Datasets:
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---
license: cc-by-4.0
tags:
- biology
- rna
- genomics
---
# Overview
mRNA half-life is a measure of the degradation rate of mRNA molecules. This experiment reports the time that the expression level of a transcript takes to decrease by half. The original data source aggregates 39 human and 27 mouse transcriptome wide datasets -- this dataset contains the mouse datasets. Several data preprocessing steps are taken, reported in the original paper. Half-life measures per gene averaged across collected datasets, and PCA is performed on the gene x half-life matrix. To reduce experimental noise, this dataset reports the value of the first principle component.
This dataset is redistributed as part of mRNABench: https://github.com/morrislab/mRNABench
# Data Format
Description of data columns:
- `target`: First PCA component of half-life measurements across aggregated datasets.
- `cds`: Binary track which reports position of first nucleotide in each codon in CDS.
- `splice`: Binary track which reports position of the 3' end of each exon, indicating splice sites.
# Data Source
This dataset is a Hugging Face redistribution of the mRNA half-life dataset originally collected in the Saluki paper (Agarwal and Kelley 2022), which itself is a collection of experimental datasets. See original paper for all data sources. The Saluki dataset is licensed under the Creative Commons Attribution 4.0 International License.
Original paper: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02811-x
Original dataset source: https://zenodo.org/records/6326409
Citation: Agarwal, V. & Kelley, D. R. The genetic and biochemical determinants of mRNA
degradation rates in mammals. Genome Biol 23, 245 (2022). |