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The impact of isolated and arrayed 10×60μm via-middle Cu TSVs on 8LM 28nm node CMOS poly-SiON P/NFETs was electrically measured for proximities >;4 μm at 27C and 105C. The largest observed shift in Ion (<;2.3%) is significantly less than that from other context-dependent sources such as dual stress liner boundaries (~10%). NanoBeam Diffraction measurements of Si strain within 5μm of TSVs were acquired for samples prepared from fully processed wafers, showing that for proximity >;1.5μm the impact of TSVs is negligible. Interaction with overlying interconnect is mitigated through optimization of post-TSV plating anneal to achieve <; 200 ÅCu pumping and by introducing a TSV unit cell designed to minimize the impact on local environment.