Cell Biology in Sydney, Australia, have identified a novel function for BAFF: it acts as a specific survival factor for Ig-secreting cells derived from memory B cells. The study suggest that in human autoimmune diseases, elevated levels of serum BAFF may contribute to the disease process by not only breaking tolerance at the immature/transitional B cell stage of development, but by also enhancing plasmablast survival.
TITLE: BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia.
View the PDF of this article at: https://www.the-jci.org/press/18025.pdf
Secret to controlling thyroid hormone production
Originating in the thyroid, the prohormone thyroxine is converted to triiodothyronine, which is essential in brain development, growth, and metabolism. A study from researchers at Brigham and Women's Hospital in Boston, reveals a novel mechanism for controlling triiodothyronine production that demonstrates the first example of enzyme activity being restored by deubiquitination.
TITLE: Deubiquitination of type 2 iodothyronine deiodinase by von HippelLindau proteininteracting deubiquitinating enzymes regulates thyroid hormone activation
Antonio C. Bianco
Harvard University, Boston, Massachusetts, USA.
View the PDF of this article at: https://www.the-jci.org/press/18348.pdf
ACCOMPANYING COMMENTARY:Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Related biology news :1
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Journal of Clinical Investigation
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