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Most Downloaded Pharmacology Biochemistry and Behavior Articles
The most downloaded articles from ScienceDirect in the last 90 days.
1. Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system
Femke T.A. Buisman-Pijlman | Nicole M. Sumracki | Jake J. Gordon | Philip R. Hull | C. Sue Carter | Mattie Tops
Recent research shows that the effects of oxytocin are more diverse than initially thought and that in some cases oxytocin can directly influence the response to drugs and alcohol. Large individual...
Grace E. Giles | Caroline R. Mahoney | Tad T. Brunyé | Aaron L. Gardony | Holly A. Taylor | Robin B. Kanarek
Energy drinks containing caffeine, taurine, and glucose may improve mood and cognitive performance. However, there are no studies assessing the individual and interactive effects of these ingredients....
3. Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia
Aysan Durukan | Turgut Tatlisumak
Ischemic stroke is a devastating disease with a complex pathophysiology. Animal modeling of ischemic stroke serves as an indispensable tool first to investigate mechanisms of ischemic cerebral injury,...
4. Chronic coffee and caffeine ingestion effects on the cognitive function and antioxidant system of rat brains
Renata Viana Abreu | Eliane Moretto Silva-Oliveira | Márcio Flávio Dutra Moraes | Grace Schenatto Pereira | Tasso Moraes-Santos
Coffee is a popular beverage consumed worldwide and its effect on health protection has been well studied throughout literature. This study investigates the effect of chronic coffee and caffeine ingestion...
Fulton Crews | Jun He | Clyde Hodge
Cortical growth and remodeling continues from birth through youth and adolescence to stable adult levels changing slowly into senescence. There are critical periods of cortical development when specific...
6. Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice
Yan Li | Aicha Abdourahman | Joseph A. Tamm | Alan L. Pehrson | Connie Sánchez | Maria Gulinello
Cognitive decline occurs during healthy aging, even in middle-aged subjects, via mechanisms that could include reduced stem cell proliferation, changed growth factor expression and/or reduced expression...
7. Food Craving and Food “Addiction” A Critical Review of the Evidence From a Biopsychosocial Perspective
Peter J Rogers | Hendrik J Smit
Although certain commonalities exist between eating and drug use (mood effects, external cue-control of appetites, reinforcement, etc.), it is argued that the vast majority of cases of (self-reported)...
Catherine Belzung | Marc Turiault | Guy Griebel
In recent years, the development and extensive use of optogenetics resulted in impressive findings on the neurobiology of anxiety and depression in animals. Indeed, it permitted to depict precisely...
Arne Mørk | Liliana P. Montezinho | Silke Miller | Crista Trippodi-Murphy | Niels Plath | Yan Li | Maria Gulinello | Connie Sanchez
The serotonergic system plays an important role in cognitive functions via various 5-HT receptors. Vortioxetine (Lu AA21004) in development as a novel multimodal antidepressant is a 5-HT3, 5-HT7 and...
10. High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels
Miriam E. Bocarsly | Elyse S. Powell | Nicole M. Avena | Bartley G. Hoebel
High-fructose corn syrup (HFCS) accounts for as much as 40% of caloric sweeteners used in the United States. Some studies have shown that short-term access to HFCS can cause increased body weight, but...
11. Fibroblast growth factor 21 protects mouse brain against d-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation
Yinhang Yu | Fuliang Bai | Wenfei Wang | Yaonan Liu | Qingyan Yuan | Susu Qu | Tong Zhang | Guiyou Tian | Siming Li | Deshan Li | Guiping Ren
Fibroblast growth factor 21 (FGF21) is a hormone secreted predominantly in the liver, pancreas and adipose tissue. Recently, it has been reported that FGF21-Transgenic mice can extend their lifespan...
12. Antidepressant-like effects of oleoylethanolamide in a mouse model of chronic unpredictable mild stress
Peng Jin | Hai-Ling Yu | Tian-Lan | Feng Zhang | Zhe-Shan Quan
Oleoylethanolamide (OEA) is an endocannabinoid analog that belongs to a family of endogenous acylethanolamides. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor...
Fulton Timm Crews | Charlotte Ann Boettiger
Alcohol and substance abuse disorders involve continued use of substances despite negative consequences, i.e. loss of behavioral control of drug use. The frontal-cortical areas of the brain oversee...
Daniel Hoyer | Jason P Hannon | Graeme R Martin
Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors (GPCRs) and one (presumably...
15. A family history of Type 1 alcoholism differentiates alcohol consumption in high cortisol responders to stress
Sejla Brkic | Bo Söderpalm | Anna Söderpalm Gordh
The differentiation between high and low cortisol responders to stress is of interest in determining the risk factors which may, along with genetic vulnerability, influence alcohol intake....
J. Jacobus | S. Bava | M. Cohen-Zion | O. Mahmood | S.F. Tapert
Nearly half of 12th graders have tried marijuana, and 6% use daily. This paper reviews studies on neuropsychological functioning, brain structure, brain function, and subjective and objective measures...
15 November 2013
Boris Tabakoff | Paula L. Hoffman
Studies of the neurobiological predisposition to consume alcohol (ethanol) and to transition to uncontrolled drinking behavior (alcoholism), as well as studies of the effects of alcohol on brain function,...
Tiffany M. Love
The hypothalamic neuropeptide oxytocin has drawn the attention of scientists for more than a century. The understanding of the function of oxytocin has expanded dramatically over the years from a simple...
19. Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures — A short review
Ivana Svíženská | Petr Dubový | Alexandra Šulcová
In the last 25 years data has grown exponentially dealing with the discovery of the endocannabinoid system consisting of specific cannabinoid receptors, their endogenous ligands, and enzymatic systems...
20. Why social attachment and oxytocin protect against addiction and stress: Insights from the dynamics between ventral and dorsal corticostriatal systems
Mattie Tops | Sander L. Koole | Hans IJzerman | Femke T.A. Buisman-Pijlman
The present article advances a neurobiological model of the reciprocal associations between social attachment and drug abuse, and social attachment and chronic stress, as overlapping systems are involved...
21. l-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters
Jinsong Xue | Hongyan Li | Xueyang Deng | Zhanqiang Ma | Qiang Fu | Shiping Ma
l-Menthone (MTN) is a Chinese old remedy extracted from the genus Mentha. It has been widely used as a cooling agent and a counterirritant for pain relief, although its antidepressant-like effects have...
Roy J. Levin
The female orgasm has been examined over the years by numerous scientific disciplines yet it still has many secrets to be disclosed. Because its physiology, especially its neurophysiology, is sparingly...
23. Cognitive consequences of cannabis use: Comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions
This review aims to compare cognitive consequence between cannabis, and stimulants and heroin with regards to attention, memory and executive functions. The available studies using brain imaging techniques...
24. The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Sheree F. Logue | Thomas J. Gould
Executive function is a collection of cognitive processes essential for higher order mental function. Processes involved in executive function include, but are not limited to, working memory, attention,...
25. Anxiolytic-like activity and GC–MS analysis of (R)-(+)-limonene fragrance, a natural compound found in foods and plants
Naiana G.P.B. Lima | Damião P. De Sousa | Flávia Cristina F. Pimenta | Mateus F. Alves | Fábio S. De Souza | Rui O. Macedo | Ricardo B. Cardoso | Liana Clébia S.L. de Morais | Margareth de Fátima F. Melo Diniz | Reinaldo Nóbrega de Almeida
The traditional use of essential oils in aromatherapy has offered numerous health benefits. However, few scientific studies have been conducted with these oils to confirm their therapeutic efficacy....