Genomes and Genes
Summary: The use of humans as investigational subjects.
Publications223 found, 100 shown here
- Balancing justice and autonomy in clinical research with healthy volunteersN E Kass
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Berman Institute of Bioethics, Baltimore, Maryland, USA
Clin Pharmacol Ther 82:219-27. 2007..Other studies enrolling healthy volunteers often are simply looking for the most scientifically sound population for the study of normal human physiology...
- Why healthy subjects volunteer for phase I studies and how they perceive their participation?Luis Almeida
Department of Research and Development, BIAL, A Av da Siderurgia Nacional, 4745 457, S Mamede do Coronado, Portugal
Eur J Clin Pharmacol 63:1085-94. 2007..To characterize the motivations and attitudes of healthy subjects who volunteer for phase I studies as well as their perception of the informed consent procedure and participation in the study...
- More than the money: a review of the literature examining healthy volunteer motivationsLeanne Stunkel
Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD, USA
Contemp Clin Trials 32:342-52. 2011..This study summarized and analyzed existing empirical research on self-reported motivations of healthy volunteers participating in studies not intended to offer benefit from participation...
- Principal investigator views of the IRB systemSimon N Whitney
Department of Family, Community Medicine, Houston Center for Education, Research on Therapeutics, Baylor College of Medicine, Houston, TX 77098 3926, USA
Int J Med Sci 5:68-72. 2008..Significant concern was expressed about the cost, inefficiency, and irrationality of IRB review. The IRB system works well for some researchers, but our results indicate that other investigators feel the costs outweigh the benefits...
- Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an updateJudith E Epstein
Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
J Infect Dis 196:145-54. 2007..In 1997, an analysis of experience with 118 volunteers indicated that mosquito inoculation of P. falciparum could be a safe, well-tolerated, reproducible, and efficient method of challenge...
- An assessment of early diagnosis and treatment of malaria by village health volunteers in the Lao PDRViengvaly Phommanivong
Institut de Francophonie pour Médecine Tropicale, Vientiane, BP 9519, Lao PDR
Malar J 9:347. 2010..Early diagnosis and treatment (EDAT) is crucial to reducing the burden of malaria in low-income countries. In the Lao PDR, this strategy was introduced in 2004-2005 and an assessment was performed at the community level in January 2007...
- Immunotherapy: bewitched, bothered, and bewildered no moreRalph M Steinman
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 6399, USA
Science 305:197-200. 2004..We suggest steps to be taken to reinvigorate basic research in human subjects as part of the mainstream of science...
- Moral imperialism and multi-centric clinical trials in peripheral countriesVolnei Garrafa
Cátedra UNESCO de Bioética, Universidade de Brasilia, Brasilia, Brasil
Cad Saude Publica 24:2219-26. 2008....
- Assessing benefits in clinical research: why diversity in benefit assessment can be riskyLarry R Churchill
Vanderbilt University, USA
IRB 25:1-8. 2003
- Informed consent for pediatric research: is it really possible?Eric Kodish
J Pediatr 142:89-90. 2003
- [Changes in the Declaration of Helsinki: economic fundamentalism, ethical imperialism and social control]V Garrafa
, , , , DF, 70910-900, Brasil
Cad Saude Publica 17:1489-96. 2001....
- Paying research subjects: an analysis of current policiesNeal Dickert
W G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
Ann Intern Med 136:368-73. 2002..Few data are available on guidelines used by research organizations to make decisions about paying subjects...
- Ethics of medical research in developing countries: the role of international codes of conductJ L Hutton
Department of Statistics, University of Newcastle, Newcastle upon Tyne, UK
Stat Methods Med Res 9:185-206. 2000..Statisticians share important responsibilities in maintaining ethical medical research in all countries...
- [Regulations, conflicts and ethics of medical research in developing countries]Marta Maciel Lyra Cabral
Departmento de Imunologia, Fundacao Oswaldo Cruz, Recife, PE, Brasil
Rev Saude Publica 40:521-7. 2006..Therefore, it is necessary to minimize the risk of exploitation of developing countries populations. The present study provides an outlook of ethical protection for human research in developing countries...
- Clinical trials and healthy volunteersPamela R Ferguson
University of Dundee, Park Place, Dundee, UK
Med Law Rev 16:23-51. 2008
- Views of midwives about ethical aspects of participation in placental perfusion studiesArja Halkoaho
Department of Nursing Science, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland
Midwifery 28:131-7. 2012..Little is known regarding the role of the midwife in recruiting mothers to participate in scientific research...
- [Ethics and medical research: principles, guidelines, and regulations]Euclides Ayres de Castilho
Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de Sao Paulo, Av Dr Arnaldo 455, 01246 903 Sao Paulo, SP, Brazil
Rev Soc Bras Med Trop 38:344-7. 2005....
- Conflicts of interest in research involving human beingsDirceu Greco
School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
J Int Bioethique 19:143-54, 202-3. 2008....
- Human experimentation in developing countries: improving international practices by identifying vulnerable populations and allocating fair benefitsKristen Farrell
University of Maryland School of Law, Baltimore, MD, USA
J Health Care Law Policy 9:136-61. 2006
- Ethical aspects in placental perfusion studies: views of the researchersA Halkoaho
University of Eastern Finland
Placenta 32:511-5. 2011..Thus, continuous effort for better research ethics is essential and requires research on research ethics...
- The age of neuroelectronicsAdam Keiper
The New Atlantis, USA
New Atlantis 11:4-41. 2006
- Experimental malaria in human volunteers: ethical aspectsH K A Visser
Neth J Med 63:41-2. 2005
- Justice and the human development approach to international researchAlex John London
Carnegie Mellon University, USA
Hastings Cent Rep 35:24-37. 2005
- Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02(A) candidate tuberculosis vaccine in purified protein derivative-negative adultsIsabel Leroux-Roels
Center for Vaccinology, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
Clin Vaccine Immunol 17:1763-71. 2010..In conclusion, Mtb72F/AS02(A) is clinically well tolerated and is highly immunogenic in TB-naïve adults. The 10- and 40-μg Mtb72F/AS02(A) vaccines show comparable safety and immunogenicity profiles...
- Principles of early stopping of randomized trials for efficacy: a critique of equipoise and an alternative nonexploitation ethical frameworkDavid Buchanan
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Kennedy Inst Ethics J 15:161-78. 2005....
- The therapeutic misconception: problems and solutionsCharles W Lidz
Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Med Care 40:V55-63. 2002..The therapeutic misconception is a serious problem for informed consent in clinical research...
- Understanding of informed consent in a low-income setting: three case studies from the Kenyan CoastC S Molyneux
Kenya Medical Research Institute, PO Box 230, Kilifi, Kenya
Soc Sci Med 59:2547-59. 2004..These themes and emerging recommendations are expected to be relevant to, and would benefit from, experiences and insights of researchers working elsewhere...
- The old faith and the new science: the Nuremberg Code and human experimentation ethics in Britain, 1946-73Jenny Hazelgrove
School of Nursing, University of Nottingham, UK
Soc Hist Med 15:109-35. 2002..In a similar move, their predecessors had helped to negotiate the Nuremberg Code in anticipation of public criticism of experimentation arising from the Nuremberg Medical Trial...
- Oversight of human participants research: identifying problems to evaluate reform proposalsEzekiel J Emanuel
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
Ann Intern Med 141:282-91. 2004....
- Research without consent: current status, 2003Michelle H Biros
Department of Emergency Medicine, Hennepin County Medical Center and the University of Minnesota School of Medicine, 701 Park Avenue South, Minneapolis, MN 55415, USA
Ann Emerg Med 42:550-64. 2003....
- The dysregulation of human subjects researchNorman Fost
JAMA 298:2196-8. 2007
- Ethics review for sale? Conflict of interest and commercial research review boardsT Lemmens
Faculty of Law, University of Toronto, 78 Queen s Park, Toronto, Ontario, Canada M5S 2C5
Milbank Q 78:547-84, iii-iv. 2000..The structure of private review tends to breach a core principle of administrative law and procedural justice. Reform of the research review system will reinforce public trust in the process...
- Ethics. Protecting communities in biomedical researchC Weijer
Department of Bioethics, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada
Science 289:1142-4. 2000Although for the last 50 years, ethicists dealing with human experimentation have focused primarily on the need to protect individual research subjects and vulnerable groups, biomedical research, especially in genetics, now requires the ..
- Human experimentation with Neisseria gonorrhoeae: progress and goalsM S Cohen
Department of Medicine, University of North Carolina at Chapel Hill 27599 7030, USA
J Infect Dis 179:S375-9. 1999..The experimental model has proven to be an efficient means of studying gonococcal infection and focusing vaccine development. In addition, this model should allow vaccines to be tested quickly and efficiently...
- International Genetic Epidemiology Society: commentary on Darkness in El Dorado by Patrick TierneyM P Baur
Department of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Genet Epidemiol 21:81-104. 2001..Ethical issues about scientific research in primitive populations deserve serious and wide discussion, but the IGES condemns the gross misrepresentation of the facts and demonization of the principal characters in this book...
- Ethics in international health research: a perspective from the developing worldZulfiqar Ahmed Bhutta
Department of Paediatrics, The Aga Khan University, Karachi, Pakistan
Bull World Health Organ 80:114-20. 2002..Only through such proactive measures can we address the emerging ethical dilemmas and challenges that globalization and the genomics revolution will bring in their wake...
- Reasons for declining to enroll in a phase I and II HIV vaccine trial after randomization among eligible volunteers in Dar es Salaam, TanzaniaEdith A M Tarimo
Division of Global Health, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e14619. 2011..The reasons for such a decision are not well known. This article describes why individuals who were randomized in a phase I and II HIV vaccine trial in Dar es Salaam, Tanzania declined to be enrolled...
- Reconstructing exposures from the UK chemical warfare agent human research programmeTj Keegan
Department of Public Health, University of Oxford, Oxford OX7 3LF, UK
Ann Occup Hyg 51:441-50. 2007..The resulting cohort study has the potential to provide information which will assist in understanding the long-term health impact of chemical warfare agent exposure on these veterans...
- Identification of Haemophilus ducreyi genes expressed during human infectionMargaret E Bauer
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Microbiology 154:1152-60. 2008..We identified three genes, lspA1, lspA2 and tadA, known to be required for virulence in humans. This is the first study to broadly define transcripts expressed by H. ducreyi in humans...
- Exposures recorded for participants in the UK Chemical Warfare Agent Human Research Programme, 1941-1989T J Keegan
Department of Public Health, University of Oxford, OX3 7LF, UK
Ann Occup Hyg 53:83-97. 2009..The study is part of a programme of epidemiological research initiated in response to service veterans' concerns about possible long-term health effects of their participation...
- Human hallucinogen research: guidelines for safetyMw Johnson
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
J Psychopharmacol 22:603-20. 2008..Incautious research may jeopardize participant safety and future research. However, carefully conducted research may inform the treatment of psychiatric disorders, and may lead to advances in basic science...
- Therapeutic misconception in clinical research: frequency and risk factorsPaul S Appelbaum
Department of Psychiatry, University of Massachusetts Medical School, USA
IRB 26:1-8. 2004
- Vulnerability to influence: a two-way streetGail E Henderson
University of North Carolina School of Medicine, USA
Am J Bioeth 4:50-2; discussion W32. 2004
- Ethical review of health research: a perspective from developing country researchersA A Hyder
Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
J Med Ethics 30:68-72. 2004....
- Rationalizing risk assessment in human subject researchCarl H Coleman
Health Law and Policy Program, Seton Hall Law School, USA
Ariz Law Rev 46:1-51. 2004
- Is the argument from marginal cases obtuse?Daniel A Dombrowski
Seattle University, Seattle, WA 98122, USA
J Appl Philos 23:223-32. 2006..The purpose of the present article is to argue that, despite Anderson's and Diamond's nuanced and perceptive treatments of the argument from marginal cases, this argument is not obtuse in either sense of the term...
- The role of institutional review boards in protecting human subjects: are we really ready to fix a broken system?Hazel Glenn Beh
William S Richardson School of Law, University of Hawaii, USA
Law Psychol Rev 26:1-47. 2002
- Pesticide testing in humans: ethics and public policyChristopher Oleskey
Center for Children s Health and the Environment, Box 1043, Mount Sinai School of Medicine, One Gustav L Levy Place, New York, NY 10029, USA
Environ Health Perspect 112:914-9. 2004..Participants also strongly encouraged active biomonitoring of every pesticide currently in use to track human exposure, particularly in vulnerable populations, and to assess adverse effects on health...
- Are the rules for research with subjects with dementia changing?: views from the fieldCarol B Stocking
Section of Geriatrics, MacLean Center for Clinical Medical Ethics, Department of Medicine, University of Chicago, IL 60637, USA
Neurology 61:1649-51. 2003..The real tradeoff between protection and difficulty in conducting research on devastating illnesses needs to be confronted when new regulations in this area are debated...
- Human experimentation: a rule gone awry?Adrian Burton
Environ Health Perspect 114:A360-2. 2006
- Establishing risk of human experimentation with drugs: lessons from TGN1412M J H Kenter
Central Committee on Research Involving Human Subjects, The Hague, Netherlands
Lancet 368:1387-91. 2006
- Is the concept of informed consent applicable to clinical research involving critically ill patients?John M Luce
San Francisco General Hospital, CA, USA
Crit Care Med 31:S153-60. 2003..Stronger research oversight may be as important as informed consent in protecting patient welfare...
- Recommendations for informed consent forms for critical care clinical trialsHenry J Silverman
University of Maryland School of Medicine, Baltimore, MD, USA
Crit Care Med 33:867-82. 2005..Many subjects enrolled in research studies have a limited understanding of the research to which they consented...
- Clinical outcome of experimental human malaria induced by Plasmodium falciparum-infected mosquitoesD F Verhage
Departments of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Neth J Med 63:52-8. 2005..The objective of this study was to evaluate infection rates and clinical safety of different protocols for human experimental malaria induced by Plasmodium falciparum-infected mosquitoes...
- Beyond informed consentZulfiqar A Bhutta
Aga Khan University, Karachi 74800, Pakistan
Bull World Health Organ 82:771-7. 2004..Further research is needed to examine the validity and user friendliness of innovations in information sharing procedures for obtaining consent in different cultural settings...
- Moving beyond compliance: measuring ethical quality to enhance the oversight of human subjects researchHolly A Taylor
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
IRB 29:9-14. 2007
- Human subjects issues and IRB review in practice-based researchLeslie E Wolf
University of California, San Francisco, San Francisco, California 94143 0903, USA
Ann Fam Med 3:S30-7. 2005..This article explores the challenges that practice-based research networks (PBRNs) face with respect to the regulatory requirements for institutional review board (IRB) review and the protection of human subjects in research...
- Ethics of innovative surgery: US surgeons' definitions, knowledge, and attitudesAngelique M Reitsma
Center for Biomedical Ethics, University of Virginia, PO Box 800758, Charlottesville, VA 22908 0758, USA
J Am Coll Surg 200:103-10. 2005..Surgeons were also invited to self-report knowledge about current federal regulations guiding human subject research and rules for informed consent for and IRB review of clinical research...
- Research on the socio-ethical impact of biomarker use and the communication processes in ECNIS NoE and NewGeneris IPBirgit Dumez
Center for Human Genetics, Department of Medicine, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
Int J Hyg Environ Health 210:263-5. 2007..A harmonized socio-ethical and legal approach not only increases the possibilities for comparison between data generated but may also allow for more equality in the protection of the rights of each citizen of the European Union...
- Human testing of pesticides: ethical and scientific considerationsAlan H Lockwood
Center for PET 115P, VA Western NY Healthcare System, 3495 Bailey Ave, Buffalo, NY 14215, USA
Am J Public Health 94:1908-16. 2004..An EPA committee that is free from political and financial conflicts of interest should review this practice...
- Challenges of ethical research in resource-poor settingsB M Dickens
Faculty of Law, University of Toronto, Toronto, Ontario, Canada
Int J Gynaecol Obstet 80:79-86. 2003..The structure and functions of research ethics review committees present difficult challenges, but they may be mitigated by enlightened international collaboration...
- Bench-to-bedside review: human subjects research--are more standards needed?David T Huang
CRISMA Laboratory, Department of Critical Care Medicine, Department of Emergency Medicine, University of Pittsburgh, 641 Scaife Hall, Pittsburgh, PA 15261, USA
Crit Care 10:244. 2006..We conclude that what is needed are not more standards per se, but rather refinement and uniformity of current standards, and their interpretation and application both to protect human subjects and to advance medicine...
- Research ethics and law of healthcare system quality improvement: the conflict of cost containment and qualityW Andrew Kofke
Department of Anesthesia, University of Pennsylvania, Philadelphia 19104 4283, USA
Crit Care Med 31:S143-52. 2003..The ethical and legal foundations exist to support the systematic practice of informing patients of their participation in some types of QI procedures...
- Money for research participation: does in jeopardize informed consent?C Grady
National Institutes of Health, USA
Am J Bioeth 1:40-4. 2001..An amount of money that is not excessive and is calculated on the basis of time or contribution may, rather than constitute an undue inducement, be an indication of respect for the time and contribution that research subjects make...
- Evaluating the quality of informed consentJeremy Sugarman
Phoebe R Berman Bioethics Institute, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Clin Trials 2:34-41. 2005..Having such means will be important to monitoring consent and testing potential improvements in the consent process...
- Ethics review procedures for research in developing countries: a basic presumption of guiltRobert H Gilman
Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
CMAJ 171:248-9. 2004
- Assessment of medical school institutional review board policies regarding compensation of subjects for research-related injuryMichael K Paasche-Orlow
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Am J Med 118:175-80. 2005..We hypothesized that informed consent language at U.S. medical schools would be particularly complex and fall short of IOM goals, especially for projects without industry sponsorship...
- Regional ethics organizations for protection of human research participantsAnne Wood
School of Law, University of California, Berkeley, Berkeley, California 94720 7200, USA
Nat Med 10:1283-8. 2004
- Educating researchers: ethics and the protection of human research participantsJulie Rothstein Rosenbaum
Yale University School of Medicine, New Haven, CT, USA
Crit Care Med 31:S161-6. 2003....
- Should society allow research ethics boards to be run as for-profit enterprises?Ezekiel J Emanuel
Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States
PLoS Med 3:e309. 2006..Critics argue that for-profit IRBs have a conflict of interest because they generate their income from clients who have a direct financial interest in obtaining approval...
- The case of Chester M. Southam: research ethics and the limits of professional responsibilityBeth Aviva Preminger
Cornell University Joan and Sanford I Weill Medical College, USA
Pharos Alpha Omega Alpha Honor Med Soc 65:4-9. 2002
- What is a "minor" increase over minimal risk?David Wendler
Department of Clinical Bioethics, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA
J Pediatr 147:575-8. 2005
- [Clinical trials in developing countries: who should define ethics?]F Béréterbide
Faculte de Medecine, Département de recherche éthique, Universite Paris Sud XI, France
Bull Soc Pathol Exot 101:102-5. 2008....
- Some questionable premises about research ethicsRuth Macklin
Albert Einstein College of Medicine, USA
Am J Bioeth 5:29-31; author reply W15-8. 2005
- Subjects or objects? Prisoners and human experimentationBarron H Lerner
Columbia University, New York, USA
N Engl J Med 356:1806-7. 2007
- Rethinking research ethicsRosamond Rhodes
Mount Sinai School of Medicine
Am J Bioeth 5:7-28. 2005..These include: the primacy of informed consent, the protection of the vulnerable, the substitution of beneficence for research's social purpose, and the introduction of an untenable distinction between innovation and research...
- Reflections on 'Rethinking research ethics'Robert J Levine
Am J Bioeth 5:1-3; author reply W15-8. 2005
- Strangers at the benchside: research ethics consultationMildred K Cho
Stanford Center for Biomedical Ethics, Center for Integration of Research on Geneticsand Ethics, Palo Alto, CA 94304, USA
Am J Bioeth 8:4-13. 2008..We make preliminary recommendations for the structure and process of research ethics consultation, based on our initial experiences in a pilot program...
- Response to Athula Sumathipala and Sisira Siribaddana, "Revisiting 'freely given informed consent' in relation to the developing world: the role of an Ombudsman" (AJOB 4:3)Bob Simpson
Am J Bioeth 5:W24-6. 2005
- Ethical considerations in phenomenological researchWendy Walker
School of Health Sciences, University of Birmingham, UK
Nurse Res 14:36-45. 2007..Wendy Walker examines some important ethical issues that researchers need to consider before and during phenomenological research. She argues that failure to address such issues means putting at risk the rights of research participants...
- Excluding particular information from consent formsNeal Dickert
Department of Health Policy and Management, Phoebe R Berman Bioethics Institute, John Hopkins University Bloomberg School of Public Health, Hampton House 348, 624 N Broadway, Baltimore, MD 21205, USA
Account Res 12:33-45. 2005..Further, we argue that the regulations ought to be amended to reflect this obligation...
- Quality-improvement research and informed consentFranklin G Miller
Department of Bioethics, National Institutes of Health, Bethesda, MD, USA
N Engl J Med 358:765-7. 2008
- Ten questions institutional review boards should ask when reviewing international clinical research protocolsDaniel W Fitzgerald
IRB 25:14-8. 2003
- A plea for pragmatism in clinical research ethicsDavid H Brendel
Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Am J Bioeth 8:24-31. 2008....
- Harming through protection?Mary Ann Baily
Hastings Center, Garrison, NY, USA
N Engl J Med 358:768-9. 2008
- Human research protections: time for regulatory reform?Karen J Maschke
Hastings Cent Rep 38:19-22. 2008
- How not to rethink research ethicsTom L Beauchamp
Georgetown University, USA
Am J Bioeth 5:31-3; author reply W15-8. 2005
- The history and moral foundations of human-subject researchJeffry Blustein
Division of Bioethics, Montefiore Medical Center and the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Am J Phys Med Rehabil 86:82-5. 2007
- Research ethics in Internet-enabled research: human subjects issues and methodological myopiaJoseph B Walther
Department of Communication, Cornell University, 336 Kennedy Hall, Ithaca, NY 14853 4203, USA
Ethics Inf Technol 4:205-16. 2002....
- The limitations of "vulnerability" as a protection for human research participantsCarol Levine
United Hospital Fund
Am J Bioeth 4:44-9. 2004..Certain individuals require ongoing protections of the kind already established in law and regulation, but attention must also be focused on characteristics of the research protocol and environment that present ethical challenges...
- Undue inducement: the only objection to payment?Ari VanderWalde
Am J Bioeth 5:25-7. 2005
- A quartet of criticismsHarold Y Vanderpool
University of Texas Medical Branch, USA
Am J Bioeth 5:16-9. 2005
- The welcome reassessment of research ethics: is "undue inducement" suspect?Howard Brody
Michigan State University, USA
Am J Bioeth 5:15-6. 2005
- Undue inducement: nonsense on stilts?Ezekiel J Emanuel
National Institutes of Health, USA
Am J Bioeth 5:9-13; discussion W8-11, W17. 2005
- Part I: what is the requirement for data sharing?Virginia A de Wolf
IRB 27:12-6. 2005
- Conflicts of interest in medical research: how much conflict should exceed legal boundaries?Kaley Klanica
Boston University School of Public Health, USA
J Biolaw Bus 8:37-45. 2005..Lastly, part four concludes by recommending a system of seven balanced reform measures that protect research subjects and the scientific integrity of medical research while encouraging scientific progress...
- The current situation regarding the establishment of national ethical guidelines for biomedical research in Thailand and its neighboring countriesSomei Kojima
Asian Center of International Parasite Control, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 36:728-32. 2005..This indicates that further efforts should be made to establish research guidelines and/or principles dealing with the human genome...
- The pharmaceutical industry's responsibility for protecting human subjects of clinical trials in developing nationsFinnuala Kelleher
Columbia Journal of Law and Social Problems, Columbia University, USA
Columbia J Law Soc Probl 38:67-106. 2004....
- Conducting ethical research in pediatrics: a brief historical overview and review of pediatric regulationsDouglas S Diekema
University of Washington, Treuman Katz Center for Pediatric Bioethics, Children s Hospital and Regional Medical Center, Seattle, Washington 98101, USA
J Pediatr 149:S3-11. 2006..Good research is ethical research, and that requires investigators who take seriously the importance of participant welfare, meaningful informed consent, and respect for research participants...
- Beginning anew: same principles, different direction for research ethicsMary Simmerling
University of Chicago, USA
Am J Bioeth 5:44-6; author reply W15-8. 2005
- Lyophilization of Plasmodium falciparum sporozoite vaccineStephen Hoffman; Fiscal Year: 2007..Additionally, a dried vaccine may accelerate a concerted world-wide effort to eradicate this devastating disease. ..
- PARP inhibitor therapy for septic shockAndrew Salzman; Fiscal Year: 2004..Based on pre-clinical porcine shock models and clinical safety studies, we expect INO-1001 to be a safe, well-tolerated and effective therapeutic in patients with septic shock. ..
- PATHOGENESIS OF HAEMOPHILUS DUCREYI INFECTIONSStanley M Spinola; Fiscal Year: 2010..Chancroid can be treated with only three types of antibiotics. The genes controlled by the stress response systems may prove to be targets of vaccines or alternative treatments for H. ducreyi infection. ..
- MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSIONSAlan Schatzberg; Fiscal Year: 1999....
- Resistant E.coli in Humans and PoultryJames Johnson; Fiscal Year: 2005..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
- PHOSPHORYLATION OF CILIARY TARGET PROTEINSMATTHIAS A SALATHE; Fiscal Year: 2010..This proposal thus may identify new therapeutic targets that could help to decrease the burden from airway disease exacerbations on individuals and on society. ..
- Harmful effects of transfusion of older stored red cells: iron and inflammationSteven Spitalnik; Fiscal Year: 2009....
- MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUSGERTRUDE BUEHRING; Fiscal Year: 2007....
- IMMUNOCHEMISTRY OF GONOCOCCAL LIPOPOLYSACCHARIDEJOHN GRIFFISS; Fiscal Year: 2003..Gonococci shed during gonorrhoea make larger LOS. The higher Mr LOS made by MS11mkC - a strain used in human experimentation -have polylactosamine structures...
- Dietary HDAC Inhibitors in Colon Cancer PreventionRoderick H Dashwood; Fiscal Year: 2010....
- Potency of cryopreserved, irradiated sporozoite vaccineStephen Hoffman; Fiscal Year: 2005..The project will also provide a method for cryopreserving unirradiated sporozoites that could be used to challenge volunteers by injection with P. falciparum in vaccine studies worldwide. ..
- Genetically Attenuated Malaria Sporozote VaccineStephen Hoffman; Fiscal Year: 2007..Success in this project has the potential to lead to development of a safe, effective, attenuated malaria vaccine. ..
- Imaging Cytolytic T Cells in Cancer Patients Using PET Reporter Genes/Reporter PrSanjiv S Gambhir; Fiscal Year: 2010..Here, we propose non-invasive imaging of therapeutic immune cells that will be infused into patients with glioma brain tumors and have been shown to kill glioma brain tumor cells. ..
- Gene-engineered dendritic cell therapy for diabeticsMassimo Trucco; Fiscal Year: 2006..The ultimate result could include less intensive or even a complete cessation of insulin replacement therapy in newly-diagnosed diabetics as well as, perhaps, a means of preventing diabetes. ..
- Inhalation Dosimetry/Exposure Index of Fiber AerosolYung Sung Cheng; Fiscal Year: 2006..Sampling devices based on this size-selection definition can be developed in the future for improved assessment of worker exposure. ..
- SEVERE PERIODONTITIS AS A RHEOLOGIC MODIFIERSTEVEN ENGEBRETSON; Fiscal Year: 2003..Dr. Engebretson will receive training in research methodology and molecular biology in order to explore the mechanisms of periodontal medicine through the conduct of human clinical studies as a career goal. ..
- Translation Research in Plasmodium vivaxSocrates Herrera; Fiscal Year: 2005..abstract_text> ..
- An ACE Inhibitor as a Treatment for Methamphetamine DependenceTHOMAS FREDERICK NEWTON; Fiscal Year: 2010..A separate human laboratory study will examine the dose-dependent effects of perindopril on MA- induced craving, though these participants will not take part in the clinical trial. ..
- An ACE Inhibitor as a Treatment for Methamphetamine DependenceThomas Newton; Fiscal Year: 2009..A separate human laboratory study will examine the dose-dependent effects of perindopril on MA- induced craving, though these participants will not take part in the clinical trial. ..
- Immune function and the progression to type 1 diabetesMark Atkinson; Fiscal Year: 2007....
- Role of Leptin in the Neuroendocrine Response to FastingChristos Mantzoros; Fiscal Year: 2004....
- PH CONTROL OF PROTEIN SYNTHESISPeter Garlick; Fiscal Year: 2003..abstract_text> ..
- PATHOGENESIS OF HAEMOPHILUS DUCREYI INFECTIONSSTANLEY SPINOLA; Fiscal Year: 1999....
- Dietary HDAC Inhibitors in Colon Cancer PreventionRoderick Dashwood; Fiscal Year: 2009....