When Cochrane looked at the Enterprise-E in the telescope in ST:FC, I admit I did have the thought that the saucer/nacelle configuration of all future Starfleet vessels was born then. There was nothing leading toward that design configuration up until that point. Cochrane did have a 2-nacelle design, but nothing to lead toward a saucer shape for the crew portion of a ship.
I had the same thought when he saw the Enterprise pass in front of the sun just before he made his first warp flight. From that angle all he got was a vague silhouette of a saucer and warp nacelles sticking out the back. That to me is where the NX-class came from.