From Dr. Schelling's site;
(V-1) The Dynamics of Lesion Formation
The development of the pattern of a lesion depends, in the final analysis, on plain mechanical principles. The first clues for determining the cause of a particular kind of injury are thus to be derived from its outer shape and inner organization. In multiple sclerosis, a sober consideration of the patterns of lesion “dissemination", i.e. of the "fibre-borne" extension of patches in the spinal cord's flanks, and the eccentric expansion of homogenous plaques from definite brain veins, will clarify several significant points:
Which forces are capable of bringing about the particular changes via the structures from which the lesions originate and in the observed directions and ranges of spread?
In which ways are the injurious forces transmitted onto the structures and zones from which the lesions arise?
From which sources do the injurious impulses arise?
Which forces control and check the lesion spread?
Reading the content of Dr. Schelling's site will give more understanding to the article of Dr. Trevor Tuckers.