S L Lake
Affiliation: Harvard University
- Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthmaAugusto A Litonjua
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Respir Res 6:52. 2005..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
- Estimation and tests of haplotype-environment interaction when linkage phase is ambiguousS L Lake
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Hum Hered 55:56-65. 2003..Simulations were run to illustrate the salient features of the method. In addition, the method was used to test for haplotype-smoking exposure interaction with data from the Childhood Asthma Management Program...
- Tests of gene-environment interaction for case-parent triads with general environmental exposuresS L Lake
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Ann Hum Genet 68:55-64. 2004..We present a test, FBAT-I, that can be used to investigate gene-environment interaction. The test uses the case-parent triad design and protects the statistical inference from potential spurious results due to population admixture...
- Family-based tests of association in the presence of linkageS L Lake
Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
Am J Hum Genet 67:1515-25. 2000..Since the A2M gene lies in a chromosomal region (chromosome 12p) that consistently has been linked to AD, association tests should be conducted under the null hypothesis that there is linkage but no association...
- Family-based tests of association in the presence and absence of known linkageL Bertram
Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
Genet Epidemiol 21:S292-7. 2001..Our results indicate that both tests generally perform comparably in either setting...