Histopathological analysis of colonic adenocarcinomas. Colonic adenocarcinoma developed in KAD rats that were not given 5-FU (A) and that were given 50 mg/kg 5-FU (B). Most of the adenocarcinomas in KAD rats that received 50 mg/kg 5-FU were smaller than those in the control group (hematoxylin and eosin stain). Bar: 500 μm. (C) Average volume of adenocarcinoma tumors grown in KAD rats that were given saline or 5-FU (50 mg/kg). The mean volume of adenocarcinoma tumors in the 5-FU-treated rats were significantly smaller than those in the non-treated rats. *: p < 0.02.
Yoshimi et al. BMC Cancer 2012 12:448 doi:10.1186/1471-2407-12-448