Estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged female mice.
|Title||Estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged female mice.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Yaghmaie, F, Saeed O, Garan SA, Voelker MA, Sternberg H, Timiras PS|
|Journal||Neuro endocrinology letters|
|Keywords||Age Factors, Aging, Animals, Arcuate Nucleus, Cell Count, Estrogen Receptor alpha, Female, hypothalamus, Immunohistochemistry, Mice, Mice, Inbred C57BL|
Changes in the neuroendocrine regulation of gonadal function, via altered hypothalamic sensitivity to peripheral hormones, are known to schedule reproductive maturation in the young and influence reproductive senescence. Estrogen (E) is a key hormone in this process. While changes in circulating levels of E over the life span are well documented, less is known about the corresponding changes in E sensitivity over the lifespan, especially during middle-age, when the initial signs of reproductive senescence emerge.
|Alternate Journal||Neuro Endocrinol. Lett.|