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|United States Patent||4,213,876|
|Crews , et al.||July 22, 1980|
A multi-purpose blood diluent especially suitable for use in electronic enumeration and sizing of blood cells, determination of hemoglobin concentration and their collective indices and platelet parameters in a single blood sample by means of suitable electronic instrumentation. The diluent is characterized as azide-free and capable of affording accurate, reproducible hematological test results from the said suitable electronic instrumentation. The diluent employs a chelating agent which functions as a bacteriostat and fungistat agent to prevent adverse growth of micro-organisms and a compatible stabilizing agent to maintain desired morphology of red blood cells and an inorganic metallic sulfate for suppressing turbidity caused by abnormal globulins and/or high leukocyte counts which are encountered in certain blood samples. Because of the capability for use of the diluent in platelet determinations by the instrumentation, the diluent further is free of detergent action which would cause bubbles capable of interfering with the enumeration of platelets by the instrumentation. A modified and adjusted embodiment of the diluent enables its use in veterinary laboratory testing applications.
|Inventors:||Crews; Harold R. (Miami, FL), Chastain, Jr.; Dave (Ft. Lauderdale, FL), Ledis; Stephen L. (Hialeah, FL)|
Coulter Electronics, Inc.
|Filed:||August 22, 1978|
|Current U.S. Class:||436/18 ; 424/533; 424/606; 424/680; 424/709; 424/713; 436/10; 436/15; 436/8; 514/311|
|Current International Class:||G01N 33/72 (20060101); G01N 33/50 (20060101); G01N 15/10 (20060101); G01N 15/12 (20060101); G01N 033/16 (); C09K 003/00 ()|
|Field of Search:||252/408 23/23B 424/2,3,101,164,258,310|
|3549994||December 1970||Rothermel et al.|
|3920400||November 1975||Scheibe et al.|
|3977995||August 1976||Louderdack et al.|
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