MHC restriction questions
Ian A. York
iayork at panix.com
Thu Oct 22 16:10:56 EST 1998
In article <362FBCED.1958 at mail.tju.edu>,
mark <mark.haynes at mail.tju.edu> wrote:
>I don't really think you need a system that can differentiate, just a system
>that deletes reactivity to peptides that find there way to the thymus and get
>presented via class i or class ii to cd8 or cd4 thymocytes respectively.
>Everything else is non-self. You don't need to be tolerant of all the intra
If "everything else is non-self", then it's differentiating between
self-and non-self. You've rephrased my point, is all.
>> that shifting the burden of discrimination from a subset of cells to all
>> cells will greatly increase the cost.
>Me neither, but I would propose that it would just be shifted to APCs and not
For MHC class I, every cell *is* an APC. So, again, you've re-phrased my
Ian York | "I'm not crazy. You're the one who's crazy. WE'VE
(iayork at panix.com) | GOT YOUR URINE AND WE'RE NOT LETTING IT GO."
| -Tjames Madison
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