Professor Gilean McVean
University Lecturer in Mathematical Genetics
mcvean at stats.ox.ac.uk
+44 (0) 1865 272860 (Department)
+44 (0) 1865 281881( Direct)
+44 (0) 1865 272595 (Fax)
Population genetics, Coalescent modelling, Statistical genetics, Pathogen evolution and variation
My research covers several areas in evolutionary biology and population genetics, combining both theoretical work and empirical analyses. Of particular interest is the analysis of recombination from population genetic data, the relationship between linkage disequilibrium and properties of the underlying genealogy, and methods for inferring genealogical history from DNA sequence data. I am a member of the Mathematical Genetics Group in the Department of Statistics.
- Spencer CC, Deloukas P, Hunt S, Mullikin J, Myers S, Silverman B, Donnelly P, Bentley D, McVean G. (2006). The influence of recombination on human genetic diversity. PLoS Genet 2:e148.
- de Bakker PI, McVean G et al (2006). A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet 38:1166-1172.
- Wilson DJ and McVean G (2006). Estimating diversifying selection and functional constraint in the presence of recombination. Genetics 172:1411-1425.
- Myers C, Bottolo L, Freeman C, McVean G and Donnelly P (2005). A fine-scale map of recombination rates and hotspots across the human genome. Science 310: 321-324.
- McVean, GAT., Myers, S., Hunt, S., Deloukas, P., Bentley, DR and Donnelly, P. (2004). The fine-scale structure of recombination rate variation in the human genome. Science 304:581-584
1994 – 1997: PhD in Dept. of Genetics, Cambridge University with Laurence Hurst
1997 – 2000: Postdoc with Brian and Deborah Charlesworth, Edinburgh University
2000 – 2004: Royal Society University Research Fellow, Dept. Statistics, Oxford
2004 – present: University Lecturer in Mathematical Genetics