miR-122 targeting HCV. The HCV RNA genome is shown with coding regions as rectangles and the 5' and 3' UTRs as lines. Structural genes are in blue and non-structural genes in purple. The two seed matches bound by miR-122 are highlighted in red in an expanded view of the 5' UTR. The sequence of miR-122 is shown in black, with the seed (nucleotides 2-8) in red. The SPC3649 molecule that targets it is shown with LNA indicated in orange (C in orange indicates LNA methylcytosine) and DNA in green. The backbone is phosphorothioate.
Roberts and Jopling Genome Biology 2010 11:201 doi:10.1186/gb-2010-11-1-201