drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the adrenergic antagonists and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see adrenergic agents). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see adrenergic alpha-agonists) are included here.
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... only ~10% of patients. Thus therapy in these cases usually targets a decrease in sympathetic tone both centrally and peripherally. Central sympatholytics such as methyldopa or clonidine can be used. Peripheral beta-adrenergic blockade may be better tolerated by these patients than by those ...
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