Brain Heart and PMS Support. 300 MG. In order for vitamins to be utilized by the body they must first be converted into their active coenzyme forms. This more potent Coenzymated B-6 is in its active form; ready to go to work immediately. Pyridoxal-5’-Phospahet (PLP or P-5’-P) is the main metabolically active coenzyme form of vitamin B-6. It is primarily in the liver that P-5’-P is synthesized from vitamin B-6 with the help of enzymes that requires B-2 zinc and magnesium for their activity. P-5’-P activates over 100 enzymes many of which are involved in the conversion of amino acids into the neurotransmitters dopamine norephinephrine and serotonin. P-5’-P is also required for the synthesis of the hemoglobin molecule. It also plays an important role in regulating homocysteine levels.