IL-17A synergizes with TNF to induce the production of MCP-1, IL-8 and MMP-1 by dermal fibroblasts. Bars represent the mean ± SEM of the levels of MCP-1, IL-8, MMP-1 and type I collagen assessed in the supernatants of dermal fibroblasts from three HD cultured in triplicate for 48 hours in the presence or absence of IL-17A (30 ng/ml) and TNF (0.01 ng/ml). Statistically significant differences were assessed by paired t-test.
HD: healthy donors; IL: interleukin; MCP-1: monocyte chemotactic protein-1; MMP-1: matrix metalloprotein-1; SEM: standard error of the mean; TGF: transforming growth factor; TNF: tumor necrosis factor.
Brembilla et al. Arthritis Research & Therapy 2013 15:R151 doi:10.1186/ar4334