Abstract:… in their work environments. The final product is intended to prevent accidents caused by individuals whose occupations require sustained periods of vigilance (e.g. pilots, truck drivers etc.) and to assist those suffering from sleep disorders. $ = TOTAL AWARD AMTS &… more
Abstract:… as part of functional cochlear implant systems. The goal of this research is a substantial improvement in the quality of sound provided by cochlear implants, permitting an even higher percentage of recipients to function normally in hearing society. $ = TOTAL AWARD AMTS &… more
Abstract:…e rate at which they are removed or destroyed by the immune system. Much of the work proposed is aimed at obtaining precise information about the behavior of small model compounds which mimic the polyethylene glycol substituents intended for ultimate use. $ = TOTAL AWARD AMTS &… more
Abstract:… on this technology. The reduced number of keys makes it possible to design a highly effective system that is smaller, lighter, and more cost- effective than today's systems, and which is also easier to learn for individuals with basic literacy. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… kinase specificity will be evaluated for their cytotoxic/cytostatic potential, and their effect on cell cycle distribution. More advanced biochemical evaluation and in vivo studies of the drug candidates will be included in Phase II of this program. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… probe, and will experimentally determine the improvement in the ability of clinicians to differentiate prostate anatomical structures. Following a successful evaluation in Phase I, they would develop the algorithm for real-time operation in Phase II. $ = TOTAL AWARD… more
Abstract:… the design and analysis of the test and its preliminary feasibility and validation study. Phases II and III work will concentrate on a wide-range validation protocol, together with optimization studies and a construction of a prototype automated instrument. $ = TOTAL AWARD… more
Abstract:… in vitro evaluation of the aerosol properties and the quality of the aerosolized DNA/vector will be done in Phase I. In Phase II, the investigators plan to commence on clinical scale product development and pre clinical studies in a primate model. $ = TOTAL AWARD AMTS &… more
Abstract:… this knowledge to teachers, who, by virtue of their profession, are at the front line of drug abuse. We will do so by engaging teachers at no expense to themselves, in workshop to be conducted by recognized experts from the scientific community. $ = TOTAL AWARD… more
Abstract:… agents will target IGF-I receptor expression through a novel mechanism of action and may be applicable to other forms of cancer. Additional success with the SCRIBE technology will also attract licensing agreements with other pharmaceutical companies. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… numerical methods with highest priorities will be implemented, producing a fully functional program. Creation and usability testing of the interface and rigorous definition of the computational requirements will demonstrate the feasibility of the software. $ = TOTAL AWARD… more
Abstract:… on (i) evaluation of the grids for performance, (iii) evaluation of all the available approaches of making a focused grid and the associated fabrication issues. In Phase II, research will concentrate on the fabrication and testing of the focused grids." $ = TOTAL … more
Abstract:… similar to TV remote controls. A prototype unit will be build in Phase I to demonstrate concepts and to develop consumer attributes through field trials. In Phase II, they will develop miniaturization concepts to make this a practical unit for home use. $ = TOTAL AWARD… more
Abstract:… ceramic package will allow the use of simple cable connectors, even for large arrays. The technology to be developed will ultimately provide the basis for interconnect systems to be used in human experimentation with neuroprosthetic applications. $ = TOTAL AWARD AMTS… more
Abstract:… related cytokines and growth factors. Results obtained from these studies will be valuable for creating long-acting versions of other members of the OH supergene family for use in treating cancer, infectious diseases and hematopoietic disorders. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… accessibility to information? Through answering these six questions, a detailed protocol for the production, testing, and evaluation of an EPSS that enhances adoptive parents' ability to deal with the problems associated with FAS will be developed. $ = TOTAL AWARD AMTS &… more
Abstract:… optimized for operation at 1480 nm. By the use of a fluorescence temperature indicator, conditions for irradiation will be determined (pulse width, power) that give optimal localized ablations with minimum thermal and mechanical shock damage to adjacent regions. $ = TOTAL … more
Abstract:… virulence and inserting these into the safe, avirulent Towne genome, a strain can be created which will confer an increased immunogenicity or replication to Towne. This new CMV will be tested to assess whether it protects recipients from CMV disease. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… and effectiveness in delivering information. Phase II will expand the software to cover the first year of a child's life and includes an efficacy study of the final product. Currently, we are in Phase I and are evaluating the Mother's Helper software. $ = TOTAL AWARD… more
Abstract:… issues of clearance, retention, organ distribution, etc. They will also develop a program to produce variants of the HSV-TK. These will be challenged with the new compounds to find the most active combination of variant enzyme and novel substrate. $ = TOTAL AWARD AMTS &… more
Abstract:… of results in a few minutes. The technology of Digital Response will benefit patients by providing a convenient and inexpensive method to monitor, at the point-of-care, the effectiveness of treatment to reduce accelerated bone loss in postmenopausal women. $ = TOTAL AWARD… more
Abstract:…rol of the laser and will be based on neonatal tissue signature change at the welding endpoint. The subsequent development of a reliable tissue welding system will provide the bond strength and the ability to grow rapidly as required in the neonate. $ = TOTAL AWARD AMTS & NOT… more
Abstract:…ase 2 SBIR) in vivo studies. The Complex Carbohydrate Research Center (CCRC) will provide guidance and assistance to us in the purification of the active moiety and will establish composition and structure of this compound at their research center. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… group to the gamma-carboxylate of glutamyl-tRNA-Gln. In eukaryotic cells, the formation of glutaminyl-tRNA-Gln is catalyzed by glutamine-tRNA synthetase, providing the opportunity to develop chemotherapeutic agents specifically targeted at bacteria. $ = TOTAL AWARD AMTS &… more
Abstract:…s within the human genome. This application focuses on determining the feasibility of (1) automated microsatellite genotyping with low error on data from automated DNA sequencers and (2) automated microsatellite genotyping using pooled DNA material. $ = TOTAL AWARD AMTS & NOT… more
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