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Most Downloaded Journal of Neuroimmunology Articles
The most downloaded articles from ScienceDirect in the last 90 days.
15 February 2015
Jian Kang | Ling Zhu | Jingli Lu | Xiaojian Zhang
Metabolomics has recently become a new technology using mass spectrometry (MS) and high-resolution proton nuclear magnetic resonance (NMR) to access metabolite profiles in biofluids or tissue extracts...
2. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
15 September 2014
Hugo González | Daniela Elgueta | Andro Montoya | Rodrigo Pacheco
Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis...
3. The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease
15 June 2015
Erdinç Dursun | Duygu Gezen-Ak | Haşmet Hanağası | Başar Bilgiç | Ebba Lohmann | Sibel Ertan | İrem L. Atasoy | Merve Alaylıoğlu | Ömür Selin Araz | Burak Önal | Ayşegül Gündüz | Hülya Apaydın | Güneş Kızıltan | Turgut Ulutin | Hakan Gürvit | Selma Yılmazer
Alzheimer's disease (EOAD, LOAD), mild cognitive impairment (MCI), Parkinson's disease (PD) and healthy controls were included to determine the serum interleukin-1s (IL-1α, IL-1β), IL-6 and alpha-2-macroglobulin...
4. Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain — Interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis
15 March 2015
Eva Kosek | Reem Altawil | Diana Kadetoff | Anja Finn | Marie Westman | Erwan Le Maître | Magnus Andersson | Mats Jensen-Urstad | Jon Lampa
The purpose of this study was to relate central inflammation to autonomic activity (heart rate variability (HRV)) in patients with rheumatoid arthritis (RA) and fibromyalgia (FM). RA patients had reduced...
5. Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level
15 November 2013
Justyna Kmiecik | Aurélie Poli | Nicolaas H.C. Brons | Andreas Waha | Geir Egil Eide | Per Øyvind Enger | Jacques Zimmer | Martha Chekenya
We characterized GBM patients' tumor and systemic immune contexture with aim to reveal the mechanisms of immunological escape, their impact on patient outcome, and identify targets for immunotherapy....
6. Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders
15 February 2015
Theoharis C. Theoharides | Marianna Athanassiou | Smaro Panagiotidou | Robert Doyle
Rett syndrome is a neurodevelopmental disorder, which occurs in about 1:15,000 females and presents with neurologic and communication defects. It is transmitted as an X-linked dominant linked to mutations...
15 June 2015
Geoffrey O. Gillard | Brian Collette | John Anderson | Jianhua Chao | Robert H. Scannevin | David J. Huss | Jason D. Fontenot
Fumarate-containing pharmaceuticals are potent therapeutic agents that influence multiple cellular pathways. Despite proven clinical efficacy, there is a significant lack of data that directly defines...
8. The immune balance between memory and regulatory B cells in NMO and the changes of the balance after methylprednisolone or rituximab therapy
15 May 2015
Chao Quan | Jingzi ZhangBao | Jiahong Lu | Chongbo Zhao | Tongjia Cai | Bei Wang | Hai Yu | Jian Qiao | Chuanzhen Lu
We aim to explore the impacts of high dose methylprednisolone therapy (HDMT) and rituximab on circulating B cells in NMO patients. Twenty-two NMO patients in the acute relapse phase were treated with...
9. Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Akt/mTOR signaling pathway in hippocampal neurons
15 May 2015
Zhaohua Xiao | Jing Peng | Lifen Yang | Huimin Kong | Fei Yin
Recently, the role of inflammation in the pathogenesis of mesial temporal lobe epilepsy (MTLE) has garnered great attention. Increasing evidence indicated that interleukin-1β (IL-1β) plays a critical...
10. Severe disease reactivation in four patients with relapsing–remitting multiple sclerosis after fingolimod cessation
15 May 2015
Benjamin Berger | Annette Baumgartner | Sebastian Rauer | Irina Mader | Niklas Luetzen | Ulrich Farenkopf | Oliver Stich
Fingolimod is a well-established, highly effective immunomodulatory treatment for patients with relapsing–remitting multiple sclerosis (RRMS). However, little is known about disease course after its...
11. Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration
15 August 2014
Lindsay J. Spielman | Jonathan P. Little | Andis Klegeris
Obesity is a growing epidemic that contributes to several brain disorders including Alzheimer's, Parkinson's, and Huntington's diseases. Obesity could promote these diseases through several different...
26 February 2010
Paul J. Pistell | Christopher D. Morrison | Sunita Gupta | Alecia G. Knight | Jeffrey N. Keller | Donald K. Ingram | Annadora J. Bruce-Keller
C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for biochemical markers...
15 April 2015
Jun-Sang Sunwoo | Soon-Tae Lee | Jung-Ick Byun | Jangsup Moon | Jung-Won Shin | Da-Eun Jeong | Gun-Hee Lee | Seong Ho Jeong | Yong-Won Shin | Keun-Hwa Jung | Doo Young Lee | Daejong Jeon | Ki-Young Jung | Manho Kim | Sang Kun Lee | Kon Chu
Contactin-associated protein-like 2 (CASPR2) is one of the target antigens of voltage-gated potassium channels (VGKC) complex antibodies. There has been relatively little information in the literature...
14. CD200+ and CD200− macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages
15 May 2015
Shirabe Matsumoto | Junya Tanaka | Hajime Yano | Hisaaki Takahashi | Kana Sugimoto | Shiro Ohue | Akihiro Inoue | Hitomi Aono | Akari Kusakawa | Hideaki Watanabe | Yoshiaki Kumon | Takanori Ohnishi
Two types of macrophages in lesion core of rat stroke model were identified according to NG2 chondroitin sulfate proteoglycan (NG2) and CD200 expression. NG2+ macrophages were CD200−, and vice versa....
15 May 2015
Robert H.P. de Meel | Alexander F. Lipka | Erik W. van Zwet | Erik H. Niks | Jan J.G.M. Verschuuren
Disease course in myasthenia gravis (MG) patients is highly variable. Prognostic factors that identify patients at risk for a more severe disease course would be helpful in clinical practice....
16. Omega-3 polyunsaturated fatty acids ameliorate neuroinflammation and mitigate ischemic stroke damage through interactions with astrocytes and microglia
15 January 2015
Adib Zendedel | Pardes Habib | Jon Dang | Leoni Lammerding | Stefanie Hoffmann | Cordian Beyer | Alexander Slowik
Omega-3 polyunsaturated fatty acids (PUFA n3) provide neuroprotection due to their anti-inflammatory and anti-apoptotic properties as well as their regulatory function on growth factors and neuronal...
17. Anti-NMDA-receptor encephalitis: A severe, multistage, treatable disorder presenting with psychosis
Klaus-Peter Wandinger | Sandra Saschenbrecker | Winfried Stoecker | Josep Dalmau
Anti-NMDA-receptor encephalitis is a severe, treatable and potentially reversible disorder presenting with memory deficits, psychiatric symptoms and seizures. Initially described in young patients with...
18. The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines
15 December 2010
Paul J. Austin | Gila Moalem-Taylor
In a large proportion of individuals nervous system damage may lead to a debilitating chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder, since recent data indicate a...
15 July 2015
A.I. Tsonis | P. Zisimopoulou | K. Lazaridis | J. Tzartos | E. Matsigkou | V. Zouvelou | R. Mantegazza | C. Antozzi | F. Andreetta | A. Evoli | F. Deymeer | G. Saruhan-Direskeneli | H. Durmus | T. Brenner | A. Vaknin | S. Berrih-Aknin | A. Behin | T. Sharshar | M. De Baets | M. Losen | P. Martinez-Martinez | K.A. Kleopa | E. Zamba-Papanicolaou | T. Kyriakides | A. Kostera-Pruszczyk | P. Szczudlik | B. Szyluk | D. Lavrnic | I. Basta | S. Peric | C. Tallaksen | A. Maniaol | C. Casasnovas Pons | J. Pitha | M. Jakubíkova | F. Hanisch | S.J. Tzartos
Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable...
20. The role of PET/CT in the evaluation of patients affected by limbic encephalitis: A systematic review of the literature
15 July 2015
Natale Quartuccio | Federico Caobelli | Laura Evangelista | Pierpaolo Alongi | Margarita Kirienko | Vincenzo De Biasi | Fabrizio Cocciolillo
Autoimmune limbic encephalitis (LE) is a rare disorder affecting the medial temporal lobe of the brain. Although brain Magnetic Resonance (MR) has been widely evaluated and is currently considered essential...
21. Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis
15 August 2015
Michael J. Turner | Petti T. Pang | Nathalie Chretien | Evis Havari | Michael J. LaMorte | Julian Oliver | Nilesh Pande | Elizabeth Masterjohn | Karen Carter | David Reczek | William Brondyk | Bruce L. Roberts | Johanne M. Kaplan | William M. Siders
Alemtuzumab, a monoclonal antibody directed against human CD52, is used in the treatment of MS. To characterize the impact of anti-CD52 administration, a monoclonal antibody to mouse CD52 (anti-muCD52)...
Michael T. Heneka | M. Kerry O'Banion
Generation and deposition of amyloid beta peptides and neurofibrillary tangle formation are key mechanisms involved in AD pathogenesis. Recent evidence suggests that inflammatory mechanisms represent...
15 April 2015
Jorge Correale | Mauricio F. Farez
Smoking worsens multiple sclerosis (MS) prognosis. Our study provides evidence that indoleamine 2,3-dioxygenase activity is reduced in MS patients who smoke, leading to increased production of IL-6...
24. Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia
15 December 2014
Britta Torgrimson-Ojerio | Rebecca L. Ross | Nathan F. Dieckmann | Stephanie Avery | Robert M. Bennett | Kim D. Jones | Anthony J. Guarino | Lisa J. Wood
Exercise intolerance, as evidenced by a worsening of pain, fatigue, and stiffness after novel exertion, is a key feature of fibromyalgia (FM). In this pilot study, we investigate whether; insufficient...
25. Oligoclonal bands in multiple sclerosis cerebrospinal fluid: An update on methodology and clinical usefulness
Hans Link | Yu-Min Huang
Two or more oligoclonal IgG bands (OB) detected by separation of cerebrospinal fluid (CSF) proteins while not demonstrable in corresponding serum reflect a local B-cell response accompanying central...