Scopus Publication Detail
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Julio C. Ruiz; Richard K. Bruick(Profiled Author: Richard K Bruick)
Journal of Inorganic Biochemistry. 2014;133:73-77.Abstract
Though essential for many vital biological processes, excess iron results in the formation of damaging reactive oxygen species (ROS). Therefore, iron metabolism must be tightly regulated. F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, regulates cellular and systemic iron homeostasis by facilitating iron regulatory protein 2 (IRP2) degradation. FBXL5 possesses an N-terminal hemerythrin (Hr)-like domain that mediates its own differential stability by switching between two different conformations to communicate cellular iron availability. In addition, the FBXL5-Hr domain also senses O
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Joel W. Thompson; Ameen A. Salahudeen; Srinivas Chollangi; Julio C. Ruiz; Chad A. Brautigam; Thomas M. Makris; John D. Lipscomb; Diana R. Tomchick; Richard K. BruickJournal of Biological Chemistry. 2012;287(10):7357-7365.
Srinivas Chollangi; Joel W. Thompson; Julio C. Ruiz; Kevin H. Gardner; Richard K. BruickJournal of Biological Chemistry. 2012;287(28):23710-23717.
Julio C. Ruiz; Scott D. Walker; Sheila A. Anderson; Richard S. Eisenstein; Richard K. BruickJournal of Biological Chemistry. 2013;288(1):552-560.
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