Genomes and Genes
nucleic acid synthesis inhibitors
Summary: Compounds that inhibit cell production of DNA or RNA.
Publications209 found, 100 shown here
- The DNA replication checkpoint response stabilizes stalled replication forksM Lopes
Istituto F.I.R.C. di Oncologia Molecolare, Via Serio 21, 20141, Milano, Italy
Nature 412:557-61. 2001..Further, Rad53 is required to properly maintain stable replication forks during the block. We propose that Rad53 prevents collapse of the fork when replication pauses...
- Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycleP Pichierri
Laboratorio di Citogenetica Molecolare e Mutagenesi, DABAC, , 01100 Viterbo, Italy
Mol Biol Cell 12:2412-21. 2001..Our findings support the hypothesis that WRN could be involved in the correct resolution of recombinational intermediates that arise from replication arrest due to either DNA damage or replication fork collapse...
- Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbitsMarcelo V Netto
The Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
J Refract Surg 22:562-74. 2006..To determine the mechanism through which topical mitomycin C prevents and treats corneal haze after photorefractive keratectomy (PRK) and to examine the effects of dosage and duration of exposure...
- BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damageAlan R Schoenfeld
Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1130, New York, NY 10029, USA
Mol Cell Biol 24:7444-55. 2004....
- Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNAXushan Wang
Cardiovascular Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 280:19298-305. 2005....
- DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologsT Wada
Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori ku, Yokohama 226, Japan
Genes Dev 12:343-56. 1998..The combination of biochemical studies on DSIF and genetic analysis of Spt4 and Spt5 in yeast, also in this issue, indicates that DSIF associates with RNA Pol II and regulates its processivity in vitro and in vivo...
- Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibitionYaron Shav-Tal
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100 Israel
Mol Biol Cell 16:2395-413. 2005....
- Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivoPatricia A Loomis
Department of Cell and Molecular Biology, Feinberg School of Medicine, Institute of Neuroscience, Northwestern University, 303 East Chicago Ave, Chicago, IL 60611, USA
J Cell Biol 163:1045-55. 2003....
- Human Asf1 regulates the flow of S phase histones during replicational stressAnja Groth
Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
Mol Cell 17:301-11. 2005....
- NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase IIM Barboric
Howard Hughes Medical Institute Departments of Medicine, Microbiology, and Immunology University of California at San Francisco 94143, USA
Mol Cell 8:327-37. 2001..Remarkably, DRB inhibition sensitized cells to TNF-alpha-induced apoptosis. Thus, NF-kappaB requires P-TEFb to stimulate the elongation of transcription and P-TEFb plays an unexpected role in regulating apoptosis...
- Topoisomerase II can unlink replicating DNA by precatenane removalI Lucas
, , 46 rue d'Ulm, F-75230 Paris Cedex 05, France
EMBO J 20:6509-19. 2001..We discuss the role of chromatin structure in driving DNA unlinking during S phase...
- Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaksOlivier Sordet
Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
EMBO Rep 10:887-93. 2009..Thus, we propose that Top1cc produce transcription arrests with R-loop formation and generate DSBs that activate ATM in post-mitotic cells...
- The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaksKatsuhiro Hanada
Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
Nat Struct Mol Biol 14:1096-104. 2007..We suggest that Mus81 suppresses chromosomal instability by converting potentially detrimental replication-associated DNA structures into intermediates that are more amenable to DNA repair...
- SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosisChristina Ivins Zito
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
J Cell Physiol 199:227-36. 2004..Taken together, these data indicate that the catalytic activity of SHP-2 is required to regulate the PI3K/Akt pathway and thus likely participates in anti-apoptotic signaling by suppressing caspase 3-mediated apoptosis...
- Global profiling of DNA replication timing and efficiency reveals that efficient replication/firing occurs late during S-phase in S. pombeMajid Eshaghi
Systems Biology, Genome Institute of Singapore, Singapore, Singapore
PLoS ONE 2:e722. 2007..Current studies of genome-wide DNA replication profiles have focused on the DNA replication timing and origin location. However, the replication and/or firing efficiency of the individual origins on the genomic scale remain unclear...
- ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1H Zhao
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
Mol Cell Biol 21:4129-39. 2001..In addition, this study implicates ATR as a direct upstream activator of Chk1 in human cells...
- Low-dose mitomycin C as a prophylaxis for corneal haze in myopic surface ablationIvey Thornton
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Ophthalmol 144:673-681. 2007..To evaluate the efficacy of low-dose (0.002%) mitomycin C (MMC) vs no prophylactic MMC (control) in reducing corneal haze after surface laser ablation...
- Activation of dormant origins of DNA replication in budding yeastC Santocanale
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK
Genes Dev 13:2360-4. 1999..These experiments show that some dormant replication origins are competent to fire during S phase and that passage of a replication fork through such origins can inactivate them...
- Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrestAnnapaola Franchitto
Laboratorio di Citogenetica Molecolare e Mutagenesi, DABAC, Universita della Tuscia, 01100 Viterbo, Italy
J Cell Biol 157:19-30. 2002..Together, these results suggest a relationship between BLM, ATR, and the RMN complex in the response to replication arrest, proposing a role for BLM protein and RMN complex in the resolution of stalled replication forks...
- Dynamic changes in subnuclear NP95 location during the cell cycle and its spatial relationship with DNA replication fociM Miura
Molecular Diagnosis and Therapeutics, Oral and Maxillofacial Radiology, Department of Oral Restitution, Graduate School, Tokyo, Japan
Exp Cell Res 263:202-8. 2001....
- Airway complications from topical mitomycin CElizabeth McCurdy Hueman
University of Texas Health Science Center San Antonio, TX 78229 3900, USA
Otolaryngol Head Neck Surg 133:831-5. 2005..The purpose of this study is to report complications related to mitomycin C use in the treatment of glottic and subglottic stenosis. Risk factors associated with these complications are identified...
- Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifosDan Qiao
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
Brain Res Dev Brain Res 147:183-90. 2003..At the same time, nicotine promotes trophic actions that protect against neurotoxicants that work through other mechanisms...
- Mitomycin: effects on laryngeal and tracheal stenosis, benefits, and complicationsR Rahbar
Department of Otolaryngology and Communication Disorders, The Children's Hospital, Boston, Massachusetts 02115, USA
Ann Otol Rhinol Laryngol 110:1-6. 2001..This study gives promising findings on the efficacy and safety of mitomycin-C as an adjuvant treatment in the management of selected cases of laryngeal and tracheal stenosis...
- Can mitomycin C really prevent airway stenosis?Jong Lyel Roh
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Laryngoscope 116:440-5. 2006..However, the efficacy of MMC is still debatable, and the potential complications of MMC use have been scarcely reported. We evaluated the efficacy and early complications of MMC in a wound model of the subglottis...
- Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shockJ M Park
National Creative Research Initiative Center for Genome Regulation, Department of Biochemistry, Yonsei University, 120 749, Seoul, South Korea
Mol Cell 8:9-19. 2001..Therefore, the activator-Mediator interaction likely underlies the initiation of signal transfer from enhancer-bound activators to the basal transcription machinery...
- Risk factors for adult laryngotracheal stenosis: a review of 74 casesYekaterina Koshkareva
Dept of Otolaryngology Head and Neck Surgery, Temple University School of Medicine, 3400 N Broad St, Kresge West 102, Philadelphia, PA 19140, USA
Ann Otol Rhinol Laryngol 116:206-10. 2007..We sought to identify risk factors for and review our experience in the management of adult acquired laryngotracheal stenosis (LTS) at an academic urban medical center...
- The role of mitomycin C in preventing synechia and stenosis after endoscopic sinus surgeryVijay K Anand
Department of Otorhinolaryngology Head and Neck Surgery, Weill Cornell Campus of New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
Am J Rhinol 18:311-4. 2004..Mitomycin C (MMC) has been used successfully in other fields to decrease postoperative scar formation. We hypothesize that the topical application of MMC reduces the incidence of stenosis and synechia formation after ESS...
- Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrestXiaoyan Lu
Department of Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 284:35325-37. 2009..These results indicate that in addition to its well studied role in promoting cell cycle progression, cyclin E also has a role in regulating cell cycle arrest in response to DNA damage...
- Increased DNA damage sensitivity of Cornelia de Lange syndrome cells: evidence for impaired recombinational repairMischa G Vrouwe
Department of Toxicogenetics, Leiden University Medical Center, Postal Zone S 6 P, PO Box 9600, 2300 RC, Leiden
Hum Mol Genet 16:1478-87. 2007..Repair at the G(1) stage is not affected in CdLS cells. Our studies indicate that CdLS cells have a reduced capacity to tolerate DNA damage, presumably as a result of reduced DNA repair through homologous recombination...
- Topical mitomycin application after laryngotracheal reconstruction: a randomized, double-blind, placebo-controlled trialC J Hartnick
Department of Pediatric Otolaryngology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
Arch Otolaryngol Head Neck Surg 127:1260-4. 2001..To explore the effect of mitomycin treatment on the pediatric airway following laryngotracheal reconstruction...
- Kinetics of HCMV immediate early mRNA expression in stably transfected fibroblastsSabine P Snaar
Department of Molecular Cell Biology, Laboratory for Cytochemistry and Cytometry, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
J Cell Sci 115:321-8. 2002..13 microm(2)/sec from this time on. Thus, it appears that these processes are tightly linked in time and space, with the splicing reaction as a rate-limiting factor...
- Treatment of complete nasal vestibule stenosis with vestibular stents and mitomycin CAmanda R Salvado
Head and Neck Surgery Department, UCLA Medical Center, Los Angeles, CA 90095, USA
Otolaryngol Head Neck Surg 138:795-6. 2008
- Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcriptionTimothy P Spann
Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
J Cell Biol 156:603-8. 2002..Furthermore, immunofluorescence observations indicate that this selective inhibition of polymerase II-dependent transcription involves the TATA binding protein, a component of the basal transcription factor TFIID...
- Intra- and postoperative application of Mitomycin C in the middle meatus reduces adhesions and antrostomy stenosis after FESSI Konstantinidis
2nd University ORL, Department, Papageorgiou Hospital, Thessaloniki, Greece
Rhinology 46:107-11. 2008..This study assesses the efficacy of topical mitomycin C in the middle meatus, intra- and postoperatively in the prevention of adhesion formation and restenosis of the maxillary sinus antrostomy...
- Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cellsO Hjertner
Institute of Cancer Research and Molecular Biology, and the Section of Hematology, Institute of Environmental Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Blood 97:516-22. 2001..BMP-4 or analogues may be attractive therapeutic agents in MM because of possible beneficial effects on both tumor burden and bone disease...
- An investigation of airway wound healing using a novel in vivo modelJ Hardillo
Department of Oto-Rhino-Laryngology Head and Neck Surgery, University Hospital St. Rafael, K.U. Leuven, Kapucijnenvoer 33, B-3000 Leuven, Belgium
Laryngoscope 111:1174-82. 2001..CONCLUSIONS: A wound healing model based on tracheal revascularization, isolation, and reimplantation was developed in rabbits. This model allowed us to study the healing of full-thickness mucosal defects inside the airway...
- Mitomycin-C in the treatment of tracheal cicatrix after tracheal reconstructionR F Ward
Department of Otolaryngology, Cornell University Medical College, Manhattan Eye, Ear and Throat Hospital, New York, NY, USA
Int J Pediatr Otorhinolaryngol 44:221-6. 1998..To demonstrate the potential use of Mitomycin-C (MMC) in the treatment of difficult and recurrent tracheal stenosis...
- Monte Carlo simulations and measurement of DNA damage from x-ray-triggered auger cascades in iododeoxyuridine (IUdR)S J Karnas
Department of Medical Biophysics, University of Western Ontario, London, Canada
Radiat Environ Biophys 40:199-206. 2001..The accentuated DNA damage may have major consequences for cell survival and may be exploitable in kilovoltage photon activation therapy (PAT) of tumors sensitized with iodine...
- Role of the cytoskeleton in secretion of chloride by shark rectal glandP Silva
Mount Desert Island Biological Laboratory, Salsbury Cove, Maine, MA 04670, USA
J Comp Physiol B 172:719-23. 2002....
- Two pathways for store-mediated calcium entry differentially dependent on the actin cytoskeleton in human plateletsJuan A Rosado
Department of Physiology, University of Extremadura, 10071 Caceres, Spain
J Biol Chem 279:29231-5. 2004....
- Corneal fibroblasts respond rapidly to changes in local mechanical stressW Matthew Petroll
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
Invest Ophthalmol Vis Sci 45:3466-74. 2004..To investigate the response of corneal fibroblasts to local changes in extracellular matrix (ECM) tension...
- Cell shape change precedes staurosporine-induced stabilization and accumulation of p27kip1Kayoko Nishi
Department of Biological Chemistry Schol of Medicine, University of Davis, Davis, California 95616, USA
Exp Cell Res 280:233-43. 2002..The results indicate that the cell shape change caused by staurosporine correlates with the accumulation of p27kip1 and that staurosporine interferes with the p27kip1-specific proteolysis activity...
- Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associatedIgnacio A Romero
Endothelial and Epithelial Cell Biology Unit, Department of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
Brain Res Mol Brain Res 105:47-59. 2002..Together these data suggest that ICAM-1 is not directly associated with ezrin and moesin in brain microvascular endothelial cells...
- Cell signaling pathways to alphaB-crystallin following stresses of the cytoskeletonNathalie Launay
EA 300 Stress et Pathologies du Cytosquelette, UFR de Biochimie, Universite Paris 7, 2 place Jussieu, 75005 Paris, France
Exp Cell Res 312:3570-84. 2006..Thus, disturbance of cytoskeleton leads by converging signaling pathways to the phosphorylation of alphaB-crystallin, which probably acts as a protective effector of the cytoskeleton...
- The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family membersMelanie Bausen
Department of Neurochemistry, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
Mol Cell Neurosci 31:376-86. 2006..Our data suggest that Mena binding to F-actin allows for gephyrin recruitment to the leading edge of uncapped actin filaments...
- Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesisIoannis P Nezis
Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Athens, Greece
Cell Motil Cytoskeleton 60:14-23. 2005..Interestingly, the mutated egg chambers are protected by staurosporine-induced apoptosis in a percentage of 40%, strongly suggesting the essential role of dcp-1 and/or pita during mid-oogenesis...
- Bombesin-dependent pro-MMP-9 activation in prostatic cancer cells requires beta1 integrin engagementClaudio Festuccia
Department of Experimental Medicine, University of L Aquila, Italy
Exp Cell Res 280:1-11. 2002..This finding supports the idea that cellular responses to growth factors may be driven by cell-matrix interactions and stresses the role of neuroendocrine factors in prostate carcinoma progression...
- IL-15 up-regulates iNOS expression and NO production by gingival epithelial cellsManabu Yanagita
Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Japan
Biochem Biophys Res Commun 297:329-34. 2002..The enhanced NO production by IL-15 was inhibited by AMT, an iNOS-specific inhibitor. These results suggest that IL-15 is a potent regulator of iNOS expression by HGEC and involved in innate immunity in the mucosal epithelium...
- Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinaseNobuo Watanabe
Department of Environmental Health Sciences, School of Public Health and Center for Free Radical Biology, University of Alabama at Birmingham, RPHB 317, 1530 3rd Ave S, Birmingham, AL 35294 0022, USA
Arch Biochem Biophys 405:231-40. 2002....
- Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2Anne Marie Preaux
Institut National de la Santé et de la Recherche Médicale U99, Hopital Henri Mondor, Creteil, France
Hepatology 36:615-22. 2002..In conclusion, apoptosis of hepatic myofibroblasts induces pro-MMP-2 activation through increased MT1-MMP expression. HEPATOLOGY 2002;36:615-622.)..
- Role of the actin cytoskeleton in store-mediated calcium entry in glioma C6 cellsPawelz Sabała
Laboratory of Signal Transduction, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Str, Warsaw, Poland
Biochem Biophys Res Commun 296:484-91. 2002..While the agonists evoke a store-mediated Ca2+ entry that is dependent on the actin cytoskeleton, thapsigargin apparently activates an additional mechanism, which is independent of the disruption of the cytoskeleton...
- Cytoskeletal changes of mesenchymal stem cells during differentiationGregory Yourek
Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA
ASAIO J 53:219-28. 2007..These data suggest human mesenchymal stem cells alter their cytoskeletal components during differentiation. Additional studies will address the mechanisms of cytoskeletal changes using biochemical and biophysical methods...
- Disruption of actin cytoskeleton and anchorage-dependent cell spreading induces apoptotic death of mouse neural crest cells cultured in vitroAtsushi Hinoue
Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Anat Rec A Discov Mol Cell Evol Biol 282:130-7. 2005..The spatially and temporally regulated expression of proteinases may be essential for the differentiation and migration of neural crest cells...
- Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1Mingzhe Zheng
Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
J Cell Sci 119:96-103. 2006..These results suggest that the adhesion-dependent actin organization regulates proteasomal turnover of HEF1 through the activity of PP2A...
- Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling componentsBrian P Head
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 281:26391-9. 2006..We conclude that microtubules and actin filaments restrict cAMP formation by regulating the localization and interaction of GPCR-G(s)-AC in lipid rafts/caveolae...
- The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and RhoZachary A Pfeiffer
Department of Biomecular Chemistry, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706 0450, USA
J Leukoc Biol 75:1173-82. 2004..These data support a model wherein p38- and Rho-dependent pathways are critical for P2X7-dependent actin reorganization and membrane blebbing, thereby facilitating P2X7 involvement in macrophage inflammatory responses...
- Fate of Streptococcus pyogenes and epithelial cells following internalizationMehran J Marouni
Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
J Med Microbiol 53:1-7. 2004..Concomitantly, intracellular and, apparently, extracellular free bacteria induce apoptosis through their cytotoxic activity, and release essential nutrients required for their growth...
- Stretch-induced contractile differentiation of vascular smooth muscle: sensitivity to actin polymerization inhibitorsAsad Zeidan
Division of Molecular and Cellular Physiology, Department of Physiological Sciences, Biomedical Center, Lund University, SE 221 84 Lund, Sweden
Am J Physiol Cell Physiol 284:C1387-96. 2003..Stretch-dependent differentiation marker expression requires an intact cytoskeleton for stretch sensing, control of protein expression via the level of unpolymerized G-actin, or both...
- Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cellsDmitry Kondrikov
Department of Medicine, Universityof Florida College of Medicine, Gainesville, FL 32610, USA
Am J Physiol Lung Cell Mol Physiol 290:L41-50. 2006..Yeast two-hybrid experiments suggested strong association between eNOS oxygenase domain and beta-actin. These results indicate increase in eNOS association with actin is responsible for greater eNOS activity in confluent PAEC...
- Mechanisms of internalization and recycling of the chemokine receptor, CCR5Anja Mueller
School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, UK
Eur J Biochem 271:243-52. 2004..These data indicate that CCR5 internalization and recycling are regulated by actin polymerization and activation of small G proteins in a Rho-dependent manner...
- T-cadherin protects endothelial cells from oxidative stress-induced apoptosisManjunath B Joshi
Department of Research, Cardiovascular Laboratories, Basel University Hospital, Basel, Switzerland
FASEB J 19:1737-9. 2005..ROS-induced changes in T-cad expression may play an important role in controlling tissue cellularity during vascular remodeling...
- Pathways for clearance of surfactant protein A from the lungDeepika Jain
Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 1 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104 6068, USA
Am J Physiol Lung Cell Mol Physiol 289:L1011-8. 2005..Thus SP-A clears the lung via a clathrin-mediated pathway that requires the polymerization of actin...
- Integrity of actin-network is involved in uridine 5'-triphosphate evoked store-operated Ca2+ entry in bovine adrenocortical fasciculata cellsMasahiro Kawamura
Department of Pharmacology I, Jikei University School of Medicine, Tokyo, Japan
J Pharmacol Sci 91:23-33. 2003....
- Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathwaysClaire R Weston
Signalling Program, The Babraham Institute, Cambridge, UK
Oncogene 22:1281-93. 2003..This may contribute to Raf- and Ras-induced cell survival at low serum concentrations...
- Mathematical modeling of airway epithelial wound closure during cyclic mechanical strainUshma Savla
Department of Biomedical Engineering, Northwestern University, Chicago, Illinois 60208, USA
J Appl Physiol 96:566-74. 2004..The contributions of spreading, migration, and mitosis were investigated both numerically and experimentally by using cytochalasin D to inhibit cell motility and mitomycin C to inhibit proliferation...
- An actin molecular treadmill and myosins maintain stereocilia functional architecture and self-renewalAgnieszka K Rzadzinska
Section on Structural Cell Biology, National Institute of Deafness and Other Communication Disorders, National Institutes of Health, Bldg 50 Rm 4249, 50 South Dr, Bethesda, MD 20892 8027, USA
J Cell Biol 164:887-97. 2004..We argue that actin renewal in the paracrystal follows a treadmill mechanism, which, together with the myosins, dynamically shapes the functional architecture of the stereocilia bundle...
- Regulation of NMDA receptors by neuregulin signaling in prefrontal cortexZhenglin Gu
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Neurosci 25:4974-84. 2005....
- Topical application of drugs influencing cytoskeleton and cell contractility affects alveolar bone loss in ratsAvinoam Yaffe
Department of Prosthodontics, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
J Periodontol 77:826-31. 2006....
- 2-Aminoethoxydiphenyl borate perturbs hormone-sensitive calcium stores and blocks store-operated calcium influx pathways independent of cytoskeletal disruption in human A549 lung cancer cellsShanthala Padar
Department of Physiology and Pharmacology, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA
Biochem Pharmacol 69:1177-86. 2005..Our study describes novel cytoskeletal-independent effects of 2-APB on Ca2+-signaling pathways, revealing differentially sensitive Ca2+-influx pathways and long-term perturbation of hormone-sensitive Ca2+ stores...
- p38 MAPK interacts with actin and modulates filament assembly during skeletal muscle differentiationAshwani Khurana
Signal Transduction Research Laboratory, Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Punjab, India
Differentiation 71:42-50. 2003..However, inhibition of p38 MAPK completely abolished the anisomycin-mediated actin remodeling. Data suggests that p38 MAPK interacts with actin and modulates actin filament rearrangement in differentiated L6E9 skeletal muscle cells...
- Role of adhesion and contraction in Rac 1-regulated endothelial barrier function in vivo and in vitroJ Waschke
Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
Am J Physiol Heart Circ Physiol 287:H704-11. 2004....
- Ca(2+) removal mechanisms in freshly isolated rabbit aortic endothelial cellsX Wang
Department of Pharmacology and Therapeutics, Vancouver Vascular Biology Research Center, University of British Columbia, Vancouver, Canada V6T 1Z3
Cell Calcium 31:265-77. 2002..These data suggest that in endothelial cells NCX and SERCA function in series to remove about half of the free Ca(2+) from the cytosol, while PMCA contributes to the other half of the Ca(2+) removal process...
- Distinct pathways in the over-expression of matrix metalloproteinases in human fibroblasts by relaxation of mechanical tensionC A Lambert
Laboratory of Connective Tissues Biology, , Tour of Pathology B23/3, 4000 Sart Tilman, , Belgium
Matrix Biol 20:397-408. 2001..These results point to the potent regulation operated by the status of the cytoskeleton on the cell phenotype, and to distinct regulatory pathways involved in the control of different MMPs expression...
- The effect of actin disrupting agents on contact guidance of human embryonic stem cellsSharon Gerecht
Harvard M I T Division of Health Sciences and Technology, USA
Biomaterials 28:4068-77. 2007..These findings further demonstrate the importance of interplay between cytoskeleton and substrate interactions as a key modulator of morphological and proliferative cellular response in hESCs on nanotopography...
- Acute modulation of the extent of apoB mRNA editing and the relative rates of syntheses of apoB48 and apoB100 in cultured rat hepatocytes by osmotic and other stress stimuliA McCahill
Institute of Biomedical and Life Sciences, University of Glasgow, Scotland
Mol Cell Biochem 208:77-87. 2000....
- Coordinated regulation of procollagens I and III and their post-translational enzymes by dissipation of mechanical tension in human dermal fibroblastsC A Lambert
Laboratory of Connective Tissues Biology, , Belgium
Eur J Cell Biol 80:479-85. 2001....
- Glycogen synthase kinase-3 regulates cytoskeleton and translocation of Rac1 in long cellular extensions of human keratinocytesLeeni Koivisto
Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada
Exp Cell Res 293:68-80. 2004..We conclude that extended lamellipodia formation in keratinocytes requires actin and tubulin assembly at the leading edge, and this process is regulated by Rac1 downstream of GSK-3...
- The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosisK Lauber
Department of Internal Medicine I, , , Germany
J Biol Chem 276:29772-81. 2001..Due to the partial loss of its CARD, the p84 multimer was devoid of caspase-9 or other caspase activity. Thus, our data indicate that Apaf-1 cleavage causes the release of caspases from the apoptosome in the course of apoptosis...
- Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cellsD Leopoldt
Department of Medicine, School of Medicine and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
J Cell Physiol 188:106-19. 2001..Thus, calyculin-A induces transient focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin, acting downstream of ROK...
- beta1 integrin and organized actin filaments facilitate cardiomyocyte-specific RhoA-dependent activation of the skeletal alpha-actin promoterL Wei
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
FASEB J 15:785-96. 2001..These observations support the concept that RhoA regulates SRF-dependent cardiac gene expression through cross-talk with beta1 integrin signal pathway via an organized actin cytoskeleton...
- The geodiamolide H, derived from Brazilian sponge Geodia corticostylifera, regulates actin cytoskeleton, migration and invasion of breast cancer cells cultured in three-dimensional environmentVanessa M Freitas
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
J Cell Physiol 216:583-94. 2008..The fact that normal cell lines were not affected by treatment with geodiamolide H stimulates new studies towards therapeutic use for this peptide...
- Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexesYi Duan
Department of Cellular and Molecular Physiology, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 105:11418-23. 2008....
- Regulation of calcineurin by growth cone calcium waves controls neurite extensionN J Lautermilch
Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0357, USA
J Neurosci 20:315-25. 2000..The results identify components of the cascade by which Ca(2+) waves act to regulate neurite extension...
- A novel model system for characterization of phagosomal maturation, acidification, and intracellular collagen degradation in fibroblastsP D Arora
Medical Research Council Group in Periodontal Physiology, The Faculty of Dentistry, and the Faculty of Medicine, Division of Respirology, University of Toronto, Toronto M5S 3E8, Ontario, Canada
J Biol Chem 275:35432-41. 2000..These studies demonstrate that the cellular machinery required for intracellular collagen degradation in fibroblasts closely resembles the vacuolar system in macrophages...
- Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticityD Frey
Friedrich Miescher Institute, CH 4058 Basel, Switzerland
J Cell Biol 149:1443-54. 2000....
- Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteinsF Degraeve
, Service de Pharmacologie et d'Immunologie, 91191 Gif sur Yvette, France
J Biol Chem 276:46849-55. 2001..These results demonstrate that statins up-regulate COX-2 expression and subsequent prostacyclin formation in human aortic smooth muscle cells in part through inhibition of Rho...
- [Cytoskeletal control of cell length regulation]M A Kharitonova
Cancer Research Center, Russian Academy of Medical Sciences, Kashirskove shosse 24, Moscow, 115478 Russia
Ontogenez 33:50-9. 2002....
- The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome cNatalie O Karpinich
Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 277:16547-52. 2002..The activation of p53 increases Bax synthesis. The translocation of Bax to the mitochondria induces the MPT, the event that releases cytochrome c and culminates in the death of the cells...
- Maintenance of the filamentous actin cytoskeleton is necessary for the activation of store-operated Ca2+ channels, but not other types of plasma-membrane Ca2+ channels, in rat hepatocytesYing Jie Wang
Department of Medical Biochemistry, School of Medicine, Faculty of Health Sciences, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia
Biochem J 363:117-26. 2002....
- Actin filament turnover removes bundles from Drosophila bristle cellsGregory M Guild
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
J Cell Sci 115:641-53. 2002..We propose that after cell elongation, maintenance falls behind turnover, resulting in the removal of this modular cytoskeleton...
- Dynamics of integrin clustering at focal contacts of endothelial cells studied by multimode imaging microscopyK Kawakami
Department of Physiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Showa-ku, Nagoya Aichi 4668550, Japan
J Cell Sci 114:3125-35. 2001..These results suggest that the clustering of integrins is mediated by actin-fiber-dependent translocation of integrins to the extending tip of focal contacts...
- Cell surface trafficking of Fas in NIT-1 cells and dissection of surface and total Fas expressionP Augstein
Gerhardt Katsch Institute of Diabetes Karlsburg e V, Greifswalder Strasse 11e, 17495 Karlsburg, Germany
Biochem Biophys Res Commun 290:443-51. 2002..It is concluded that inflammatory insults specifically induce translocation of Fas to the beta-cell surface and that interference with cell surface Fas expression is a new strategy to improve beta-cell survival in inflamed islets...
- Synergistic enhancement of apoptosis by DNA- and cytoskeleton-damaging agents: a basis for combination chemotherapy of cancerX Shang
National Institute of Bioscience and Human Technology, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
Anticancer Res 21:2585-9. 2001..03. Thus, apoptosis in many tumor cell lines is synergistically enhanced by various combinations of DNA- and cytoskeleton-damaging agents...
- Centrosome cohesion is regulated by a balance of kinase and phosphatase activitiesP Meraldi
Department of Cell Biology, Max-Planck-Institute for Biochemistry, D-82152 Martinsried, Germany
J Cell Sci 114:3749-57. 2001..These studies highlight the importance of protein phosphorylation in the control of centrosome cohesion, and they point to Nek2 and PP1 alpha as critical regulators of centrosome structure...
- Inducible nitric oxide synthase in vascular smooth muscle cells from prehypertensive spontaneously hypertensive ratsA Singh
MRC Multidisciplinary Research Group on Hypertension, , , , Canada
Am J Hypertens 9:867-77. 1996..These differences between VSMC from prehypertensive SHR and WKY may indicate a pathophysiological role of iNOS in early blood pressure elevation in SHR...
- Cytoskeletal inhibitors, anti-adhesion molecule antibodies, and lectins inhibit hepatocyte spheroid formationMasaki Nakamura
Department of Internal Medicine I, Okayama University Medical School, Japan
Acta Med Okayama 56:43-50. 2002..Based on the interactions between lectins and hepatocytes in the present study, hepatocytes appear to contain an N-linked complex or N-linked hybrid glycosylated chains...
- Differential regulation of choriocarcinoma gene expression by DNA synthesis inhibitorsJ L Arbiser
Division of Endocrinology, Children s Hospital, Boston, MA 02115
Endocr J 40:263-8. 1993..This indicates that the downregulation of c-myc gene expression is insufficient to stimulate the expression of all the placental genes stimulated by MTX...
- Effects of inhibitors of RNA and protein synthesis on the subcellular distribution of the eukaryotic translation initiation factor, eIF-5A, and the HIV-1 Rev proteinX P Shi
Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
Biol Signals 6:143-9. 1997..Our findings are consistent with our previous conclusion that eIF-5A is associated with the ER through ribosomes and support a role for eIF-5A in protein synthesis...
- Human cytomegalovirus replicates abortively in polymorphonuclear leukocytes after transfer from infected endothelial cells via transient microfusion eventsG Gerna
Servizio di Virologia, Area Infettivologica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, 27100 Pavia, Italy
J Virol 74:5629-38. 2000....
- Differences in wound-induced changes in cell-wall peroxidase activities and isoform patterns between seedlings of Prosopis tamarugo and Prosopis chilensisGabriele Lehner
Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
Tree Physiol 23:443-52. 2003..tamarugo prior to wounding, and the activity of acidic cell-wall peroxidases increased after wounding in P. tamarugo but not in P. chilensis, we conclude that P. tamarugo is more tolerant to wound stress than P. chilensis...
- Comparison of lesions induced by intra-articular injections of quinolones and compounds damaging cartilage components in rat femoral condylesS Takada
Drug Safety Research Center, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
J Toxicol Environ Health 42:73-88. 1994..Disruption of the collagen framework is suspected to contribute to their development. Involvement of altered DNA metabolism may play a role in the chondrocyte necrosis that occurs early in the specific sites...
- Mechanism of sgk action in the collecting ductGeza Fejes Toth; Fiscal Year: 2005..abstract_text> ..
- MECHANISMS OF SYNAPTIC PLASTICITY IN THE HIPPOCAMPUSRobert Malenka; Fiscal Year: 1993..This in turn may eventually lead to pharmacological interventions which either promote the ability to learn and remember or retard the deterioration of this ability...
- TRANSFORMATION ASSOCIATED ENHANCEMENT OF DRUG RESISTANCEANNA HILL; Fiscal Year: 1993..These studies will allow us to test whether transformed cells have higher rates of genome instability and whether genome instability plays an important role in acquired drug resistance...
- REGULATION OF P53 STABILITY BY SER315 PHOSPHORYLATIONMats Ljungman; Fiscal Year: 2002..We will express wild-type or mutant CDC14 in MCF7 cells and study what effect it will have on basal and induced levels of p53. ..
- Novel Antifungal Strategies for Lethal MucormycosisAshraf Ibrahim; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- INTEGRIN REGULATION AND FUNCTIONS IN ADULT BRAINChristine Gall; Fiscal Year: 2007..As a consequence these findings are important for understanding basic mechanisms of neuronal communication and survival in the adult CNS. ..
- HDAC4 Viability: Unique Mechanisms and FunctionGary Kao; Fiscal Year: 2007..When aspects of this unique and vital feedback loop are interrupted, cellular death ensues. ..
- DEVELOPMENT OF AN IN VITRO WOUND HEALING MODELFrederick Grinnell; Fiscal Year: 2008..Specific Aim #3 focuses on the factors that contribute to apoptosis of cells undergoing stressed matrix contraction. ..
- NICHD Institutional Training for PediatriciansKathryn Edwards; Fiscal Year: 2007..3.) Evaluate the success of the training program through both process and outcomes evaluation. (4.) Implement continuous quality improvement procedures that will enhance the PPOR components, curriculum, and overall program. ..
- QUINOLONE RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUSDavid Hooper; Fiscal Year: 2007..abstract_text> ..
- FUNCTION OF RAS ACTIVITY LATE IN THE CELL CYCLEDennis Stacey; Fiscal Year: 2006..Studies of related molecules will also be performed. Eventually, it is our goal to understand in detail the role of G2 events in the control of cell growth. ..
- Attenuation of mucous cell metaplasia by RadMary Chang; Fiscal Year: 2006..In summary, we have proposed a comprehensive approach utilizing combined in vitro, cell, and in vivo methods to test our hypothesis. ..
- Role of myosin-1 in membrane and actin dynamicsChristina King Smith; Fiscal Year: 2005..3) To determine the relationship between the mechanical activity of myo1c and membrane dynamics. We will express myo1c mutants that have altered motor properties, and we will examine the effect of these mutants on membrane dynamics. ..
- Regulation of Lung Epithelial Fibrinolysis by UrokinaseSreerama Shetty; Fiscal Year: 2005..This information could hasten the development of new, mechanism-based interventions for lung disorders, including acute lung injury or lung neoplasia. ..
- Chemokines, nitric oxide, and myocardial depressionBysani Chandrasekar; Fiscal Year: 2005..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
- CELL ADHESION MOLECULES OF MAMMALIAN FERTILIZATIONJanice Evans; Fiscal Year: 2008..This research also will also address fundamental questions in cell adhesion biology by examining this interesting, biologically relevant cell-cell interaction event. ..
- CYTOTOXIC NITROGEN HETEROCYCLESEdwin Vedejs; Fiscal Year: 2008..abstract_text> ..
- LAMIN A PROGERIA MUTATIONS AND NUCLEAR FUNCTIONRobert D Goldman; Fiscal Year: 2010..These collective studies will provide important insights into how hLA mutations cause the defects seen in progeria. ..
- Regulation of Xenopus Embryonic Development by TGFbeta Superfamily Ligands and SMMALCOLM R WHITMAN; Fiscal Year: 2010..The study of TGF superfamily ligands provides a common approach, and a common set of molecular tools, with which to understand the regulation of these important physiological processes. ..
- Targeting Tumor Angiogenesis with G-Quadruplex BindersDaekyu Sun; Fiscal Year: 2010..abstract_text> ..
- INTERMEDIATE FILAMENT CELL SURFACE INTERACTIONSRobert D Goldman; Fiscal Year: 2010....
- MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSEDavid R Brown; Fiscal Year: 2010....
- Molecular Physiology of Polycystin-2Horacio F Cantiello; Fiscal Year: 2010..Our studies will provide a more complete understanding of polycystin-2 function, and will define the molecular basis of cystic diseases, including ADPKD. ..
- Functional assessment of donor-host cell couplingMICHAEL RUBART VAN DER LOHE; Fiscal Year: 2009..The studies proposed here will address fundamental hypotheses regarding the fate of donor cells following cellular transplantation into normal and injured hearts. ..
- Purine Analog Anti-Mycobacterial Drug DevelopmentWilliam Parker; Fiscal Year: 2009..tb activity;and (4) design and synthesis of purine and purine nucleoside analogs with selective activity against M. tb. ..
- INTERMEDIATE FILAMENT CELL SURFACE INTERACTIONSRobert Goldman; Fiscal Year: 2008..The latter include the formation of Mallory bodies in alcoholic liver disease and Lewy bodies in Parkinson's disease. ..
- The Zebrafish Radioresponse for High-Throughput and -Content Molecular ScreeningGary Kao; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Architecture of Basal Fiber Components in the LensKRISTIN AL GHOUL; Fiscal Year: 2008..The proposed studies represent a logical extension of our previous work and will advance the field by defining the molecular organization of the BMC during normal and abnormal fiber end migration. ..
- Regulation of ribonucleotide reductase in Aedes aegyptiDAPHNE PHAM; Fiscal Year: 2005..We will then use the basal factors to trap the blood-meal inducible factors. ..
- MECHANISM AND REGULATION OF ACTIN-BASED RETROGRADE FLOWJOHN HENSON; Fiscal Year: 2005..4. To study the inducible transformation of coelomocytes from a lamellipodial to a filopodial form. ..
- ROLE OF THE FAS ANTIGEN IN OVARIAN CELL APOPTOSISSUSAN QUIRK; Fiscal Year: 2004..Understanding pathways that promote or prevent susceptibility of ovarian cells to apoptosis may lead to development of novel therapies for ovarian and other cancers. ..
- AUTOANTIGEN RNA HELICASE II/GUBenigno Valdez; Fiscal Year: 2003..This study may also provide an impetus for understanding the pathological roles of RH-II/Gu on the elicitation of autoimmune responses. ..
- DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEMTheodore Slotkin; Fiscal Year: 2003....
- Actin and myosins in organelle motilityChristina King Smith; Fiscal Year: 2003..The proposed research will contribute to a better understanding of actin-dependent organelle motility, a universal characteristic of eukaryotic cells. ..
- TRANSLATIONAL CONTROL MEDIATED BY MRNA STRUCTUREMarilyn Kozak; Fiscal Year: 2002..The reason why 40S ribosome/factor complexes protect "extra" sequences, which are accessible to RNase in 80S initiation complexes, will be studied. ..
- Regulation of Fibrogenesis by the Dietary FlavonoidsDennis Ricupero; Fiscal Year: 2002....
- DNA LIGASE I AS A POTENTIAL TARGET FOR ANTICANCER DRUGSDaekyu Sun; Fiscal Year: 2002..3) Test whether DNA ligase I inhibition produces antitumor activity using antisense strategy in preclinical in vitro and in vivo evaluation systems. 4) Develop a sensitive and reproducible assay for DNA ligase I. ..
- COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDYPhilip Chen; Fiscal Year: 2002....
- TRANSCRIPTIONAL REGULATION OF INSECT FERRITINDAPHNE PHAM; Fiscal Year: 2002....
- INTRACELLULAR TRAFFICKING OF TROPOELASTINFrederick Grinnell; Fiscal Year: 2002....
- DIABETIC AUTONOMIC NEUROPATHYPhillip Low; Fiscal Year: 2001..abstract_text> ..
- BEHAVIORALLY INDUCED NEUROCHEMICAL PLASTICITYChristine Gall; Fiscal Year: 2001..The proposed work will provide a first test for their presence in regions engaged learning behaviors. ..
- PROLACTIN AND ENDOTHELIAL WOUND REPAIR IN VITROCARRIE MERKLE; Fiscal Year: 2001..State-of-the-art imaging techniques, including light microscopy and electron microscopy, and biochemical methods, e.g. the polymerase chain reaction and Western blot analysis, will be employed. ..
- GENETIC MECHANISMS OF ESTROGEN ATHEROPROTECTIONAmparo Villablanca; Fiscal Year: 2003..Advances in our basic understanding of mechanisms of hormone action could lead to more effective strategies for treatment of coronary artery disease in both men and women. ..
- ATR in Human Cancer and Anticancer TherapyWilliam Cliby; Fiscal Year: 2004..Using xenograft models we will develop a gene therapy model of ATR disruption to test the safety and efficacy of targeting ATR for anticancer therapy. ..
- Peripheral Nerve IschemiaPhillip Low; Fiscal Year: 2004..We will then define the therapeutic windows and evaluate the mechanisms of production of hypothermic and antioxidant neuroprotection (Specific aim number 2) from reperfusion injury. ..
- Control of topoisomerose II through the cell cycleDennis Stacey; Fiscal Year: 2004..Perhaps our studies of these slowly cycling cells will yield information of value in understanding these temporarily non-cycling tumor cells and their sensitivity to drug treatment. ..
- MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITYTheodore Slotkin; Fiscal Year: 2004..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
- Treatment of Fungal Infections with ATAK CellsAshraf Ibrahim; Fiscal Year: 2004..Furthermore, the genetic construct targeting ATAK cells to Candida can easily be adapted to any other pathogen against which a MAb has been raised. ..
- CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASESreerama Shetty; Fiscal Year: 2004..abstract_text> ..
- RADIODIAGNOSIS & RADIOTHERAPY OF LUNG CANCER METASTASESAMIN KASSIS; Fiscal Year: 2004....
- Molecular mechanism of antibiotic rifampicin actionIrina Artsimovitch; Fiscal Year: 2006..Finally a set of rules for design of more potent rifamycin-like antibiotics will be formulated to achieve the long-term goal of knowledge-based creation of the new generation of antibacterial drugs. ..
- Podocyte Protein Alterations Induced by GlucocorticoidsRichard Ransom; Fiscal Year: 2005..Identification of a potential mechanism for glucocorticoid action in the treatment of NS would permit the development of more highly targeted and less toxic therapies for this very common form of kidney disease. ..
- Fetal & Adolescent Nicotine Effects on CNS 5HT SystemsTheodore Slotkin; Fiscal Year: 2003..abstract_text> ..
- INDUCTION OF MAMMARY CANCER BY SIGNALING MOLECULESSteven Anderson; Fiscal Year: 2003..These studies will provide new information about the effect of the prolactin receptor upon mammary epithelial cells, and whether suppression of apoptosis in Important in mammary carcinogenesis. ..
- THERAPY FOR GASTROINTESTINAL DISORDERSElizabeth Dial; Fiscal Year: 2002..Development of this therapeutic potential for rhLF will fulfill a crucial need for a way to safely administer NSAIDs. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
- Zinc transport and homeostasis in cortical neuronsRobert Colvin; Fiscal Year: 2002..What is the identity of Zn2+ containing compartments in the cell body and processes of cortical neurons?..
- Biochemical analysis of Pol II elongation complexes and mechanismCRAIG KAPLAN; Fiscal Year: 2007..Insights into Pol II function will allow a better understanding of how Pol II may be misregulated in disease states in other species, such as humans. [unreadable] [unreadable] [unreadable]..