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13. Which of the following is incorrect? Use of NSAIDs in the third trimester of pregnancy may result in ...
A. Premature closure of ductus arteriosis
B. Premature birth
C. Renal effects on the foetus
D. Dyspepsia, vomiting, epigastric pain, reflux oesophagitis
E. Foetal death
14. Inhibition of cox-1 reduces the levels of protective prostaglandins. Inhibition of prostoglandin synthesis in the GI tract causes which one of the following?
A. Increased gastric acid secretion
B. Diminished bicarbonate secretion
C. Diminished mucous secretion
D. Diminished production of protective mediators in the stomach and small intestine
E. All of the above
15. How are NSAIDs metabolised and excreted from the body? Select one answer from the following
A. Most are metabolised and excreted exclusively in bile
B. Most are excreted unchanged through the kidneys
C. Most are metabolised in the liver and excreted as inactive compounds into the urine
D. All of the above
16. Which statement is wrong?
A. PPIs and H2-receptor blocking agents protect the stomach to some extent from NSAID-induced damage
B. Misoprostol also provides some protection against NSAID induced damage
C. Enteric coated tablets definitely protect gastric mucosa
D. NSAIDs should be taken immediately after meals
E. Slow release tablets have no value where stomach lining protection is concerned
17. After how many days (approximately) of unsatisfactory response, can any specific NSAID be replaced with another?
18. Which one of the following statements about cox-2 inhibitors is incorrect?
A. They only inhibit cox-2 produced prostaglandins mainly required to control pain, fever, and inflammation
B. They are induced. ie they only become active in the presence of inflammation
C.They are also present in the kidneys, and they produce prostacyclin which increases thrombotic tendencies which has a negative effect on the kidneys
D. They are supposed to protect the GI tract against the ill effects of NSAIDs - bringing the risk to zero
E. They increase atherogenesis and thrombogenesis tendencies