Critical appraisal of a large population-based case–control study
This chapter presents an example of the application of the scheme for critical appraisal: large population-based case-control study entitled ‘Risk of breast cancer in relation to lifetime alcohol consumption’, published in the Journal of the National Cancer Institute in 1995. This large case-control study has shown a regular positive association between recorded alcohol intake and breast cancer risk. The results are generally consistent with the results of other observational studies, most of which, however, would be open to the same limitations.
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