The overall goals of research in the Krause laboratory are to define the molecular mechanisms that regulate hematopoiesis and leukemogenesis using bone marrow derived stem and progenitor cells with the hopes of translating the findings to improved strategies for bone marrow/stem cell transplantation as well as for developing novel strategies for treating leukemia and lymphoma.
In addition, my laboratory is determining the extent to which marrow-derived cells can differentiate into epithelial cells (termed adult cell plasticity) and assessing how this correlates with tissue damage, as well as the mechanisms by which it occurs.
The Krause Laboratory is pursuing three projects:
- Defining the molecular mechanism(s) that regulate gene expression during developmental hematopoiesis
- Exploring mechanisms of leukemogenesis
- Pluripotent stem cell differentiation into functional parathyroid cells
- Understanding how bone marrow derived cells become mature lung epithelial cells