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Tetrahydrocannabinol, or THC, the psychoactive ingredient of marijuana, can alter the hypothalamic-pituitary-gonadal axis by acting directly on the hypothalamus and altering the gonadotropin-releasing hormone (GnRH) or by altering neural transmitters in the central nervous system, which affect the hypothalamus.
36) The use of synthetic GnRH agonists in many species has been shown to initially cause hyperstimulation, followed by suppression of the hypothalamic-pituitary-gonadal axis by causing down-regulation of GnRH receptors in the pituitary gland.
Fertility can also be compromised by chemotherapy, radiotherapy of the hypothalamic-pituitary-gonadal axis or surgery.
These neurons are part of the hypothalamic-pituitary-gonadal axis essential in maintaining the delicate balance of GnRH release.
The Hypothalamic-Pituitary-Gonadal Axis in Teleost Fish.
Taken together, our morphologic, endocrinologic, and in vino gene activation assay data suggest two hypotheses: a) there is an androgenic substance(s) in the FLE and/or b) there is a mixture of endocrine-active substances that alter the hypothalamic-pituitary-gonadal axis.
Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the developing male rat.
Of equal complexity, the hypothalamic-pituitary-gonadal axis has been shown in both sexes to be sensitive to disruption by environmental agents that affect gonadotropin secretion, steroidogenesis, receptor binding, or signal transduction.