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In medicine, sclerosis (also spelled sclerosus in the names of a some disorders) refers to the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue.
- Amyotrophic lateral sclerosis, sometimes known as Lou Gehrig's disease, a progressive, incurable, usually fatal disease of motor neurons.
- Hippocampal sclerosis, a brain damage often seen in individuals with temporal lobe epilepsy.