TE 406