Quality care is our passion
“ CFM is providing new standards in tissue repair. ”
CFM is continuously investigating new drug compounds to ensure cutting edge therapies in trauma care at great length.
CFM’s lead compound is VANADIS® (bis(maltolato)oxovanadium (BMOV)). The main focus is the development of therapeutics to stop and prevent secondary tissue injury, caused by direct injuries such as a blast injury(traumatic brain injury), a heart attack, results from Road Traffic Crashes (RTC) and burns caused by fire and enhance tissue repair.
Organic vanadium compounds with vanadium in its 4+ state (V4+, vanadyl), especially BMOV, are very stable and mostly act at the places where their action is required: the active metabolite of BMOV, vanadate, is released under acidic conditions, which is also the case at injured or ischemic tissue.
The chemical structure of BMOV is shown in Fig. VI, the arrows point at the 4+ vanadyl ion.
Wound Repair: the curse of fibrosis
In general, the wound repair process occurs in almost all tissues after exposure to almost any destructive stimulus. Thus the sequence of events that follows a burn, for example, is remarkably similar to that following a MI (heart attack), a spinal-cord injury or a gunshot wound, despite the different types of insult and the different organs affected.
Likewise, scar formation that occurs during wound repair leads to similar tissue dysfunction wherever it takes place.
VANADIS®, a powerful fibrosis inhibitor
VANADIS® prevents secondary tissue injury, which is the result of direct injury (like a heart or brain attack, a burn wound or a wound on the battlefield,) and preserves blood vessels.
Secondly, it stimulates pathways (several types of growth factors like TGF-β, VEGF, EGF, IGF and other important proteins), required for tissue repair.
The Insulin pathways are a key element to many tissue repair pathways. Reversible phosphorylation of proteins is an important regulatory mechanism. Vanadium compounds are known for their phospho-mimicking and Insulin-mimicking properties.
Vanadium is known to reduce apoptosis (programmed cell death) through different pathways and also acts as free radical scavenger. Vanadium compounds also enhance antioxidant systems due to stimulatory effects on anti-oxidant enzyme activities and anti-oxidant enzyme expression, through Nrf2 activation in association with the up-regulation of GCLC.
Therefore it has certain effects on the immune response. The adult immune system is considered to be the main cause of bad wound healing. A leading hypothesis is that the immune system is involved in the switch between the regeneration and fibrotic healing, because human fetuses, which heal without scarring, have immature immune systems.
It is thought that organic vanadium (4+) compounds put the injured tissue in some kind of a reversible fetal state, which improves healing without scarring.