Received 4 January 2010
In the title compound, C16H15N3O3, the dihedral angle between the pyridine and benzene rings is 7.66 (5)°. The crystal packing is consolidated by intermolecular C-HO and O-HN interactions, which link the molecules into zigzag chains propagating along . The chains are further linked into a three-dimensional network by N-HO, C-HN, C-HO and C-H interactions.
For the synthesis, see: Lourenco et al. (2008). For the tuberculostatic activities of isoniazid derivatives, see: Janin (2007). For related structures, see: Naveenkumar et al. (2009a,b,c); Shi (2005). For the stability of the temperature controller used for the data collection, see: Cosier & Glazer (1986).
Data collection: APEX2 (Bruker, 2009); cell refinement: SAINT (Bruker, 2009); data reduction: SAINT; program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL; software used to prepare material for publication: SHELXTL and PLATON (Spek, 2009).
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: HB5304 ).
This research was supported by Universiti Sains Malaysia (USM) under the University Research Grant (No. 1001/PFARMASI/815005). HKF and CKQ thank USM for the Research University Golden Goose Grant (No. 1001/PFIZIK/811012). HSNK and CKQ are grateful financial assistance through a USM fellowship.
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