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This study reports the preparation and analysis of a potentiometric multisensor for detecting pH, uric acid, and glucose levels. The pH sensor was based on a ruthenium dioxide (RuO2) sensing membrane. The potentiometric uric acid and glucose biosensors consisted of immobilized uricase and glucose oxidase (GOD) enzymes on the RuO2 sensing membrane. The ruthenium dioxide sensing membrane was first deposited on silicon and polyethylene terephthalate (PET) substrates using a sputtering system. A graphical measurement interface for the multisensor was also designed using National Instrument LabVIEW software. The potentiometric uric acid biosensor based on a ruthenium dioxide membrane on PET and silicon substrates can be determined in the linear ranges from 2 to 8 mg/dl with a 0.995 and 0.998 linear regression, respectively. In addition, the potentiometric glucose biosensor based on a ruthenium dioxide thin film on PET and silicon substrates shows that the measurement ranges from 40 to 360 mg/dl at sensitivities of 0.348 and 0.468 mV(mg/dl)-1, respectively. This study also investigates wireless monitoring (Bluetooth) and remote monitoring (Web-based) of the multisensor's measurement system and integrates the utility of the developed sensors for homecare or healthcare in the future.