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Fluid shear stress may play an important role in regulating cell activities and motility of growth factors in artery remodeling, atherosclerosis and re-stenosis process. 3-D computational models based on a multi-cell experimental model are introduced and solved to quantify shear stress distributions on cell surfaces under physiological setting. Combined with experimental data, relationship between fluid shear stress and endothelial cell activities can be established. Cell geometry and membrane mechanical properties affect micro flow environment leading to considerable changes in shear stress distributions and various cell activities such as cell migration and activation of cell migration signaling mechanisms.