Joshua Z Press
Affiliation: University of British Columbia
- Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalitiesJoshua Z Press
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
BMC Cancer 8:17. 2008..The mechanism of BRCA1/2 loss is a potential method of subclassifying high grade serous carcinomas...
- Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomasLindsay A Brown
Genetic Pathology Evaluation Centre of the Prostate Centre, University of British Columbia, Room 509, JBRC, 2660 Oak St, Vancouver, BC, Canada V6H 3Z6
Gynecol Oncol 100:264-70. 2006..Here, we investigate the role of EMSY, a recently described BRCA2 interacting protein, as a key element of the 11q13 amplicon in ovarian cancer. EMSY maps to 11q13.5 and is amplified in 13% of breast and 17% of ovarian carcinomas...
- Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapyJoshua Z Press
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, B C, Canada V6H 3V5
Gynecol Oncol 110:256-64. 2008..The response to conventional chemotherapy and novel molecular targeted chemotherapy is assessed in one of the transplantable xenograft lines...