The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system (for further information, see http://neuroscienceblueprint.nih.gov/). This Funding Opportunity Announcement (FOA) is released in affiliation with the Neuroscience Blueprint, with Institutes and Centers participating independently. This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop innovative neuroscience educational tools to be used by or benefit children in kindergarten through 12th grade (K-12). Educational tools can be designed using any media (e.g., paper, electronic, etc.) or format (e.g., simulations, games, videos, notebooks, etc.) for use in or out of school settings, targeting children in groups or alone, with or without adult or teacher participation. Innovative neuroscience educational tools should promote neuroscience knowledge acquisition and application of that knowledge to one’s own life, promote an interest in neuroscience learning and careers, and present a positive and realistic representation of the diversity of people who engage in neuroscience-related research and occupations. Educational tools targeted to increase the diversity of students (i.e., Native American, Black, Hispanic, female, disabled, or otherwise underrepresented) pursuing neuroscience learning are especially encouraged.