RegistryFixer, part of V Communications' Fix-It Utilities 5 ($49.95 direct) made more changes than any of the other products.
When the program finds multiple entries for moved files, it relies on the user to identify the correct one. While tedious, this is safer than just letting the program guess. Additional safety features include per-item undo, protection of specific Registry items, and a full report of all changes. A unique tree view clarifies the relationships among found problems, and the user interface is the slickest of the bunch. Though the suite consists of more than just a Registry cleaner, RegistryFixer is our Editors' Choice in this category.