Why it shoots so smooth and accurate is with reason,as is everything else about the revolver. The Python has exceeded the industry standards since it's introduction in 1955, with a left hand barrel twist of 6 rifling grooves, as opposed to 5 for most others, and a twist rate of 1 in 14 inches, as opposed to the industry standard of 1 in 18 3/4 inches. The barrel also has an inner surface that is polished to a mirrored smoothness like no other revolver manufacturer. Another noted feature of the barrel is the bore diameter that tapers by 1/1000 of an inch toward the muzzle, forcing the bullet deeper into the rifling.
The action of the Python has at least six individual hand polishing and honing steps performed. The trigger stroke and hammer fall are longer than those of the S&W, Ruger, Taurus, or Dan Wesson, which some may feel is bad, but in fact, it's good because the longer hammer fall provides a harder strike on the frame mounted firing pin. With a lighter trigger action, this longer hammer fall, provides a more reliable primer ignition, while providing the Python with a positive trigger return, from shot to shot.
Assisting in the cylinder lockup is the "Second Hand", which rises under the first hand, locking the cylinder motionless in place at the moment of the shot.
These are some of the differences I've found with the Python, as opposed to other revolvers.