Sean Klepper M.D.
Artur Zembowicz M.D....
Also known as: tubular apocrine adenoma, tubulopapillary hidradenoma, papillary tubular adenoma
- Rare benign tumor with a predilection for the scalp, cheek, axilla and breast
- Most common in adults, with a female predominance
- Sometimes associated with an organoid nevus or syringocystadenoma papilliferum
- Presents as a slowly growing, well-circumscribed dermal or subcutaneous nodule
- Well-circumscribed dermal or occasionally subcutaneous nodule which may communicate with the epidermis
- Composed of variably-sized tubules lined by two or more layers of apocrine-type cells: cuboidal to columnar with abundant eosinophilic cytoplasm and uniform round to oval nuclei
- Some of the cells show decapitation secretion and an outer myoepithelial layer is focally present.
- Many cases show cyst formation with papillae or pseudopapillae protruding into the lumen.
- Dense fibrous stroma which contains few inflammatory cells, in contrast to syringocystadenoma papilliferum
- The luminal surface is strongly positive for EMA and CEA.