PAMAM can be used as excellent drug carrier of vivo transport and metabolism.
Serum albumin is the most abundant protein in the plasma, plays an important role of acidity remains,storage and carrying of amino acids, fatty acids and drugs.Reaction research of PAMAM Dendrimers and Bovine Serum Albumin is important to clarify the PAMAM as a drug carrier transporter distribution and metabolism in the body . Specifically as follows: (1) end with G4.0 and G3.0 PAMAM dendrimer of the amino group is primarily through electrostatic interactions to combine with BSA (bovine serum albumin).G3.5 PAMAM with ester end group with BSA may by hydrogen bonding, hydrophobic interactions and van der Waals forces and other forces.(2)dendrimer with amino end group interact with BSA much stronger than ester end group.Meanwhile, with the increase of the number of terminal amino group and the Generation,the binding enhanced.(3) using emission fluorescence, the synchronous fluorescence and Rees to study PAMAM and BSA's mechanism of action, the peak shape changes of the fluorescence spectrum identifies putting PAMAM could change conformation of BSA,tryptophan residues around the base of the environment has become more hydrophobic and in the movement limited environment. Weihai CY Dendrimer Technology Co.,Ltd forwards from "Different PAMAM Dendrimers with Bovine Serum Albumin" Huaijing Zhang,Hua He ,Shanshan Li,Jinrong Lu, Chuong, Pham Huy analysis of China Pharmaceutical University, Department of Chemistry, Nanjing 210009, China Chimica Sinica 2010 68 17 1741 to 1748