Neurotrophic rationale in glaucoma: A TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo
Article first published online: 28 FEB 2007
Copyright © 2007 Wiley Periodicals, Inc.
Volume 67, Issue 7, pages 884–894, June 2007
How to Cite
Shi, Z., Birman, E. and Saragovi, H. U. (2007), Neurotrophic rationale in glaucoma: A TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo. Devel Neurobio, 67: 884–894. doi: 10.1002/dneu.20360
- Issue published online: 16 MAY 2007
- Article first published online: 28 FEB 2007
- Manuscript Accepted: 1 NOV 2006
- Manuscript Revised: 21 OCT 2006
- Manuscript Received: 1 SEP 2006
- Canadian Institutes of Health Research. Grant Numbers: MT13265, MOP57690, CI-CFAA-41478
- National Institutes of Health. Grant Numbers: CA82642, NS38569, CA74289
- ocular hypertension
Glaucoma is a major cause of vision impairment, which arises from the sustained and progressive apoptosis of retinal ganglion cells (RGC), with ocular hypertension being a major risk or co-morbidity factor. Because RGC death often continues after normalization of ocular hypertension, growth factor-mediated protection of compromised neurons may be useful. However, the therapeutic use of nerve growth factor (NGF) has not proven effective at delaying RGC death in glaucoma. We postulated that one cause for the failure of NGF may be related to its binding to two receptors, TrkA and p75. These receptors have distinct cellular distribution in the retina and in neurons they induce complex and sometimes opposing activities. Here, we show in an in vivo therapeutic model of glaucoma that a selective agonist of the pro-survival TrkA receptor was effective at preventing RGC death. RGC loss was fully prevented by combining the selective agonist of TrkA with intraocular pressure-lowering drugs. In contrast, neither NGF nor an antagonist of the pro-apoptotic p75 receptor protected RGCs. These results further a neurotrophic rationale for glaucoma. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007.