SAPPutative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
|SMART accession number:||SM00513|
|Interpro abstract (IPR003034):|
The SAP motif is a 35-residue motif, which has been named after SAF-A/B, Acinus and PIAS, three proteins known to contain it. The SAP motif is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. As the sap motif of SAF-A has been shown to be essential for specific DNA binding activity, it has been proposed that it could be a DNA-binding motif [(PUBMED:10694879)].
A multiple alignment of the SAP motif reveals a bipartite distribution of strongly conserved hydrophobic, polar and bulky amino acids separated by a region that contains a glycine. Secondary structure predictions suggest that the SAP motif could form two alpha helices separated by a turn [(PUBMED:10694879)].
Some proteins known to contain a SAP motif are listed below:
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- Evolution (species in which this domain is found)
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