Abstract: A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, 1H-NMR, and 13C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.
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He, J.; Söderling, E.; Österblad, M.; Vallittu, P.K.; Lassila, L.V.J. Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans. Molecules 2011, 16, 9755-9763.
He J, Söderling E, Österblad M, Vallittu PK, Lassila LVJ. Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans. Molecules. 2011; 16(11):9755-9763.
He, Jingwei; Söderling, Eva; Österblad, Monica; Vallittu, Pekka K.; Lassila, Lippo V. J. 2011. "Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans." Molecules 16, no. 11: 9755-9763.