Published Studies Related to Demerol Injection (Meperidine)
Meperidine for uterine dystocia and its effect on duration of labor and neonatal
acid-base status: a randomized clinical trial. 
CONCLUSION: Because of the absence of any beneficial effect of meperidine on
Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. [2011.03]
BACKGROUND AND OBJECTIVE: Shivering causes various adverse disturbances and interferes with monitoring. The optimal dose of intrathecal meperidine to prevent shivering without producing other side-effects remains unknown. This prospective randomised double-blinded study was conducted to compare the antishivering effects of two different doses of intrathecal meperidine... CONCLUSION: The use of intrathecal meperidine for caesarean section during spinal anaesthesia for the prevention of shivering cannot be recommended as its use is associated with increased incidence of nausea and vomiting.
Preemptive peritonsillar ketamine infiltration: postoperative analgesic efficacy versus meperidine. [2011.02]
OBJECTIVES: The current study was planned to assess post-tonsillectomy analgesic efficacy of pre-emptive peritonsillar ketamine infiltration with or without bupivacaine in comparison to meperidine alone or in combination with bupivacaine... CONCLUSION: Peritonsillar injection of a combination of bupivacaine and ketamine provided efficient postoperative analgesia after adenotonsillectomy and achieved higher parents' satisfaction for the outcome of surgery. The used drugs' combination and volume could be recommended as a routine preemptive analgesic policy for children assigned for adenotonsillectomy.
Ondansetron and meperidine prevent postoperative shivering after general anesthesia. [2011.02]
BACKGROUND: Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. The aim of this study was to examine the preventive effects of Ondansetron and Meperidine on postoperative shivering... CONCLUSION: Ondansetron can effectively reduce post operative shivering.
Ondansetron and meperidine prevent postoperative shivering after general
postoperative shivering... CONCLUSION: Ondansetron can effectively reduce post operative shivering.
Clinical Trials Related to Demerol Injection (Meperidine)
Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Recruiting]
The aim of the present study is to compare patients discharge time from the recovery unit
between remifentanil only group and combination group (midazolam + meperidine) during
Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP [Recruiting]
Endoscopic retrograde cholangiopancreatography (ERCP) takes a longer time and is more
complex to perform than the other parallel procedures, causing discomfort to patients. It is
commonly performed under sedation endoscopy. Until recently, the combination administration
of midazolam and opioid has been widely used as standard therapy due to its superior
sedation effect compared to the other sedation agents. Midazolam, however, has problems,
such as an insufficient sedation effect and an intermittent paradoxical response.
Unlike midazolam, propofol has no antagonist and may cause problems such as respiratory
depression, and has a narrow therapeutic range for the sedation effect, consequently
requiring supervision by experienced experts, although it has a better sedation effect than
midazolam. Due to these disadvantages, propofol is clinically less useful than midazolam.
Meanwhile, dexmedetomidine, a selective α2 adrenergic agonist, is known to maintain the
proper level of sedation and has a weak influence on respiratory depression. Recent studies
have shown positive results with dexmedetomidine in relation with the sedation effect for
surgery patients under local anesthesia or in intensive care units.
As such, extensive studies are being conducted on the use of dexmedetomidine in endoscopic
procedures due to the increased attention to dexmedetomidine. This notwithstanding, the
clinical usefulness of dexmedetomidine is still debatable. In particular, studies on the use
of dexmedetomidine for ERCP are very rare.
Given the recent idea that dexmedetomidine may exert a synergistic effect in combination
with midazolam, these authors endeavored to prospectively compare and analyze the sedation
effect and adverse events, including respiratory depression, of the combination therapy of
midazolam and meperidine, both of which have been widely used in patients undergoing ERCP,
and of the combination therapy of midazolam, meperidine, and dexmedetomidine.
The small-scale comparative study on the combination administration of propofol and
fentanyl, which has a high risk of causing complications, and on the single administration
of dexmedetomidine is the only study on the sedation effect of dexmedetomidine in the ERCP
procedure that has yet been conducted; there has been no study that investigated the effect
of the combination administration of dexmedetomidine and other drugs in the ERCP procedure.
This study is thus expected to contribute to the development of guidelines on sedation in
the ERCP procedure.
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety
of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate
release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain
following third molar extraction.
Comparison of A Single Dose Combination of Methadone and Morphine With Morphine Alone for Treating Post-Operative Pain [Recruiting]
Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray
(MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo
in patients with moderate to severe post-surgical pain following orthopedic surgery. After
initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24)
hours will be evaluated. The rescue dose remained the same for each.