Denny Duquette (Jeffrey Dean Morgan)
Closet millionaire Denny Duquette died during May sweeps from complications following heart-transplant surgery at Seattle Grace Hospital. He is survived by a fiancée, Isobel ''Izzie'' Stevens, a surgical intern who may have contributed to his death prior to attending a prom. (Don't ask.) More importantly, though, Duquette leaves behind a blueprint for how men can look hot and stubbly while stricken and attached to tubes, heart monitors, and even LVAD machines.