Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.
- Waybrant, B., Pearce, T.R., Wang, P., Sreevatsan, S., and Kokkoli, E. "Development and Characterization of an Aptamer Binding Ligand of Fractalkine Using Domain Targeted SELEX", Chem. Comm., 2012, 48 (80): 10043-10045.
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