- The influenza C virus glycoprotein (HE) exhibits receptor-binding (hemagglutinin) and receptor-destroying (esterase) activities
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029
Virology 160:419-25. 1987
..In analogy to the parainfluenza virus HN protein, the influenza C virus glycoprotein was termed HE, because it possesses hemagglutinin and esterase (receptor-destroying) activity...
- Mapping the antigenic and genetic evolution of influenza virus
Derek J Smith
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Science 305:371-6. 2004
..Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution...
- Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins
Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, Ontario, Canada
Vaccine 26:6068-76. 2008
..remarkable specificity against the viral sequences and robustness of quantitatively analyzing the viral hemagglutinins even under stringent conditions...
- Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates
Y P Lin
Division of Virology, National Institute for Medical Research, Mill Hill, London, United Kingdom Dise
Proc Natl Acad Sci U S A 97:9654-8. 2000
..This common feature emphasizes the apparent propensity of avian viruses with this genetic complement to infect humans and highlights the potential for the emergence of a novel human pathogen...
- Resistant influenza A viruses in children treated with oseltamivir: descriptive study
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Lancet 364:759-65. 2004
..Our aim was to investigate oseltamivir resistance in a group of children treated for influenza...
- Type A influenza virus surveillance in free-flying, nonmigratory ducks residing on the eastern shore of Maryland
R D Slemons
Department of Veterinary Preventive Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA
Avian Dis 47:1107-10. 2003
- 9-O-acetylated sialic acids have widespread but selective expression: analysis using a chimeric dual-function probe derived from influenza C hemagglutinin-esterase
Glycobiology Program, Cancer Center, University of California, San Diego, La Jolla 92093
Proc Natl Acad Sci U S A 91:7782-6. 1994
..Thus, 9-O-acetylation is more widespread than previously thought and occurs on specific molecules and cell types...
- Bilayer conformation of fusion peptide of influenza virus hemagglutinin: a molecular dynamics simulation study
Department of Chemistry, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
Biophys J 87:14-22. 2004
..The average hydrophobic thickness of the lipid phase close to the N-terminus is reduced in comparison with the average hydrophobic thickness of a pure dimyristoyl phosphatidylcholine bilayer...
- Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection
Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic
J Gen Virol 88:951-5. 2007
..It is concluded that antibodies specific to the antigenically conserved HA2 glycopolypeptide that exhibit fusion-inhibition activity can contribute to the protection of infected mice and mediate more effective recovery from infection...
- Molecular dynamics simulations of the influenza hemagglutinin fusion peptide in micelles and bilayers: conformational analysis of peptide and lipids
Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
J Mol Biol 354:1129-41. 2005
..An extension of the classical surfactant theory of Israelachvili based on shapes is proposed to introduce the concept of a "dynamically induced shape" of the membrane lipids by the peptide...
- Plasticity of influenza haemagglutinin fusion peptides and their interaction with lipid bilayers
National Institute for Medical Research, London, United Kingdom
Biophys J 88:25-36. 2005
..These results confirm that the sequence can adopt different folds in different environments. The plasticity and the conformational dependence on the local environment could be used to better understand the function of fusion peptides...
- Measles virus strains circulating in Central and West Africa: Geographical distribution of two B3 genotypes
D Waku Kouomou
INSERM U404, CERVI, Lyon Cedex, France
J Med Virol 68:433-40. 2002
..2 genotype is found in West Africa. In Nigeria and Ghana, the viruses co-circulate. The identification of these viruses will permit more meaningful epidemiological studies after the proposed increase in measles vaccination coverage...
- Genetic characterization of wild-type measles viruses circulating in suburban Khartoum, 1997-2000
H S El Mubarak
Institute of Virology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
J Gen Virol 83:1437-43. 2002
..Our study demonstrates a remarkable genetic stability of an endemically circulating MV strain...
- Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype
Nature 292:72-5. 1981
- Glycan analysis in cell culture-based influenza vaccine production: influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin
Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, 39106 Magdeburg, Germany
Vaccine 27:4325-36. 2009
..In contrast to this, a principal switch of the N-glycan type attached to HA was observed when comparing different virus types (A and B) and subtypes (H1N1 and H3N2)...
- Receptor-binding properties of modern human influenza viruses primarily isolated in Vero and MDCK cells and chicken embryonated eggs
Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho Maklaya 16 10, 117997 Moscow, Russia
Virology 313:473-80. 2003
..These HA mutations disturb the observed strict 6'SLN specificity of recent human influenza viruses...
- Phylogenetic and restriction fragment length polymorphism analyses of hemagglutinin (H) protein of canine distemper virus isolates from domestic dogs in Japan
Laboratory of Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai Minato ku, Tokyo 108 8639, Japan
Virus Res 109:59-63. 2005
..Thus, the RFLP method is useful for differentiating the infections with field CDV strains from the vaccine strains in clinical cases...
- Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses
Aleksandr S Lipatov
Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, Georgia, United States of America
PLoS Pathog 4:e1000102. 2008
- Genetic characterization of contemporary wild-type measles viruses from Vietnam and the People's Republic of China: identification of two genotypes within clade H
S L Liffick
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, 30333, Atlanta, GA, USA
Virus Res 77:81-7. 2001
..Sequence analysis of measles viruses imported into the United States from either China or Vietnam demonstrated that this designation of genotypes will be helpful in future measles surveillance activities...
- Comparative analyses of canine distemper viral isolates from clinical cases of canine distemper in vaccinated dogs
N T Lan
Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889 2192, Japan
Vet Microbiol 115:32-42. 2006
..These results surely indicate that wild strains of CDV from dogs with a vaccination history were not reversed vaccine virus, and that the dogs showed characteristics of recent CD in Japan...
- Interspecies and intraspecies transmission of triple reassortant H3N2 influenza A viruses
Hadi M Yassine
Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA
Virol J 4:129. 2007
..Identifying viruses with varying inter- and intra-species transmission potential should be useful for further studies on the molecular basis of interspecies transmission...
- Pathobiology of H5N2 Mexican avian influenza virus infections of chickens
D E Swayne
US Department of Agriculture, Southeast Poultry Research Laboratory, Athens, GA, USA
Vet Pathol 34:557-67. 1997
- Origin of the pandemic 1957 H2 influenza A virus and the persistence of its possible progenitors in the avian reservoir
J R Schafer
St Jude Children s Research Hospital, Department of Virology Molecular Biology, Memphis, Tennessee 38105
Virology 194:781-8. 1993
..We conclude that antigenically conserved counterparts of the human Asian pandemic strain of 1957 continue to circulate in the avian reservoir and are coming into closer proximity to susceptible human populations...
- Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells
Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
J Virol 77:9943-50. 2003
..Our results indicate that Vero cells stably expressing canine SLAM are highly sensitive to CDV in clinical specimens and that only a single amino acid substitution in the hemagglutinin can allow the virus to adapt to marmoset SLAM...
- Receptor-binding properties of swine influenza viruses isolated and propagated in MDCK cells
Alexandra S Gambaryan
Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, 142782 Moscow, Russia
Virus Res 114:15-22. 2005
- Genetic analysis of measles viruses isolated in Morocco
Institute of Health, Rabat, Morocco
J Med Virol 68:441-4. 2002
..Knowledge of the indigenous strain of measles virus circulating in Morocco will help to describe viral transmission pathways and should contribute to efforts to evaluate the effectiveness of future vaccination campaigns...
- Sequence analysis of measles virus strains collected during the pre- and early-vaccination era in Denmark reveals a considerable diversity of ancient strains
L Siig Christensen
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
APMIS 110:113-22. 2002
- Neutralizing B cell response in measles
Fabienne B Bouche
Department of Immunology and WHO Collaborating Center for Measles, Laboratoire National de Santé, Luxembourg, Luxembourg
Viral Immunol 15:451-71. 2002
..Major neutralizing epitopes have been mapped mainly on the hemagglutinin protein with monoclonal antibodies, producing an increasingly comprehensive map of functional domains...
- Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine
Diane E Webster
Department of Medicine, Monash University Medical School, Alfred Hospital, Prahran, Victoria 3181, Australia
J Virol 76:7910-2. 2002
..This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology...
- H1 genotype of measles virus was detected in outbreaks in Japan after 2000
Laboratory of Viral Infection, Kitasato Institute for Life Sciences, Tokyo, Japan
J Med Virol 70:642-8. 2003
..However, some D3 and H1 strains were not completely neutralized with low levels of neutralizing antibody, and maintaining high levels of measles antibodies would be required for the control measles outbreaks...
- Polarized glycoprotein targeting affects the spread of measles virus in vitro and in vivo
Institute of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
J Gen Virol 85:1019-27. 2004
..These data strongly suggest that basolateral targeting of MV glycoproteins helps to overcome the epithelial barrier and thereby facilitates the systemic spread of MV infection in vivo...
- Large-scale preparation of biologically active measles virus haemagglutinin expressed by attenuated vaccinia virus vectors
Department of Research and Development, Chiba Serum Institute, 2 6 1 Kohnodai, Ichikawa, Chiba 272 0827, Japan
Microbes Infect 4:1035-44. 2002
..Such recombinant haemagglutinin preparations will be useful in diagnostic tests that measure functional anti-measles immunity and investigate the biological functions and structure of the haemagglutinin...
- The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD150)
Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Arch Virol 147:195-203. 2002
..Thus, the measles virus hemagglutinin can induce downregulation of SLAM in cells either expressing or coming in contact with it...
- Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution
Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Sciences, Utrecht University, 3584 CL, Utrecht, The Netherlands
Proc Natl Acad Sci U S A 105:9065-9. 2008
..Our findings offer unique insights into the structural and functional consequences of independent protein evolution after interviral gene exchange and open potential avenues to broad-spectrum antiviral drug design...
- Surveillance of avian and swine influenza in the swine population in Taiwan, 2004
Happy K Shieh
Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
J Microbiol Immunol Infect 41:231-42. 2008
- Multiple genotypes of nonpathogenic H6N2 influenza viruses isolated from chickens in California
R J Webby
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Avian Dis 47:905-10. 2003
..Analysis of the remaining gene segments of the California viruses revealed that three distinct genotypes of H6N2 viruses were present...
- Baculovirus display of fusion protein of Peste des petits ruminants virus and hemagglutination protein of Rinderpest virus and immunogenicity of the displayed proteins in mouse model
Md Masmudur Rahman
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
Virology 317:36-49. 2003
..The antigenic epitopes of the recombinant proteins were properly displayed and the recombinant virus particles induced immune response in mice against PPRV or RPV...
- Successful mucosal immunization of cotton rats in the presence of measles virus-specific antibodies depends on degree of attenuation of vaccine vector and virus dose
Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str 7, 97078 Wuerzburg, Germany
J Gen Virol 84:2145-51. 2003
..This study demonstrates that a lower degree of attenuation is required to be able to immunize in the presence of MV-specific antibodies...
- Effective primary isolation of wild-type canine distemper virus in MDCK, MV1 Lu and Vero cells without nucleotide sequence changes within the entire haemagglutinin protein gene and in subgenomic sections of the fusion and phospho protein genes
John A Lednicky
Department of Pathology, Loyola University Medical Center, 2160 South First Street, Maywood, IL 60153, USA
J Virol Methods 118:147-57. 2004
..Different viral phenotypes and genotypes were detected. The conservation of H gene sequences in primary CDV isolates suggests that MDCK, MV1 Lu, and Vero cells express proper receptors for wild-type CDV...
- [Influenza viruses which preconditioned the epidemic rise in Russia in 2002-2003. A resumed circulation of influenza viruses similar to V/Victoria/2/87]
V T Ivanova
Vopr Virusol 49:12-7. 2004
..A study of paired sera obtained from patients showed a growth of antibodies to the etalons of influenza A(H1N1), A(H3N2) and B viruses of the season in question, which confirmed the virology data...
- Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA and M2 proteins
George P Leser
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
Virology 342:215-27. 2005
..Quantification of the distribution of surface expressed HA by examining serial sections of virus-infected cells suggests that the HA-containing microdomains give rise to regions of influenza assembly and budding...
- Development of quantitative gene-specific real-time RT-PCR assays for the detection of measles virus in clinical specimens
Kimberly B Hummel
Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, 1600 Clifton Road, Mailstop C 22, Atlanta, GA 30333, USA
J Virol Methods 132:166-73. 2006
- Expression of hemagglutinin esterase protein from recombinant mouse hepatitis virus enhances neurovirulence
Department of Microbiology, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6076, USA
J Virol 79:15064-73. 2005
- New measles genotype, Uganda
Uganda Virus Research Institute, Entebbe, Uganda
Emerg Infect Dis 11:1522-6. 2005
..Therefore, Ugandan viruses should be considered a new, proposed genotype (d10). This new sequence information will expand the utility of molecular epidemiologic techniques for describing measles transmission patterns in eastern Africa...
- Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes
Institute of Virology, Philipps University Marburg, Hans Meerwein Str 2, D 35043 Marburg, Germany
J Gen Virol 89:687-96. 2008
- The cowpox virus fusion regulator proteins SPI-3 and hemagglutinin interact in infected and uninfected cells
Peter C Turner
Department of Molecular Genetics and Microbiology, Box 100266 1600 SW Archer Road, ARB R2 231, University of Florida, Gainesville, FL 32610 0266, USA
Virology 347:88-99. 2006
..The HA-binding domain in SPI-3 resided in the C-terminal 229 residues, and did not include helix D, which mediates cofactor interaction in many other serpins...
- Identification of trypsin I as a candidate for influenza A virus and Sendai virus envelope glycoprotein processing protease in rat brain
Trong Quang Le
Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima 770 8503, Japan
Biol Chem 387:467-75. 2006
..Our results suggest that trypsin I in the brain potentiates virus multiplication in the pathogenesis and progression of influenza-associated encephalopathy or encephalitis...
- Immunoglobulin g antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response
Ianko D Iankov
Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA
J Virol 80:8530-40. 2006
..The findings point to a new model for the pathogenesis of atypical MV infection observed after immunization with formalin-inactivated MV vaccine and underscore the importance of the anti-F response after vaccination...
- Autocatalytic activation of influenza hemagglutinin
Jeong H Lee
Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 220 South 33rd Street, Philadelphia, PA 19104, USA
J Mol Biol 364:275-82. 2006
..These observations imply a feedback mechanism involving self-catalyzed refolding of HA and thus suggest a mechanism similar to the autocatalytic refolding and aggregation of prions...
- Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain
Emmie de Wit
Department of Virology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
J Virol 79:12401-7. 2005
..The data presented suggest that vaccine candidates based on low-pathogenicity avian influenza A viruses, which can be prepared ahead of pandemic threats, can be efficacious if an effective adjuvant is used...
- Paramyxoviruses: different receptors - different mechanisms of fusion
Ronald M Iorio
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Trends Microbiol 16:135-7. 2008
- Use of Vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virus
Chien Hsiung Pan
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
Clin Vaccine Immunol 15:1214-21. 2008
..The use of Vaxfectin-formulated DNA is a promising approach to the development of a measles vaccine for young infants...
- Neuraminidase activity assays for monitoring MDCK cell culture derived influenza virus
Deba Prasad Nayak
Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstreet 1, D 39106 Magdeburg, Germany
J Virol Methods 122:9-15. 2004
..Based on the hemagglutinin and neuraminidase activity of the clarified and inactivated virus harvest, the overall recovery after gel filtration was about 34.4% and 119.5%, respectively...
- Genetic characterization of H1N1, H1N2 and H3N2 swine influenza virus in Thailand
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
Arch Virol 153:1049-56. 2008
..Furthermore, amino acid substitutions were detected either at the receptor binding site or the antigenic sites of the hemagglutinin gene...
- Virus-like particle (VLP) vaccine conferred complete protection against a lethal influenza virus challenge
Jose M Galarza
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
Viral Immunol 18:244-51. 2005
- A seven-segmented influenza A virus expressing the influenza C virus glycoprotein HEF
Department of Microbiology, Mount Sinai School of Medicine, Box 1124, One Gustave L Levy Place, New York, NY 10029, USA
J Virol 82:6419-26. 2008
..These results support a selective mechanism of viral RNA recruitment to the budding site...
- Infectivity studies of influenza virus hemagglutinin receptor binding site mutants in mice
Emory University School of Medicine, Atlanta, GA 30322, USA
J Virol 82:5079-83. 2008
..The capacity of the Y98F mutant to induce antibody responses and the structural locations of HA reversion mutations are examined...
- Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles
Chien Hsiung Pan
W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:11581-8. 2005
..Viremia was cleared within 14 days, but MV RNA was detectable for 4-5 months. These studies suggest that complete clearance of MV after infection is a prolonged, phased, and complex process influenced by prior vaccination...
- Interactions among measles virus hemagglutinin, fusion protein and cell receptor signaling lymphocyte activation molecule (SLAM) indicating a new fusion-trimer model
National Key Lab of Virology, College of Life Scince, Wuhan University, Hu Bei, Wuhan 430072, P R China
J Biochem Mol Biol 38:373-80. 2005
..So fusion protein not only is involved in the fusion but also might directly interact with the SLAM to be a new fusion-trimer model, which might account for the infection mechanism of measles virus...
- Relative contributions of measles virus hemagglutinin- and fusion protein-specific serum antibodies to virus neutralization
Rik L De Swart
Department of Virology, Erasmus MC, Rotterdam, The Netherlands
J Virol 79:11547-51. 2005
..These results demonstrate that measles virus neutralizing antibodies are mainly directed to the H protein...
- Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination
Martin O Ota
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Infect Dis 195:1799-807. 2007
..No single peptide dominated the response. We conclude that H is an important stimulus for CD8+ T cell as well as for antibody responses in HLA-A2-positive individuals...
- Efficiency of measles virus entry and dissemination through different receptors
Molecular Medicine Program, Mayo Foundation, Rochester, Minnesota 55905, USA
J Virol 76:7460-7. 2002
..To verify the importance of these observations for human infections, we examined MV entry into peripheral blood mononuclear cells and observed that viruses with asparagine 481 H proteins infect these cells more efficiently...
- Measles virus exploits dendritic cells to suppress CD4+ T-cell proliferation via expression of surface viral glycoproteins independently of T-cell trans-infection
, IFR 74, CERVI, , Lyon, France
Cell Immunol 214:173-83. 2001
- Sequence analysis of hemagglutinin and nucleoprotein genes of measles viruses isolated in Korea during the 2000 epidemic
B K Na
Department of Virology, National Institute of Health, 122-701, Seoul, South Korea
Virus Res 81:143-9. 2001
..4% for the H protein and up to 6.5% for the N protein. Phylogenetic analyses of nucleotide sequences and deduced amino acid sequences of the H and N genes revealed that all Korean viruses were grouped into the clade H1...
- Adaptation of wild-type measles virus to tissue culture
Diane Waku Kouomou
INSERM U 404, CERVI, 69365 Lyon Cedex 07, France
J Virol 76:1505-9. 2002
..The presence of human SLAM expressed in the Vero cells rapidly gave rise to fusion and lower yields of infectious virus...
- C3d enhancement of neutralizing antibodies to measles hemagglutinin
T D Green
Department of Microbiology and Immunology, School of Medicine, East Carolina University, Brody Health Sciences Building, 600 Moye Boulevard, Greenville, NC 27858-4354, USA
Vaccine 20:242-8. 2001
..In addition, sH-3C3d elicited higher neutralizing antibody titers that inhibited MV induced plaque formation...
- Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles
M J Schnell
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 93:11359-65. 1996
..Recombinant VSVs carrying foreign antigens on the surface of the virus particle may be useful for viral targeting, membrane protein purification, and for generation of immune responses...
- The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity
V von Messling
Molecular Medicine Program, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
J Virol 75:6418-27. 2001
..All these characteristics were found to be predominantly mediated by the H protein regardless of the viral backbone used...
- Measles virus circulation in Argentina: 1991-1999
P R Barrero
, , Buenos Aires, Argentina
Arch Virol 146:815-23. 2001
..The C1 genotype has not been detected since 1994 and the finding that a single D6 virus was found in November 1999 demonstrates that wild type viruses are still circulating among a partially covered population...
- Disruption of Akt kinase activation is important for immunosuppression induced by measles virus
Institute for Virology and Immunobiology, , , Germany
Nat Med 7:725-31. 2001
..Thus, we show here that MV exploits a novel strategy to interfere with T-cell activation during immunosuppression...
- Mechanism of measles virus-induced suppression of inflammatory immune responses
J C Marie
INSERM U503, CERVI, Immunobiologie Fondamentale et Clinique, 69365, Lyon, France
Immunity 14:69-79. 2001
..These results introduce a novel model for testing the immunosuppressive potential of anti-measles vaccines and reveal a specific mechanism of MV-induced modulation of inflammatory reactions...
- Importance of the cytoplasmic tails of the measles virus glycoproteins for fusogenic activity and the generation of recombinant measles viruses
Institute of Virology, Philipps University of Marburg, Marburg, Germany
J Virol 76:7174-86. 2002
..Thus, glycoprotein truncation does not interfere with the successful generation of recombinant MV if fusion competence is maintained...
- Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion
Markus U Ehrengruber
Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
J Virol 76:5720-8. 2002
..The detected localization of MV proteins suggests that local microfusion events may be mediated by the F protein at sites of synaptic contacts and is consistent with a mechanism of retrograde transmission of MV infection...
- The haemagglutinin protein is an important determinant of measles virus tropism for dendritic cells in vitro
Institute for Virology and Immunobiology, , Versbacher Str. 7, , Germany
J Gen Virol 82:1835-44. 2001
..This study suggests that the MV H protein plays an important role in determining cell tropism to immune cells and this may play an important role in the induction of immunosuppression in vivo...
- Evaluation of the replication and immunogenicity of recombinant human parainfluenza virus type 3 vectors expressing up to three foreign glycoproteins
Mario H Skiadopoulos
Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Virology 297:136-52. 2002
..Thus, it is possible to use a single HPIV vector expressing two foreign gene inserts to protect infants and young children from the severe lower respiratory tract disease caused by the three major human PIV pathogens...
- CDw150(SLAM) is a receptor for a lymphotropic strain of measles virus and may account for the immunosuppressive properties of this virus
E C Hsu
Amgen Research Institute, 620 University Avenue, Suite 706, Toronto, Ontario, M5G 2C1, Canada
Virology 279:9-21. 2001
..These infections were independent of the presence of CD46 on the host cell surface. Interaction of measles virus with CDw150(SLAM) could explain the immunosuppressive properties of this virus...
- Application of deglycosylation and electrophoresis to the quantification of influenza viral hemagglutinins facilitating the production of 2009 pandemic influenza (H1N1) vaccines at multiple manufacturing sites in China
National Institute for the Control of Pharmaceutical and Biological Products, No 2, Tiantan Xili, Beijing, 100050, PR China
Biologicals 38:284-9. 2010
..The alternative method for vaccine quantification enabled the Chinese health authority to approve H1N1 vaccine 1 month earlier than otherwise possible...
- NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus
Department of Microbiology and Immunology and the National Institute for Biotechnology in the Negev, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
J Virol 84:3789-97. 2010
..This study shed light on the O-glycan sequences involved in the interaction of glycoprotein and viral hemagglutinins and may help in the design of agents inhibitory to hemagglutinin for influenza treatment.
- Functional and structural analysis of the sialic acid-binding domain of rotaviruses
Departamento de Genetica y Fisiologia Molecular, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
J Virol 71:6749-56. 1997
..Tyrosines were primarily targeted since tyrosine has been involved in the interaction of other viral hemagglutinins with SA...
- A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide
National Institute for the Control of Pharmaceutical and Biological Products, The State Food and Drug Administration, Beijing, P R China
Nat Protoc 5:14-9. 2010
..The entire procedure takes only 5 h and can be applied to the quantitative determination of virtually all influenza viral HAs using a single antibody targeting the fusion peptide...
- Role of the key mutation in the selective binding of avian and human influenza hemagglutinin to sialosides revealed by quantum-mechanical calculations
Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
J Am Chem Soc 132:16862-72. 2010
The selective binding between avian and human influenza A viral hemagglutinins (HA) subtype H3 and Neu5Acα2-3 and α2-6Gal (avian α2-3, human α2-6) is qualitatively rationalized by the fragment molecular orbital (FMO) method...
- Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus
Anwar M Hashem
Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada
Biochem Biophys Res Commun 403:247-51. 2010
..Here we demonstrate that these universal antibodies bind to the viral hemagglutinins in native conformation presented in infected mammalian cell cultures and neutralize multiple subtypes of ..
- The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46
Tal I Arnon
Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
Blood 103:664-72. 2004
..This residue plays a critical dual role in NKp46 interactions with both viral hemagglutinins and the unknown tumor ligands via different mechanisms...
- Humoral response to influenza hemagglutinin: oligoclonal spectrotype and failure of thymopentin as immunoadjuvant
Istituto di Medicina Interna, Universita di Padova, Italia
Gerontology 41:3-10. 1995
..These results further emphasize the limited immunogenicity of influenza vaccination and the inefficacy of TP-5 as immunoadjuvant, in this model of vaccination...
- Hemadsorption expressed by cloned H genes from subacute sclerosing panencephalitis (SSPE) viruses and their possible progenitor measles viruses isolated in Osaka, Japan
Department of Virology, Osaka City University Medical School, Osaka, Japan
Microbiol Immunol 45:59-68. 2001
- Sequence divergence of measles virus haemagglutinin during natural evolution and adaptation to cell culture
B K Rima
School of Biology and Biochemistry, The Queen s University of Belfast, UK
J Gen Virol 78:97-106. 1997
..In contrast, rodent brain-adapted viruses displayed a lot of amino acid sequence variation from normal MV strains. There was no convincing evidence for recombination between MV genotypes...
- Inhibition of influenza virus fusion by polyanionic proteins
Groningen Utrecht Institute for Drug Exploration GUIDE, University of Groningen, Department of Physiological Chemistry, Faculty of Medical Sciences, The Netherlands
Biochem Pharmacol 53:995-1003. 1997
- Preparation of influenza virosome vaccine with muramyldipeptide derivative B30-MDP
Tokyo R and D Center, Daiichi Pharmaceutical Co, Ltd, Japan
J Microencapsul 14:79-90. 1997
- [Anti-measles DNA-immunization in experiment: immunogenicity and safety]
N L Maksimov
Vopr Virusol 50:4-9. 2005
..And it was present on days 7 and 14 in the red bone marrow, spleen, muscular tissue, lungs and fatty tissue. On day 21 the plasmid DNA was not detected in any of the investigated organs...
- In vitro assessment of attachment pattern and replication efficiency of H5N1 influenza A viruses with altered receptor specificity
Department of Virology and National Influenza Center, Erasmus MC, P O Box 2040, 3000CA Rotterdam, Netherlands
J Virol 84:6825-33. 2010
- Recent structural solutions for antibody neutralization of viruses
P L Stewart
Dept of Molecular and Medical Pharmacology, UCLA School of Medicine 90095 1770, USA
Trends Microbiol 5:229-33. 1997
..Crystallography and cryoelectron microscopy can reveal the structural relationship between receptor-binding sites and neutralization epitopes, as well as whether molecular rearrangements occur upon antibody binding...
- Genetic and antigenic characterization of measles viruses that circulated in Korea during the 2000-2001 epidemic
Byoung Kuk Na
Department of Virology, National Institute of Health, Seoul, Korea
J Med Virol 70:649-54. 2003
- An investigation of incorporation of cellular antigens into vaccinia virus particles
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
J Gen Virol 83:2347-59. 2002
..Lastly, the VV haemagglutinin was absent from one-third of IEV and CEV/EEV particles, whereas other EEV antigens were present in all these virions...
- Atomic-resolution simulations predict a transition state for vesicle fusion defined by contact of a few lipid tails
Peter M Kasson
Department of Chemistry, Stanford University, Stanford, California, United States of America
PLoS Comput Biol 6:e1000829. 2010
..Our results thus suggest that the specific molecular properties of individual lipids are highly important to vesicle fusion and yield an explicit structural model that could help explain the mechanism of catalysis by fusion proteins...
- [The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice]
Iu A Desheva
Vopr Virusol 52:27-30. 2007
- Selectively receptor-blind measles viruses: Identification of residues necessary for SLAM- or CD46-induced fusion and their localization on a new hemagglutinin structural model
Molecular Medicine Program, Mayo Clinic, and Virology and Gene Therapy, Mayo Graduate School, Rochester, Minnesota 55095, USA
J Virol 78:302-13. 2004
..Selectively receptor-blind viruses will be used to study MV pathogenesis and may have applications for the production of novel vaccines and therapeutics...
- Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis virus. III. Nucleotide sequence of the hemagglutinin gene
Laboratory Animal Research Center, University of Tokyo, Japan
Virus Genes 4:163-72. 1990
..These results suggested that the H protein of the Yamagata-1 strain of defective SSPE virus is structurally and functionally similar to that of the Edmonston strain of MV...
- Recombinant wild-type measles virus containing a single N481Y substitution in its haemagglutinin cannot use receptor CD46 as efficiently as that having the haemagglutinin of the Edmonston laboratory strain
Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
J Gen Virol 87:1643-8. 2006
..This may be a reason why few CD46-using MVs are detected in vivo...
- Modeling of the endosomolytic activity of HA2-TAT peptides with red blood cells and ghosts
Ya Jung Lee
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
Biochemistry 49:7854-66. 2010
..Taken together, these results suggest a model for the endosomolytic activity of the peptide and provide the basis for the molecular design of future delivery agents...
- Genetic basis for T cell recognition of a major histocompatibility complex class II-restricted neo-self peptide
D M Cerasoli
Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Exp Med 182:1327-36. 1995
..Thus, tolerance to PR8 S1 as a self peptide does not limit the diversity of the T cell response to S1(K113)...
- Molecular mimicry by major histocompatibility complex molecules and peptides accounts for some alloresponses
R I Lechler
Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
Immunol Lett 34:63-9. 1992
..These data support the concept that allorecognition in some responder/stimulator combinations can be explained by cross-reactivity at the level of the MHC molecule and the peptide...