I said I WOULD SHOOT HIM IN THE GROIN AREA
Trouble with small calibers is usually they come in small sizes that are hard to shoot. Be it because of small grips, or sights (if any), or sight radius, or combination of the three.
As a result precise shot placement can be much harder than with a larger caliber gun.
Now when someone is trying to crack your scull with a St. Louis slugger or ventilate you with any variety of knife or gun, I'd say a groin shot would kill but not stop. And stopping is what SD is all about. I do not want to swap pain with the bad guy nor end up in the hospital cause the guy keep a 'shooten.
If my .22/.32/,380 was the size of say a Sig 232 then I'd go for the eye socket IF I AM VERY SKILLED. If not, COM. If the pistol was the size of a TCP, then COM is the only real choice.