Home Antibody All anti-AP2M1 antibodies
Also for AP2M1 (NM_001025205)
|AP2M1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human AP2M1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens adaptor-related protein complex 2, mu 1 subunit (AP2M1), transcript variant 2|
|AP50; CLAPM1; mu2|
Entrez Gene 1173 Human
Entrez Gene 11773 Mouse
Entrez Gene 116563 Rat
|The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.|
|Druggable Genome EndocytosisHuntington's disease|
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Western blot analysis of AP2M1 in human kidney tissue lysate with AP2M1 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of AP2M1 in mouse kidney tissue with AP2M1 antibody at 2.5 ug/ml.