a veteran provider of extreme-scale grid computing software and services, announced
today the spin-off of Parabon NanoLabs, a subsidiary dedicated to designing
and producing breakthrough products at the nano-scale. The company will initially
focus on developing nano-scale sensors for therapeutics, diagnostics and other
molecular detection systems, although the technology and resultant nanostructures
have potentially limitless applications, ranging from detergent additives to
next-generation electronics. The ability to precisely manipulate matter at the
nano-scale is expected to usher in the Nanotechnology Revolution, which the
National Science Foundation (NSF) estimates as having a market potential of
$1 trillion by 2015.
In a radical departure from carbon-based (C60) nanotechnologies, such as buckyballs
and carbon nanotubes, which gained media attention early in the millennium,
the key to Parabon NanoLab’s approach is synthetic DNA. Although DNA is
best known as a carrier of genetic information, individual strands of DNA can
be synthesized to have any sequence of bases (commonly represented by the letters
A, C, G and T). Because certain sequences of DNA are mutually attractive, strands
can be “programmed” with sequences that cause them to “swim
to the right spot,” with respect to one another, and then bind to form
nanostructures of virtually any shape. By attaching DNA strands to other types
of molecular subcomponents (e.g., therapeutics, nanoparticles or enzymes), nanostructures
can be richly functionalized to form novel macromolecules with uses across countless
application domains. The ability of DNA structures to self-assemble in this
manner allows designer macromolecules to be deliberately and precisely engineered
and then mass-produced – feats not achievable with any other nanotechnologies.
“The challenge to orchestrating successful self-assembly of a given design,”
according to Dr. Steven Armentrout, Parabon Founder and CEO, “is determining,
from the countless possibilities, the rare few sets of DNA sequences that satisfy
all of the design constraints. For that, we depend on inSequio.” Developed
by Parabon over the past four years, the inSequio Sequence Design Studio is
a one-of-a-kind computer-aided design (CAD) application that optimizes DNA sequences
for nano-engineering using grid-scale computing capacity.
A single DNA strand of just 135 bases has more possible sequence arrangements
than the estimated number of atoms in the universe and some nanostructures have
more than 15,000 bases. Since evaluation of each candidate sequence set requires
compute-intensive molecular dynamics calculations, the computational workload
to discover effective sequences is vast. Co-Founder and Chief Scientist of Parabon
NanoLabs, Dr. Michael Norton, who is also a professor at Marshall University,
believes this is why others have not tackled the sequence optimization problem.
“Without the grid-scale capacity Parabon provides, solving a problem of
this magnitude doesn’t seem possible,” he says, “so people
shied away from it.”
By simultaneously employing the power of thousands of computers on the Frontier®
Grid Platform, the inSequio optimizer discovers ideal sequences for nano-assembly.
Utilizing this revolutionary technology, scientists within Parabon NanoLabs
are creating a catalog of proprietary nano-products for licensing in several
domain areas including cancer therapeutics, biometrics and bio-weapons defense.
In addition, Parabon NanoLabs provides custom design and fabrication services
for companies and researchers seeking to nano-enable their products.
According to Dr. Chris Dwyer, another co-founder of Parabon NanoLabs, and a
professor at Duke University, the company formed to capitalize on the commercial
opportunities made possible by its technology. Dr. Dwyer stated, “Beginning
with the microfabrication of transistors in the 1960s, control of matter at
the micro-scale enabled the era of electronic miniaturization that ultimately
led to the Information Revolution. An even greater opportunity exists with the
Nanotechnology Revolution and we’ve attracted the right combination of
talent and technology to realize it.”