Genomes and Genes
Charles E Glatt
Affiliation: University of California
- Pharmacogenetics of monoamine transportersCharles E Glatt
Center for Neurobehavioural Genetics, University of California Los Angeles, USA
Pharmacogenomics 4:583-96. 2003..This review will discuss the clinical pharmacology of the monoamine transporters, their molecular genetic variability and the results of several association studies of the transporters and psychoactive drug response...
- Re-screening serotonin receptors for genetic variants identifies population and molecular genetic complexityCharles E Glatt
UCLA Center for Neurobehavioral Genetics, Gonda Center, Los Angeles, California, USA
Am J Med Genet B Neuropsychiatr Genet 124:92-100. 2004..We discuss the implications of these findings and propose methods to address complexity in genetic association studies...
- Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2)Sherry E Breidenthal
UCLA Center for Neurobehavioural Genetics, Gonda Center, Los Angeles, California 90095 1761, USA
Psychiatr Genet 14:69-72. 2004..We screened the complete protein coding sequence of the newly identified neuronal form of tryptophan hydroxylase (TPH2) for genetic variants...
- Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's diseaseAngelika D Wahner
Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095 1772, USA
Neurosci Lett 413:274-8. 2007..54, 95% CI: 0.32-0.90). Results were similar when combining all races. These findings and the paucity of similar studies suggest a need for further inquiry into the association between GSTs, smoking, and PD risk...
- Association analysis of candidate genes for neuropsychiatric disease: the perpetual campaignCharles E Glatt
Center for Neurobehavioral Genetics, UCLA, Rm 3506 Gonda Center, 695 Charles Young Drive South, Los Angeles, CA 90095, USA
Trends Genet 18:307-12. 2002..As genomic technologies advance, massive genotyping of large samples should allow identification of alleles that contribute to psychopathology...
- Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in womenCharles E Glatt
Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10028, USA
Hum Mol Genet 15:299-305. 2006..This finding is consistent with the prediction that increased sequestration of dopamine in secretory vesicles by VMAT2 is protective for PD...