More information about David Ornitz and his laboratory: bio sketch,
research interests, selected publications and laboratory resources.
Selected laboratory protocols, such as: alkaline
plasmid prep, BrdU immunohistochemistry, LacZ embryo staining, RNase
protection assay and many others.
Information and graphics concerning fibroblast growth factor research,
such as: FGF family tree, FGFR mutations, FGF specificity data and
Neurobiology and the function of Intracellular FGFs(iFGFs): Intracellular Fibroblast Growth Factors (iFGFs) are important regulators of the activity of many different neurons in the brain and throughout the body
Regulation of cochlear development and regeneration by Fibroblast Growth Factor 20. We have identified FGF20 as an essential signal that regulates the development of sensory receptors in the inner ear. Mice lacking FGF20 are viable, healthy and congenitally deaf.
Many of the human craniosynostosis and chondrodysplasia syndromes are caused by missense mutations in the genes encoding FGF receptors (FGFRs) 1, 2 and 3.
Fibroblast Growth Factors (FGFs) have been proposed as important regulators of growth and function of the heart and as important angiogenic factors.
Mice lacking FGF9 have defects in lung branching and lung mesoderm
proliferation. These mice also have a male to female sex reversal
secondary to decreased growth of testicular mesenchyme and failure
of normal Sertoli and Lydig cell development.
Links to other programs within the School of Medicine, and to other
areas of interest.
Members, Alumni and Contact Information