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Most Downloaded Brain Research Articles
The most downloaded articles from ScienceDirect in the last 90 days.
1. Restoration of vision in blind individuals using bionic devices: A review with a focus on cortical visual prostheses
21 January 2015
Philip M. Lewis | Helen M. Ackland | Arthur J. Lowery | Jeffrey V. Rosenfeld
The field of neurobionics offers hope to patients with sensory and motor impairment. Blindness is a common cause of major sensory loss, with an estimated 39 million people worldwide suffering from total...
Available online 8 January 2015
John C. Gensel | Bei Zhang
The injured spinal cord does not heal properly. In contrast, tissue repair and functional recovery occur after skin or muscle injuries. The reason for this dichotomy in wound repair is unclear but inflammation,...
24 October 2014
Cathy Mitchelmore | Lene Gede
Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels...
Available online 28 April 2015
Ruihe Lin | Lorraine Iacovitti
Neural stem cells (NSCs) critical for the continued production of new neurons and glia are sequestered in distinct areas of the brain called stem cell niches. Until recently, only two forebrain sites,...
18 August 2015
Graham A.W. Rook | Christopher A. Lowry | Charles L. Raison
The immune system influences brain development and function. Hygiene and other early childhood influences impact the subsequent function of the immune system during adulthood, with consequences for...
9 May 2012
Y.K. Chang | J.D. Labban | J.I. Gapin | J.L. Etnier
There is a substantial body of literature related to the effects of a single session of exercise on cognitive performance. The premise underlying this research is that physiological changes in response...
Available online 8 April 2015
Turgay Dalkara | Luis Alarcon-Martinez
Increases in neuronal activity cause an enhanced blood flow to the active brain area. This neurovascular coupling is regulated by multiple mechanisms: Adenosine and lactate produced as metabolic end-products...
8. miR-126 promotes angiogenesis and attenuates inflammation after contusion spinal cord injury in rats
22 May 2015
Jianzhong Hu | Lei Zeng | Jianghu Huang | Guan Wang | Hongbin Lu
MicroRNAs are a class of small RNAs that regulate the expression of target mRNAs by inhibiting translation or destabilizing target mRNAs. miR-126 is a microRNA that is highly enriched in endothelial...
18 August 2015
Parizad M. Bilimoria | Beth Stevens
The role of microglia in healthy brains is just beginning to receive notice. Recent studies have revealed that these phagocytic cells control the patterning and wiring of the developing central nervous...
10. The effect of exercise-induced arousal on cognitive task performance: A meta-regression analysis
23 June 2010
Kate Lambourne | Phillip Tomporowski
The effects of acute exercise on cognitive performance were examined using meta-analytic techniques. The overall mean effect size was dependent on the timing of cognitive assessment. During exercise,...
19 September 2006
Martha J. Farah | David M. Shera | Jessica H. Savage | Laura Betancourt | Joan M. Giannetta | Nancy L. Brodsky | Elsa K. Malmud | Hallam Hurt
Growing up in poverty is associated with reduced cognitive achievement as measured by standardized intelligence tests, but little is known about the underlying neurocognitive systems responsible for...
12. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
12 November 1971
J. O'Keefe | J. Dostrovsky
13. Cdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia
Available online 26 March 2015
Fang-Hu | Hong-Hai Zhang | Bin-Xia Yang | Jin-Lu Huang | Jian-Liang Shun | Fei-Juan Kong | Peng-Xu | Zhi-Guo Chen | Jin-Miao Lu
Background: The mechanisms underlying cyclin-dependent kinase 5 (Cdk5)-mediated thermal hyperalgesia induced by inflammation remain poorly understood. In the present study, we examined thermal hyperalgesia...
Available online 9 April 2015
Alexxai V Kravitz | Dardo Tomasi | Kimberly H LeBlanc | Ruben Baler | Nora D. Volkow | Antonello Bonci | Sergi Ferré
It is widely believed that substance use disorder (SUD) results from both pre-alterations (vulnerability) and/or post-alterations (drug effects) on cortico-striatal circuits. These circuits are essential...
15. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB
29 November 2006
Ying Xu | Baoshan Ku | Lu Tie | Haiyan Yao | Wengao Jiang | Xing Ma | Xuejun Li
Curcuma longa is a major constituent of the traditional Chinese medicine Xiaoyao-san, which has been used to effectively manage stress and depression-related disorders in China. Curcumin is the active...
16. COBRA: A prospective multimodal imaging study of dopamine, brain structure and function, and cognition
1 July 2015
N. Nevalainen | K. Riklund | M. Andersson | J. Axelsson | M. Ögren | M. Lövdén | U. Lindenberger | L. Bäckman | L. Nyberg
Cognitive decline is a characteristic feature of normal human aging. Previous work has demonstrated marked interindividual variability in onset and rate of decline. Such variability has been linked...
10 March 2015
This review on the role of glial fibrillary acidic protein (GFAP) as a biomarker for astroglial pathology in neurological diseases provides background to protein synthesis, assembly, function and degeneration....
22 May 2015
Wen Zong | Shuoyang Liu | Xiaotong Wang | Jian Zhang | Tingting Zhang | Ziyi Liu | Dongdong Wang | Aizhen Zhang | Minsheng Zhu | Jiangang Gao
Trio is a guanine nucleotide exchange factor with multiple guanine nucleotide exchange factor domains. Trio regulates cytoskeleton dynamics and actin remodeling and is involved in cell migration and...
19. Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers
11 September 2014
J.E. Swain | P. Kim | J. Spicer | S.S. Ho | C.J. Dayton | A. Elmadih | K.M. Abel
Brain networks that govern parental response to infant signals have been studied with imaging techniques over the last 15 years. The complex interaction of thoughts and behaviors required for sensitive...
Available online 8 May 2015
Sava Sakadžić | Jonghwan Lee | David A. Boas | Cenk Ayata
Central nervous system (CNS) function and dysfunction are best understood within a framework of interactions between neuronal, glial and vascular compartments comprising the neurovascular unit (NVU),...
21. Genetic causes of amyotrophic lateral sclerosis: New genetic analysis methodologies entailing new opportunities and challenges
14 May 2015
Giuseppe Marangi | Bryan J. Traynor
The genetic architecture of amyotrophic lateral sclerosis (ALS) is being increasingly understood. In this far-reaching review, we examine what is currently known about ALS genetics and how these genes...
Available online 23 October 2014
Graciano Leal | Pedro M. Afonso | Ivan L. Salazar | Carlos B. Duarte
The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of activity-dependent plasticity at excitatory synapses in the mammalian central nervous system. In particular,...
Available online 22 January 2015
Arturas Volianskis | Grace France | Morten S. Jensen | Zuner A. Bortolotto | David E. Jane | Graham L. Collingridge
N-methyl-d-aspartate receptors (NMDARs) are known for their role in the induction of long-term potentiation (LTP). Here we start by reviewing the early evidence for their role in LTP at CA1 synapses...
Available online 23 March 2015
Luokun Xie | Shao-Hua Yang
The central nervous system (CNS) has long been recognized as a site of ‘immune privilege’ because of the existence of the blood brain barrier (BBB) which presumably isolates CNS from the peripheral...
14 May 2015
Jean-Philippe Richard | Nicholas J. Maragakis
The ability to reprogram adult somatic cells into pluripotent stem cells that can differentiate into all three germ layers of the developing human has fundamentally changed the landscape of biomedical...