Abstract: Four new bibenzyl derivatives were isolated, together with other known bibenzyls, by bioassay-guided fractionation of a CHCl3-MeOH extract of Notholaena nivea Desv. (Pteridaceae) aerial parts. The structures were elucidated by NMR, ESIMS and other spectral analyses. Their antioxidative effects towards superoxide, lipidic peroxidation and the 2,2'-azino-bis-3-ethilbenzothiazoline-6-sulfonic acid (ABTS) radical were assayed. Results showed that the compound 3,12-dihydroxy-5-methoxybibenzyl (6) is the most active compound in the ABTS free-radical scavenging test, while in the coupled oxidation of β-carotene and linoleic acid assay the compound 5,12-dihydroxy-3-methoxydibenzyl-6-carboxylic acid (1) exerted the highest activity after 1h. A superoxide anion enzymatic test was also carried out and the results were confirmed by an inhibition of xanthine oxidase activity assay. The putative protective role played by compounds 1 and 6 on the injurious effects of reactive oxygen metabolites on the intestinal epithelium, using a Caco-2 human cell line, was investigated. H2O2-induced alterations were prevented by preincubating the cells with compounds 1 and 6.
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Cioffi, G.; Montoro, P.; Ugaz, O.L.D.; Vassallo, A.; Severino, L.; Pizza, C.; Tommasi, N.D. Antioxidant Bibenzyl Derivatives from Notholaena nivea Desv.. Molecules 2011, 16, 2527-2541.
Cioffi G, Montoro P, Ugaz OLD, Vassallo A, Severino L, Pizza C, Tommasi ND. Antioxidant Bibenzyl Derivatives from Notholaena nivea Desv.. Molecules. 2011; 16(3):2527-2541.
Cioffi, Giuseppina; Montoro, Paola; Ugaz, Olga Lock De; Vassallo, Antonio; Severino, Lorella; Pizza, Cosimo; Tommasi, Nunziatina De. 2011. "Antioxidant Bibenzyl Derivatives from Notholaena nivea Desv.." Molecules 16, no. 3: 2527-2541.