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- Animal models - ethical considerations
- Animal models for studies on tissue healing
- Is the number of animals (experimental teeth) sufficient to prove or disprove a hypothesis?
- Will the examination procedure of the healing result be possible to evaluate with a reasonable accuracy?
- Statistical methods to be used in histologic studies
Abstract – In vivo studies are sometimes needed to understand healing processes after trauma. For several reasons, not the least ethical, such studies have to be carefully planned and important considerations have to be taken into account about suitability of the experimental model, sample size and optimizing the accuracy of the analysis. Several manuscripts of in vivo studies are submitted for publication to Dental Traumatology and rejected because of inadequate design, methodology or insufficient documentation of the results. The authors have substantial experience in experimental in vivo studies of tissue healing in dental traumatology and share their knowledge regarding critical considerations when planning experimental in vivo studies.