Virtual Cells Could Speed Drug Discovery
Researchers have developed software that simulates the workings of individual bacterial cells, which could accelerate drug discovery and help fight cancer and bioterrorism.Using programs developed to simulate stock markets and warfare, researchers at the University of Chicago have developed software to simulate a more complicated process: the workings of an individual bacterial cell. The tool, called AgentCell, could speed drug discovery and help fight cancer and bioterrorism. Researchers could get results in less time using virtual cells rather than real ones. They also could avoid working with dangerous pathogens. And so far, digital experiments predicting how bacteria will swim in response to environmental cues have produced results similar to those from experiments using real bacteria, for both single cells and bacteria populations, according to a paper published this month in the journal Bioinformatics by Philippe Cluzel, Thierry Emonet and others at the University of Chicagos Institute for Biophysical Dynamics.
The "digital cells" are virtual versions of the species E. coli, the microbial equivalent of a laboratory rat. These digital bacteria can sense likely food molecules in a virtual environment. They can transmit biochemical signals to their flagella, whiplike structures that bacteria use for locomotion, correctly mimicking how the bacteria will move.