16-March-2010 - Anesthesia increases risk of developing Alzheimer’s disease in patients with genetic predisposition
Madrid, Spain –The use of repetitive anesthesia with isoflurane (one of the most common anesthetics by inhalation) increases the risk of developing changes similar to those observed in AD brains in mice with mutations of the amyloid precursor protein (APP). This is the main conclusion of Spanish researchers coordinated by Doctors Maria Ángeles Mena and Justo García de Yébenes, from CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas). The work has been published an authoritative publication in this area of pathlogy: Journal of Alzheimer’s Disease. Other participants in the study are Juan Perucho, Isabel Rubio, María J. Casarejos, Ana Gómez, José A. Rodríguez-Navarro, Rosa M. Solano, from the Neurobiology and Neurology Departments at Hospital Ramón y Cajal in Madrid.
The findings suggest a possible mechanism of developing Alzheimer. Some epidemiological studies have shown an increased prevalence of AD in patients undergoing anesthesia and surgery. Doctor Justo García de Yébenes states that “before surgery requiring anesthesia, it may be ideal to know the genetic background of the patients so that the drugs used and the pattern of anesthesia may be personalized accordingly.”
The linkage between the repetitive use of isoflurane anesthesia and the development of AD changes in mice with mutations indicates the advisability of testing for genetic risk factors for AD in patients prior to surgery. Until recently, the most important genetic risk factor for AD was the presence of the allele E4 of the apolipoprotein E, but recently other genetic polymorphisms of risks have been identified. Once these polymorphisms of risks are identified and their relative impact on the pathogenesis of AD are known, a simple, automatic test for risk of AD should be performed in patients, namely the elderly, undergoing surgery under general anesthesia and the anesthetic procedure should be modified accordingly. A personalized clinical model that would enable the reduction of the patient’s potential risk for AD would reduce the risk of anesthesia.
The research has been based on the application of anesthesia twice a week during three months in normal mice and in mice with mutations (7-10 months old) that produce AD (known as APPswe ). The results show alterations produced in the brain of mice with mutations very similar to those observed in patients that have already developed Alzheimer’s disease.
Study highlights :
AD usually is the main cause of dementia for people over 65
Memory loss, language problems, incapacity for decision making and discernment are some of the main traits of this disease.
Excellence of CIBERNED researchers
Doctor María Ángeles Mena, study coordinator, Director of Neuropharmacology at Hospital Ramón y Cajal, main CIBERNED co-researcher of Hospital Ramón y Cajal.
Doctor Justo García de Yébenes focuses on care of patients suffering neurodegenerative diseases and on the research of its molecular aspects. Director of neurodegenerative diseases unit at Hospital Ramón y Cajal, Madrid.
Other participants in this study are Juan Perucho, Isabel Rubio, María J. Casarejos, Ana Gómez, José A. Rodríguez-Navarro, Rosa M. Solano, from the Neurobiology and Neurology Departments at Hospital Ramón y Cajal in Madrid.