Ipilimumab: In Previously Treated Patients with Advanced Melanoma
Sanford M – Novel immune–related events that are not typical of other anticancer agents, most commonly dermatologic and gastrointestinal disorders, can occur with ipilimumab, necessitating specific monitoring and management protocols. In the phase III trial, grade 3/4 immune–related adverse events occurred in 10–15% of ipilimumab 3 mg/kg recipients versus 3% of gp100 peptide vaccine plus placebo recipients. In all, 2.1% of patients died as a result of treatment–related adverse events, with half of the deaths attributed to immune–related adverse events.
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