It depends on what your intended use for the gun is. For small-to-medium sized thin-skinned game like whitetail deer, the 150gr loadings would probably be preferable but for larger, thicker skinned, and/or dangerous game like bears, the heavier bullets would probably be a wiser choice.
Smith, and Wesson, and Me. -H. Callahan
Well waddaya know, one buwwet weft! -E. Fudd
All bad precedents begin as justifiable measures. -J. Caesar