Inflammation meets oxidation: NF-kappa B as a mediator of initial lesion development in atherosclerosis
Kütük, Özgür and Başağa, Hüveyda (2003) Inflammation meets oxidation: NF-kappa B as a mediator of initial lesion development in atherosclerosis. Trends in molecular medicine, 9 (12). pp. 549-557. ISSN 1471-4914
Official URL: http://dx.doi.org/10.1016/j.molmed.2003.10.007
Transcription factor nuclear factor-κB (NF-κB) and its target genes are involved in the pathogenesis of atherosclerosis, in addition to many other diseases. Monocyte recruitment into subendothelial space is primarily mediated by NF-κB-dependent gene expression, and this event is a crucial milestone, because it is nearly impossible to reverse the progression of the lesion after this point. Recent advances in our understanding of atherosclerosis as a disease of childhood enforces the necessity of developing novel approaches for prevention and treatment. Here, the authors address NF-κB as a major therapeutic target, especially for preventive measures, in the light of two main hypotheses of atherosclerosis: oxidation and inflammation.
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