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CAPLUS COPYRIGHT 2013 ACS
||Preparation of triazolylpyridine derivatives and analogs for use as DGAT-1 inhibitors
||Devita, Robert J.; He, Shuwen; Liu, Jian; Cernak, Timothy A.; Krikorian, Arto D.; Yang, Ginger Xuqiang; Wu, Zhicai; Yu, Yang; Shen, Dong-Ming; Lai, Zhong; Hong, Qingmei; Nargund, Ravi P.
||Merck Sharp & Dohme Corp., USA
||PCT Int. Appl., 119pp. CODEN: PIXXD2
Title compds. I [T = bond or O; U = (un)substituted Ph, pyridinyl, pyrimidinyl, etc.; V and X independently = CH or N; Y and Z independently = N, CH, or CR2; R1 = alkoxy, (un)substituted pyridinyl, cyclohexanyl, etc.; R2 = (un)substituted alkyl, Ph, cycloalkyl, etc.; R3 = halo, CN, alkyl or alkoxy and is optionally present at one of more of the ring carbons; provided at least one X, Y, or Z is N], and their pharmaceutically acceptable salts, are prepd. and disclosed as DGAT-1 inhibitors. Thus, e.g., II was prepd. by a multistep procedure (prepn. given). Select I were evaluated in hDGAT1 assays (data given).
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