Ferric C. Fang, MD
Professor of Laboratory Medicine and Microbiology
Email: click here
Phone: (206) 221-6770
The Fang laboratory studies bacterial pathogenesis; in particular, the antimicrobial actions of phagocyte-derived reactive oxygen and nitrogen species and the strategies used by pathogenic microbes to resist these host defenses. Specific projects include the identification of novel nitric oxide targets in Salmonella enterica and Staphylococcus aureus, the role of iron metabolism in host-Salmonella interactions, the activation of Salmonella virulence gene expression by alternative sigma factors and other transcriptional regulators, the mechanisms by which reactive nitrogen and oxygen species damage microbial DNA or impair DNA replication, and the development of a humanized mouse model for typhoid fever.
[Additional publication references and online abstracts available at http://myprofile.cos.com/fang5858.
Fang FC, DeGroote MA, Foster JW, Bumler AJ, Ochsner U, Testerman T, Bearson S, Gird JC, Xu Y, Campbell G and Laessig T. Virulent Salmonella typhimurium has two periplasmic Cu,Zn-superoxide dismutases. Proc Natl Acad Sci USA 96:7502-7507, 1999.
Vazquez-Torres A, Jones-Carson J, Bumler AJ, Falkow S, Valdivia R, Brown W, Le M, Berggren R, Parks WT, Fang FC. Extraintestinal dissemination of Salmonella via CD18-expressing phagocytes. Nature 401:804-808, 1999.
Vazquez-Torres A, Xu Y, Jones-Carson J, Holden DW, Lucia SM, Dinauer MC, Mastroeni P, Fang FC. Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase. Science 287:1655-1658, 2000.
Vazquez-Torres A, Jones-Carson J, Mastroeni P, Ischiropoulos H, Fang FC. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro. J Exp Med 192:227-237, 2000.
Vazquez-Torres A, Fantuzzi G, Edwards C 3d. Dinarello CA and F.C. Fang. Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in TNFp55 receptor-deficient macrophages. Proc Natl Acad Sci USA 98:2561-2565, 2001.