Yang, Xiao-Dong and Roy Mahapatra, Debiprosad and Melnik, Roderick VN (2007) Simulation of RNA silencing pathway for time-dependent transgene transcription rate. In: AIP Conf. Proc., 952.Full text not available from this repository.
The synthesis of dsRNA is analyzed using a pathway model with amplifications caused by the aberrant RNAs. The transgene influx rate is assumed time-decaying considering the fact that the number of transgenes can not be infinite. The dynamics of the transgene induced RNA silencing is investigated using a system of coupled nonautonomous ordinary nonlinear differential equations which describe the model phenomenologically. The silencing phenomena are detected after a period of transcription. Important contributions of certain parameters are discussed with several numerical examples.
|Item Type:||Conference Paper|
|Additional Information:||Copyright of this article belongs to American Institute of Physics.|
|Keywords:||macromolecules;computer aided analysis;nonlinear differential equations|
|Department/Centre:||Division of Mechanical Sciences > Aerospace Engineering (Formerly, Aeronautical Engineering)|
|Date Deposited:||22 Oct 2011 07:34|
|Last Modified:||22 Oct 2011 07:34|
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