A schematic illustration of the LIGAP method. LIGAP implements a statistical analysis of multiple lineage commitment, as shown here, or other time-course profiles. LIGAP considers all possible comparisons between cell subsets, quantifies a probabilistic model fit for each partition, and summarizes the individual probabilities into differential regulation scores. The case of three lineages, Th0, Th1 and Th2 is shown.
Äijö et al. BMC Genomics 2012 13:572 doi:10.1186/1471-2164-13-572