Pathology for Urologists
Sertoli Cell-Only Syndrome
- Patients present with normal external genitalia, well-developed secondary sex characteristics, and azoospermia.
- Elevated FSH, normal/elevated LH, and normal/low testosterone.
- Seminiferous tubules contain only Sertoli cells with rare scattered spermatogonia.
- Low-power impression is a "wind-swept" appearance to the tubules
- Five variants have been described, based upon the nature of the Sertoli cells.