ScienceDaily Nicole Giese Rura 27 April 2012
Whitehead Institute researchers have pulled STR identification into the 21st Century by creating lobSTR, a three-step system that accurately and simultaneously profiles more than100,000 STRs from a human genome sequence in one day — a feat that previous systems could never complete. The lobSTR algorithm first scans an entire genome to identify all STRs and what nucleotide pattern is repeated within those stretches of DNA. Then, lobSTR notes the non-repeating sequences flanking either end of the STRs. These sequences anchor each STR’s location within the genome and determine the number of repeats at the STRs. Finally, lobSTR removes any “noise” to produce an accurate description of the STRs’ configuration.
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