During pursuits alongside other guards, Agiles would usually catch up to a target first, and injure them with the short blades they wielded.
Agiles' attacks were neither powerful nor particularly damaging. Instead, they compensated with their speed, and their ability to dodge most enemy attacks. This rapid form of combat made them deadly in large groups.
The Assassin Ezio Auditore da Firenze could most easily defeat them with patience, by either taunting them or waiting for them to attack, then countering. Roman Agiles were skilled enough to only be defeated in this manner, or during a kill streak.
Alternatively, Agiles could be defeated with a chain of attacks, should they lower their arms and begin panting, indicating that they were tired. This tactic was explained to Ezio by the mercenary trainer in Monteriggioni.
During pursuits, Agiles could follow a target easily across both streets and rooftops alike. They would often strike with a dagger as soon as they came within range, slowing the enemy down and allowing their allies to catch up.
Certain Agiles possessed a shinier and more abstract armor design, distinguishing them as higher-ranked and more skillful than regular Agiles.
- Thieves (including La Volpe, Rosa and Ugo), Checco and Ludovico Orsi, the Cento Occhi, Followers of Romulus, and Hermeticists all possessed freerunning capabilities similar to Agiles.
- In Assassin's Creed II, Agiles were the first enemies to be seen on horseback, in the memory "Romagna Holiday."
- Girolamo Savonarola's lieutenant, the Guard Captain, set ambushes for his enemies using Archers and multiple Agile guards.
- During the Tank sequence in the Assassin's Creed: Brotherhood memory "Hell on Wheels," Agiles could be seen using guns for the first time.
- Papal Guards and Janissaries also possessed the same speed and agility as Agiles, despite being much taller and of heavier build.