L-cell carcinoid tumor (tubular carcinoid)
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 20 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
See also carcinoid and goblet cell carcinoid
● Carcinoid tumor, much less common than classic tumors with insular pattern (EC-cell tumors); cell of origin is usually the L-cell, which produces enteroglucagons and peptide YY (Arch Pathol Lab Med 2010;134:1612)
● Minimal metastatic potential
● Small nodules at tip, often not identified grossly
● Columns, ribbons, acini or small tubules of small round cells with pale eosinophilic cytoplasm and round/oval nuclei with small nucleoli
● No/rare mitotic activity
● No insular masses
● May have dominant glandular, infiltrative pattern resembling metastatic carcinoma
Left: typical carcinoid (insular pattern); right: L-cell carcinoid (tubular carcinoid)
● Chromogranin B, synaptophysin, CEA, glucagon, peptide YY, pancreatic polypeptide
● Mucin, chromogranin A (usually)
● Well-differentiated metastatic adenocarcinoma: CK7/CK20 staining is nonspecific and represents potential diagnostic pitfall (J Clin Pathol 2012;65:666)
End of Appendix > Other tumors > L-cell carcinoid tumor (tubular carcinoid)
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