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You should not use this medication if you are allergic to sumatriptan (Imitrex), naproxen (Aleve, Anaprox, Naprosyn), or if you have a history of asthma or allergic reaction caused by aspirin or other NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.
Do not take sumatriptan and naproxen if you have:
- liver disease;
- untreated or uncontrolled high blood pressure; or
- a history of heart disease, angina (chest pain), blood circulation problems, heart attack, stroke, or heart bypass surgery (also called coronary artery bypass graft, or CABG).
Do not take sumatriptan and naproxen if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or phenelzine (Nardil) in the past 14 days.
Do not take sumatriptan and naproxen within 24 hours before or after taking any of the following medicines:
- almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex), or zolmitriptan (Zomig); or
- ergot medicine such as methysergide (Sansert), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), methylergonovine (Methergine).
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before taking sumatriptan and naproxen, tell your doctor if you have:
- high blood pressure;
- congestive heart failure;
- epilepsy or other seizure disorder;
- liver disease;
- kidney disease; or
- coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).
FDA pregnancy category C. Sumatriptan and naproxen may be harmful to an unborn baby. Tell your doctor if you are pregnant before you take this medication. Taking naproxen during the last 3 months of pregnancy may result in birth defects. Do not take sumatriptan and naproxen during pregnancy without your doctor’s advice.
Sumatriptan and naproxen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Medicines available over the counter contain aspirin, naproxen, or other medicines similar to naproxen (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.
Do not drink alcohol while taking sumatriptan and naproxen. Alcohol can increase the risk of stomach bleeding caused by naproxen.
Sumatriptan and naproxen can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Seek emergency medical attention if you think you have used too much of this medicine.
Symptoms of a sumatriptan and naproxen overdose are unknown, but may include dizziness, drowsiness, heartburn, stomach pain, nausea, vomiting, breathing problems, black or bloody stools, coughing up blood, and seizure (convulsions).
Since sumatriptan and naproxen is taken only when needed, it does not have a daily dosing schedule.
Do not take more than 2 sumatriptan and naproxen tablets in 24 hours.
Get emergency medical help if you have any of these signs of an allergic reaction: runny or stuffy nose; hives; wheezing or trouble breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you a serious side effect such as:
- chest pain or pressure, tight feeling in your neck or jaw, pain spreading to your arm or shoulder;
- sudden numbness or weakness, confusion, problems with vision, speech, or balance;
- bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- urinating less than usual or not at all;
- pale skin, weakness, easy bruising, flu symptoms;
- swelling or rapid weight gain;
- numbness, tingling, pale or blue-colored appearance in your fingers or toes;
- severe blistering, peeling, and red skin rash;
- seizure (convulsions); or
- anxiety, restlessness, high fever, sweating, memory problems, trouble concentrating, loss of coordination, vomiting, diarrhea, fast heart rate, hallucinations, or fainting.
Less serious side effects may include:
- dizziness, drowsiness;
- constipation, dizziness, indigestion, dry mouth;
- warmth, numbness, or tingly feeling;
- redness in your face;
- tight muscles; or
- mild pressure or heavy feeling in any part of your body.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can interact with sumatriptan and naproxen. Below is just a partial list. Tell your doctor if you are using:
- a blood thinner such as warfarin (Coumadin);
- lithium (Eskalith, Lithobid);
- methotrexate (Rheumatrex, Trexall);
- probenecid (Benemid);
- a diuretic (water pill) such as furosemide (Lasix);
- steroids (prednisone and others);
- aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), meloxicam (Mobic), and others;
- an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others;
- a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others; or
- an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).
This list is not complete and there may be other drugs that can interact with sumatriptan and naproxen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
naproxen-sumatriptan, sumatriptan-naproxen, and Treximet
Available Strengths & Dosages
|oral||tablet||500 mg-85 mg|
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Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04