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Prince Nguy?n PhÃºc B?u H?i (1915-January 28 1972) of the Nguyen Dynasty was diplomat for South Vietnam and a world famous cancer researcher who published more than 1000 papers.
Born in 1915, Buu Hoi
was a native of the former imperial capital of Hue.He
was a great-great-grandson of Emperor Minh Mang, who had ruled Vietnam from 1820 until 1841.
was also a Confucianist, instilled with a sense of duty to family and service to the nation.In contrast to his
ancestors, Buu Hoi
was also a secular-minded Buddhist, and his
mother later became a Buddhist nun under the dharma name Thich Dieu Hue.His
father Ung Uy headed the Privy Council of the Imperial Family
secondary schooling at the Lycee Albert Sarraut
, a prestigious French-established school for the upper-class in Hanoi, the colonial capital of Vietnam.He
then studied for a degree in pharmacy at the University of Hanoi
while simultaneously auditing courses from the Faculty of Medicine.He
had developed an interest in science from his
youth, noting that this was "because of the desire of his
mother and partly because of his
own belief in the human value of science".He was just twenty years old when he was awarded his degree.He
subsequently left Vietnam in 1935 to study in Paris and was never to return as a resident.There Buu Hoi
had befriended Ngo Dinh Nhu, the younger brother of Ngo Dinh Diem while in France.
...This formed a bond between the two men which saw Buu Hoi later serve in the diplomatic corps and as a scientific advisor for Diem.
There Buu Hoi
met Louis de Broglie, a French aristocrat and Nobel prize winner of physics known for his work in the wave particle duality of quantum physics.
career was briefly interrupted by the outbreak of World War II.He
volunteered in the French Army
and served until the Fall of Paris to Nazi Germany in May 1940.He
then found himself in Toulouse in the southern zone under the fascist puppet Vichy France government.
...At around the same period in 1944, Buu Hoi met Antoine Lacassagne, the Director of Biological Research at the Radium Institute.
As a result, this exposed Lacassagne to what to be the scientific foundation of his
highly fruitful collaboration with Buu Hoi
.At the time, the electronic theory of molecular structure was in its formative years and was not considered as a vehicle by biologists for explaining phenomena, however Lacassagne saw promise in the prospect of Schmidt's hypothesis in attempting to explain carcinogenesis by a combination of elements of electron quantum theory, geometry and chemical structure.This required an interdisciplinary approach, and Buu Hoi's
training in organic chemistry provided him with a wide range of tools to apply in the investigation of the roots of cancer.
...They began publishing joint research immediately, despite Buu Hoi not officially joining the Radium Institute until 1947.This occurred when he became head of the newly established Department of Organic and Medicinal Chemistry and Maitre de Recherches at the CNRS.
After 13, Buu Hoi
team relocated from the Radium Institute
to larger facilities at the Institute of Chemistry of Natural Substances
in 1960.The new quarters was part of the National Centrer of Scientific Research laboratory group at Gif-sur-Yvette, about 24 km from Paris.He
reached the pinnacle of the CNRS
supported research hierarchy in 1962 with a promotion to Director of Research ("Exceptional" class).Around 1967, he established further research groups under his guidance; one at Orleans at the Marcel Delepine Center and a second at the Lannelogue Institute at Vanves.
The scientific discoveries of Buu Hoi
spanned a wide range.He
was trained as an organic chemist and achieved international recognition in his
own right in the field, but he
was able to span to into other fields.This was attributed to his
intuitive intelligence and a vast memory which was credited with his
ability to grasp the essence of a biological problem sometimes only vaguely related to organic chemistry.He
came to be regarded as the most original and productive scientists in exploring the structure activity relationships of polynuclear carcinogens.His
research spread beyond chemical carcinogenesis.He
also published widely in organic chemistry, pharmacology, therapeutics, epidemiology and biochemistry.He started his research career with investigations on chaulmoogric and hypocarpic acids in his Polytechnique laboratory.
At the time, these were the only products used for treating leprosy.Within a few years, he
had established himself as an international authority in the chemotherapy of the disease.He
delineated the tole of the cyclopentene ring and its double bond and of the chain length in determining the toxicity and leprostatic activity of these compounds.