Graduate Training in Neuroscience
University of Washington
Member, Division of Basic Sciences, Fred Hutchinson Cancer Research Center; Affiliate Professor, Department of Biochemistry
Our lab studies signaling events that control the architecture of the developing brain. We use biochemistry, cultured neurons and gene targeting in mice to dissect the mechanisms that coordinate neuron migrations during development of the cortex and other brain regions. We are particularly interested in the roles of protein phosphorylation and the ubiquitin-proteasome pathway. Methods include mouse knockouts, neuronal cultures, RNA interference, in utero electroporation and immunocytochemistry.
Migrating neocortical neurons, labeled by in utero electroporation and imaged using time-lapse confocal microscopy in a brain slice