Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H.
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):742-7.
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Two amyloid species (Abeta40 and Abeta42/43) are enerated at TGN and ER, respectively. The question is how they change to an insoluble form in brain tissue in an age-dependent and pathological manner.