Sharon P Moore
Affiliation: National Cancer Institute
- Analysis of a Ty1-less variant of Saccharomyces paradoxus: the gain and loss of Ty1 elementsSharon P Moore
Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, PO Box B, Frederick, MD 21702 1201, USA
Yeast 21:649-60. 2004..The results indicate that Ty1 retrotransposition occurs at a much higher rate than elimination, suggesting that copy-number-dependent co-factors or environmental conditions contribute to the loss of Ty elements in this genome...
- Functional analysis of N-terminal residues of ty1 integraseSharon P Moore
Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
J Virol 83:9502-11. 2009..Our results suggest that the histidine/cysteine residues are important for steps in transposition prior to integration, while the hydrophobic residues function in IN multimerization...
- Retrotransposon suicide: formation of Ty1 circles and autointegration via a central DNA flapDavid J Garfinkel
National Cancer Institute, P O Box B, Frederick, MD 21702 1201, USA
J Virol 80:11920-34. 2006..These results suggest that Ty1-specific mechanisms minimize copy number and raise the possibility that special DNA structures are a targeting determinant...
- Ty1 copy number dynamics in SaccharomycesDavid J Garfinkel
Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21701 1201, USA
Genetics 169:1845-57. 2005..Ty1 gain/loss ratios obtained under different conditions suggest that copy number oscillates over time by altering the rate of retrotransposition, resulting in the diverse copy numbers observed in Saccharomyces...