Valerie M Schwitzgebel
Affiliation: University of Geneva
- Hepatic nuclear factor-3 (HNF-3 or Foxa2) regulates glucagon gene transcription by binding to the G1 and G2 promoter elementsBenoit R Gauthier
Unite de Diabetologie Clinique, Centre Medical Universitaire, 1211 Geneve 4, Switzerland
Mol Endocrinol 16:170-83. 2002..We suggest that HNF-3 may play a dual role on glucagon gene transcription by 1) inhibiting the transactivation potential of Pax6 on the G1 and G3 elements and 2) direct activation through G1 and G2...
- Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1Valerie M Schwitzgebel
Pediatric Endocrinology and Diabetology, Geneva University Hospital, CH 1211 Geneva, Switzerland
J Clin Endocrinol Metab 88:4398-406. 2003..We conclude that the IPF1 level is critical for human pancreas formation...
- Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in lifeEmmanuel Somm
Department of Pediatrics, Geneva University Hospitals, 1211 Geneva 14, Switzerland
Endocrinology 149:6289-99. 2008..These results prove a direct association between fetal nicotine exposure and offspring metabolic syndrome with early signs of dysregulations of adipose tissue and pancreatic development...
- Prenatal nicotine exposure and the programming of metabolic and cardiovascular disordersEmmanuel Somm
Department of Pediatrics, Geneva University Hospitals, Switzerland
Mol Cell Endocrinol 304:69-77. 2009....
- Perinatal exposure to bisphenol a alters early adipogenesis in the ratEmmanuel Somm
Faculty of Medicine, University of Geneva, Geneva, Switzerland
Environ Health Perspect 117:1549-55. 2009..The causes of the current obesity pandemic have not been fully elucidated. Implication of environmental endocrine disruptors such as bisphenol A (BPA) on adipose tissue development has been poorly investigated...
- Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and functionEric Marthinet
Pediatric Endocrinology and Diabetology, Children s Hospital, 6, rue Willy Donze, CH 1211 Geneva, Switzerland
J Clin Endocrinol Metab 90:5401-6. 2005..A loss of function of K(ATP) channels causes depolarization of beta-cells and congenital hyperinsulinism (CHI), a disease presenting with severe hypoglycemia in the newborn period...