Seattle Biomedical Research Institute
307 Westlake Avenue North, Suite 500
Malcolm Gardner is working in conjunction with other scientists in Seattle BioMed's Malaria Program and the University of Washington to exploit the genome sequences of human and rodent malaria parasites to discover and validate new targets for anti-malarial drugs and vaccines. He is also collaborating with the Aderem Lab to investigate the immune responses and gene expression patterns in the peripheral blood of volunteers participating in clinical trials of experimental vaccines. The goal is to identify immune signatures that are generated early after immunization that predict protection against malaria infection. These protective signatures could then guide the development of more effective vaccines.