importance in metabolism...or in strict aerobes, however. Instead, in these organisms two molecules of acetyl coenzyme A give rise to the net synthesis of a four-carbon intermediate of the TCA cycle via a route known as the glyoxylate cycle. In this route (Figure 8), the steps of the TCA cycle that lead to the loss of carbon dioxide (see , , and ) are bypassed. Instead of being oxidized to oxalosuccinate, as...Similar reasoning, though in the opposite sense, can be applied to the control of another anaplerotic sequence, the glyoxylate cycle (Figure 8). The biosynthesis of cell materials from the two-carbon compound acetate is, in principle, akin to biosynthesis from TCA cycle intermediates. In both processes, it is the availability of intermediates such as PEP and pyruvate that determines the rate at...
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