Description of Research: Powel Kazanjian
MEDICAL RESEARCH: AIDS ASSOCIATED OPPORTUNISTIC INFECTIONS
Our group is interested in how OIs have been influenced
by antimicrobial prophylaxis and HIV therapy.
Host Defense Defects: Phagocytes
Our work has shown that microbicidal activity in AIDS
patients is reduced, possibly due to impaired leukotriene
synthesis, and that addition of cytokines augments
intracellular killing, possibly by upregulating 5-lipoxegenase
Sulfa Prophylaxis and Pneumocystis carinii drug resistant
We have shown that sulfa prophylaxis use in AIDS patients
with PCP is associated with mutations in the sulfa
binding site of the P carinii DHPS gene, but not yet
influenced response to sulfa therapy.
HAART Responses and OI Incidence Rates
We have shown that an incomplete virologic reduction
is a significant risk factor for OI, and in patients
with multi-resistant HIV, maintaining virologically
failing regimens reduces OI rates and maintains CD4
HISTORICAL RESEARCH: EPIDEMIC DISEASES THROUGHOUT
We are exploring the initial reluctance to accept
the scientific finding that bubonic plague was the
cause of a 1901 outbreak in San Francisco and the
eagerness to accept sterilization procedures to halt
the spread of commercial botulism in 1922 to gain
a greater understanding of how new ideas become incorporated
into the medical profession. This work is used to
provide the historic roots to current AIDS, public
health, and research trends.
Gandhi T, Wei W, Amin K, Kazanjian P. Effect of Maintaining HAART on AIDS Events in Late Stage HIV-Infected Patients with Inadequate CD4 and Viral Responses. Clin Infect Dis 2006; 42:878-84.
Weber J, Weberova J, Carobene M, Mirza M, Martinez-Picado J, Kazanjian P, and Quiñones-Mateu ME. Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness. J of Virol Methods 2006; 136(1):102-17.
Riddell J, Kaul D, Karakousis P, Gallant J, Mitty J, and Kazanjian, P. Mycobacterium avium complex immune reconstitution inflammatory syndrome: long term outcomes. J Transl Med 2007; 5(1):50.
Gandhi T, Nagappan V, Cinti S, Wei W, and Kazanjian P. Long-term immunologic and virologic responses in patients with highly resistant HIV infection who are treated with an incompletely suppressive antiretroviral regimen. Clin Infect Dis 2007; 45(8):1085-92.
Markowitz M, Slater L, Schwartz R, Kazanjian P, Hathaway B, Wheeler D, Goldman M, Neubacher D, Mayers D, Valdez H, McCallister S, and the BI 1182.2 Study Team. Long-term efficacy and safety of Tipranavir boosted with Ritonavir in HIV-1-infected patients failing multiple protease inhibitor regimens: 80-week data from a phase 2 study. JAIDS 2007; 45(4) 401-10.
Kazanjian, P. Frederick G. Novy and the Rat Virus. Annals of Internal Medicine. 2012;156:234-237.
Riddell J, Quint D, Kazanjian P. Hematogenous Coagulase Negative Staphylococcal Vertebral Body Osteomyelitis. Infect Dis Clin Pract 20(6):400-403, November 2012.
Kazanjian, P. Frederick Novy and the 1901 San Francisco Plague Commission Investigation. Clinical Infectious Disease 2012 Nov 15;55(10):1373-8
Kazanjian, P. The Origin of AIDS, Book Review. Medical History (In Press).
Kazanjian, P. The AIDS Pandemic in Historic Perspective. Journal of the History of Medicine and Allied Sciences 67 (4) 2012.