|meta Protein DisOrder prediction System|
Input protein amino acid sequences in plain text or FASTA format into the form. Multiple FASTA formatted inputs are not acceptable. The server accepts the 20 single letter codes for standard amino acids. The code 'X' generally used for non-standard amino acids can not be accepted. Too long sequences with lengths greater than 500 residues are not accepted because of the limitation of predictors.
|Amino acid||Single letter code|
Although it depends on the length of query protein and condition of each component server, metaPrDOS usually takes from 5 to 10 minutes to predict a protein sequence. Occasionally, some external servers would not reply to our forwarded query within an hour (predefined limit in metaPrDOS server), because they may be down temporally or they may set a limit to handle a request in a single day from the same IP address. At that time, metaPrDOS will make a prediction using all available prediction results. For the purpose, we prepared trained meta-predictors for all combination of predictor in advance.
No AA Pred Probability -------------------------- 1 A * 0.85 2 W * 0.76 3 L * 0.82 4 E * 0.84 5 A * 0.82 6 Q * 0.79 7 E * 0.80 8 E * 0.79 9 E * 0.75 10 E 0.68 11 V 0.61 12 G 0.53 --------------------------
The middle part shows the plot of disorder tendency of each residue along the sequences. Residues beyond the red threshold line in this plot are predicted to be disordered. The user can change the size of the plot through the web-interface and also check the prediction results of each external prediction methods.
Occasionally, some external servers did not reply to our forwarded query within an hour (predefined limit in the metaPrDOS server) because they may have been down temporarily or they may set a limit to handle requests in a single day from the same IP address. At that time, metaPrDOS will make a prediction using all available prediction results. The prediction method used for meta prediction can be checked at this part. When the number of available servers was limited, the performance of the meta approach deteriorated. The performance of such cases can be checked at prediction performances for all combinations of each component predictor page.