Nalmefene Side Effects
It is possible that some side effects of nalmefene may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to nalmefene: parenteral injection
Side effects include:
Nausea, vomiting, tachycardia, hypertension.
For Healthcare Professionals
Applies to nalmefene: injectable solution
Gastrointestinal side effects have occurred commonly, with nausea and vomiting observed in 18% and 9%, respectively, of treated patients. Diarrhea and dry mouth have been reported in less than 1% of patients.
Cardiovascular adverse effects including tachycardia, hypertension, hypotension, vasodilation, bradycardia, and arrhythmia have been reported in 5% or fewer of treated patients.
Nervous system side effects including postoperative pain, dizziness, headache, fever, and chills have been reported in less than 5% of treated patients. Somnolence, depression, agitation, nervousness, tremor, confusion, and myoclonus have been reported in less than 1% of patients.
Nalmefene administration may precipitate acute and extended withdrawal symptoms in opioid-dependent patients.
A 21-year-old male with no significant past medical history had decreased respirations following an exploratory laparotomy for presumed appendicitis. The patient developed acute pulmonary edema after receiving 75 mcg nalmefene in 25 mcg increments over 10 minutes. Clinical resolution of symptoms was prompt after supplemental oxygen and furosemide. It took 36 hours for the chest X-ray to improve.
Respiratory side effects have included pharyngitis (less than 1%). Pulmonary edema is an uncommon effect that has occurred with nalmefene administration.
Dermatologic side effects have infrequently included pruritus (less than 1%).
Genitourinary side effects have included rare reports of urinary retention (less than 1%).
Other side effects including fever (3%) and chills (1%) have been reported.
More about nalmefene
- Other brands: Revex
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