- Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion proteinS Chandler
British Biotech Pharmaceuticals Ltd, Cowley, Oxford, UK
Biochem Biophys Res Commun 228:421-9. 1996..Thus, in common with several other MMPs, macrophage metalloelastase has a broad substrate range which extends beyond that of elastin alone...
- Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overviewS Chandler
British Biotech Pharmaceuticals Limited, Cowley, Oxford, UK
J Neuroimmunol 72:155-61. 1997..MMP expression will contribute to the tissue destruction and inflammation in MS. Drugs which inhibit MMP activity are effective in animal models of MS and may prove to be useful therapies in the clinic...