since a long time I'm looking for data in RRMS about the average...
- annualized relapse rate
- annualized new MRI lesions
- annualized change in EDSS
I also asked my neuro about that but he didnt know.
I'm aware of the fact that in RRMS these parameters may change with dissease duration (e.g. 1 or 15 years from diagnosis), age or sex.
So a reasonable way would be to gether these infomation for a variety of groups (age, sex, etc).
Does anyone of you have any data on that subject?
One curious example was a phase-II laquinimod study where in the placebo group the annualized new MRI lesion count was 9,6 (way too much). I guess the average might be around 1,5 - 2.
Just for example these two different placebo groups (9,6 or 1,5) would shed a completly different light on a drug in trial that reduces the lesion count to, lets say 0,9.
In the fist case its less than 10% of the placebo count in the second case
its sill more than 50%.
I think it would be very important to know about the average values, to evaluate the outcomes of a certain drug-trial.
Treatment: Gilenya since 01/2011, CCSVI both IJV ballooned 09/2010, Tysabri stopped after 24 Infusions and positive JCV antibody test, after LDN, ABX Wheldon Regime for 1 year.