Crumley, Andrew B.C.
An investigation of the relationship between the inflammatory response and outcome in patients with gastro-oesophageal cancer.
MD thesis, University of Glasgow.
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The thesis reviews the literature regarding the relationship between the local and systemic inflammatory responses and outcome in patients with gastro-oesophageal cancer. The study chapters then examine the relationship between the systemic inflammatory response and survival, in operable and inoperable disease and within, a cohort treated with palliative chemotherapy. The local inflammatory response and its relationship with tumour related factors, the systemic inflammatory response and survival, was examined in patients who underwent potentially curative surgery Also, the clinical utility of a systemic inflammation based score (Glasgow Prognostic Score) as a part of clinical staging, was then examined. The importance of these studies in a scientific and clinical context are discussed. Future work is also discussed.
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