|| List of recent Cornea-related patents
|Method of accelerating corneal wound healing|
The topical ophthalmic use of 5,6,7-trihydroxyheptanoic acid and analogs for the acceleration of corneal wound healing in humans, is disclosed.. .
|Inhibitor for corneal epithelial cell death, inhibitor characterized by combining hyaluronic acid and flavin adenine dinucleotide|
A combination of hyaluronic acid or a salt thereof and flavin adenine dinucleotide or a salt thereof can be an inhibitor for corneal epithelial cell death induced by ultraviolet irradiation and/or dryness because it significantly inhibits the decline of the number of living cells in corneal epithelial cells induced by ultraviolet irradiation or dryness.. .
|Device and method to assist treatment of the cornea|
A method and device for assisting treatment of the cornea, the device including a memory (4), an interface (8) capable of receiving and supplying data, a processing unit (6) for calculating and supplying to the interface (8) an ophthalmological value for use in the treatment of the cornea, a scheduler (10) which configured, upon receipt of initial central keratometric index (kc) data and initial asphericity value (qi) data at the interface (8), to store those data in the memory (4), to call the processing unit (6) with the initial central keratometric index (kc) and initial asphericity value (qi) data as well as with target asphericity value (qv) data in order to calculate a peripheral keratometric index (kp), to store the corresponding data in the memory (4) and to supply them to the interface (8).. .
|Eye drop formulation with enhanced properties by combining sodium hyaluronate with carboxymethylcellulose|
Embodiments described herein relate to formulations for and methods of use for eye drop formulations comprising carboxymethyl cellulose (cmc) and hyaluronic acid (ha) with an improved distribution on the cornea during blinking.. .
|Ectocornea-like sheet and method of constructing the same|
It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells.
|Bi-radial patient interface|
To improve the precision of ophthalmic surgical procedures by reducing corneal wrinkling, a patient interface for an ophthalmic system can include an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system; a contact portion, configured to dock the patient interface to an eye; and a contact element, coupled to the contact portion, configured to contact a surface of a cornea of the eye as part of the docking of the patient interface to the eye, and having a central portion with a central radius of curvature rc and a peripheral portion with a peripheral radius of curvature rp, wherein rc is smaller than rp.. .
|Corneal stiffening for treating astigmatism|
Methods are provided for treating astigmatism in an eye of a patient. An axis of greater curvature of the eye is determined.
|Compositions and methods for treating injuries to the visual system of a human|
Methods and compositions for treating injuries to the neural system of a human eye and corresponding structures in the brain are designed to degrade gylcosaminoglycans (gags) within chondroitin sulphate proteoglycans (cspg) using chondroitinase abc (cabc), preserving neural architecture and protecting the visual system from progressive damage after vascular insult of the optic nerve and/or other portions of the visual system. The methods include delivering the cabc composition by topically applying the composition onto the patient's cornea, stereotactic injections into the related anatomy, delivery by micro-osmotic pumps, delivery by nanoparticles and/or nanocapsules, and delivery through intravitreal implants..
|Double function tilting head ophthalmic instrument|
Systems for performing sequential multiple function ophthalmic measurements using separate measurement instruments, by mechanical switching between the instruments. In prior art systems, the separate measurement instruments are stacked, and transfer between them is performed by means of a linear mechanical motion stage.
|Capsulotomy device with suction cup compression chamber|
A surgical device and procedure are provided for smoothly and easily accessing tissue to perform microsurgery, including a capsulotomy of a lens capsule of an eye. The device includes a handpiece with a tip for insertion into an incision in the cornea of the eye.
|Antigen binding constructs|
The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain fc region of an antibody, wherein each epitope binding domain in capable of binding to vegf, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with vegf signalling, such as diabetic macular edema (dme), wet age-related macular degeneration (wet amd). Diabetic retinopathy, retinal vein occlusion (rvo), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs..
|Compositions derived from stem cell released molecules & methods for formulation thereof|
Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (srm's) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and srm's can be derived from one or more distinct cell lines.
|Systems using eye mounted displays|
A display device is mounted on and/or inside the eye. The eye mounted display contains multiple sub-displays, each of which projects light to different retinal positions within a portion of the retina corresponding to the sub-display.
|Anterior corneal shapes and methods of providing the shapes|
Methods of determining a desired shape for the anterior surface of the cornea in vision correction procedures.. .
|Ophthalmic treatment device, system, and method of use|
Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye).
|Silk compositions and methods of using same|
The present invention provides for silk-derived compositions for treating a wide variety of ocular conditions. The composition is produced by processing the silk cocoon into a water-based solution (i.e., a dissolved silk), which is then cast into a film.
|Biometric authentication using the eye|
An apparatus and method for authenticating a subject using the eye as an identifying biometric, in particular the shape of the cornea. An image projection device generates and projects an image of a pattern, of plural discrete points, onto at least a part of the cornea of the eye.
|Sensor system for determining the control signals activating ciliary muscles|
In a sensor system for determining the control signal supplied to the ciliary muscles of an eye for adjusting the focal length of the lens of an eye, a contact element of an electrically non-conductive material and provided with sensors is disposed on the cornea of the eye so that the sensors are arranged in contact with an annular area of the cornea next to the ciliary eye muscles so as to be able to sense the focal adjustment signals supplied to the ciliary muscles and the sensed adjustment signals are supplied to a signal processing unit which provides a control signal to a lens system with adjustable focal length for adjusting the focal length thereof depending on the focal adjustment signals of the ciliary eye muscles.. .
|Ocular pressure regulation|
Disclosed are devices and methods of treating an ocular disorder including forming a self-sealing incision in a cornea into an anterior chamber of an eye; introducing through the incision a fluid drainage tube having a distal end, a proximal end and a longitudinal, internal lumen extending through the fluid drainage tube, wherein at least the proximal end passes through the anterior chamber; and implanting the distal end of the fluid drainage tube in fluid communication with the suprachoroidal space such that the proximal end of the fluid drainage tube remains in fluid communication with the anterior chamber.. .
|Method and a device for monitoring pupil|
The invention provides a method of monitoring the pupil of a subject, wherein a sensor for observing the pupil is arranged between the cornea and the eyelid covering the cornea, the sensor is powered through the eyelid, and the pupil-observation signals delivered by the sensor are collected through the eyelid.. .
|Ophthalmological laser method and apparatus|
The present invention relates to a femtosecond laser ophthalmological apparatus and method that creates a flap on the cornea for lasik refractive surgery or for other applications that require removal of corneal and lens tissue at specific locations such as in corneal transplants, stromal tunnels, corneal lenticular extraction and cataract surgery. The femtosecond laser is transferred to a hand piece module via a rotating mirror arm module.
|Ophthalmic aberrometer capable of subjective refraction|
The present invention contemplates an ophthalmic aberrometer combining measurements of wavefront aberrations and subjective refraction into a single instrument and refers both measurements to the same corneal plane the present invention also contemplates an ophthalmic aberrometer employing an open field and subjective correction to overcome instrument myopia and to ensure accurate measurement of the best-corrected visual acuity in addition to measurement of wavefront aberrations. The present invention further contemplates an ophthalmic aberrometer implementing an optical relay with adjustable optical power compensation to eliminate the need for flipping plurality sets of trial lenses for defocus correction.
|Shape memory polymer intraocular lenses|
A shape memory polymer (smp) intraocular lens may have a refractive index above 1.45, a tg between 10° c. And 60° c., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum.
|Corneal multi-plane incision using a surgical laser setup calculations interface|
An apparatus and a method are described for setting up a medical laser machine configured to be used in eye surgery for making a multi-planar incision. In various embodiments, a software interface is provided to receive, from a user, one or more dimensional measurements of an eye of a patient as input, automatically calculate precise geometric and other setup parameters, based on a set of equations, of a multi-planar incision for the patient's eye, and provide the calculated parameters to the user for setting up the medical laser machine to make the incision..
|Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes|
Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided..
|Method for preparing corneal endothelial cell|
The present invention relates to a method for preparing corneal endothelial progenitor cells by adherent culturing a cell population isolated from corneal endothelial cell tissue at a low density by using a serum-free medium. The present invention also relates to a method for preparing corneal endothelial cells by differentiation-inducing the corneal endothelial progenitor cells obtained by the aforementioned method.
|Large diopter range real time sequential wavefront sensor|
Example embodiments of a large dynamic range sequential wavefront sensor for vision correction or assessment procedures are disclosed. An example embodiment optically relays a wavefront from an eye pupil or corneal plane to a wavefront sampling plane in such a manner that somewhere in the relaying process, the wavefront beam from the eye within a large eye diopter range is made to reside within a desired physical dimension over a certain axial distance range in a wavefront image space and/or a fourier transform space.
|Compensation systems and methods for flap induced aberrations|
Embodiments of the present invention encompass systems and methods for customized vision treatments that account for effects associated with corneal flap creation.. .
|System and method for monitoring change of intraocular pressure and contact lens for sensing change of intraocular pressure|
A system and a method for monitoring change of intraocular pressure and a contact lens for sensing change of intraocular pressure are provided. The contact lens includes a first material layer and a first pattern.
|Crosslinker enhanced repair of connective tissues|
A protein crosslinker delivery device includes a body and a protein crosslinker held in a synthetic or natural biodegradable polymer. The body, a coating on the body, or an attachment to the body can contain the protein crosslinker holding biodegradable polymer.
|After-treatment of refraction correction by ophthalmic surgery|
A planning system for generating control data, a treatment device for ophthalmic surgery to correct refraction, and a method for generating control data for such a treatment device, by which method it is easily possible to continue an interrupted treatment or correct a previous treatment. To this end, the planning system has calculating means for defining a corneal incision surface, wherein the calculating means determine the new corneal incision surface such that the existing corneal incision surface is incised by at least a part of the new corneal incision surface at an angle of between 60° and 120°..
|Laser system and method for correction of induced astigmatism|
There is provided a system, apparatus and methods for developing laser systems that can create precise predetermined clear corneal incisions that are capable of reducing induced astigmatism. The systems, apparatus and methods further provide laser systems that can provide these incisions at or below bowman's membrane..
|High-order optical correction during corneal laser surgery|
Systems and methods related to corneal ablation for treatment of one or more high-order optical aberrations are provided. A method includes providing a defect-correcting prescription, determining an ablation profile to impose the prescription on the cornea, and determining a sequence of laser-energy ablations to impose the ablation profile on the cornea.
|Method for preparing corneal donor tissue for refractive eye surgery utilizing the femtosecond laser|
A method of accurately fabricating a non-human donor corneal tissue for implantation into a recipient human cornea, the method comprising the steps of: removing corneal tissue from a donor with a femtosecond laser; placing the corneal tissue in a fixative solution for a selected time interval to cross-link the collagen fibrils in the tissue and prevent swelling of the corneal tissue; and shaping the tissue to provide a conical inlay of a selected shape and thickness having one or more radial extensions. The method is such that the corneal inlay may be attached to the peripheral corneal and/or the sclera.
|Shielded intraocular probe for improved illumination or therapeutic application of light|
An intraocular light probe has a mask or shield affixed at its distal end thereof which forms a directed light beam for intraocular application of light to target tissues or intraocular application of therapeutic light. The mask or shield serves to more fully focus, intensify and direct the beam toward the target tissues.
|Eye coverings for corneal healing and methods of use|
Methods for providing faster visual and functional recovery of patients following ocular therapy such as ocular therapy involving manipulation of the ocular tissue and/or associated with a lesion external to the optical region and ocular therapy involving incising the ocular tissue and implanting a device within the optical region are disclosed. Methods of healing a trauma wound to a cornea and methods of protecting an eye of a patient from potential injury are also disclosed.
|Sodium channel blocker delivery system with scleral lens|
A scleral lens is provided with a sodium channel blocker or a sodium channel modulator disposed in the pre-corneal tear film between the scleral lens and the cornea. This system can be used to deliver sodium channel blockers or a sodium channel modulators not currently used because of poor bioavailability.
|Device for assisting in the preparation of an operation on the human eye|
According to an exemplary embodiment, a device (12) for assisting in the preparation of an operation on the human eye (14) for the purpose of generating a corneal flap by means of a microkeratome system (10) includes: an input interface arrangement (50) that permits at least the input of data relating to a set value of at least one flap parameter and also to at least one patient-related parameter; a computer (46) that has been set up to access a stored data collection (44) of several surgical data records, each of which includes a post-operative actual value of at least one flap parameter, a value for at least one patient-related parameter and configuration data of the microkeratome system, the computer (46) having been set up to ascertain, on the basis of the data collection (44) in a manner depending on the input data, configuration information that represents a proposed configuration of the microkeratome system (10); an output interface arrangement (48) for outputting the configuration information.. .
|Medical tools for small incision eye surgery|
Systems, devices and methods for performing small incision dlek include providing a corneal transplantation donor tissue graft; then forming the tissue graft into an implantable configuration using the flexible substrate. Related medical kits and tools for forming a compact or rolled donor tissue graft are also described..
|Ophthalmic surgical device for capsulotomy|
A surgical device and procedure are provided for performing microsurgery, including a capsulotomy of a lens capsule of an eye. The device has an elastically deformable cutting element mounted within an elastomeric suction cup.