Affiliation: Johann Wolfgang Goethe University
- Neurodegeneration in ataxia telangiectasia: what is new? What is evident?Franziska Hoche
Department of Neuropediatrics, Goethe University Frankfurt, Germany, EU
Neuropediatrics 43:119-29. 2012..Second, biochemical and molecular biological studies aimed at deciphering the pathomechanisms of this progressive disorder are necessary for the development of promising future therapies...
- Rare brain biopsy findings in a first ADEM-like event of pediatric MS: histopathologic, neuroradiologic and clinical featuresFranziska Hoche
Department of Neuropediatrics, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt, Germany
J Neural Transm 118:1311-7. 2011..This pattern was corresponding to the early active multiple sclerosis subtype I of Lucchinetti et al. (Ann Neurol 47(6):707-717, 2000)...
- Extracerebellar MRI-lesions in ataxia telangiectasia go along with deficiency of the GH/IGF-1 axis, markedly reduced body weight, high ataxia scores and advanced ageMatthias Kieslich
Department of Pediatrics, Goethe University Frankfurt, Germany
Cerebellum 9:190-7. 2010..This may point to a major role of IGF-1 and nutritional status in neuroprotective signaling...
- Spinocerebellar ataxia type 2 (SCA2): identification of early brain degeneration in one monozygous twin in the initial disease stageFranziska Hoche
Institute of Clinical Neuroanatomy, Dr Senckenberg Anatomy, Goethe University, 60590, Frankfurt am Main, Germany
Cerebellum 10:245-53. 2011..Since they were already involved in our patient within 3 years after disease onset, we think that we were for the first time able to identify the early brain targets of the pathological process of SCA2...