Reaction: diphosphate + H2O = 2 phosphate
Systematic name: diphosphate phosphohydrolase
Comments: Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC 18.104.22.168 (alkaline phosphatase) or EC 22.214.171.124 (glucose-6-phosphatase). A form of this enzyme with a molecular mass of about 90 kDa is found in tonoplasts of plants and fungi, where it imports protons from the cytosol into the vacuolar lumen.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9024-82-2
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2. Kunitz, M. Crystalline inorganic pyrophosphatase isolated from baker's yeast. J. Gen. Physiol. 35 (1952) 423-450.
3. Rafter, G.W. Pyrophosphate metabolism in liver mitochondria. J. Biol. Chem. 235 (1960) 2475-2477.