- Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiaeFrederico Augusto Vieira Castro
Departamento de Bioquimica, Laboratório de Investigação de Fatores de Estresse, Instituto de Quimica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
PLoS ONE 3:e3999. 2008..However, due to differences in structures and diverse pharmacological effects, the exact toxicity mechanisms exerted by quinones are far from elucidatation...
- Synthesis, characterization and biological activities of mononuclear Co(III) complexes as potential bioreductively activated prodrugsElizabeth Teixeira Souza
Departamento de Quimica Inorganica, Instituto de Quimica, Universidade Federal do Rio de Janeiro, 21945 970 Rio de Janeiro, RJ, Brazil
J Inorg Biochem 103:1355-65. 2009..These data reveal the potential of 1 and 2 as bioreductively activated prodrugs, since their oxidized forms do not present expressive activities when compared to their reduced forms...