ACADEMIC APPOINTMENTS, PROFESSIONAL POSITIONS, AND HONORS
Positions and Employment:
Postdoctoral Research Fellow, Department of Radiology, University of Utah, Salt Lake City, UT, 1994-1995
MR Applications Engineer, GE Medical Systems, Milwaukee, WI, 1995-1997
MR Physicist, Applied Science Laboratory, GE Medical Systems, Milwaukee, WI, 1997-1999
Visiting Scientist, Department of Radiology, Johns Hopkins University, Baltimore, MD, 1997-1999
Assistant Professor (Research) of Radiology, University of Chicago, Chicago, IL, 2000-2002
Associate Professor of Psychiatry/Radiology, University of Colorado Denver, Denver, CO, 2002-2009
Professor of Psychiatry/Radiology, University of Colorado Denver, Denver, CO, 2009-present
Stauffer Award, the Association of University Radiologists (1993)
Genius of Invention Award, GE-Medical Systems (1997)
Patent Award, GE-Medical Systems (1998)
Young Investigator Award, American College of Cardiology, Anaheim, California (2000)
Nine (9) US patents in magnetic resonance imaging awarded. Two filings pending.
Mentoring of a post-doctoral research fellow, 2009-2012
SCHOLARSHIPS AND PUBLICATIONS
Selected Peer-Reviewed Publications:
Reeder SB, Du YP, Lima JA, Bluemke DA, “Advanced cardiac MR imaging of ischemic heart disease”, Radiographics, 2001;21:1047-74.
Du YP, McVeigh ER, Bluemke DA, Silber HA, Foo TKF, “A comparison of prospective and retrospective respiratory navigator gating in 3D MR coronary angiography”, Interntl J Cardiac Imaging, 2001;17:287-94.
Silber HA, Bluemke DA, Ouyang P, Du YP, Post WS, Lima JAC, "The Relationship between Vascular Wall Shear Stress and Flow-Mediated Dilation: Endothelial Function Assessed by Phase-Contrast Magnetic Resonance Angiography", J Am College Cardiology, 2001;38:1859-65.
Du W, Du YP, Bick U, Fan X, MacEneany PM, Zamora MA, Medved M, Karczmar GS, “High Spectral and Spatial Resolution MR Imaging of Breast”, Radiology, 2002;224:577-85.
Du YP, Zhou XJ, Bernstein MA, “Correction of Concomitant Magnetic Field-Induced Image Artifacts in non-axial echo-planar imaging”, Magn Reson Med, 2002;48:509-15.
Karczmar GS, Du W, Medved M, Bick U, MacEneaney P, Du YP, Fan X, Zamora M, Lipton M. "Spectrally inhomogeneous effects of contrast agents in breast lesions detected by high spectral and spatial resolution MRI", Academic Radiology, 2002;S2:S352-4.
Du YP. Prospective Navigator Gating With A Dual Acceptance Window Technique To Reduce Respiratory Motion Artifacts In 3D MR Coronary Angiography. Int. J. Cardiac Imaging. 2003;19:157-62.
Du W, Du YP, Fan X, Zamora MA, Karczmar GS. Reduction of spectral ghost artifacts in high resolution echo-planar spectroscopic imaging of water and fat resonances. Magn Reson Med. 2003;49:1113-20.
Du YP, Saranathan M, Foo TKF. An accurate, robust and computational efficient navigator algorithm. J. Cardiac MR. 2004;6:483-90.
Medved M, Fan X, Du W, Du YP, MacEneaney P, Culp RM, Newstead G, Kelcz F, Olopade O, Zamora MA, Karczmar GS. MRI of the Fourier components of inhomogeneously broadened water resonances in breast: a new source of MRI contrast. Magn Reson Med. 2004;52:193-6.
Du W, Karczmar GS, Uftring SJ, Du YP, Anatomical and Functional Brain Imaging Using High Resolution Echo-Planar Spectroscopic Imaging at 1.5 Tesla, NMR in Biomedicine, 2005;18:235-41.
Beresford TP, Arciniegas DB, Alfers J, Clapp L, Martin B, Beresford HF, Du YP, Liu D, Shen D, Davatzikos C, Laudenslager ML. Hypercortisolism in alcohol dependence and its relation to hippocampal volume loss. J Stud Alcohol. 2006;67:861-7.
Beresford TP, Arciniegas DB, Alfers J, Clapp L, Martin B, Du YP, Liu D, Shen D, Davatzikos C, Hippocampus Volume Loss Due to Chronic Heavy Drinking, Alcoholism: Clinical and Experimental Research, 2006;30:1866-70.
Du YP, Dalwani M, Wylie K, Claus E, Tregellas JR. Reducing Susceptibility Artifacts in fMRI Using Volume-Selective Z-Shim Compensation. Magn Reson Med. 2007;57:396-404.
Tregellas JR, Davalos DB, Rojas DC, Waldo MC, Gibson L, Wylie K, Du YP, Freedman R, Increased Hemodynamic Response in the Hippocampus, Thalamus and Prefrontal Cortex During Abnormal Sensory Gating in Schizophrenia, Schizophrenia Research, 2007;92:262-72.
Tanabe J, Crowley T, Hutchison K, Miller D, Johnson G, Du YP, Zerbe G, Freedman R. Ventral striatal blood flow is altered by acute nicotine but not withdrawal from nicotine. Neuropsycho-pharmacology. 2008;33:627-33.
Du YP, Chu R, Hwang D, Brown MS, Kleinschmidt-DeMasters BK, Simon JH. Fast multi-slice mapping of the myelin water fraction using multi-compartment analysis of T2* relaxation at 3 Tesla – A preliminary post-mortem study. Magn Reson Med. 2007;58:865-70.
Filbey FM, Claus E, Audette AR, Niculescu M, Banich MT, Tanabe J, Du, YP, Hutchison KE. Exposure to the Taste of Alcohol Elicits Robust Activation of the Mesocorticolimbic Neurocircuitry. Neuropsychopharmacology. 2008;33:1391-401.
Du YP, Jin Z. Simultaneous acquisition of MR angiography and venography (MRAV). Magn Reson Med. 2008;59:954-8.
Jin Z, Xia L, Du YP. Reduction of Artifacts in Susceptibility Weighted MR Venography of the Brain. J Magn Reson Imaging. 2008;28:327-33.
Tregellas JR, Ellis J, Shatti S, Du YP, Rojas DC. Increased hippocampal thalamic-prefrontal responses during a novel sensory gating task in schizophrenia. Amer. J. Psychiatry. 2009;166:354-60.
Hwang D, Du YP, Improved myelin water quantification using spatially regularized nonnegative least squares algorithm. J Magn Reson Imaging. 2009;30:203-208.
Du YP, Jin Z, Hu Y, Tanabe J. Multi-echo MR angiography and venography in the brain at 3T, J Magn Reson Imaging. 2009;30:449-454.
Medved M, Newstead GM, Fan X, Du YP, Olopade OI, Shimauchi A, Zamora MA, Karczmar GS. Fourier component imaging of water resonance in the human breast provides markers for malignancy. Phys Med Biol. 2009;54:5767-5779.
Du YP, Jin Z, Robust tissue-air volume segmentation of MR images based on the statistics of phase and magnitude: Its applications in the display of susceptibility weighted imaging of the brain, J Magn Reson Imaging. 2009;30:722-731.
Banich MT, Burgess GC, Depue BE, Ruzic L, Bidwell LC, Hitt-Laustsen S, Du YP, Willcutt EG. The neural basis of sustained and transient attentional control in young adults with ADHD. Neuropsychologia. 2009;47:3095-3104.
Tregellas JR, Olincy A, Johnson L, Tanabe J, Shatti S. Martin LF, Singel D, Du YP, Soti F, Kem WR, Freedman R. Functional magnetic resonance imaging of the effects of a nicotinic agonist in schizophrenia. Neuropsychopharmacology. 2010;35:938-42.
Burgess GC, Depue BE, Ruzic L, Willcutt EG, Du YP, Banich MT. Attentional control activation relates to working memory in attention-deficit/hyperactivity disorder, Biological Psychiatry. 2010;67:632-40.
Hwang D, Kim D, Du YP. In vivo multislice mapping of myelin water content using T2* decay. Neuroimage, in press.
Grants and Contracts:
1 P50 MH086383-01 (Freedman) 08/01/2009-07/31/2014
NIH/NIMH Conte Center Grant
Basic to Clinical Molecular Neurobiology of Nicotinic Receptors in Schizophrenia
This proposed Center studies the effects of polymorphisms in genes related to schizophrenia, such as CHRNA7, on a variety of phenotypes associated with the illness. These phenotypes include the expression of CHRNA7 and other genes in post mortem brain, the function of olfactory neurons, the hemodynamic response of brain to complex stimuli, and sensory gating abnormalities in adults and in infants at risk for schizophrenia. The aim of the neuroimaging project is to examine the degree to which genetic variation in CHRNA7 influences cognitive function and brain activation in humans as assessed by functional MRI (fMRI). This subcontract provides responsibility for the stable functioning of the magnet, for aid in creation and implementation of pulse sequences and quality control of images on this brain mapping project.
Core Co-PI, (M. Banich, PI) 02/2008-01/2013.
NIMH, P50 MH079485
Determinants of Executive Function and Dysfunction, Center grant
This center grant uses behavioral, fMRI, EEG, and computational methods to examine the neurobiological, psychological and computational underpinnings of Executive Function. The center consists of 5 projects that examine different aspects or influences on executive function (control processes, learning and memory, emotion, development, and genetics. This subcontract core provides responsibility for the stable functioning of the magnet, for optimization of imaging protocol and for aid in creation and implementation of pulse sequences and quality control of images on this brain mapping project.
Subcontract PI, (M. Banich, PI) 08/2004 – 08/2009
RO1 MH070037-01, NIMH
Brain Mapping and genetics of Executive Function in ADHD
This study investigates the neuronal substrate of attentional function in patients with ADHD using fMRI. This subcontract provides responsibility for the stable functioning of the magnet, for aid in creation and implementation of pulse sequences and quality control of images on this brain mapping project.
Co-investigator, (T. Crowley, PI) 06/2007-05/2012
Study Section, NIDA, DA009842.
Child Psychopathology and Developmental Disabilities
The objective of this research is to better understand whether substances diminish the capacity to inhibit behavior by altering brain processing of risky decisions, or do pre-existing, anatomically-based variations of brain processing produce risk-taking propensities, or both.
Pilot grant (Du) 02/2009-01/2011
Colorado Clinical and Translational Sciences Institute
Detection of Micro-hemorrhage in Traumatic Brain Injury Using Magnetic Resonance Imaging
The goal of this pilot grant is to investigate the feasibility of using MR susceptibility weighted imaging technique to detect micro-hemorrhage in military personnel recently returned from the battle fields in Iraq and Afghanistan and who have symptoms of traumatic brain injury.