Description: Calcium D-Glucarate 90c is available by Douglas Laboratories.
amni® original formula
A Dietary Supplement
Calcium D-Glucarate, provided by Douglas Laboratories, is a natural supplement of D-glucaric acid bound to calcium.
Calcium D-Glucarate may be a useful
dietary supplement for those who wish to supplement their diet with
D-glucaric acid as a precursor to D-glucaro- 1, 4-lactone.
Calcium D-glucarate enhances the body’s
natural defenses against environmental toxins and excess steroid
hormones. Through the actions of its metabolite D-glucaro-1,4-lactone,
calcium-d-glucarate indirectly favors glucuronidation, an important
system that the body relies upon to deactivate and eliminate toxins and
steroid hormones. Glucuronidation is a conjugation process through
which potentially carcinogenic environmental toxins, such as polycyclic
aromatic hydrocarbons and nitrosamines, and excess steroid hormones are
During glucuronidation, the enzyme glucuronosyl
transferase catalyzes the conjugation of free carcinogens and steroid
hormones to glucuronic acid. The resulting glucuronide-bound toxins and
hormones can then be safely excreted in bile and urine. The body also
deconjugates glucuronide-bound end products. The release of
glucuronide-bound substances is beneficial in some circumstances, for
example, when the excretion of steroid hormones is undesirable. Yet,
the deconjugation process, which works via the enzyme
beta-glucuronidase, can result in the re-release of harmful toxins back
into the body.
The benefits of calcium D-glucarate are
realized indirectly through the action of its metabolite Dglucaro-
1,4-lactone, which inhibits the deconjugating enzyme beta-glucuronidase
found in both blood and tissue. Inhibition of beta-glucuronidase causes
a net increase in glucuronidation, and thereby enhances a primary
detoxification pathway in the body. Animal studies have documented a
decrease in B-glucuronidase activity in breast, liver, colon, skin,
lung, and prostate tissue following oral administration of calcium
Once ingested, Calcium D-glucarate is converted to
Dglucaric acid in the presence of gastric HCl. The body normally
maintains an equilibrium between D-glucaric acid and its two
metabolites, D-glucaro-1,4-lactone and D-glucaro-6,3-lactone. Calcium
D-glucarate provides a slow-release source of D-glucaro-1,4-lactone.
When taken directly, D-glucaro- 1,4-lactone is metabolized quite
quickly and is excreted from the body usually within 1-2 hours of its
administration. Calcium D-glucarate, however, is metabolized slowly,
remaining in the body for 5 or more hours after ingestion. This results
in maintenance of stable levels of D-glucaro-1,4-lactone for long
periods of time. D-glucaric acid is produced endogenously in small
amounts. It is also present in some fruits and vegetables, including
oranges, apples, grapefruit, broccoli and other cruciferous vegetables.
Serving Size: 1 Capsule
Servings Per Container: 90
Amount Per Serving
(From 500 mg of Calcium D-Glucarate)
Gelatin (capsule), Cellulose, Water, Magnesium Stearate
As a dietary supplement, adults take 1 to 2 capsules daily or as directed by your healthcare professional.
KEEP OUT OF REACH OF CHILDREN.
For optimal storage conditions, store in a cool, dry place.
Tamper resistant package, do not use if outer seal is missing.
(35-65% relative humidity)
These statements have not been evaluated by the Food and Drug
Administration. These products are not intended to diagnose, treat
cure, or prevent any diseases.