Mitophagy in fibromylagia (FM) patients. (a) Decreased mitochondrial mass in blood mononuclear cells (BMCs) from FM patients. Citrate synthase specific activity in BMCs from control and FM patients was performed, as described in Materials and Methods. Data represent the mean ± SD of three separate experiments. *P < 0.001 between control and FM patients. (b) Ultrastructure of BMCs from FM patients. The control BMCs show mitochondria with a typical ultrastructure. Autophagosomes with mitochondria (arrows) were present in BMCs from a representative FM patient (P6); Bar = 1 μm.
Cordero et al. Arthritis Research & Therapy 2010 12:R17 doi:10.1186/ar2918