Many of us enjoy foods that are high in sugar, fat, salt, or a combination of the three; take savoury biscuits for example. Dr. David Kessler’s The End of Overeating explores in detail the art and science behind the creation of highly palatable foods. Despite their appeal, most of us are able to exhibit adequate control when consuming or over consuming these foods. However, there is a subset of the population for whom control over these foods becomes problematic and can result in unhealthy weight gain or obesity. For these individuals, consumption can become life threatening. Why is it that some who wish to reduce their intake of these foods are not able to do so? Continue reading
The medication that provides significant relief from debilitating motor disturbances in people with Parkinson’s disease appears to cause a range of psychiatric disturbances that are as distressing and difficult to treat as the motor symptoms they aim to relieve.
Parkinson’s disease is usually treated with dopamine replacement therapy (DRT). This involves daily dosing with either levodopa (a precursor to the neurotransmitter, dopamine) or dopamine agonists (such as pramipexole and ropinirole) that mimic the effects of dopamine in the brain. The aim of DRT is to reduce the effects of the loss of dopaminergic neurons in specific regions of the brain involved in controlling bodily movement. However, dopamine is also a key neurotransmitter in a range of cognitive processes from executive control and memory to motivation and bonding. It is perhaps unsurprising that many Parkinson’s patients experience adverse psychiatric and cognitive side-effects from taking large doses of dopamine every day.
Parkinson’s patients can experience severe anxiety, depression and mania and have a higher risk of suicide. A significant minority of Parkinson’s patients treated with dopamine replacement therapy will also develop impulsive and compulsive behaviours that appear to be caused by their medication. These include pathological gambling and hypersexuality, and compulsive eating and shopping. In rare cases, patients have committed criminal offences. Continue reading