Assessment of coagulation with 6% hydroxyethyl starch 130/0.4 in cesarean section
Korean Journal of Anesthesiology, 04/27/2012
Oh CS et al. – Blood coagulation in parturients may be compromised at high dilution ratios of HES 130/0.4 (6%) to blood. Nevertheless, the infusion of 1,000ml of HES 130/0.4 (6%) in normal parturients did not significantly affect blood coagulation.
Forty parturients scheduled for cesarean sections were assigned randomly to receive either 500 or 1,000ml of HES 130/0.4 (6%).
Rotation thromboelastometry (ROTEM) measurements were performed before and after administering HES 130/0.4 (6%).
In addition, blood samples obtained from 20 randomly selected parturients were diluted 10% to 40% using HES 130/0.4 (6%), and ROTEM measurements were performed before and after dilution.
The changes from baseline and the effects of dilution were analyzed by ROTEM parameters.
Infusions of 500 or 1,000ml of HES 130/0.4 (6%) in the parturients altered the clot formation time, α angle, and maximal clot firmness, although all remained within normal ranges.
HES 130/0.4 (6%) affected in vitro blood coagulation in parturients' blood containing 10, 20, 30, and 40% HES.
The clotting time was prolonged at each dilution percentage, but remained within the normal range.
Other parameters showed an impairment of the coagulation system.
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