Tag: "nucleus" at medical news
Pathway links inflammation, angiogenesis and breast cancer
...NF"B) from the cytosol, allowing it to move to the nucleus
and activate genes that promote cancer growth. ...mmed cell death. IKKa then works separately in the nucleus
and IKK in the cytosol to induce cancer through separate pathways....
Hormone regulates fondness for food
...were reduced. One of the striatal regions - the nucleus
accumbens - was especially responsive to pictures ...broccoli. In healthy volunteers, activation of the nucleus
accumbens by appetising foods was only found when the person was hungry (following an overnight fast...
Chemical in brain acts like a fuel gauge
...e presence of hormones released by paraventricular nucleus
activity. The same paraventricular neurons lit up in both sets of animals, and the animals displayed similar increases in hormone levels, suggesting that norepinephrine plays a role in transmitting the hypoglycemia warning. Norepinephrine is cap...
Paying taxes, according to the brain, can bring satisfaction
...ily ancient regions deep in the brain the caudate nucleus
and the nucleus
accumbens fired when subjects saw the charity get the money. The activation was even larger when pe...
Possible new breast cancer gene
...specifically, modification of proteins in the cell nucleus
by another protein called ubiquitin that are tightly bound to DNA are responsible for signaling BRCA1 via Rap80 to action. Rap80 binds to specific types of ubiquitin that concentrate at DNA damage sites, enabling BRCA1 to be recruited to sites of d...
Scavenger cells may have role blocking obesity, Stanford study shows
...esistance. They focused on a molecule found in the nucleus
of cells called PPAR-gamma, which has been implicated in how cells detect fatty acids, the building blocks of dietary fat. The researchers bred genetically engineered mice that did not have the PPAR-gamma molecule in their macrophages. It turned ou...
Veterans exposed to Agent Orange have higher rates of prostate cancer recurrence
... fat and is believed to make its way into the cell nucleus
and work as a tumor promoter. In the past, relatively higher mortality rates have been found in chemical plant workers and farmers with prostate cancer who were exposed to dioxin, the researchers write in their abstract. Dioxins impact is dose-rela...
Study implicates protein as a trigger of advanced prostate cancer recurrence
...altering the now inactive androgen receptor in the nucleus
of prostate of cells, according to a series of experiments conducted by lead author Dr. Nupam P. Mahajan, assistant professor of pharmacology, and other Lineberger scientists. The kinase activates the receptor via phosphorylation by adding a phospha...
Sleep deprivation can threaten competent decision-making
...pinal cord of humans. The authors found that the nucleus
accumbens, an area in the brain involved with the anticipation of reward, becomes selectively more active when high risk-high payoff choices were made under conditions of sleep deprivation. Further, the number of high risk decisions did not increase...
Your brain and hormones may conspire to make you fat
...ings indicate that leptin signaling in the arcuate nucleus
is an important determinant of both energy homeostasis and glucose metabolism. Steven B.Heymsfield, M.D., is the executive director of clinical research and metabolism at Merck & Co., Inc., in Rahway, New Jersey. In his talk, Development of an NPY5...
Study finds role of mid-brain in integrating heart and respiratory response to exercise
... patients underwent stimulation of the subthalamic nucleus
(STN) for Parkinsons disease; four had globus pall... the actual onset of movement, whereas subthalamic nucleus
(STN) activity decreased. During exercise itself, PAG activity further increases alongside increas...
UD receives $1.9 million for new spintronics center
...s activities. "We already have a strong research nucleus
in this area at the University," Xiao said. "We're looking forward to bringing people together, having a center where people can talk together and work together. By bringing together the strengths of different faculty, we hope to generate significant...
Renegade RNA -- Clues to cancer and normal growth
...plans to force other microRNAs and siRNAs into the nucleus
to turn off specific sets of genes. Mendell's team is actively hunting for additional hidden microRNA elements that control other aspects of their behavior in cells. They also are curious to figure out what miR-29b is doing in the nucleus. Becaus...
New research identifies gene important for nicotine's effects on the brain
... a molecule called CREB in a brain area called the nucleus
accumbens. CREB is able to change the properties ...lly altered virus that blocks CREB activity in the nucleus
accumbens blocks nicotine reward. "We and other researchers have begun to make very strong links be...
Autoimmune disease triggered if T cells miss a single protein early on
...from previous work involving a protein in the cell nucleus
called Aire (for autoimmune regulator), which regulates the expression of some 300 to 1,000 antigens in the thymus. Humans and mice lacking the normal Aire gene suffer from multiple autoimmune diseases including diseases that target the thyroid, adre...
'Tribbles' protein implicated in common and aggressive form of leukemia
...tch of sorts, activating gene transcription in the nucleus
of many types of cells, and depending on the biochemical context, turns certain pathways on and others off. Pear and colleagues knew from fruit fly studies that the Tribbles protein was linked to cell growth and cell-fate determination and is clos...
Antiprotons 4 times more effective than protons for cell irradiation
...the antiproton would annihilate with a part of the nucleus
of an atom in a tumour cell. The fragments produced from the energy released by the annihilation would be projected into adjacent tumour cells, which are in turn destroyed. "CERN is a unique facility for this work. It is the only place in the world...
Stress triggers relapse in meth abuse, OHSU study finds
...esponses, Mark suggests. These regions include the nucleus
accumbens, prefrontal cortex, neostriatum and amygdala. Mark's lab also is studying the effects the neurotransmitters dopamine and acetylcholine have on stress response. "We want to find those areas of the brain that are sensitive to the (2-DG) str...
Researchers discover mechanism that determines when detailed memories are retained
...tion of a section of the rats' brains known as the nucleus
basalis, which relays commands to the auditory cor...e. During some experiments, the stimulation of the nucleus
basalis was weak, whereas in other animals the stimulation was stronger. When the tones were replaye...
Penn researchers find Lou Gehrig's, FTD disease protein
...nd is widely expressed throughout the body, in the nucleus
of many cell types. Its function has been implicated in editing the transcription of the genetic code and also as a scaffold protein for another motor neuron protein. The discovery that TDP-43 is the disease protein in the most common form of FTD and...
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