Genomes and Genes
Affiliation: University of Ottawa
- Estimating the stochastic bifurcation structure of cellular networksCarl Song
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
PLoS Comput Biol 6:e1000699. 2010....
- Quantitative epistasis analysis and pathway inference from genetic interaction dataHilary Phenix
Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada
PLoS Comput Biol 7:e1002048. 2011..Strikingly, when the analyses of the two traits are combined, the method correctly infers ~80% of the known relationships without any false positives...
- Identification of response-modulated genetic interactions by sensitivity-based epistatic analysisCory Batenchuk
Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada
BMC Genomics 11:493. 2010....
- Stochasticity in gene expression: from theories to phenotypesMads Kaern
Department of Cellular and Molecular Medicine and Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H8M5, Canada
Nat Rev Genet 6:451-64. 2005..It can provide the flexibility needed by cells to adapt to fluctuating environments or respond to sudden stresses, and a mechanism by which population heterogeneity can be established during cellular differentiation and development...
- A chance at survival: gene expression noise and phenotypic diversification strategiesDawn Fraser
Ottawa Institute of Systems Biology, Ottawa, Canada
Mol Microbiol 71:1333-40. 2009..Here, we discuss different scenarios where gene expression noise might bestow a selective advantage under stress, highlighting a potentially fundamental role of stochastic mechanisms in the evolution of microbial survival strategies...
- A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamicsRobin E C Lee
Regenerative Medicine Program, Ottawa Health Research Institute, Sprott Centre for Stem Cell Research, Ottawa, Canada
PLoS ONE 3:e2956. 2008..Our results demonstrate multiple non-death roles for yca1 in the cell cycle...
- Gene expression noise facilitates adaptation and drug resistance independently of mutationDaniel A Charlebois
Department of Physics, University of Ottawa, Ontario, Canada
Phys Rev Lett 107:218101. 2011..We examine how this effect contributes to the development of drug-resistant cancer cells, and demonstrate that permanent immunity can arise independently of mutations...
- Physics takes another stab at biological design principlesDaniil Zhuravel
Mol Syst Biol 1:2005.0029. 2005
- The engineering of gene regulatory networksMads Kaern
Center for BioDynamics, Department of Biomedical Engineering, and Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA
Annu Rev Biomed Eng 5:179-206. 2003....
- Noise in eukaryotic gene expressionWilliam J Blake
Center for BioDynamics, Center for Advanced Biotechnology, Bioinformatics Program, and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
Nature 422:633-7. 2003..This result has implications for the role of noise in phenotypic variation and cellular differentiation...
- Estimations of intrinsic and extrinsic noise in models of nonlinear genetic networksMatthew Scott
Center for Theoretical Biological Physics, Department of Physics, University of California, San Diego, La Jolla, California, 92093 0374, USA
Chaos 16:026107. 2006..The methods allow for rapid estimations of intrinsic and extrinsic noise and should prove useful in the analysis of natural genetic networks and when constructing synthetic gene regulatory systems...
- Predictable trends in protein noiseKristin Baetz
Nat Genet 38:610-1. 2006
- Programmable cells: interfacing natural and engineered gene networksHideki Kobayashi
Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, 44 Cummington Street, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:8414-9. 2004..Our work represents a step toward the development of "plug-and-play" genetic circuitry that can be used to create cells with programmable behaviors...