Down syndrome (DS), also called Trisomy 21, is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. It affects about 1 in every 800 babies born in the United States.
The physical features and medical problems associated with Down syndrome can vary widely from child to child. While some kids with DS need a lot of medical attention, others lead healthy lives.
Though Down syndrome can't be prevented, it can be detected before a child is born. The health problems that may go along with DS can be treated, and many resources are available to help kids and their families who are living with the condition.
Normally, at the time of conception a baby inherits genetic information from its parents in the form of 46 chromosomes: 23 from the mother and 23 from the father. In most cases of Down syndrome, a child gets an extra chromosome 21 — for a total of 47 chromosomes instead of 46. It's this extra genetic material that causes the physical features and developmental delays associated with DS.
Although no one knows for sure why DS occurs and there's no way to prevent the chromosomal error that causes it, scientists do know that women age 35 and older have a significantly higher risk of having a child with the condition. At age 30, for example, a woman has about a 1 in 1,000 chance of conceiving a child with DS. Those odds increase to about 1 in 400 by age 35. By 40 the risk rises to about 1 in 100.
Kids with Down syndrome tend to share certain physical features such as a flat facial profile, an upward slant to the eyes, small ears, and a protruding tongue.
Low muscle tone (called hypotonia) is also characteristic of children with DS, and babies in particular may seem especially "floppy." Though this can and often does improve over time, most children with DS typically reach developmental milestones — like sitting up, crawling, and walking — later than other kids.
At birth, kids with DS are usually of average size, but they tend to grow at a slower rate and remain smaller than their peers. For infants, low muscle tone may contribute to sucking and feeding problems, as well as constipation and other digestive issues. Toddlers and older kids may have delays in speech and self-care skills like feeding, dressing, and toilet teaching.
Down syndrome affects kids' ability to learn in different ways, but most have mild to moderate intellectual impairment. Kids with DS can and do learn, and are capable of developing skills throughout their lives. They simply reach goals at a different pace — which is why it's important not to compare a child with DS against typically developing siblings or even other children with the condition.
Kids with DS have a wide range of abilities, and there's no way to tell at birth what they will be capable of as they grow up.
While some kids with DS have no significant health problems, others may experience a host of medical issues that require extra care. For example, almost half of all children born with DS will have a congenital heart defect.
Kids with Down syndrome are also at an increased risk of developing pulmonary hypertension, a serious condition that can lead to irreversible damage to the lungs. All infants with Down syndrome should be evaluated by a pediatric cardiologist.
Approximately half of all kids with DS also have problems with hearing and vision. Hearing loss can be related to fluid buildup in the inner ear or to structural problems of the ear itself. Vision problems commonly include strabismus (cross-eyed), near- or farsightedness, and an increased risk of cataracts.
Regular evaluations by an otolaryngologist (ear, nose, and throat doctor), audiologist, and an ophthalmologist are necessary to detect and correct any problems before they affect language and learning skills.
Other medical conditions that may occur more frequently in kids with DS include thyroid problems, intestinal abnormalities, seizure disorders, respiratory problems, obesity, an increased susceptibility to infection, and a higher risk of childhood leukemia. Upper neck abnormalities are sometimes found and should be evaluated by a doctor (these can be detected by cervical spine X-rays). Fortunately, many of these conditions are treatable.
Two types of prenatal tests are used to detect Down syndrome in a fetus: screening tests and diagnostic tests. Screening tests estimate the risk that a fetus has DS; diagnostic tests can tell whether the fetus actually has the condition.
Screening tests are cost-effective and easy to perform. But because they can't give a definitive answer as to whether a baby has DS, these tests are used to help parents decide whether to have more diagnostic tests.
Diagnostic tests are about 99% accurate in detecting Down syndrome and other chromosomal abnormalities. However, because they're performed inside the uterus, they are associated with a risk of miscarriage and other complications.
For this reason, invasive diagnostic testing previously was generally recommended only for women age 35 or older, those with a family history of genetic defects, or those who've had an abnormal result on a screening test.
However, the American College of Obstetrics and Gynecology (ACOG) now recommends that all pregnant women be offered screening with the option for invasive diagnostic testing for Down syndrome, regardless of age.
If you're unsure about which test, if any, is right for you, your doctor or a genetic counselor can help you sort through the pros and cons of each.
Screening tests include:
Diagnostic tests include:
After a baby is born, if the doctor suspects DS based on the infant's physical characteristics, a karyotype — a blood or tissue sample stained to show chromosomes grouped by size, number, and shape — can be done to verify the diagnosis.
If you're the parent of a child diagnosed with Down syndrome, you may at first feel overwhelmed by feelings of loss, guilt, and fear. Talking with other parents of kids with DS may help you deal with the initial shock and grief and find ways to look toward the future. Many parents find that learning as much as they can about DS helps ease some of their fears.
Experts recommend enrolling kids with Down syndrome in early-intervention services as soon as possible. Physical, occupational, and speech therapists and early-childhood educators can work with your child to encourage and accelerate development.
Many states provide free early-intervention services to kids with disabilities from birth to age 3, so check with your doctor or a social worker to learn what resources are available in your area.
Once your child is 3 years old, he or she is guaranteed educational services under the Individuals with Disabilities Education Act (IDEA). Under IDEA, local school districts must provide "a free appropriate education in the least restrictive environment" and an individualized education plan (IEP) for each child.
Where to send your child to school can be a difficult decision. Some kids with Down syndrome have needs that are best met in a specialized program, while many others do well attending neighborhood schools alongside peers who don't have DS. Studies have shown that this type of situation, known as inclusion, is beneficial for both the child with DS as well as the other kids.
Your school district's child study team can work with you to determine what's best for your child, but remember, any decisions can and should involve your input, as you are your child's best advocate.
Today, many kids with Down syndrome go to school and enjoy many of the same activities as other kids their age. A few go on to college. Many transition to semi-independent living. Still others continue to live at home but are able to hold jobs, thus finding their own success in the community.
|National Down Syndrome Society (NDSS) NDSS strives to ensure that all people with Down syndrome have the opportunity to achieve their full potential in community life. Call: (800) 221-4602|
|March of Dimes The March of Dimes seeks to prevent birth defects, infant mortality, low birthweight, and lack of prenatal care.|
|American College of Obstetricians and Gynecologists (ACOG) This site offers information on numerous health issues. The women's health section includes readings on pregnancy, labor, delivery, postpartum care, breast health, menopause, contraception, and more.|
|Genetic Counseling Genetic counselors work with people who are either planning to have a baby or are pregnant to determine whether they carry the genes for certain inherited disorders. Find out more.|
|Genetic Testing Advances in genetic testing have improved doctors' ability to diagnose and treat certain illnesses.|
|Kids With Special Needs Lots of kids have special needs. Find out more in this article for kids.|
|When Your Baby Is Born With a Health Problem If you're expecting a baby, it's important to understand that certain health problems and complications can't be prevented, no matter how smoothly the pregnancy goes.|
|When Your Baby Has a Birth Defect If your child has a birth defect, you don't have to go it alone - lots of people and resources are available to help you.|
|Down Syndrome What's up with Down syndrome? Find out in this article for kids.|
|Birth Defects Birth defects are relatively common. Some are minor and cause no problems; others cause major disabilities. Learn about the different types of birth defects, and how to help prevent them.|
|FAQs: Prenatal Tests Find out what tests are available to keep you informed of your -- and your baby's -- health throughout pregnancy.|
|What Is the Triple Screen Test? Find out what the experts have to say.|
|Camps for Kids With Special Needs There are many camp choices for kids with special needs. From highly specialized camps to regular camps that accommodate kids with special needs, options abound.|
|What Is the Multiple Marker Test? Expectant mothers usually are offered a blood test called the multiple marker test, sometimes called a triple screen or a quad screen. Find out what it measures.|
|Babysitting: Caring for Kids With Special Needs What's the best way to feel confident about caring for a kid with special needs? Know what to expect! Here are tips on looking babysitting kids with autism, Down syndrome, and ADHD.|
|What Is an Intellectual Disability? Mental retardation is an old-fashioned term for problems with learning and developing. Find out more in this article for kids.|
|Individualized Education Programs (IEPs) Some kids may be eligible for individualized education programs in public schools, free of charge. Understanding how to access these services can help you be an effective advocate for your child.|
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