Seminars in Immunology
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- Sciencedirect from 1993, CSA, Proquest, Gale, Rcgp, and Ingenta
TWEAK/Fn14 axis: the current paradigm of tissue injury-inducible function in the midst of complexities.
TNF-like weak inducer of apoptosis (TWEAK), a TNF family ligand, and its only known signaling receptor, FGF-inducible molecule-14 (Fn14), have emerged as a key molecular pathway regulating tissue responses after acute tissue injury and in contexts of chronic injury and disease, including autoimmunit...
Ectodysplasin research--where to next?
Ectodysplasin (Eda) is the most studied tumor necrosis ligand in the field of developmental biology. In all vertebrates studied so far, inactivating germline mutations in Eda lead to the genetic disease called hypohidrotic ectodermal dysplasia (HED). In humans, HED is a life-threatening condition in...
The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury
Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Seq...
Cancer vaccines: the state of the art.
The TNF family: only the surface has been scratched.
B cell maintenance and function in aging.
We discuss the changes that occur in the B lymphocyte compartment of mice and humans as they progress to old age, focusing on recent advances in this important area of research. Primary areas considered include increased morbidity and mortality in the elderly following infection, and decreased respo...
Cell surface immunoglobulin receptors in B cell development
We assess the regulatory functions of different components of the sIg receptor complex during early development in experimental systems from evolutionarily distinct species....
Challenges and opportunities in targeting the costimulation pathway in solid organ transplantation
Highlights ► Costimulation pathways are involved in T cell regulation. ► Belatacept blocks an important costimulatory pathway (CD28:CD80/86). ► In transplantation belatacept has demonstrated significant renal preservation. ► Optimal use of belatacept is in a lower intensity regimen in EBV...
Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation
Highlights ► Gfi1 is required for T-cell development. ► Gfi1 is required for B-cell development and restricts Immunoglobulin production. ► Gfi1 promotes Th2 development and inhibits Th17 and iTreg development.
Temporal and spatial regulatory functions of the V(D)J recombinase.
In developing lymphocytes, V(D)J recombination is subject to tight spatial and temporal regulation. An emerging body of evidence indicates that some of these constraints, particularly with respect to locus specificity and cell cycle phase, are enforced by regulatory cues that converge directly on th...