Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: December 15, 2004
Publication Date: April 1, 2006
Citation: Motil, K.J. 2006. Peptic ulcer disease. In: McMillian, J.A., Feigin, R.D., DeAngelis, C.D., Jones, M.D., editors. Oski's Pediatrics: Principles and Practice of Pediatrics. 4th edition. Philadelphia, PA: Lippincott Williams & Wilkins. p. 1932-1937. Technical Abstract: Peptic ulcer disease (PUD) is an ulcerative condition of the stomach or duodenum that may be accompanied by mucosal inflammation. PUD is classified as primary when it occurs in healthy children and as secondary when underlying disorders associated with injury, illness, or drug therapy co-exists. Primary peptic ulcers are usually chronic, more often duodenal in origin, and frequently associated with the infectious agent Helicobacter pylori, whereas secondary ulcers are usually acute, more often gastric in location, often induced by physiologic stress or drug ingestion, and generally unrelated to an infectious status. Although PUD is relatively uncommon in children, the discovery of H. pylori and its association with peptic ulcers has led to a re-evaluation of the traditional approach to the diagnosis and treatment of ulcer disease in children.