Updated on 22 August 2013
In the study, obese rats were fed chemical compounds that depleted microphages that led to inflammation activation and onset of type 2 diabetes. Then when these rats were genetically altered to rid them of the endocannabinoid receptors, progression of type 2diabetes slowed. This led to the surmise that by selectively blocking the expression of cannabinoid receptors on macrophages, the beta cells in pancreases could be protected and thus reduce the severity of type 2 diabetes.
The researchers have concluded that it may be possible to identify suitable drug targets that could reverse the action of cannabinoids in triggering inflammation and death of beta cells leading to type 2 diabetes.
" To understand type 2 diabetes, a public health threat that affects young and old alike, we need to consider all the factors at play, " said Dr Monica Skarulis, who was also part of the study. "We hope that what we have learned from this research will help us develop new strategies to prevent and treat the condition."