Biocoral® is a biomaterial containing Calcium Carbonate (>98%) derived from Natural Coral and is used as a bone graft substitute Biocoral® ensures a BONE REGENERATION by its affinity to bone cells and its interconnected porosity similar to cancellous bone.
Biocoral® is the only natural wholly mineral bone graft substitute having a highly porous architecture, which is formed from naturally occurring aragonite crystal with three-dimensional interconnectivity allowing for optimum formation of new bone.
Biocoral® is constituted of over 98% Calcium carbonate in the crystalline form (Aragonite)
Several components are present at levels equivalent to those found in mammalian bone, notably trace elements, which play a vital role in the process of mineralization and in the activation of enzymatic reactions in bone cells.
Two trace elements have specifics effects:
Strontium is involved in the formation and growth of the crystalline component of bone, protects calcification mechanisms and increasesmineralization. Furthermore, Strontium levels are higher in the most active bone structure the metaphysis and bone callus.
Fluorine in proper quantity increases bone formation by direct effects on proliferation of cellular precursors of osteoblasts.
- Natural Calcium Carbonate (CaCO3),
- 3 dimensional randomly interconnected pore,
- Pore size: 150µm,
- Porosity: 50% allowing an ideal newly bone formation.
The porosity architecture of Biocoral® is in the form of aragonite crystalline. The regular structures of pores, their volume, their size and the thickness of their walls are the special characteristics of Biocoral®. The open porosity of Biocoral®, allows the blood cells and bone marrow cells (blood, anions, cations, etc...) to spread and infiltrate in its core which speed up the bone ingrowths. Biocoral® present the remarkable mechanical resistance qualities associated to its porosity (50% and 20%) similar to those of the cancellous and cortical bone respectively.
The natural choice for new bone growth
Biocoral® is biocompatible and safe
The perfect biocompatibility of Biocoral® has been demonstrated by standardized studies realized in vitro and in vivo and has been confirmed in all human clinical indications for bone substitution and bone regeneration.
Biocoral® safety is appropriate for all indicated use and there is No risk of virus transmission by the product).
Biocoral® is bioactive.
Biocoral® because of its unique activity and dune only to its mineral and architectural characteristics (Aragonite Crystal and Porosity), once placed is bony sites is quickly impregnated with autogenous blood or bone marrow, with a proved calcification from the day 9th.
Experiments show the attraction of bone cells by Biocoral® and the early bone formation directly in contact to Biocoral®.
|HISTOLOGIC ANALYSIS OF FUSION MASS|
Phase 1: Invasion by blood cells and extravasated bone marrow.
Phase 2: Vascularization (v: vessels).
Phase 3: Resorption of Biocoral® by osteoclasts (oc: osteoclast).
Phase 4: Bone neoformation with osteoblastic (ob: osteoblast) apposition and concomitant resorption.
Phase 5: Remodeling of neoformed tissue to produce the architecture of the recipient bone.
Biocoral® bioactivity, together with its osteoconductive and osteophilic properties, induces specific biological activity in the recipient bone, similar to the physiological natural bone metabolism. This activity leads to graduate resorption of Biocoral® by osteoclasts and its replacement by osteoblasts in newly formed bone.
The natural POROSITY
Biocoral® porosity is similar to cancellous bone. The volume, organization and regularity of pores support the bone cells invasion, the implant stabilization, vascularization and bone formation.
The "natural" strength
Biocoral® 50% porosity is at least 5 times stronger than cancellous bone and biocoral 20% porosity is at least as strong as fresh cortical bone.
Biocoral® is resorbed progressively and replaced by neoformed bone.
Resorption of the calcium carbonate skeleton of Biocoral® is due to the enzyme content (carbonic anhydrase) released by the osteoclasts.
Biocoral® is a natural ceramic of calcium carbonate supporting the mineralisation of the neoformed bone by liberating its natural mineral elements.
Section of Biocoral® 50% porosity
Section of Human femural cortex
Section of human cancellous bone
Section of Biocoral®