Again, weighing your ammo w/ charges less than 5gr will be pointless. Just pay attention to what you are doing. Doubling a charge on ANY press is just lack of attention. Some people are better off not reloading because they can't be dilligent. Nothing wrong with that, "a man has got to know his limitations".
"Given adequate penetration, a larger diameter bullet will have an edge in wounding effectiveness. It will damage a blood vessel the smaller projectile barely misses. The larger permanent cavity may lead to faster blood loss. Although such an edge clearly exists, its significance cannot be quantified".