The collarette is the region of the iris separating the pupillary portion from the ciliary portion. It is typically defined as the region where the sphincter muscle and dilator muscle overlap.
The iris is usually strongly pigmented, with colors ranging from brown to green, blue, grey, and hazel (which is how it earned its name, iris being Greek for "rainbow" 1). Occasionally its color is due to lack of pigmentation, as in the pinkish-white of oculo-cutaneous albinism, or to obscuration of its pigment by blood vessels, as in the red of an abnormally vascularised iris. Despite the wide range of colors, there is only one pigment that contributes substantially to normal human iris color, the dark pigment called melanin. Structurally, this huge molecule is only slightly different from its equivalent found in skin and hair.
Melanin is yellowish-brown to dark brown in the stromal pigment cells, and black in the iris pigment epithelium, which lies in a thin but very opaque layer across the back of the iris. Most human irises also show a condensation of the brownish stromal melanin in the thin anterior border layer, which by its position has an overt influence on the overall color. The degree of dispersion of the melanin, which is in subcellular bundles called melanosomes, has some influence on the observed color, but melanosomes in the iris of humans and other vertebrates are not mobile, and the degree of pigment dispersion cannot be reversed. Abnormal clumping of melanosomes does occur in disease and may lead to irreversible changes in iris color (see heterochromia, below). Colors other than brown or black are due to selective reflection and absorption from the other stromal components. Sometimes lipofuscin, a yellow "wear and tear" pigment also enters into the visible eye color, especially in aged or diseased green eyes (but not in healthy green human eyes).
Caucasian babies are born with blue eyes since they have not deposited enough melanin in the stroma, and selective absorption and scattering of the light reflected at the epithelium render it blue. If they deposit a high amount, their eyes turn black or brown, with a smaller degree they remain blue or gray.
The optical mechanisms by which the non-pigmented stromal components influence eye color are complex, and many erroneous statements exist in the literature. Simple selective absorption and reflection by biological molecules (hemoglobin in the blood vessels, collagen in the vessel walls and stroma) is the most important element. Rayleigh scattering and Tyndall scattering, (which also happen in the sky) and diffraction also occur. Raman scattering, and constructive interference, as in the feathers of birds, do not contribute to the color of the human eye, but interference phenomena are important in the brilliantly colored iris pigment cells (iridophores) in many animals. Interference effects can occur at both molecular and light microscopic scales, and are often associated (in melanin-bearing cells) with quasi-crystalline formations which enhance the optical effects. Interference is recognised by characteristic dependence of color on the angle of view, as seen in eyespots of some butterfly wings, although the chemical components remain the same.
Blue is one of the possible eye colors in humans. The "blue" allele, existing in the Bey2 and Gey genes of chromosome 15, is recessive. This means that both genes must have both blue alleles i.e. "blue-blue", in a person with blue eyes. If one of the alleles were not "blue" ("green" for Gey or "brown" for Bey2) then the person would have those colored eyes respectively. As either allele (though not both) can be passed on to offspring it is perfectly possible for someone who does not have blue eyes to have blue-eyed children. In general, blue eyed parents have blue eyed children; rare exceptions occur due to genes which control the pathway to determining eye color. Though this explanation gives an idea of eye color delineation, it is incomplete, and all the contributing factors towards eye color and its variation are not fully understood. Autosomal recessive/dominant traits in iris color are inherent in other species but coloration can follow a different pattern. In the Scincidae species: Corucia zebrata - underlined, autosomal recessive color is black, where autosomal dominant color is yellow-green. (Subspecies comparison of the Genus Corucia - Leeway Corucia Research Center - LCRC, Polyphemos, 2006).
Iris color can be sexually dimorphic. With many Cacatua (cockatoo) species, males have a black iris and females , a reddish / brown iris.
Heterochromia (also known as a heterochromia iridis or heterochromia iridium) is an ocular condition in which one iris is a different color from the other iris (complete heterochromia), or where the part of one iris is a different color from the remainder (partial heterochromia or sectoral heterochromia). Uncommon in humans, it is often an indicator of ocular disease, such as chronic iritis or diffuse iris melanoma, but may also occur as a normal variant. Sectors or patches of strikingly different colors in the same iris are less common. Alexander the Great and Anastasios the First were dubbed dikoro*s (dikoros, "with two pupils") for their patent heterochromias. In their case, this was not a true dicoria (two pupils in the same iris). Real polycoria can be due to disease but is most often due to previous trauma or surgery.
In contrast, heterochromia and variegated iris patterns are common in veterinary practice. Siberian Huskies show heterochromia, possibly analogous to the genetically-determined Waardenburg syndrome of humans. Some white cat fancies (e.g., white Persians) may show striking heterochromia, with the most common pattern being one uniformly blue, the other green. Striking variation within the same iris is also common in some animals, and is the norm in some species. Several herding breeds, particularly those with a blue merle coat color (such as Australian Shepherds and Border Collies) may show well-defined blue areas within a brown iris as well as separate blue and darker eyes. Some horses (usually within the white, spotted, palomino or cremello groups of breeds) may show amber, brown, white, and blue all within the same eye, without any sign of eye disease.
One eye with a white or bluish-white iris is also known as a walleye.
When used as a descriptive term in medicine, the meaning of "red eye" is quite different, and indicates that the bulbar conjunctiva is reddened due to dilatation of superficial blood vessels. Leaving aside rarities, it indicates surface infection (conjunctivitis), intraocular inflammation (e.g., iridocyclitis) or high intraocular pressure (acute glaucoma or occasionally severe, untreated chronic glaucoma). This use of "red eye" implies disease. The term is therefore not used in medicine for ocular albinism, in which the eye is otherwise healthy despite an obviously red pupil and a translucent pinkish iris due to reflected light from the fundus. "Red eye" is used more loosely in veterinary practice, where investigation of eye diseases can be difficult, but even so albinotic breeds are easily recognised and are usually described as having "pink eye" rather than "red eye".