I've taken large bodied deer with both 35 Remington and .243 rifles. Yet size of wound channels were similar which explains why the animals dropped in their tracks. The widest wound channel I've ever observed was on an antelope hunt several years ago. One of the hunters in camp took a buck with his 220 Swift rifle. Inside of the animal looked like a grenade exploded within the chest cavity!
Fire up the grill! Deer hunting IS NOT catch and release.