Effects of hypothyroid treatment on cold-acclimation responses. Percentage difference in (A) Ucrit, (B) active metabolic rate, (C) metabolic scope, (D) maximal lactate dehydrogenase (LDH) activity, (E) muscle mRNA transcript levels and (F) liver mRNA transcript levels in cold-acclimated and warm-acclimated hypothyroid fish (blue and red, respectively) relative to normal thyroid fish. H, significant effect of hypothyroid treatment; AT × H, significant interaction between acclimation temperature and hypothyroid treatment.
Little et al. BMC Biology 2013 11:26 doi:10.1186/1741-7007-11-26