Type of Document Master's Thesis Author Sanna, Chaitanya Ramesh URN etd-07102006-161019 Title Patterns of Two Types of Overlapping Genes in Five Mammalian Genomes Degree Master of Science Department Computer Science Advisory Committee
Advisor Name Title Zhang, Liqing Committee Chair Heath, Lenwood S. Committee Member Tu, Zhijian Jake Committee Member Keywords
- 3'- UTR
- overlapping genes
- same strand
- different strand
Date of Defense 2006-06-28 Availability restricted AbstractIncreasing evidence suggests that overlapping genes is a common phenomenon in eukaryotic genomes too and are not restricted to prokaryotes alone. Here we determined overlapping genes in a set of orthologous genes in the genomes of human, chimp, mouse, rat, and dog and contrasted the patterns of overlapping between two principal types of overlapping genes, the same-strand-overlapping genes and different-strand-overlapping genes. The two types of overlapping genes are compared with respect to their frequencies, overlap lengths, region of overlap, and conservation of overlap in five species. Our results suggest the following: different-strand-overlaps are more common, both types show different patterns with respect to overlap lengths and regions of overlap, different-strand-overlapping genes are more evolutionarily conserved, and 3'-UTR evolution plays an important role in transitions between non-overlapping genes and overlapping genes.
The thesis also presents a review of related work in terms of history, origin, types, biological significance of overlapping genes, human diseases associated with them, and their comparison in prokaryotes and eukaryotes.
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