Dengue (DENG-gey) fever is a mosquito-borne disease that occurs in tropical and subtropical areas of the world. Mild dengue fever causes high fever, rash, and muscle and joint pain. A severe form of dengue fever, also called dengue hemorrhagic fever, can cause severe bleeding, a sudden drop in blood pressure (shock) and death.
Millions of cases of dengue infection occur worldwide each year. Dengue fever is most common in Southeast Asia and the western Pacific islands, but the disease has been increasing rapidly in Latin America and the Caribbean.
Researchers are working on dengue fever vaccines. For now the best prevention is to reduce mosquito habitat in areas where dengue fever is common.
Sept. 19, 2014
- Ferri FF. Ferri's Clinical Advisor 2015: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2015. https://www.clinicalkey.com. Accessed July 18, 2014.
- Papadakis MA, ed., et al. Current Medical Diagnosis & Treatment 2014. 53rd ed. New York, N.Y.: The McGraw-Hill Companies; 2014. http://accessmedicine.mhmedical.com/book.aspx?bookId=330. Accessed June 28, 2014.
- Nathan MB, et al. Dengue: Guidelines for diagnosis, treatment, prevention and control. Geneva, Switzerland: World Health Organization; 2009. http://www.who.int/rpc/guidelines/9789241547871/en/. Accessed July 19, 2014.
- Sinha G. Sanofi's dengue vaccine first to complete phase 3. Nature Biotechnology. 2014;32:605.
- Rothman AL. Prevention and treatment of dengue virus infection. http://www.uptodate.com/home. Accessed July 14, 2014.
- Capeding MR, et al. Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: A phase 3, randomised, observer-masked, placebo-controlled trial. The Lancet. In press. Accessed July 18, 2014.