JHU biomedical engineering primary faculty
Sridevi V. Sarma, PhD
Assistant Professor, Department of Biomedical Engineering
Institute for Computational Medicine
Office: Hackerman Hall 316C
Ph.D., MIT, Electrical Engineering and Computer Science (EECS), Minor in Brain and Cognitive Sciences
S.M., MIT, Electrical Engineering and Computer Science (EECS)
B.S., Cornell University, Electrical Engineering
My research interests are centered in three key areas: closed-loop deep brain stimulation for Parkinsons Disease (PD); closed-loop stimulation for epilepsy; and brain-machine interactive control of fast movements.
With respect to closed-loop deep brain stimulation (DBS) for Parkinsons Disease, my focus is on the modeling of basal ganglia (in health and PD), the modeling effect of DBS, and feedback control design of DBS strategies.
Seizure detection from invasive EEG signals, and seizure foci localization from invasive EEG signals are central to analysis of closed-loop stimulation of epilepsy.
Brain-machine interactive control of fast movements entails the modeling of cerebro-cerebellar regions from human and primate data, as well as optimization the design of a decoder-compensator.
Santaniello S, Sherman D, Thakor N, Eskandar E, Sarma SV. (2012) Optimal Control-Based Bayesian Detection of Clinical and Behavioral State Transitions. IEEE Trans Neural Syst Rehabil Eng. 2012 Sep;20(5):708-19. Epub 2012 Aug 8. PMID: 22893447 [PubMed – in process]
Sarma SV, Cheng ML, Eden UT, Williams Z, Brown EN, Eskandar E. (2012) The Effects of Cues on Neurons in the Basal Ganglia in Parkinson’s Disease. Front Integr Neurosci. 2012;6:40. PMC3405280
Santaniello S, Montgomery EB, Gale JT, Sarma SV (2012) Non-stationary Discharge Patterns in Motor Cortex under Subthalamic Nucleus Deep Brain Stimulation: A Review. Front Integr Neurosci. 6:35. PMC3385519
Agarwal R and Sarma SV. (2012) Performance limitations of relay neurons. PLoS Comput Biol. Aug;8(8):e1002626. PMC3415468
Saxena S, Schieber M, Thakor N, and Sarma SV (2012). Aggregate Input-Output Models of Neuronal Populations. IEEE Trans Biomed Eng. 2012 Jul;59(7):2030-9. PMID: 22552544[PubMed – in process]
Agarwal R, Sarma SV. (2011) Effects of Deep Brain Stimulation Frequency on Pallidal-Thalamic Activity in Parkinson’s Disease: A Computational Study. Journal of Computational Neuroscience, Volume 33, Issue 1 (2012), Page 151–167.
Santaniello S, Burns SP, Golby A, Singer J, Anderson WS, Sarma SV (2011). Quickest Detection of Seizure Onsets in Drug-Resistant Patients: An Optimal Control Approach. Epilepsy & Behavior, 22, pp 49–60. PMC 3280702.