- Factors influencing T cell activation and programmed death 1 expression in HIV-infected children
Department of Paediatrics, University of Oxford, Oxford, United Kingdom
AIDS Res Hum Retroviruses 28:465-8. 2012
..Further understanding of the factors that drive immune activation in children is critical to developing future therapeutic strategies in this population...
- Gag-specific CD4+ T-cell responses are associated with virological control of paediatric HIV-1 infection
Department of Paediatrics, University of Oxford, UK
AIDS 25:1329-31. 2011
..43, P < 0.001), suggesting that preservation of this cell population may be an important goal of therapeutic/vaccine strategies...
- Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants
Department of Paediatrics, University of Oxford, Oxford, UK
AIDS 22:1333-43. 2008
..Data on treatment outcome in sub-Saharan African infants exposed to single-dose nevirapine are urgently required. This feasibility study addresses efficacy of infant antiretroviral therapy in this setting...
- Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate
Julia G Prado
Department of Pediatrics, University of Oxford, Oxford OX1 3SY, UK
J Virol 84:492-502. 2010
..These data underline the importance of virus-host interactions and highlight the contribution of viral attenuation through Gag-specific CD8(+) T-cell escape mutations, among other factors, in the control of pediatric HIV infection...
- HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering
Philippa C Matthews
Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
J Virol 83:4605-15. 2009
..In conclusion, these data highlight the fact that HLA can be a strong selection force for both intra- and interclade HIV evolution at a population level...
- Central role of reverting mutations in HLA associations with human immunodeficiency virus set point
Philippa C Matthews
Department of Paediatrics, Peter Medawar Building for Pathogen Research, United Kingdom
J Virol 82:8548-59. 2008
..The significance of these results is in highlighting the rationale for an HIV vaccine that can induce these broad responses...
- HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells
Department of Paediatrics, University of Oxford, South Parks Road, Oxford, UK
AIDS 24:491-502. 2010
..The balance between pro-inflammatory Th17 and immunoregulatory Tregs may be critical in HIV pathogenesis. This study addressed changes in CD161, Th17 and Treg subsets during untreated HIV infection...
- International perspectives, progress, and future challenges of paediatric HIV infection
Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK
Lancet 370:68-80. 2007
- High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis
HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa
AIDS 21:1253-61. 2007
..To determine the natural history of HIV infection following peripartum single-dose nevirapine (sd-NVP) prophylaxis in a resource-limited country, and to assess implications for antiretroviral therapy (ART) roll-out programmes...
- Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, 4013 Durban, South Africa
AIDS Res Hum Retroviruses 24:265-70. 2008
..Among untreated infants HIV-specific CD4(+) responses were detected sporadically indicating a dysfunctional immune response in the face of constant exposure to high levels of viremia...
- HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load
Christine M Rousseau
Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
J Virol 82:6434-46. 2008
- Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients
Paul A Goepfert
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 205:1009-17. 2008
..In addition to their direct implications for HIV-1 vaccine design, these data suggest that CTL-induced viral polymorphisms and their associated in vivo viral fitness costs could have a significant impact on HIV-1 pathogenesis...
- Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants
Christina F Thobakgale
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa
J Virol 81:12775-84. 2007
..Moreover, the detection of virus-specific CD8+ T-cell responses in the first days of life in most in utero-infected infants is encouraging for HIV vaccine interventions in infants...
- Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes
Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
J Virol 81:3667-72. 2007
..These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia...
- CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
Nat Med 13:46-53. 2007
..These population-based data, suggesting the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection, are of relevance to HIV vaccine design and evaluation...