James M Beck
Affiliation: University of Colorado Denver
- Combined exposure to cigarette smoke and nontypeable Haemophilus influenzae drives development of a COPD phenotype in miceShyamala Ganesan
Department of Pediatrics and Communicable Diseases, University of Michigan, 1150 W, Medical Center Dr, Ann Arbor, MI 48109 5688, USA
Respir Res 15:11. 2014..Therefore, CS may interact with other factors, particularly respiratory infections, in the pathogenesis of airway remodeling in COPD...
- Abnormalities in host defense associated with HIV infectionJames M Beck
Medicine Service, Veterans Affairs Eastern Colorado Health Care System, Denver, CO 80220, USA
Clin Chest Med 34:143-53. 2013..This review summarizes the pulmonary host defense deficits in HIV-infected individuals, focusing on lymphocytes, alveolar macrophages, and neutrophils...
- The microbiome of the lungJames M Beck
Pulmonary Section, Medical Service, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, MI, USA
Transl Res 160:258-66. 2012..As this field advances over the next several years, we anticipate that studies using larger cohorts, multicenter designs, and longitudinal sampling will add to our knowledge and understanding of the lung microbiome...
- Critical roles of inflammation and apoptosis in improved survival in a model of hyperoxia-induced acute lung injury in Pneumocystis murina-infected miceJames M Beck
Department of Veterans Affairs Medical Center, Ann Arbor, MI 48105, USA
Infect Immun 77:1053-60. 2009..murina-infected mice exposed to hyperoxic stress by inhibition of inflammation and apoptosis...
- Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expressionJill C Todt
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Care System, Ann Arbor, MI, 48109 2399, USA
Respir Res 14:33. 2013..We investigated whether smoking reduces expression by human lung macrophages (Mø) of receptors for viral nucleic acids and, if so, the effect on CXCL10 production...
- The immunocompromised host: HIV infectionJames M Beck
Division of Pulmonary and Critical Care Medicine 111G, University of Michigan Medical School, and Medical Service, Department of Veterans Affairs Medical Center, 2215 Fuller Road, Ann Arbor, MI 48105, USA
Proc Am Thorac Soc 2:423-7. 2005..An improved understanding of these events in the lung during HIV infection could lead to specific interventions aimed at restoration of deficient function...
- Pneumocystis murina infection and cigarette smoke exposure interact to cause increased organism burden, development of airspace enlargement, and pulmonary inflammation in micePaul J Christensen
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
Infect Immun 76:3481-90. 2008..P. murina and cigarette smoke exposure interact to cause increased lung inflammatory cell accumulation. These findings establish a novel animal model system to explore the role of Pneumocystis species in the pathogenesis of COPD...