The last century has witnessed remarkable progress in our understanding and treatment of epilepsy. Long regarded as a disorder of the possessed and deranged, epilepsy is now accepted as a bona fide medical condition, with well-defined clinical symptoms, reliable diagnostic modalities, and effective therapeutic options that dramatically improve clinical outcomes and enhance quality of life. The book captures the spirit and enthusiasm of those remarkable achievements. It is a collection of works detailing the progress made in our knowledge of the disorder, the advances in different diagnostic modalities, and the continuing development of various treatment options. In addition, the book also highlights the progress made in health-related topics such as social epileptology and the globalization of epilepsy care. It ends with a somewhat iconoclastic piece challenging several of our ongoing assumptions of epilepsy care – perhaps serving as an impetus for further research as we head into the new century.