Very likely. It's not always true a spiritual rapture blocks out the world.
No. A spiritual ecstasy is totally different to anything produced by mood enhancing drugs. In this condition the ability to reason, to remember, to move oneself etc is totally suspended. Serotonin and doparmine can improve one's feelings of happiness and profoundly influence someone who is suffering from depression. But a person taking it is conscious, can move freely, can remember things etc. A person experiencing a spiritual ecstasy in insensible to the outside world.
The emotional and physical aspect of it sure, like someone with schizoaffective disorder may be going through anxiety or love bipolar and see angles or hear demons.