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Dariush Mozaffarian, MD, Cardiology, answeredMany experts shy away from any iron supplementation for men. That's because men -- like women who no longer menstruate -- aren't typically losing much iron. For that reason, supplements aimed specifically at men generally reduce iron or drop it from the formula. This can help prevent iron overload, which can stem from taking more iron than necessary through supplements. Iron overload may also occur because of a common genetic defect that occurs more often in men than women. Iron overload can damage the liver and other body tissues, raising the risks for diabetes, heart disease, arthritis, and liver cancer.