Zhang, Xiaohui and Xu, Yao-Zhong
NMR and UV studies of 4-Thio-2′-deoxyuridine and its derivatives.
Molecules, 16(7) pp. 5655–5664.
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5-Substituted-4-thio-2’-deoxyuridine nucleosides have been chemically synthesized and studied by NMR and UV spectroscopy. The results have been analyzed and discussed in connection with the previous data. The imino proton signal and the carbon signal of the thiocarbonyl group in the 5-substituted-4-thio-2’-deoxyuridines were found to be at much lower field, offering a potential for monitoring these modified bases at the DNA level. All 4-thionucleosides have strong absorptions at around 340 nm and consequently would be useful as potential UVA-induced anticancer agents.
||2011 The Authors
|Project Funding Details:
|Funded Project Name||Project ID||Funding Body|
|Not Set||Not Set||The Open University, UK|
|Not Set||Not Set||the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, China|
||NMR; UV; 4-thiothymidine; DNA
||Science > Life, Health and Chemical Sciences
|Interdisciplinary Research Centre:
||Biomedical Research Network (BRN)
||07 Jul 2011 14:42
||11 Mar 2014 20:35
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