CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine
May 1st, 2012
Microbiology and Immunology publish this investigation article
A CpG-enriched recombinant plasmid (pUC18-CpG) as an adjuvant of foot-and-mouth disease (FMD) killed vaccine was tested for immunization and vaccination challenge in a porcine model. Our preliminary results had indicated that the recombinant plasmid could enhance the humoral immune response triggered by the traditional oil-adjuvant vaccine after the initial inoculation. A subsequent vaccination-challenge test showed an increased PD(50) (50% protective dose) value. Thus, coadministration of the recombinant plasmid with the oil-adjuvant vaccine helped illicit an immune response earlier than that elicited by the administration of the vaccine alone. Our results showed that pUC18-CpG can be a potent immunoadjuvant for the traditional FMD killed vaccine and can greatly enhance the traditional vaccine`s efficacy when administered in combination with it
Guo X., Jia H., Zhang Q., Yuan W., Zhu G., Xin T., Zhu H. and Sanchez-Vizcaino JM..