Preprotachykinin is the precursor of two common and important peptide neurotransmitters substance P and neurokinin A (also called "substance K"). These two neuropeptides are both members of the tachykinin neuropeptide family and have roles in many biological processes from pain transmission to blood pressure control. Preprotachykinin is found in both the central nervous system and the periphery.
KRAUSE JE, CHIRGWIN JM, CARTER MS, et al. 3 RAT PREPROTACHYKININ MESSENGER-RNAS ENCODE THE NEUROPEPTIDES SUBSTANCE-P AND NEUROKININ-A PNAS 84(3):881-885. 1987
NAKANISHI S., STRUCTURE AND REGULATION OF THE PREPROTACHYKININ GENE TiNS 9(1):41-44. 1986.