The stela is one of at least two such monuments erected by King Kamose in the Great Temple of Amun at Karnak. It commemorates the king's military victories over the Hyksos ruler, Apophis.
The main text consists of 38 lines of Kamose's glorifying account of his victory at the Hyksos capital, Avaris, in the Delta. In addition, it quotes the text of a letter intercepted by Kamose's army, sent by Apophis to his ally, the King of Kush, asking him for military aid against the onslaught of "Kamose, the Valiant." The text of the stela continues with a description of Kamose's triumphant return to Thebes.
The man shown in the lower left is Neshy, the Overseer of the Courtiers and Chief of the Treasurers, who was commissioned by Kamose to erect this stela destined to "rest in its place in Karnak in the Theban province forever and ever."