Potential role of HOT in T1D. In individuals at high risk of developing T1D or in patients with T1D, the balance is tilted
toward the prodiabetogenic process. HOT could push the balance either toward the prodiabetogenic pathway or toward the antidiabetogenic
pathway. The outcome may be determined by multiple factors. NFκB, nuclear factor κB; RORγT, retinoid-related orphan receptor
γ T; HO-1, hemeoxygenase 1.