[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27) NF - (NMe - G) - A - (NMe - I) - L
% Peak Area By HPLC ≥ 95%
This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.