- Leong, K.W. and Liao, I.C. and Yim, E. and Lim, S. and Wan, A. and Wen, J. and Chew, S.Y. and Chua, K.N. and Ramakrishna, S. and Mao, H.Q., Controlled release systems designed for regenerative medicine,
Transactions - 7th World Biomaterials Congress
pp. 189 - .
(last updated on 2007/04/13)
The features of two fibrous controlled release systems where the drug-loaded fibers are fabricated by electrospinning and polyelectrolyte complexation (PEC) were investigated. The controlled release behavior of drugs from the fibers comprising the biodegradable copolymer of polycaprolactone (PCL) and poly(ethylphosphate) (PCLEEP) was also investigated. The copolymers were synthesized through ring-opening polymerization of caprolactone and ethyl ethylene phosphate (EEP). The results show that delicate compounds such as proteins can better retain their bioactivity in encapsulation process involving PEC.
Cells;Controlled drug delivery;Tissue;Biochemical engineering;Hydrogels;Drug products;DNA;Bone;Polyelectrolytes;Synthesis (chemical);Copolymers;Complexation;Encapsulation;Biodegradation;Ring opening polymerization;Biocompatibility;