The actor, who founded the Demi and Ashton Foundation (DNA) with his wife Demi Moore to raise awareness of child sex slavery, responded to a critical article in the magazine that took issue with statistics used by the foundation.
"There are not 100,000 to 300,000 children in America turning to prostitution every year," the article read. "The statistic was hatched without regard to science. It is a bogeyman. "
Kutcher defended the accuracy of his figures and attacked the magazine for the content of its classified advertisements.
"Speaking of data, maybe you can help me... How much $ did your 'escorts' in you classifieds on backpage make last year? (sic)" he wrote on Twitter. "How many of your girls selling themselves in your classifieds are you doing age verification on?
"Find another way to justify that YOUR property facilitates the sale of HUMAN BEINGS. If you ever want 2 have a productive conversation about how 2 end human trafficking as oppose to belittling my efforts lmk."
"REAL MEN DON'T BUY GIRLS and REAL NEWS PUBLICATIONS DON'T SELL THEM... I'm just getting started!!!!!!!! BTW I only PLAYED stupid on TV."
Village Voice wrote back: "Don't spout phony statistics which are then used to justify millions in spending for 'awareness'.
"Victims need beds and counseling. Why would police departments across the country have a bias to downplay their arrest data on underage prostitution?"
They added: "Which sounds more plausible: A limited but persistent problem whose underlying causes are homelessness and drug use, or invisible sex slaves in Third World proportions somehow stashed around the country by networks of cyber-pimps?
"Here's why @aplusk's mythical sex slave numbers matter: activists use them to target legal adult freedoms, not underlying teen problems."
Watch Ashton Kutcher star in a DNA Foundation 'Real Men Don't Buy Girls' campaign video below: