Home Antibody All anti-PYCARD antibodies
Also for PYCARD (NM_013258)
|ASC antibody was raised against a synthetic peptide corresponding to amino acids 182 to 195 of human ASC .|
||ELISA, WB: 1 ug/ml, ICC: 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens PYD and CARD domain containing (PYCARD), transcript variant 1|
|ASC; CARD5; TMS; TMS-1; TMS1|
Entrez Gene 29108 Human
|Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1 (1-3). Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3,4). Overexpression of ASC/TMS1 induced DNA fragmentation (4). ASC/TMS1 is expressed in a variety of human and mouse tissues (1, 2)|
|Druggable Genome NOD-like receptor signaling pathwayCytosolic DNA-sensing pathway|
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Western blot analysis of ASC in HL60 whole cell lysate in the absence (A) or presence (B) of blocking peptide (2287P) with ASC antibody at 1 ug /ml.
Immunocytochemistry of ASC in HL60 cells with ASC antibody at 5 ug/mL.