Figure 1: Optimisation based on single AP dataset. (a) Top panels: optimised model generated APs overlaid with experimental APs recorded from central sinoatrial node (cSAN), peripheral sinoatrial node (pSAN), and right atrial (RA) intact myocytes from rabbit sinoatrial tissue preparations. Lower panels: corresponding ionic and leakage currents generated by each cell model. (b) Phase plot ( versus ) of model APs overlaid with experimental data. The experimental voltage derivatives were obtained from first order finite differencing of the membrane voltage data.