Genomes and Genes
complement membrane attack complex
Summary: A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
Publications200 found, 100 shown here
- CD59 efficiently protects human NT2-N neurons against complement-mediated damageE D Pedersen
Institute of Immunology, Rikshospitalet HF, University of Oslo, Oslo, Norway
Scand J Immunol 66:345-51. 2007..In conclusion, CD59 is essential for protecting human NT2-N neurons against complement-mediated damage, which is known to occur in a number of clinical conditions including stroke...
- Complement-associated deposits in the human retinaAditya Seth
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
Invest Ophthalmol Vis Sci 49:743-50. 2008..The purpose of this study was to investigate complement activation and associated inflammatory mechanisms in normal, aged human retina...
- Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularizationJuan Liu
Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock, Arizona 72205, USA
J Biol Chem 286:20991-1001. 2011The present study investigated the interactions among the complement membrane attack complex (MAC), CCL2, and VEGF that occur in vivo during the development of choroidal neovascularization (CNV)...
- Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complexFleur Bossi
Department of Physiology and Pathology, University of Trieste, Trieste, Italy
J Immunol 173:6921-7. 2004..SC5b-9 induced opening of interendothelial junctions in mesenteric endothelium documented by transmission electron microscopy...
- The tick salivary protein Salp15 inhibits the killing of serum-sensitive Borrelia burgdorferi sensu lato isolatesTim J Schuijt
Leiden University Medical Centre, Department of Medical Microbiology, University of Leiden, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Infect Immun 76:2888-94. 2008..In the presence of normal human serum, serum-sensitive Borrelia burgdorferi requires protection against complement-mediated killing, which is provided, at least in part, by the binding to the tick salivary protein Salp15...
- Elevated membrane attack complex in human choroid with high risk complement factor H genotypesRobert F Mullins
University of Iowa, 4135E MERF, 375 Newton Rd, Iowa City, IA 52242, United States
Exp Eye Res 93:565-7. 2011..05), independent of whether the eyes showed signs of early AMD. Our results provide evidence that high-risk CFH genotypes may affect AMD risk by increased deposition of MAC around the aging choriocapillaris...
- Inhibition of the complement membrane attack complex by Schistosoma mansoni paramyosinJiusheng Deng
Departments of Human Microbiology Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Infect Immun 71:6402-10. 2003..Taken together, these findings suggest that an exogenous form of S. mansoni paramyosin inhibits activation of the terminal pathway of complement and thus has an important immunomodulatory role in schistosomiasis...
- Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarctionM Meuwissen
Department of Cardiology, Academic Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
J Clin Pathol 59:196-201. 2006..C reactive protein (CRP), an important serum marker of atherosclerotic vascular disease, has recently been reported to be active inside human atherosclerotic plaques...
- CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degenerationNalini S Bora
Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Immunol 178:1783-90. 2007..Thus, our results suggest that the inhibition of complement by soluble CD59 may provide a novel therapeutic alternative to current treatment...
- PRELP protein inhibits the formation of the complement membrane attack complexKaisa E Happonen
Department of Laboratory Medicine, Division of Medical Protein Chemistry, Wallenberg Laboratory, Skane University Hospital, Lund University, S 20502 Lund, Sweden
J Biol Chem 287:8092-100. 2012..The net outcome of PRELP-mediated complement inhibition will highly depend on the local concentration of other complement modulating molecules as well as on the local concentration of available complement proteins...
- Level of complement activity predicts cardiac dysfunction after acute myocardial infarction treated with primary percutaneous coronary interventionSune Haahr-Pedersen
Department of Cardiology P, Gentofte University Hospital, Niels Andersens Vej 65, Copenhagen, Denmark
J Invasive Cardiol 21:13-9. 2009..We evaluated the potential association between MBL and sC5b-9 in plasma and subsequent cardiac dysfunction in patients with STEMI treated with primary percutaneous coronary intervention (pPCI)...
- Soluble CD59 expressed from an adenovirus in vivo is a potent inhibitor of complement deposition on murine liver vascular endotheliumJarel Gandhi
Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
PLoS ONE 6:e21621. 2011..This result, unanticipated based on prior studies, suggests that the use of non membrane-targeted sCD59 as an anti-complement therapy be re-visited...
- A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degenerationSiobhan M Cashman
Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
PLoS ONE 6:e19078. 2011..We propose that the above approaches warrant further exploration as potential approaches for alleviating complement mediated damage to ocular tissues in AMD...
- Comparison of two laboratory methods for the determination of serum resistance in Borrelia burgdorferi isolatesP Kraiczy
Institute of Medical Microbiology, University Hospital, Frankfurt, Germany
Immunobiology 201:406-19. 2000..The IFA, however, is regarded as superior to the GIA owing to the obvious ease of performance and its rapid capability for the classification of even very slow growing isolates...
- Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathyJing Zhang
Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
Diabetes 51:3499-504. 2002..These are novel clues for probing how diabetes affects and damages vascular cells...
- Complement membrane attack complex formation and infectivity of Trichinella spiralis and T. nativa in ratsAnu Näreaho
Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
Vet Parasitol 159:263-7. 2009..nativa have efficient mechanisms to protect themselves against complement attack. The difference in infectivity for rats between the two species, however, is not due to a differential resistance to complement membrane attack complex.
- The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activationKathy Triantafilou
Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
J Cell Sci 126:2903-13. 2013..This is the first study that links non-lethal effects of sublytic MAC attack with inflammasome activation and provides a mechanism by which sublytic MAC can drive inflammation and apoptosis. ..
- CD59a deficiency exacerbates accelerated nephrotoxic nephritis in miceDaniel Turnberg
Rheumatology Section and Department of Histopathology, Faculty of Medicine, Hammersmith Campus, Imperial College, London
J Am Soc Nephrol 14:2271-9. 2003..The lack of CD59a, by allowing unregulated MAC deposition, exacerbates the renal injury in this model of immune complex-mediated glomerulonephritis...
- A common fold mediates vertebrate defense and bacterial attackCarlos J Rosado
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Science 317:1548-51. 2007..Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection...
- The terminal complement complex inhibits apoptosis in vascular smooth muscle cells by activating an autocrine IGF-1 loopThomas P Zwaka
Department of Internal Medicine II, University of Ulm, Germany
FASEB J 17:1346-8. 2003..We conclude that C5b-9 inhibits apoptosis in SMCs by inducing an autocrine IGF-1 loop. This mechanism may contribute to the accumulation of SMCs in early human atherosclerotic lesions...
- Necrotizing myopathy with microvascular deposition of the complement membrane attack complexJ De Bleecker
Department of Neurology, Ghent University Hospital, Ghent, Belgium
Clin Neuropathol 23:76-9. 2004..The link between the muscle fiber necrosis and the microangiopathy is unclear. Absence of prominent inflammatory changes in a diagnostic muscle biopsy does not exclude the diagnosis of a treatable autoimmune inflammatory myopathy...
- Endotoxin-induced lung inflammation is independent of the complement membrane attack complexR B Brauer
Department of Surgery, Immunology and Hygiene, Klinikum rechts der Isar, Technische Universitat Munchen, D 81675 Munich, Germany
Infect Immun 68:1626-32. 2000....
- Extensive deposits of complement C3d and C5b-9 in the choriocapillaris of eyes of patients with diabetic retinopathyVerena B Gerl
Department of Ophthalmology, University of Mainz, Mainz, Germany
Invest Ophthalmol Vis Sci 43:1104-8. 2002..To determine the presence of activated complement components in eyes affected by diabetic retinopathy...
- Insights into the human CD59 complement binding interface toward engineering new therapeuticsYuxiang Huang
Department of Microbiology and Immunology, Medical University of South Carolina, South Carolina 29403, USA
J Biol Chem 280:34073-9. 2005..Based on the enhanced activity of membrane-bound mutant CD59 molecules, clinically relevant soluble mutant CD59-based proteins were prepared and shown to have up to a 3-fold increase in complement inhibitory activity...
- Beyond lysis: how complement influences cell fateDuncan S Cole
Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
Clin Sci (Lond) 104:455-66. 2003..Here we review some of these non-classical activities of complement and stress the roles that they may play in maintaining the integrity of the organism...
- Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegenerationZhi Qi Xiong
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 23:955-60. 2003..Deposition of the complement MAC in cortical gray matter may contribute to epileptic seizures and cell death in diverse diseases of the human brain...
- The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplificationMorten Harboe
Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, NO 0027 Oslo, Norway
Mol Immunol 47:373-80. 2009..In conclusion, the down-stream effect of LP activation depends strongly on AP amplification in normal human serum and in the C2 bypass pathway...
- Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetesXuebin Qin
Hematology Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Diabetes 53:2653-61. 2004..We conclude that glycation inactivation of hCD59 that leads to increased MAC deposition may contribute to the extensive vascular pathology that complicates human diabetes...
- Cellular response to injury in membranous nephropathyMasaomi Nangaku
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
J Am Soc Nephrol 16:1195-204. 2005..Improved understanding of the role of complement in the pathogenesis of MN and of the cellular response to C5b-9 attack creates several new opportunities for therapeutic intervention that may benefit patients with MN in the future...
- Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injuryP F Stahel
Department of Surgery, University Hospital, Zurich, Switzerland
J Neurotrauma 18:773-81. 2001..998; p < 0.05). These data demonstrate for the first time that terminal pathway complement activation occurs after head injury and suggest a possible pathophysiological role of complement with regard to posttraumatic BBB dysfunction...
- The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injuryConstantino Fondevila
Dumont University of California at Los Angeles Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095, USA
Liver Transpl 14:1133-41. 2008..This is the first report using a clinically relevant liver cold ischemia model to show that local MAC inhibition attenuates IRI cascade in OLT recipients...
- Terminal complement complex C5b-9-treated human monocyte-derived dendritic cells undergo maturation and induce Th1 polarizationYongwen Chen
Laboratory of Immunoregulation, Institute of Immunology, PLA, The Third Military Medical University, Chongqing, P R China
Eur J Immunol 37:167-76. 2007..Our results are the first to report that DC are potential immunoregulatory targets of C5b-9, suggesting that C5b-9 bridges innate and acquired immunity by inducing DC maturation...
- Factor H-related protein-5: a novel component of human glomerular immune depositsBrendan Murphy
Department of Nephrology, St Vincent s Hospital, Melbourne, Victoria, Australia
Am J Kidney Dis 39:24-7. 2002..This study shows FHR-5 to be strongly associated with glomerular complement deposition and suggests a role in complement activation or regulation. It may be an important mediator of glomerular disease...
- Decay accelerating factor (CD55)-mediated attenuation of complement: therapeutic implications for age-related macular degenerationKelly N Ma
Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02111, USA
Invest Ophthalmol Vis Sci 51:6776-83. 2010..Here the investigators test the hypothesis that increasing the expression of decay accelerating factor (CD55) on RPE cells may result in reduced MAC-mediated damage...
- C5b-9 complement complex in autoimmune demyelination and multiple sclerosis: dual role in neuroinflammation and neuroprotectionHorea Rus
University of Maryland at Baltimore, School of Medicine, Department of Neurology, 655 W Baltimore Street, BRB 12 016, Baltimore, MD 21201, USA
Ann Med 37:97-104. 2005..These findings indicate that activation of complement C5b-9 plays a pro-inflammatory role in the acute phase of the disease, but may also be neuroprotective during the chronic phase of the disease...
- Glomerular deposition and urinary excretion of complement factor H in idiopathic membranous nephropathyMorito Endo
Division of Nephrology, Internal Medicine II, Nihon University School of Medicine, Tokyo, Japan
Nephron Clin Pract 97:c147-53. 2004....
- Critical protection from renal ischemia reperfusion injury by CD55 and CD59Koei Yamada
Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 172:3869-75. 2004..Our findings suggest a rationale for anti-complement therapies aimed at preventing microvascular injury during ischemia reperfusion, and the CD55(-/-)CD59(-/-) mouse provides a useful animal model in this regard...
- Sublytic terminal complement attack induces c-fos transcriptional activation in myotubesTudor D Badea
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Neuroimmunol 142:58-66. 2003..We propose that c-fos gene transcription associated with myotube dedifferentiation is induced by C5b-9 through ERK1-mediated assembly of serum response factor-ternary complex...
- Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host diseaseFlorin Niculescu
Department of Medicine, Division of Rheumatology and Clinical Immunology, Baltimore, MD 21201, USA
Exp Mol Pathol 79:136-45. 2005..These results indicate a role for both adaptive immunity and innate immunity in this model of GVHD and support its use in modeling human acute GVHD in the nonmyeloablative setting...
- Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathyM Endo
Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
Nephrol Dial Transplant 13:1984-90. 1998..The present study was undertaken to elucidate whether the lectin pathway was involved in the pathogenic mechanism of IgA-N...
- Evaluation of adenovirus-delivered human CD59 as a potential therapy for AMD in a model of human membrane attack complex formation on murine RPEKasmir Ramo
Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, USA
Invest Ophthalmol Vis Sci 49:4126-36. 2008....
- Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand bindingLeslie L Lovelace
Department of Chemistry and Biochemistry and School of Medicine, University of South Carolina, Columbia, SC 29208, United States
Mol Immunol 45:750-6. 2008..These results suggest a role for C8alpha in regulating access to the putative C8gamma ligand binding site...
- Predominant role for C5b-9 in renal ischemia/reperfusion injuryW Zhou
Department of Nephrology and Transplantation, Guy s Hospital, London, United Kingdom
J Clin Invest 105:1363-71. 2000..The membrane attack complex of complement is a potential target for prevention of I/R injury in this model...
- Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complexGongxiong Wu
Department of Medicine, Brigham and Women s Hospital, Laboratory forTranslational Research, Harvard Medical School, Cambridge, MA 02139, USA
Circ Res 104:550-8. 2009..CD59 is a key regulator of complement membrane attack complex (MAC) assembly...
- Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domainPrimrose Musingarimi
Department of Chemistry and Biochemistry and School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
Biochemistry 41:11255-60. 2002..Results from activity assays suggest that residues within this segment also mediate binding and incorporation of C8 into the MAC...
- Incorporation of human complement C8 into the membrane attack complex is mediated by a binding site located within the C8beta MACPF domainCharity L Brannen
Department of Chemistry and Biochemistry and the School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
Mol Immunol 44:960-5. 2007..Furthermore, results indicate the principal binding sites for C8alpha and C5b-7 are located within this domain, and that C8beta binding specificity is not determined by the N- and C-terminal modules...
- Generation and phenotyping of mCd59a and mCd59b double-knockout miceXuebin Qin
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Hematol 84:65-70. 2009..We report here that total abrogation of mCd59 function in mCd59ab(-/-) mice results in complement-mediated hemolytic anemia that is rescued by the deficiency of C3 in compound mCd59ab(-/-)/C3(-/-) mice...
- Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunitDaniel J Slade
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
J Mol Biol 379:331-42. 2008..Also observed is structural conservation of the MACPF signature motif Y/W-G-T/S-H-F/Y-X(6)-G-G in alphaMACPF and Plu-MACPF, and conservation of several key glycine residues known to be important for refolding and pore formation by CDCs...
- CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cellsA Davies
MRC Molecular Immunopathology Unit, MRC Centre, Cambridge, United Kingdom
J Exp Med 170:637-54. 1989....
- Functional characterization of the lectin pathway of complement in human serumAnja Roos
Department of Nephrology, C3P, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
Mol Immunol 39:655-68. 2003..This assay offers novel possibilities for patient diagnostics as well as for the study of disease association with the LP...
- Complement activation in angiotensin II-induced organ damageErdenechimeg Shagdarsuren
Medical Faculty of the Charite, Franz Volhard Clinic, and HELIOS Klinikum Berlin, Germany
Circ Res 97:716-24. 2005..VSMC from dTGR are more sensitive for C3 activation. Our data show that, in this Ang II-induced model, complement activation is a major participant and suggest that TNF-alpha and CRP may play a role in its induction...
- CD59a is the primary regulator of membrane attack complex assembly in the mouseSivasankar Baalasubramanian
Complement Biology Group, Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Cardiff, United Kingdom
J Immunol 173:3684-92. 2004..Erythrocyte CD59b did not inhibit complement lysis except when CD59a was absent or blocked. These data confirm that CD59a is the primary regulator of complement membrane attack in mouse...
- Intracerebroventricular injection of the terminal complement complex causes inflammatory reaction in the rat brainClaudia Casarsa
Department of Physiology and Pathology, University of Trieste, Trieste, Italy
Eur J Immunol 33:1260-70. 2003..Elevated concentration of IL-1 beta was also found in the cerebrospinal fluid and in periventricular areas of rats treated with TCC...
- C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneysMasaomi Nangaku
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Am Soc Nephrol 13:928-36. 2002..Treatment to reduce C5b-9 attack in tubular cells may slow progression and facilitate recovery...
- CD59a deficiency exacerbates ischemia-reperfusion injury in miceDaniel Turnberg
Rheumatology Section, Eric Bywaters Centre, London, United Kingdom
Am J Pathol 165:825-32. 2004....
- Effects of membrane attack complex of complement on apoptosis in experimental autoimmune encephalomyelitisTeodora Niculescu
University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
Ann N Y Acad Sci 1010:530-3. 2003..These results indicate that C5 and possibly MAC may be required for the limitation of inflammatory response within the central nervous system...
- Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitisNicole Tramontini
Pfizer Global Research and Development, Ann Arbor, Michigan, USA
Arthritis Rheum 50:2633-9. 2004..Hence, we studied rabbits deficient in the MAC component C6 to determine if MAC mediated urate crystal-induced arthritis...
- Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient miceViola W Y Leung
Vascular Science Section, Imperial College, National Heart and Lung Institute, the Division of Investigative Sciences, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
Am J Pathol 175:1757-67. 2009..Because upstream complement activation is potentially protective, this study underlines the importance of DAF in shielding the arterial wall from the atherogenic effects of complement...
- Neonatal porcine Sertoli cells inhibit human natural antibody-mediated lysisJannette M Dufour
Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
Biol Reprod 72:1224-31. 2005..This suggests that NPSCs may be able to survive humoral-mediated rejection in a clinical situation...
- C5b-9 terminal complement complex assembly on apoptotic cells in human arterial wall with atherosclerosisFlorin Niculescu
Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Exp Mol Pathol 76:17-23. 2004..In conclusion, some apoptotic cells carry C5b-9 deposits, suggesting that complement might be activated by apoptotic cells and involved in the promotion of apoptosis, contributing to the progression of atherosclerotic lesions...
- Role of complement and complement membrane attack complex in laser-induced choroidal neovascularizationPuran S Bora
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, 301E Muhammad Ali Boulevard, Louisville, KY 40202, USA
J Immunol 174:491-7. 2005..It is possible that a similar mechanism may be involved in the pathophysiology of other angiogenesis essential diseases...
- Binding of human complement C8 to C9: role of the N-terminal modules in the C8 alpha subunitJeffery J Scibek
Department of Chemistry and Biochemistry and School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
Biochemistry 41:14546-51. 2002..These results indicate that both N-terminal modules in C8alpha have a role in forming the principal binding site for C9 and that binding may be dependent on a cooperative interaction between these modules and the C8alpha MACPF domain...
- Involvement of the ERK mitogen-activated protein kinase in cell resistance to complement-mediated lysisS Kraus
Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Clin Exp Immunol 123:366-74. 2001..In conclusion, cell desensitization by sublytic doses of the complement membrane attack complex involves a signalling cascade that includes PKC-mediated ERK activation.
- Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South AsiansM A Siezenga
Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
Clin Exp Immunol 157:98-103. 2009..4, 95% confidence interval 1.8-15.8). These results suggest that enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians...
- The architectural transition of human complement component C9 to poly(C9)R G DiScipio
La Jolla Institute for Experimental Medicine, CA 92037, USA
Mol Immunol 36:575-85. 1999..As a consequence of circular polymerization the midsection of the polypeptide chain becomes exposed as each C9 lengths to fashion a volute form. reserved...
- Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defenseMichael A Hadders
Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands
Science 317:1552-4. 2007..Proteins of the complement membrane attack complex (MAC) and the protein perforin share a common MACPF domain that is responsible for membrane ..
- Time course of complement activation and inhibitor expression after ischemic injury of rat myocardiumA Vakeva
Department of Bacteriology and Immunology, University of Helsinki, Finland
Am J Pathol 144:1357-68. 1994..Deposition of C1 and late C components also starts during the early hours (2 to 4 hours) after ischemia. Subsequent loss of the protective CD59 antigen may initiate postinjury clearance of the irreversibly damaged tissue...
- Complement activation, endothelial dysfunction, insulin resistance and chronic heart failureMette Bjerre
Medical Research Laboratories, Clinical Institute and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark
Scand Cardiovasc J 44:260-6. 2010....
- C5b-9 does not mediate chronic tubulointerstitial disease in the absence of proteinuriaGopala K Rangan
Division of Nephrology, University of Washington Medical Center, Seattle, Washington, USA
Kidney Int 67:492-503. 2005..Here, we examined whether C5b-9 has a pathogenic role in tubulointerstitial disease in the absence of proteinuria...
- Anti-disialoside antibodies kill perisynaptic Schwann cells and damage motor nerve terminals via membrane attack complex in a murine model of neuropathySusan K Halstead
Division of Clinical Neurosciences, Institute of Neurological Sciences, University of Glasgow Southern General Hospital, Glasgow G51 4TF, UK
Brain 127:2109-23. 2004..This is the first demonstration that complement mediated pSC injury occurs in a model of autoimmune neuropathy and provides a rationale for investigating the possibility of pSC injury in equivalent conditions in man...
- Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritisLihua Bao
Section of Nephrology, The University of Chicago, Chicago, IL 60637, USA
Lab Invest 87:357-64. 2007..Our findings suggest that activation of C3 is strongly associated with experimental ICGN while downstream formation of C5b-9 is of lesser pathogenic importance in this model...
- [The role of complement in physiology and pathology]Izabela Klaska
Centrum Biologii Medycznej, Polska Akademia Nauk, Łódź, Poland
Postepy Hig Med Dosw (Online) 61:167-77. 2007....
- A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a severe renal injury with predominant glomerular endothelial damageMasashi Mizuno
Department of Nephrology, Nagoya University Graduate School of Medicine, Japan
Am J Pathol 171:402-14. 2007..The demonstration that PsTX-T and PsTX-115 were highly nephrotoxic acting via induction of complement activation suggests that inhibition of complement might be used to prevent acute renal damage following envenomation by P. semoni...
- Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypassHarold L Lazar
Department of Cardiothoracic Surgery, Boston University School of Medicine and Boston Medical Center, Boston, Mass 02118, USA
Circulation 110:II274-9. 2004....
- [Inhibitory effect of hDAF displayed on yeast cells on deposition of complement on the yeast cells]Bo Guo
Department of Immunology, Third Military Medical University, Chongqing 400038, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:269-71. 2004..To investigate whether the hDAF displayed on the surface of yeast cells can inhibit the deposition of C5b-9...
- Possible mechanism for medial smooth muscle cell injury in diabetic nephropathy: glycoxidation-mediated local complement activationNoriko Uesugi
Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
Am J Kidney Dis 44:224-38. 2004..We focused on medial smooth muscle cell (SMC) injury and the involvement of glycoxidation and complement activation...
- Serum anti-cholesterol antibodies in chronic hepatitis-C patients during IFN-alpha-2b treatmentAdrienn Biro
3rd Department of Medicine, Semmelweis University, Budapest, Hungary
Immunobiology 207:161-8. 2003..The correlation between the ACHA and C5b-9 levels indicate, that the ACHA may play a role in the complement activation in CHC...
- Subversion of complement activation at the bacterial surface promotes serum resistance and opsonophagocytosis of Francisella tularensisAbdelhakim Ben Nasr
Department of Microbiology and Immunology, Medical Research Building, University of Texas Medical Branch, Galveston, TX, USA
J Leukoc Biol 84:77-85. 2008..C3b inactivation also leads to inefficient MAC assembly, which contributes to the ability of this bacterium to resist complement lysis...
- Comparison of inflammatory responses after off-pump and on-pump coronary surgery using surface modifying additives circuitJanine M Quaniers
Department of Surgery, Biostatistics, University of Liege, Liege, Belgium
Ann Thorac Surg 81:1683-90. 2006..Because of the central role of extracorporeal circulation (EC), off-pump coronary bypass surgery is deemed preferable. Do different modalities of EC challenge this view?..
- The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in miceB P Morgan
Department of Pathology, School of Medicine, Cardiff University, Cardiff, UK
Clin Exp Immunol 146:294-302. 2006..These findings provoke us to suggest that current anti-C therapeutics targeting MAC assembly will be beneficial in MG patients resistant to conventional therapies...
- Recent advances on the complement system of teleost fishH Boshra
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 413 Rosenthal, 3800 Spruce St, Philadelphia, PA 19104, USA
Fish Shellfish Immunol 20:239-62. 2006..Such studies will be pivotal in providing new insights into complement-related mechanisms of recognition and defense that are essential to maintaining fish homeostasis...
- Disodium Disuccinate Astaxanthin (Cardax) attenuates complement activation and reduces myocardial injury following ischemia/reperfusionD Adam Lauver
Department of Pharmacology, University of Michigan Medical School, 1301C MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
J Pharmacol Exp Ther 314:686-92. 2005....
- Letter in response to A. Agrawal: 'CRP after 2004'Carmen W van den Berg
Mol Immunol 43:292-3. 2006
- Terminal complement complex in septic shock with capillary leakage: marker of complement activation?T Schuerholz
Friedrich Schiller University, Department of Anaesthesiology and Intensive Care, Jena, Germany
Eur J Anaesthesiol 22:541-7. 2005..The aim of this study was to evaluate the value of terminal complement complex (C5b-9) plasma levels as a marker for complement activation in septic shock with concomitant capillary leak syndrome...
- A case of renal sarcoidosis with complement activation via the lectin pathwayShinji Hagiwara
Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
Am J Kidney Dis 45:580-7. 2005..From this case of renal sarcoidosis, it is hypothesized that P acnes may be involved in pathogenesis of granulomatous interstitial nephritis and that it plays a role in glomerular complement activation via the lectin pathway...
- Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injuryJoshua M Thurman
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA, and Department of Pathology, University Hospital Dubrava, Zabreb, Croatia
J Am Soc Nephrol 17:707-15. 2006..Thus, use of an inhibitory mAb to mouse factor B effectively prevented activation of complement in the kidney after I/R and protected the mice from necrotic and apoptotic injury of the tubules...
- Complement activation in diabetic ketoacidosis brainsWilliam H Hoffman
Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
Exp Mol Pathol 80:283-8. 2006....
- [Membranous glomerulonephritis (membranous nephropathy): Pathogenesis, pathophysiology, and therapy]Teiko Ohashi
Fourth Department of Internal Medicine, Kidney Center, Tokyo Women s Medical University
Nihon Rinsho 64:417-21. 2006
- Terminal complement complex (C5b-9) in children with recurrent hemolytic uremic syndromeFriederike Prüfer
Universitäts Klinik für Kinder und Jugendheilkunde, Innsbruck, Austria
Semin Thromb Hemost 32:121-7. 2006..This may play an important role in the inferior outcome of these patients. The isolated substitution of factor H, or other complement inhibitors to block TCC formation, may represent useful therapies for these patients...
- The pathology of multiple sclerosis is location-dependent: no significant complement activation is detected in purely cortical lesionsBianca P Brink
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 64:147-55. 2005..In contrast, in the purely cortical lesions, the extent of complement deposition in general was low. In conclusion, the role of complement in MS pathogenesis seems lesion location-dependent...
- Retinal synthesis and deposition of complement components induced by ocular hypertensionMarkus H Kuehn
Department of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Exp Eye Res 83:620-8. 2006..The results show that complement activation occurs in the retina that has been subjected to elevated IOP, and may have implications in pathophysiology of glaucoma...
- C5b-9 complement complex in autoimmune demyelination: dual role in neuroinflammation and neuroprotectionHorea Rus
Department of Neurology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
Adv Exp Med Biol 586:139-51. 2006
- Complement activation during sepsis in humansHeike Schreiber
Dept of Traumatology, Hand, Plastic, and Reconstructive Surgery, Steinhoevelstr 9, 89075 Ulm, Germany
Adv Exp Med Biol 586:217-26. 2006
- The complement system in central nervous system diseasesHorea Rus
Department of Neurology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Autoimmunity 39:395-402. 2006..These findings strongly suggest that complement activation and membrane assembly of C5b-9 can play a role in injury but can also provide neuroprotection depending on the pathophysiological context...
- Pathological study on the relationship between C4d, CD59 and C5b-9 in acute renal allograft rejectionS Nishi
Blood Purification Center, Niigata University Hospital, Niigata City, Japan
Clin Transplant 18:18-23. 2004..The substantially expressed CD59 on PTC may affect this dissociation between C4d and C5b-9 on PTC. The intensive deposition of C5b-9 on TBM in acute rejection cases may suggest an independent immunological injury attacking tubular cells...
- The membrane attack complex of complement induces caspase activation and apoptosisAlma J Nauta
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 32:783-92. 2002..Apoptosis as a consequence of complement-mediated cell damage may provide an explanation for the presence of apoptosis in inflammatory processes, for instance in hyperacute xenograft rejection...
- Marked activation of complement and leukocytes and an increase in the concentrations of soluble endothelial adhesion molecules during cardiopulmonary resuscitation and early reperfusion after cardiac arrest in humansBernd W Böttiger
Department of Anesthesiology, University of Heidelberg, Germany
Crit Care Med 30:2473-80. 2002..We studied different specific markers of these processes during and after cardiopulmonary resuscitation in humans...
- Complement activation in chromosome 13 dementias. Similarities with Alzheimer's diseaseAgueda Rostagno
Department of Pathology, School of Medicine, New York University, 550 First Avenue, New York, NY 10016, USA
J Biol Chem 277:49782-90. 2002..The data suggest that the chronic inflammatory response generated by the amyloid peptides in vivo might be a contributing factor for the pathogenesis of FBD and FDD and, in more general terms, to other neurodegenerative conditions...
- Complement's participation in acquired immunityClaus Henrik Nielsen
Institute for Inflammation Research, Rigshospitalet, University Hospital Copenhagen, Denmark
J Leukoc Biol 72:249-61. 2002..The aim of this review is to describe the present status of our understanding of complement's participation in acquired immunity and the regulation of autoimmune responses...
- Leaked protein and interstitial damage in the kidney: is complement the missing link?N S Sheerin
Department of Nephrology and Transplantation, Guy s Hospital, King s College London, London, UK
Clin Exp Immunol 130:1-3. 2002
- Complement activates the c-Jun N-terminal kinase/stress-activated protein kinase in glomerular epithelial cellsHongwei Peng
Department of Medicine, McGill University Health Center, McGill University, Montreal, Quebec, Canada
J Immunol 169:2594-601. 2002..AA may activate the NADPH oxidase, leading to production of reactive oxygen species, which in turn mediate the activation of JNK. The functional role of JNK activation is to limit or protect GECs from complement attack...
- MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIAGREGORY STAHL; Fiscal Year: 2007..abstract_text> ..
- Innate Immunity, Biomarkers and Myocardial InfarctionGregory L Stahl; Fiscal Year: 2010....
- Complement Activation on Neisseria meningitidisSanjay Ram; Fiscal Year: 2013..The studies proposed in this application will help us better understand how this pathogen escapes killing by complement and will ultimately aid in the development of better vaccines against meningococcal meningitis. ..
- The Role of Complement System in GlaucomaMarkus H Kuehn; Fiscal Year: 2012..We propose to determine the functional significance of complement system activation, a recently described and potential cytotoxic process, which occurs in the glaucomatous retina. ..
- Alternative Pathway Inhibitors for Orphan IndicationREKHA BANSAL; Fiscal Year: 2013..We will also conduct Rabbit PK-PD studies in phase II. These studies are essential for the development of a new therapeutic with potentially better benefits. ..
- Pore Formation by Cholesterol Dependent CytolysinsRodney K Tweten; Fiscal Year: 2013..significant effort to investigate other MACPF proteins that play important roles in immune defense (complement membrane attack complex), development (astrotactins), diseases caused by eukaryotic pathogens such as Toxoplasma and malaria,..
- RNAi-based functional analysis of schistosome CD59-like as complement regulatorsGreice Krautz-Peterson; Fiscal Year: 2013..abstract_text> ..
- Role of C7 in Resistance to Neisseria InfectionsMichael C Braun; Fiscal Year: 2011....
- Complement and ethanol-induced liver injury.Laura E Nagy; Fiscal Year: 2010....
- REPERFUSION INJURY AND THE LECTIN COMPLEMENT PATHWAYCHARLES COLLARD; Fiscal Year: 2001..End of Abstract) ..
- STRUCTURE/FUNCTION OF TERMINAL COMPLEMENT PROTEINSJames M Sodetz; Fiscal Year: 2010..The interaction of these proteins will be studied in detail and the results could lead to the development of drugs that control the formation and function of the complex. ..
- Anti-Properdin MoAb as a novel therapeutics for arthritisREKHA BANSAL; Fiscal Year: 2007..NovelMed has filed a patent on such inhibitors and additional patents are in preparation. [unreadable] [unreadable] [unreadable]..
- Role of C5a versus C5b-9 in Myocardial Ischemia and Reperfusion InjuryBenjamin Guikema; Fiscal Year: 2007..Drugs currently available may be better used to protect the heart from damage following a heart attack. [unreadable] [unreadable] [unreadable] [unreadable]..
- SERODIAGNOSIS AND IMMUNOPROPHYLAXIS OF AMEBIASISDavid Lyerly; Fiscal Year: 1999..The lectin also mediates amebic resistance to the human complement membrane attack complex. Preliminary evidence indicate that the recombinant-expressed lectin is a more specific ..
- NOVEL INFLAMMATORY MEDIATORS IN GLOMERULONEPHRITISElias Lianos; Fiscal Year: 1992....
- Improving Kidney Transplant Outcome with a Novel Complement InhibitorSHELLEY MAVES; Fiscal Year: 2007..Eventually, this therapeutic could also be used to treat acute and chronic humoral rejection, glomerulonephritis and other autoimmune diseases. [unreadable] [unreadable] [unreadable]..
- Complement Inhibitors for Macular DegenerationREKHA BANSAL; Fiscal Year: 2009..Potent activity of Bikaciomab in vitro, ex vivo and in vivo makes the drug as a potential therapeutic for not only AMD but also for several diseases where alternative pathway plays an important role in disease pathology. ..
- Innate Immunity in Gastrointestinal IschemiaMelanie Hart; Fiscal Year: 2006..The specific aims are as follows: 1) characterize the complement pathways involved in G/JR and 2) determine the role of complement in apoptosis following GI/R. ..
- Novel Treatments to Abolish Inflammatory Mediators in HemodialysisREKHA BANSAL; Fiscal Year: 2009..It is hoped that such an approach will eventually result in improved morbidity and mortality in the patients suffering from End Stage Kidney Failure. Public Health Relevance Statement Page 7 ..
- HUMORAL MECHANISMS OF INJURY IN SURVIVING NEPHRONSKarl Nath; Fiscal Year: 1992....
- Targeting complement inhibitors to the human proximal tubuleRichard Quigg; Fiscal Year: 2007..Although these are considered pilot and high-risk studies, successful completion could give us treatments for immediate use in clinical studies. [unreadable] [unreadable] [unreadable]..
- Immune evasion by the human blood fluke Schistosoma man*John Hay; Fiscal Year: 2005..SCIP-1 has been postulated in the ability of the schistosome parasite to resist the effects of the complement membrane attack complex. The major aims of this proposed research are: a...
- BASIS OF BACTERIAL KILLING BY COMPLEMENTALFRED ESSER; Fiscal Year: 2000..A two-arm screening and selection mechanism will be employed to identify mutants that are resistant to the cytotoxic action of recombinant C9 exported into the periplasm and to C9 present in serum. ..
- DISTAL COMPLEMENT COMPONENTS IN IMMUNE RENAL INJURYWilliam Couser; Fiscal Year: 2001DESCRIPTION (Adapted from Investigator's Abstract): The complement membrane attack complex (C5b-9) is a major mediator of antibody-induced glomerular diseases...
- MOLECULAR ANALYSIS OF COMPLEMENT COMPONENT C5BRIAN TACK; Fiscal Year: 1992..The collective data for this extended gene family will be used to analyze the pattern of protein structural domain segregation...
- Novel Anti-Inflammatories for Cardiopulmonary BypassREKHA BANSAL; Fiscal Year: 2009..Humanized version of the monoclonal is expected to produce similar results and thus provide patient benefit in cardiopulmonary bypass. ..
- Novel Anti-Inflammatories for Cardiopulmonary BypassREKHA BANSAL; Fiscal Year: 2005..Rekha Bansal is a co-author of a patent "Process for inhibiting complement activation via the alternative pathway ", US patent 6,333,034, issued December 25, 2001 ..
- Terminal complement components in myocardial ischemiaDeepak Bhole; Fiscal Year: 2004..There is a strong potential for development of therapeutic molecules which provide protection from MI/R injury, based on the 'results obtained from this project. ..
- Nebulizing Eculizumab for intrapulmonary C5 inhibitionYi Wang; Fiscal Year: 2006..Activities proposed in the phase II grant would include drug manufacturing of Phase I &II materials, IND filings and the execution of the clinical trial [unreadable] [unreadable]..
- MOLECULAR BASIS OF THE PLATELET STORAGE LESIONTherese Wiedmer; Fiscal Year: 2001..Those conditions are considered optimal that maximize the activity of aminophospholipid traslocase and minimize that of the intracellular Ca2+-activated PL scramblase. ..
- COMPLEMENT EXPRESSION IN ALZHEIMER'S DISEASE BRAINSteven Johnson; Fiscal Year: 1993..Aged humans have elevated serum C which may impinge upon ability of brain to respond to neurodegeneration...
- INTRACELLULAR TARGETING/ANTI-VIRAL AGENTS AND AIDSNANCY STERNBERGER; Fiscal Year: 1990....
- TARGET CELL ACTIVATION BY TERMINAL COMPLEMENT COMPLEXESMOON SHIN; Fiscal Year: 2001..This hypothesis will be explored by identifying the steps of mitochondrial pathway apoptosis affected by C5b-9, and by investigating C5b-9-mediated regulation of the pro- and anti-apoptotic BCL-2 family of proteins. ..
- Interaction Between CD59 and Its Complement LigandsStephen Tomlinson; Fiscal Year: 2006CD59 is a membrane-bound glycoprotein that inhibits the formation of the complement membrane attack complex (MAC or C5b-9) on host cells...
- Assembly and Control of the Complement Membrane Attack ComplexRonald T Ogata; Fiscal Year: 2010..A clearer picture of the MAC will provide insights into the design of drugs that control MAC assembly and injury in these prevalent and devastating human diseases. ..
- BACTERIAL RESPONSES TO THE C5B-9 COMPLEX OF COMPLEMENTJOHN DANKERT; Fiscal Year: 1999..125I-labeled C8 will be used to assess the number of C5b-8 complexes per cell. ..
- PROTEINS OF THE ENDOTHELIAL CELL SURFACEJORDAN POBER; Fiscal Year: 2001..by more classical inflammatory/vasoactive mediators such as histamine,by injurious stimuli such as complement membrane attack complex and by the local differentiation of the EC, determined by surrounding cells and matrix molecules...
- Immune Renal InjuryMichael Vaughan; Fiscal Year: 2006..The ultimate goal of this grant is to identify new targets for potential therapies in order to reduce the heavy burden of disease in patients with glomerular disease. [unreadable] [unreadable] [unreadable]..
- Regulation of Oligodendrocyte SurvivalHorea Rus; Fiscal Year: 2006..Our proposed studies will provide an unique model system to elucidate the biology of sublethally injured OLG and may lead to the identification of regulatory factors that can enhance OLG survival and remyelination. ..
- Activation and regulation of the lectin pathwayNenoo Rawal; Fiscal Year: 2007..abstract_text> ..
- Complement System and the EyeNALINI BORA; Fiscal Year: 2004..Suppression of EAAU by soluble complement regulatory protein(s), and 3. Characterization of 55 kDa complement inhibitor present in normal human aqueous humor/vitreous. ..
- Interaction between host cells and multicomponent material matrixWEIYUAN KAO; Fiscal Year: 2009..e., human blood-derived macrophages, dermal fibroblasts, and keratinocytes) using monoculture and binary cell culture systems. (3) To ascertain IPN efficacy in vivo in modulating the host reaction and healing. ..
- COMPLEMENT REGULATION IN FETOMATERNAL TOLERANCEHector Molina; Fiscal Year: 2003..Also it will also enable us to analyze the role of C and the RCA proteins in fetomaternal tolerance and in the reproductive system. ..
- REGULATION OF HUMORAL IMMUNITY BY COMPLEMENT RECEPTORSHector Molina; Fiscal Year: 2001..Following backcrossing into CR1/CR2 deficient mice, the immune response to different antigens will then be evaluated. These experiments will clarify the different roles of these proteins in the immune response. ..
- Idiopathic Anterior Uveitis and Type I CollagenNALINI BORA; Fiscal Year: 2009..These observations should also allow the development of effective therapy based on selective antigen specific modulation of the immune response in the treatment of this disease. ..
- Pathogenesis of Endotoxin-Induced Acute Renal FailurePatrick Cunningham; Fiscal Year: 2006..abstract_text> ..
- 5TH INTERNATIONAL PODOCYTE CONFERENCEStuart Shankland; Fiscal Year: 2004..3. To facilitate cross-talk between clinicians and scientists with the ultimate goal of improving prognosis, treatment and care of patients with glomerular disease. ..
- Gene Expression in Inflammatory MyopathiesSteven Greenberg; Fiscal Year: 2005..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..
- AGE-RELATED MACULOPATHY: COMPLEMENT-MEDIATED EVENTSLINCOLN JOHNSON; Fiscal Year: 2005....
- Preventing choroidal neovascularization by long-term transscleral drug deliveryPURAN BORA; Fiscal Year: 2006..For proof-of-concept, we will use a novel, human protein-based therapy that has shown great potential in preliminary animal studies. [unreadable] [unreadable] [unreadable] [unreadable]..
- BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICSWEIYUAN KAO; Fiscal Year: 2001..The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing. ..
- C1q-complement and hypoxic-ischemic injury in the developing brain.Vadim S Ten; Fiscal Year: 2010....
- The CXCR4-SDF-1 Axis in Metastatic RhabdomyosarcomaMariusz Ratajczak; Fiscal Year: 2009..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
- Mechanisms of Complement-Mediated Damage in SCIAileen Anderson; Fiscal Year: 2007....
- Mechanisms of SCI Recovery after hCNS Stem Cell GraftsAileen Anderson; Fiscal Year: 2008....
- Complement Activation and Renal Ischemia/Reperfusion InjuryJOSHUA THURMAN; Fiscal Year: 2008..unreadable] [unreadable]..
- Borrelia lipoproteins with the cerebral microcirculationDiego Cadavid; Fiscal Year: 2007..2. Investigate whether Vspl enters BMEC. 3. Determine whether Vspl crosses BMEC barriers. 4. Identify the structural features that mediate the interaction of Vspl with BMEC. [unreadable] [unreadable]..
- MECHANISMS OF PODOCYTE INJURYStuart Shankland; Fiscal Year: 2005..Taken together, the overall goal is to show novel mechanisms underlying podo injury, so that ultimately, specific therapeutic strategies can be developed to reduce podo injury in the development of glomerular sclerosis. ..
- BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICSWEIYUAN KAO; Fiscal Year: 2007....
- Genomics and Proteomics for Vision ResearchLINCOLN JOHNSON; Fiscal Year: 2007..This project will also foster a significant expansion of vision-related research efforts by providing resources that will attract new investigators interested in genomic and proteomic approaches to problems in vision. ..