CoA_bindingCoA binding domain
|SMART accession number:||SM00881|
|Description:||This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.|
|Interpro abstract (IPR003781):||This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.|
|GO function:||cofactor binding (GO:0048037)|
Click on the following links for more information.
- Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing CoA_binding domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CoA_binding domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing CoA_binding domain in the selected taxonomic class.
- Cellular role (predicted cellular role)
Cellular role: metabolism
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Wolodko WT, Fraser ME, James MN, Bridger WA
- The crystal structure of succinyl-CoA synthetase from Escherichia coli at2.5-A resolution.
- J Biol Chem. 1994; 269: 10883-90
- Display abstract
The x-ray crystal structure of succinyl-CoA synthetase (SCS) fromEscherichia coli has been determined by the method of multiple isomorphousreplacement to a resolution of 2.5 A. Crystals of SCS are tetragonal witha space group of P4(3)22 and unit cell dimensions of a = b = 98.47 A and c= 400.6 A. One molecule of SCS (142 kDa) is contained in the asymmetricunit. The current model has been refined to a conventional R factor of21.6% with root mean square deviations from ideal stereochemistry of 0.022A for bond lengths and 3.25 degrees for bond angles. The quaternaryorganization of the E. coli enzyme is an alpha 2 beta 2 heterotetramer. Inthis tetramer, the alpha-subunits interact only with the beta-subunits,whereas the beta-subunits interact to form the dimer of alpha beta-dimers.The two active site pockets are located at regions of contact betweenalpha- and beta-subunits. One molecule of coenzyme A is bound to eachalpha-subunit at a typical nucleotide-binding motif, and His-246 of eachalpha-subunit is phosphorylated. This phosphohistidine, a catalyticintermediate, is stabilized by two helix dipoles (the "power" helices),one from each of the two subunit types. A short segment of thebeta-subunit from one alpha beta-dimer is in close proximity to theCoA-binding site of the other alpha beta-dimer, providing a possiblerationale for the overall tetrameric structure.
- Structure (3D structures containing this domain)
3D Structures of CoA_binding domains in PDB
PDB code Main view Title 1cqi Crystal Structure of the Complex of ADP and MG2+ with Dephosphorylated E. Coli Succinyl-CoA Synthetase 1cqj CRYSTAL STRUCTURE OF DEPHOSPHORYLATED E. COLI SUCCINYL-COA SYNTHETASE 1euc CRYSTAL STRUCTURE OF DEPHOSPHORYLATED PIG HEART, GTP-SPECIFIC SUCCINYL-COA SYNTHETASE 1eud CRYSTAL STRUCTURE OF PHOSPHORYLATED PIG HEART, GTP-SPECIFIC SUCCINYL-COA SYNTHETASE 1iuk The structure of native ID.343 from Thermus thermophilus 1iul The structure of cell-free ID.343 from Thermus thermophilus 1jkj E. coli SCS 1jll Crystal Structure Analysis of the E197betaA Mutant of E. coli SCS 1oi7 The Crystal Structure of Succinyl-CoA synthetase alpha subunit from Thermus Thermophilus 1scu THE CRYSTAL STRUCTURE OF SUCCINYL-COA SYNTHETASE FROM ESCHERICHIA COLI AT 2.5 ANGSTROMS RESOLUTION 1xcb X-ray Structure of a Rex-Family Repressor/NADH Complex from Thermus Aquaticus 1y81 Conserved hypothetical protein Pfu-723267-001 from Pyrococcus furiosus 2csu Crystal structure of PH0766 from Pyrococcus horikoshii OT3 2d59 hypothetical protein from Pyrococcus horikoshii OT3 2d5a hypothetical protein from Pyrococcus horikoshii OT3 2dt5 Crystal Structure of TTHA1657 (AT-rich DNA-binding protein) from Thermus thermophilus HB8 2duw Solution structure of putative CoA-binding protein of Klebsiella pneumoniae 2e6u Crystal structure of hypothetical protein PH1109 from Pyrococcus horikoshii 2fp4 Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GTP 2fpg Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GDP 2fpi Crystal structure of pig GTP-specific succinyl-CoA synthetase from polyethylene glycol 2fpp Crystal structure of pig GTP-specific succinyl-CoA synthetase from polyethylene glycol with chloride ions 2nu6 C123aA Mutant of E. coli Succinyl-CoA Synthetase 2nu7 C123aS Mutant of E. coli Succinyl-CoA Synthetase 2nu8 C123aT Mutant of E. coli Succinyl-CoA Synthetase 2nu9 C123aT Mutant of E. coli Succinyl-CoA Synthetase Orthorhombic Crystal Form 2nua C123aV Mutant of E. coli Succinyl-CoA Synthetase 2scu A detailed description of the structure of Succinyl-COA synthetase from Escherichia coli 2vt2 Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex 2vt3 Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex 2yv1 Crystal Structure of Succinyl-CoA Synthetase Alpha Chain from Methanocaldococcus jannaschii DSM 2661 2yv2 Crystal Structure of Succinyl-CoA Synthetase Alpha Chain from Aeropyrum pernix K1 3ikt Crystal structure of a Rex-family repressor/DNA/NAD+ complex from Thermus aquaticus 3ikv Crystal structure of a Rex-family repressor R90D mutant from Thermus aquaticus 3il2 Crystal structure of a Rex-family repressor R90D mutant/DNA complex from Thermus aquaticus 3keo Crystal Structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+ 3keq Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+ 3ket Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae bound to a palindromic operator 3q9n In silico and in vitro co-evolution of a high affinity complementary protein-protein interface 3q9u In silico and in vitro co-evolution of a high affinity complementary protein-protein interface 3qa9 Crystal Structure of Prb (PH1109 protein redesigned for binding) 3ufx Thermus aquaticus succinyl-CoA synthetase in complex with GDP-Mn2+
- Links (links to other resources describing this domain)
PFAM CoA_binding INTERPRO IPR003781