March 4, 2015
UR BME Seminar Series
University of Rochester
Department of Biomedical Engineering Seminar Series
“Integrating 3D Printing and Nanobiomaterials for Complex Tissue Regeneration”
Presented by: Lijie Grace Zhang, PhD Department of Mechanical and Aerospace Engineering Department of Medicine The George Washington University
Thursday, February 19, 2015 at 8:30 am
River Campus Robert B. Goergen Hall Sloan Auditorium, Room 101
Cells within the human body are in intimate contact with a 3D nanostructured extracellular matrix composed of numerous organic and inorganic components. As a result, one of the revolutionary changes in the field of biomaterials and tissue engineering is to develop biologically inspired nanomaterials and advanced 3D biofabrication techniques to create complex tissue construct mimicking native tissue. However, related studies are limited. Therefore, the main objective of our research is to develop novel biologically inspired nanomaterials and advanced 3D printing techniques to fabricate the next generation of nanocomposite scaffolds for complex tissue regeneration. For this purpose, we designed and synthesized innovative biologically inspired nanomaterials (i.e., nano hydroxyapatites, carbon nanomaterials, DNA based self-assembly nanotubes, and core-shell nanospheres with bioactive factors). Through 3D printing in our lab, a series of biomimetic tissue scaffolds with nano and micro features were fabricated. Our results show that these 3D printed nanocomposite scaffolds have not only improved mechanical properties but also excellent cytocompatibility properties for enhancing various cell growth and differentiation, thus promising for complex tissue regeneration.
ECE Colloquia Series
ECE Distinguished Speaker Series
ECE Seminar Series: Associate Professor Sharon Weiss, Wednesday, March 4th
Distinguished Speaker Series
Wednesday, March 4th from 12:00 – 1:00PM
101 Goergen Hall
Abstract: The accurate and rapid detection of chemical and biological molecules is important for a wide range of applications spanning medical diagnostics, food safety, environmental monitoring, and homeland security. In most cases, molecular detection by optical means gives the best combination of sensitivity, reproducibility, and ease of implementation. The sensitivity of optical biosensors is fundamentally derived from the level interaction between light and the target molecules to be detected. This light-matter interaction can be strengthened by either designing the sensor structure in such a way as to promote strongly confined fields in selected regions where molecules can attach or by increasing the number of target molecules that are captured in regions where light is localized. This talk will discuss both approaches to increasing light-matter interaction, and hence sensitivity, of optical biosensors. In particular, several biosensor designs, including photonic crystals with multiple defect holes, suspended ring resonators, and Bloch surface wave structures will be described in the silicon-on-insulator and porous silicon materials systems. A method of in-situ bioreceptor synthesis will also be discussed as a means of increasing bioreceptor density. Several illustrative examples of specific molecular detection using optical biosensors with enhanced light-matter interaction will be presented.
Bio: Sharon Weiss is currently Associate Professor of Electrical Engineering, Associate Professor of Physics, and Deputy Director of the Vanderbilt Institute of Nanoscale Science and Engineering at Vanderbilt University. She received her BS and PhD degrees from the Institute of Optics at the University of Rochester. Prof. Weiss has been awarded a Presidential Early Career Award for Scientists and Engineers (PECASE), an NSF CAREER award, and an ARO Young Investigator Award. Her research interests are primarily in the areas of photonics, optoelectronics, nanoscience and technology, and optical properties of materials.
University of Rochester Department of Electrical and Computer Engineering