Meta-analysis vs. t statistic performance. a.) Heat maps of randomly generated DMRs among 5 cases and 5 controls where 20,40,60,80, and 100% of probes are significant. The foreground and background panes depict DMRs spanning 5 and 30 probes, respectively. b.) Density plots of the percentage of significant probes within DMRs detected by BioTile (blue) and the average t-test method (red).
Guintivano et al. BMC Bioinformatics 2013 14:76 doi:10.1186/1471-2105-14-76