Flux balance analysis accounting for metabolite dilution
1 The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel
2 The Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
3 Computer Science Department, Technion - Israel Institute of Technology, Haifa 32000, Israel
Genome Biology 2010, 11:R43 doi:10.1186/gb-2010-11-4-r43Published: 16 April 2010
Additional file 1:
ASAP growth conditions. Excel file including the growth conditions used to model the ASAP experiments used by both FBA and MD-FBA.
Format: XLSX Size: 15KB Download file
Additional file 2:
ASAP experimental optical density values. Excel file including the experimentally measured OD values taken from the ASAP database.
Format: XLSX Size: 64KB Download file
Additional file 3:
Reaction activity difference across subsystems. Figure showing the mean reaction activity difference between FBA and MD-FBA across the different metabolic subsystems available in the model.
Format: XLSX Size: 59KB Download file
Additional file 4:
Gene essentiality analysis results. Excel file containing the gene essentiality predictions by FBA and MD-FBA as well as the experimental gene essentiality data.
Format: XLSX Size: 198KB Download file
Additional file 5:
Cofactor dilution-related demand activity predictions. Excel file containing MD-FBA's predictions for the dilution related growth-demand synthesis of the three cofactors: 10-formyltetrahydrofolate (10fthf), 2-octaprenyl-6-hydroxyphenol (2ohph) and FAD across different gene knockouts.
Format: XLSX Size: 52KB Download file