Insulin Pills and Tablets
Insulin pills, also known as insulin tablets, remain at an early stage of clinical trials with several companies racing to establish this as a credible alternative to insulin injections.
Giving diabetes patients the chance to avoid the pain of needles has been the goal of many pharmaceutical companies for many years.
However, a drugmaker has yet to success in encapsulating insulin into a one-off dose, easily swallowed like any other tablet.
Difficult to ingest
Insulin is a particularly difficult drug to ingest orally.
It is a protein that degrades in the stomach and small intestine, making it almost impossible to design oral delivery which works.
The past has seen massive oral insulin efforts flop, including the inhalable insulin Exubera.
However, major drugmakers are thought to be working on the insulin pill, Novo Nordisk amongst them.
Direct to the liver
The theory is ideal for people with diabetes. Insulin delivery via the stomach would transport the much needed hormone directly to the liver, where it could mimic the action of endogenous insulin.
In fact, the future could see insulin pills making diabetes management considerably more safe and convenient, not to mention eliminating prevalent needle phobia.
At this stage, insulin remains too complex a protein to survive within the environment of the body. Leading pharmaceutical companies are thought to be using protein engineering to bring the insulin pull one step closer.
Insulin pills have been talked about as a possibility for years but are still at least some years off.
One problem is that insulin gets broken down by the chemicals in the stomach and small intestine. The second problem is to find a way to get the insulin to pass through the intestinal wall.
The challenge has been to develop a pill that can successfully transport the insulin to the bloodstream without being broken down by the gut.
There are a few companies that are currently looking to develop the world’s first marketable insulin pill. A number of clinical trials have taken place but to date, no pill has been successful enough in the crucial third phase of clinical studies.
There seems to be hope but it could yet take years before it happens. Keep in touch with the Diabetes Newsletter and we’ll bring you news of any success in insulin pill development.
The researchers are thought to be indentifying which enzymes attack the molecule, and what processes they use. In theory the insulin pill will one day be able to navigate the stomach without being broken down.