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> zovirax na mnie nie działa
Zadziala, jesli bedziesz go prawidlowo stosowac. Zowirax krem nie ma wplywu na
opryszczeke wargowa, w kazdym razie nie wiekszy niz placebo.
Tobie potrzebne jest leczenie acyklowirem (moze byc Zovirax, ale Heviran jest
tanszy) ok 800 mg na dobe doustnie przez kilka miesiecy. To kosztowne, lepiej
nie robic tego bez kontroli lekarza, ale dziala.
Referencje (dwie przykladowe, ale jest tego naprawde mnostwo):
Spruance SL. Prophylactic chemotherapy with acyclovir for recurrent herpes
simplex labialis. J Med Virol. 1993;Suppl 1:27-32. The medical literature was
reviewed and 11 clinical trials of prophylactic topical or peroral acyclovir for
the suppression of recurrent herpes simplex labialis were identified. The
results of these trials showed that prophylactic topical acyclovir was mostly
ineffective, but that prophylactic peroral acyclovir, in doses ranging from 400
to 1,000 mg/day, reduced the frequency of herpes labialis during treatment by
50-78%. The reduction in the frequency of episodes of herpes labialis with
acyclovir prophylaxis is less than the suppressive effect that has been reported
for herpes genitalis (50-78% vs. 80-90%). In trials of prophylactic acyclovir
for herpes labialis induced by experimental ultraviolet radiation, 26% of
induced lesions developed within 48 hours of radiation exposure ("immediate"
lesions) and, in contrast to "delayed" lesions that developed 2-7 days
post-irradiation, were not suppressed by the antiviral compound. It is proposed
that these treatment-unresponsive immediate lesions have an atypical
pathogenesis, possibly involving latency of herpes simplex virus in the labial
epithelium, and that these may be responsible for the apparent difference
between herpes labialis and genitalis in the degree of benefit from prophylactic
Prophylactic oral acyclovir in outbreaks of primary herpes simplex virus type 1
infection in a closed community K Kuzushima, T Kudo, H Kimura, S Kido, N Hanada,
M Shibata, K Nishikawa and T Morishima Oral acyclovir was given prophylactically
to 37 children in the early stages of three outbreaks of herpes simplex virus
type 1 (HSV-1) infection and the results were compared with those in untreated
control subjects in two other outbreaks. The rates of seroconversion to HSV were
significantly reduced in children treated with acyclovir compared with control
subjects (91% vs 27%, P less than .001). The incidence of symptomatic disease
was also significantly reduced (82% vs 0%, P less than .001). In some children
receiving prophylactic acyclovir, anti-HSV antibody titers did not rise despite
the presence of replicative HSV on throat swabs just before the start of
treatment. Restriction endonuclease analysis of isolated HSV-DNA confirmed that
one strain was responsible for the five outbreaks. No resistance to acyclovir
was detected during the study, and no adverse effects of treatment were noted.
In conclusion, short-term prophylactic acyclovir may limit the spread and reduce
clinical manifestations of HSV infections in closed communities, although this
use should be restricted to communities where severe symptoms are observed.
Volume 89, Issue 3, pp. 379-383, 03/01/1992
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