N J Timpson
Affiliation: University of Bristol
- TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health StudyNic J Timpson
Department of Social Medicine, University of Bristol, United Kingdom
Am J Clin Nutr 81:1005-11. 2005..Recent observations have implicated 2 common haplotypes of TAS2R38 in the determination of bitter compound-tasting ability...
- Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and ChildrenMartin D Tobin
Departments of Health Sciences and Genetics, Genetic Epidemiology Group, University of Leicester, Leicester, United Kingdom
Hypertension 52:974-9. 2008..Our study suggests that previously reported effects of WNK1 variants on blood pressure are mediated via effects on the gradient of blood pressure change with age...
- C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomizationN J Timpson
MRC Centre for Causal Analysis in Translational Epidemiology, Bristol University, Bristol, UK
Int J Obes (Lond) 35:300-8. 2011....
- Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participantsNicholas J Timpson
Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Department of Social Medicine, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Am J Clin Nutr 92:375-82. 2010..To date, there are no confirmed genetic correlates of circulating concentrations of L-ascorbic acid...
- Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomizationNicholas J Timpson
MRC Centre for Causal Analysis in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
Cancer Epidemiol Biomarkers Prev 19:1341-8. 2010..Whether this represents a causal association or is a result of confounding or bias is unclear. We assessed the potential for using genetic variation in lactase persistence as a tool for the study of this relationship...
- The fat mass- and obesity-associated locus and dietary intake in childrenNicholas J Timpson
MRC CAiTE Centre, Department of Social Medicine, Bristol University, Bristol, UK
Am J Clin Nutr 88:971-8. 2008..A region of chromosome 16 containing the fat mass-and obesity-associated gene (FTO) is reproducibly associated with fat mass and body mass index (BMI), risk of obesity, and adiposity...
- Mendelian randomization: application to cardiovascular diseaseNicholas J Timpson
MRC CAiTE Centre, School of Social and Community Medicine, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK
Curr Hypertens Rep 14:29-37. 2012..The potential and the possible limitations of this approach within the cardiovascular field are presented in this review...
- Age- and puberty-dependent association between IQ score in early childhood and depressive symptoms in adolescenceB Glaser
The MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK
Psychol Med 41:333-43. 2011..Our study examines the relationship between total intelligence quotient (IQ) score at age 8 years, and depressive symptoms at 11, 13, 14 and 17 years...
- The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participantsDebbie A Lawlor
MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
PLoS ONE 3:e3011. 2008..Our objective was to examine the association between CRP genetic variant +1444C>T (rs1130864) and CHD risk in the largest study to date of this association...
- Lactase persistence-related genetic variant: population substructure and health outcomesGeorge Davey Smith
MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
Eur J Hum Genet 17:357-67. 2009..19 (0.87, 1.64). The lactase persistence variant could contribute to the examination of data for the existence of, and then statistical control for, population substructure in genetic association studies...
- Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variableDebbie A Lawlor
Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
PLoS Med 5:e33. 2008..If true, this would result in the obesity epidemic progressing across generations irrespective of environmental or genetic changes. It is therefore important to robustly test this hypothesis...
- A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesityTimothy M Frayling
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
Science 316:889-94. 2007..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
- Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetesEleftheria Zeggini
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
Science 316:1336-41. 2007..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
- Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levelsWei Min Chen
Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
J Clin Invest 118:2620-8. 2008....
- Newly identified loci that influence lipid concentrations and risk of coronary artery diseaseCristen J Willer
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
Nat Genet 40:161-9. 2008..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
- Common variants near MC4R are associated with fat mass, weight and risk of obesityRuth J F Loos
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Nat Genet 40:768-75. 2008....
- Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and ChildrenNicholas J Timpson
Department of Social Medicine, Bristol University, Bristol, UK
BMC Genet 8:51. 2007..Our aim was to examine the relationships between bitter tasting ability and variation at the TAS2R38 locus and to assess the role of psychosocial factors in explaining residual, within group, variation in tasting ability...
- Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMIRachel M Freathy
Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Rd, Exeter, EX1 2LU, UK
Diabetes 57:1419-26. 2008..Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits...
- C-reactive protein and its role in metabolic syndrome: mendelian randomisation studyNicholas J Timpson
Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK
Lancet 366:1954-9. 2005..Our aim was to generate estimates of the association between plasma CRP and metabolic syndrome phenotypes that were free from confounding and reverse causation, to assess the causal role of this protein...
- Letter by Timpson et al regarding article, "Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level"Nicholas J Timpson
Circulation 114:e256. 2006
- A common variant of HMGA2 is associated with adult and childhood height in the general populationMichael N Weedon
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
Nat Genet 39:1245-50. 2007..There are few examples of common genetic variants reproducibly associated with human quantitativetraits; these results represent, to our knowledge, the first consistently replicated association with adult and childhood height...
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetesEleftheria Zeggini
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Nat Genet 40:638-45. 2008..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
- Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's diseaseSheila A Fisher
Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
Nat Genet 40:710-2. 2008..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...