Complete Genome of Hepatitis E Virus from Laboratory Ferrets
Figure. . Phylogenetic relationships among genotypes 1–4 and wild boar, rabbit, rat, avian, bat, and ferret isolates of hepatitis E virus. Nucleic acid sequence alignment was performed by using Clustal X 1.81 (www.clustal.org/clustal2/). Genetic distance was calculated by using Kimura’s 2-parameter method. Phylogenetic trees with 1,000 bootstrap replicates were generated by using the neighbor-joining method (Njplot 2.3, http://njplot.sharewarejunction.com/) based on A) the entire genome and B) open reading frame 2. Items in boldface indicate strains isolated in this study. Numbers along branches indicate bootstrap values. Scale bars indicate nucleotide substitutions per site.