SCCA Lymphoma Clinical Trials
RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody BC8, can find cancer cells and carry cancer-killing substances to them without harming normal cells. Giving iodine I 131 monoclonal antibody BC8 before an autologous stem cell transplant may be an effective treatment for lymphoma.
PURPOSE: This phase I trial is studying the side effects and best dose of iodine I 131 monoclonal antibody BC8 when given before an autologous stem cell transplant in treating patients with lymphoma that has relapsed or not responded to treatment.
|Ages Eligible for Study:||18 Years and older|
|Genders Eligible for Study:||Both|
|Accepts Healthy Volunteers:||No|
Histologically confirmed lymphoma, including 1 of the following:
B-cell or T-cell non-Hodgkin lymphoma (NHL)
- Documented CD45 antigen expression in tumor specimens
- Must have CD45+ cells adjacent to the Reed Sternberg cells
Must have received at least 1 prior standard systemic therapy AND have documented recurrent or refractory disease
- Patients with mantle cell lymphoma or other high-risk NHL (e.g., T-cell NHL) may be in first complete remission or partial remission
Meets 1 of the following criteria:
- Tumor mass amenable to core needle biopsy during the dosimetry phase
Measurable tumor mass with ≥ 1 site of involvement measuring 2.0 cm in largest dimension on CT imaging (for purposes of planar and/or SPECT/CT imaging tumor dosimetry)
- Disease that does not allow tumor dosimetry allowed
No circulating lymphoma cells by morphology or flow cytometry (> 0.1%) at or near the time of peripheral blood stem cell (PBSC) collection (if unpurged/unselected PBSC are to be used)
- Patients with cryopreserved PBSC that are negative (≤ 0.1%) by flow cytometry are eligible
Must have ≥ 4x 10^6 CD34/kg autologous hematopoietic stem cells (HSC) available
- Patients who underwent prior autologous HSC transplantation must have ≥ 2 x 10^6 CD34/kg autologous HSC available
- No CNS lymphoma
See this trial at ClinicalTrials.gov
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
- Talk to your health care providers first before making decisions about your health care.
- Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.