"Cities of different sizes draw on different types of skills. This distribution of skills is also a function of industry structure which can be driven by region size. Manufacturing is overrepresented in small and medium sized cities while knowledge and standardized services are more located in bigger cities The chart below shows that larger cities have a mix of employment in occupations requiring higher average levels of analytical and social intelligence skills, whereas average physical skill content of occupations does not differ significantly by city size. Very large cities, defined by population greater than 2 million such as New York, NY or Washington, DC, draw most heavily on social intelligence skills."
This report from the Martin Prosperity Institute compares physical, social intelligence and analytical skillsets against the sized of cities where these skillsets tend to have more demand.