DNA methylation distribution in CGI and non-CGI regions. Distribution of DNA methylation in specific gene regions is shown. Each gene region is further divided into bins that correspond to beta values with 0.1 intervals. The area of each bin corresponds to total number of CpGs. The overall distribution and the mean of beta value of the CpGs in each gene region are shown as a box plot. (A) DNA methylation is low in promoter areas, but high in non-CGI regions of all gene areas (B). (A-B) The numbers on the x-axis correspond to total number of CpGs in each gene region; also the x-axis shows different genomic regions, and the y-axis shows the beta values.
Lokk et al. Genome Biology 2014 15:r54 doi:10.1186/gb-2014-15-4-r54