Bertram, Smolen, Sherman, Mears, Atwater, Martin, Soria, 1995
This model runs in both COR and PCEnv to reproduce the figures shown in the original paper. The units have been checked and they are consistent.
ABSTRACT: S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated current (CRAC). We support this hypothesis with additional data, and present a theoretical model which accounts for most known data on muscarinic effects. Additional phenomena, such as the biphasic responses of beta-cells to changes in glucose concentration and the depolarizing effects of the sarco-endoplasmic reticulum calcium ATPase pump poison thapsigargin, are also accounted for by our model. The ability of this single hypothesis, that CRAC is present in beta-cells, to explain so many phenomena motivates a more complete characterization of this current.
The complete paper reference is cited below:
A Role for Calcium Release-Activated Current (CRAC) in Cholinergic Modulation of Electrical Activity in Pancreatic Beta-Cells, Richard Bertram, Paul Smolen, Arthur Sherman, David Mears, Illani Atwater, Franz Martin and Bernat Soria, 1995, Biophysical Journal, 68, 2323-2332. PubMed ID: 7647236