January 22, 2027: Dr. Hagiru Sato and his scientists from Japan, Canada, America, and Britain begin work on a matter-energy transfer machine.
February 11, 2033: First machine tested successfully after over one hundred failed tests. Controversy over the destructive nature of the technology ignites.
July 18, 2033: A catastrophic incident with an energy-matter transfer machine destroys Hiroshima, a devastation not seen since the Atomic Bomb dropped nearly 90 years before. Japanese officials move to ban the technology, Western powers urge them allow it, despite the mishap
April 22, 2035: First sighting of infected individuals. Most are animals, some Humans are susceptible to infection. Most seen around the ruins of Hiroshima, which has not been rebuilt.
May 13, 2035: Northern Japan is split off from its Southern half, as a nation wide quarantine is in enacted. Anarchy soon spreads through the infected regions. 15% of the humans are immune to the disease and show no side effect. 84.9% are affected fatally by the disease, which causes cancerous growths. 1% of those exposed are shown to successfully mutate. The "Virus" is found to be a spreadable corruption of genetic material, which causes rapid mutation in infected individuals. All large animal life above ground soon become mutated.
January 1, 2040: 98% of all animals in Japan are wiped out; ecosystems rules entirely by infected individuals.
May 8, 2048: Japanese Defense Force engages infected individuals to preserve quarantine. Coordinated attacks by infected humans and animals are seen. High levels of intelligence confirmed.
May 10, 2048: They fail, the nation of Japan ceases to exist.
October 13, 2048: The United States Carrier George W. Bush is attacked and sunk by an unknown force. Later revealed to be a coordinated attack by the infected. Use of Atomic weapons to destroy all life on Japan considered, but denied.
February 12, 2052: Remaining inhabitants of Japan have appeared, by outward observers, to have begin adopting the infected ones into their religions. Part of this religion is a total weapons ban, and the banning of violence against infected individuals. This is surprisingly effective at ceasing conflict with the infected individuals.
April 2, 2055: Infected have seem to spread to North America. Military preparedness results in far more contained infection. Hundreds of thousands in North America, Canada, and Mexico die.
March 11, 2061: The United States Army begins experimenting with the combat prowess of the infected animals, who are shown to have a friendly connection to humans who treat them well, much like dogs. Initial tests exceed expectations. Later that year, China, North Korea, Russia, and Vietnam sign the Kommu Pact, ensuring protection against the now overpowered west.
July 2, 2063: The Kommu alliance declares war on the United States. Infected used to great effect.
November 9, 2066: The war ends. Communist states are dissolved, all of Asia is now under the control of NATO.
December 25, 2072: The now divided regions that were once Japan begin to open up to the outside world. Mostly through scientific trade off.
February 1, 2081: Japanese scientists sneak into heavily infected Brazil. They recover the DNA of what they believe is to be one of the first infected. Beliefs are that the infected are actually the next phase in evolution, and to find one of the originals would help better the understanding. There are many tried-and-failed cloning attempts, before the final experiment is successful. The result of this experiment, capable of self-induced Energy-Matter transference, is responsible for for the deaths of before escaping.
May 22, 2081: Ash Ketchum turns 10 years old.