Oral COTI-2 is Effective as a Single Agent And in Combination With Gemcitabine in an Animal Model of Human Pancreatic Cancer
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|Wednesday, 09 December 2009 17:00 (UTC + 1)|
London, Ontario, December 9, 2009 / b3c newswire / - Critical Outcome Technologies Inc. (COTI) (TSX Venture: COT) announced positive results today from animal experiments carried out at a prominent Canadian cancer research facility. This new series of experiments adds to the already impressive data package for COTI-2, demonstrating efficacy as a single agent and in combination with first line therapies with low toxicity in seven different animal models of human cancers.
• COTI-2 as a single agent demonstrated efficacy comparable to gemcitabine.
“Pancreatic cancer remains the most lethal cancer and effective new treatments are urgently needed. The results of these experiments indicate that chronically administered oral COTI-2 is a well tolerated single agent with efficacy comparable to the first-line agent gemcitabine, and there is enhanced efficacy in combination with gemcitabine in an animal model of human pancreatic cancer,” said Dr. Wayne Danter, President and CSO of COTI. “These results are significant because they add to the impressive data set of COTI-2, showing effectiveness, particularly in combination with first and second line agents, against multiple cancers and low toxicity.”
"We are delighted with these new scientific results providing evidence supporting the commercial potential of oral COTI-2 in pancreatic cancer. COTI looks forward to sharing this new data with parties who have expressed interest in a commercial partnership related to COTI-2," said Mr. Michael Cloutier, CEO of COTI.
About Pancreatic Cancer
According to the World Health Organization (WHO) pancreatic cancer is the 13th most common cancer worldwide. WHO states that over 232,000 new cases of pancreatic cancer are diagnosed each year across the globe. According to the National Cancer Institute of the United States (US) an estimated 42,470 individuals will be diagnosed with pancreatic cancer in 2009 in the US and 35,240 will die from this cancer. Incidence and mortality rates have remained steady for the last 30 years, indicating a great need for better, more efficacious treatments. The reasons for poor survival include the insidious and aggressive nature of the tumors, late diagnosis, low rates of resection and the lack of effective therapies. According to WHO, there is currently no early diagnostic test or population based screening procedure for pancreatic cancer. Due to the lack of diagnostics, even better treatments will be necessary to overcome pancreatic cancer in later disease stages.
About Critical Outcome Technologies Inc. (COTI) - www.criticaloutcome.com
COTI is formed around a unique computational platform technology called CHEMSAS®, which allows for the accelerated identification, profiling and optimization of targeted small molecules potentially effective in the treatment of human diseases for which current therapy is either lacking or ineffective. Currently, six targeted libraries of lead compounds are under active development; small cell lung cancer, multiple sclerosis, HIV integrase inhibitors, acute myelogenous leukemia, colorectal cancer and Alzheimer’s disease.
For further information, please visit the website at www.criticaloutcome.com or contact:
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