Each chewable tablet contains:
Praziquantel USP…. 50 mg
Pyrantel Pamoate USP… 144 mg
Febantel BP… 150 mg
For the control of the following gastrointestinal tapeworms and roundworms of dogs and puppies. Ascarids : Toxocara Canis, Toxascaris leonine (adult and late immature forms).
Hookworms : Uncinaria stenocephala, Ancylostoma caninum (adults).
Whipworms : Trichuris vulpis (adults).
Tapeworms: Echinococcus species, Taenia species, Dipylidium caninum (adults and immature forms).
Dosage: For oral administration only.
The recommended dose rates are: 15 mg/kg bodyweight febantel, 14.4 mg/kg pyrantel peanut and 5 mg/kg praziquantel. - 1 Prazital Plus Chewable Tablet per 10 kg bodyweight;
The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment. - For routine control adult dogs should be treated every 3 months. For routine treatment a single dose is recommended. In the event of heavy roundworm infestations repeat dose should be given after 14 days.
Puppies and small dogs
1/2-2 kg bodyweight = 1/4 Prazital Plus Chewable Tablet
2-5 kg bodyweight = 1/2 Prazital Plus Chewable Tablet
5-10 kg bodyweight = 1 Prazital Plus Chewable Tablet
10-15 kg bodyweight = 11/2 Prazital Plus Chewable Tablet
15-20 kg bodyweight = 2 Prazital Plus Chewable Tablet
20-25 kg bodyweight = 2% Prazital Plus Chewable Tablet
25-30 kg bodyweight = 3 Prazital Plus Chewable Tablet
- For routine treatment a single dose is recommended.
Puppies should be treated at 2 weeks of age and every 2 weeks until 12 weeks of age. Thereafter they should be treated at 3 month intervals. It is advisable to treat the bitch at the same time as the puppies.
- For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every two weeks until weaning.
Use During Pregnancy and Lactation:
- Consult a veterinary surgeon before treating pregnant animals for roundworms.
- The product may be used during lactation.
- Do not exceed recommended dose when treating pregnant bitches.
Contraindications, warnings, etc.:
- Do not use simultaneously with piperazine compounds.
- User safety: In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog's food, should wash their hands afterwards.
Storage: Store below 25°C.
KEEP OUT OF REACH OF CHILDREN
The product contains anthelmintics active against roundworms and tapeworms. The product contains three active substances: Febantel, Pyrantel ennbonate (bonnet) and Praziquantel.
Praziquantel is a partially hydrogenated pyrazino-isoquinoline derivative used widely as an anthelmintic for both human and veterinary use.
In this fixed combination pyrantel and febantel act against all relevant nematodes (ascarids, hookworms, and whipworms) in dogs. In particular the activity spectrum covers Toxocara Canis, Toxascaris leonine, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis. This combination shows synergistic activity in the case of hookworms and febantel is effective against T. vulpis.
The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular Taenia spp, Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against all adult and immature forms of these parasites.
Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis of the nematodes and thereby allow removal from the gastrointestinal system by peristalsis. Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerization. Formation of nnicrotubules is thereby prevented, resulting in disruption of structures vital to the normal functioning of the helminth. Glucose uptake in particular is affected, leading to a depletion in cellular ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.
Praziquantel is very rapidly absorbed through the parasite's surface and distributed throughout the parasite. Both in vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite integument, resulting in the contraction and paralysis of the parasites. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid visualization of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.
Benzinnidazoles possess a wide safety margin. Pyrantel is not absorbed systemically to any extent Praziquantel also has a wide safety margin, beyond five-times overdose.
The product is well tolerated in dogs
Since it contains praziquantel, the product is effective against Echinococcus multilocularis, which does not occur in the UK but is becoming more common in some European countries. As a precautionary measure to prevent establishment of E. multilocularis in the UK and Ireland, it is recommended that all dogs entering the country travelling either under the Pets scheme (UK only) or going into quarantine (UK & Ireland) be treated with praziquantel.
For Veterinary Use Only.
Not for human use - for treatment of animals only.