- Repeated administration of berberine inhibits cytochromes P450 in humansYing Guo
Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Xiangya School of Medicine, 110 Xiang Ya Road, Changsha, Hunan 410078, People s Republic of China
Eur J Clin Pharmacol 68:213-7. 2012..Many studies have reported interactions between berberine-containing products and cytochromes P450 (CYPs), but little is known about whether berberine alters CYP activities in humans, especially after repeated doses...
- Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in miceYing Guo
Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, 410078 Hunan, People s Republic of China
J Ethnopharmacol 138:111-8. 2011..It is also widely used in Asian countries for diabetes, hypertension, and hypercholesterolemia therapy...
- CYP2D plays a major role in berberine metabolism in liver of mice and humansYing Guo
Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University Changsha, Hunan, People s Republic of China
Xenobiotica 41:996-1005. 2011..CYP2D plays a major role in berberine biotransformation, therefore, CYP2D6 pharmacogenetics and potential drug-drug interactions should be considered when berberine is used...