AP-1 activation in response to Ang II treatment. Simulated normalized Total AP-1 activity (solid line) corresponds to the sum of ppc-Fos:ppc-Jun (heavy dashed line) and ppc-Jun:ppc-Jun (light dashed line), and can be compared to experimentally measured AP-1 DNA binding activity (circles with error bars) in the literature . Experimental data is shown according to the reported numerical values of Optical Density measurements (right axis). Model-predicted AP-1 levels have been normalized according to the normalization procedures described in the Methods section.
Miller et al. BMC Systems Biology 2010 4:171 doi:10.1186/1752-0509-4-171