User: Is the molecule with the SMILES COC(=O)N1CCN(C(=O)Cc2ccc(Cl)c(Cl)c2)[C@@H](CN2CCCC2)C1 permeable through the membrane separating circulating blood and extracellular brain fluid?
Assistant: Yes, it is permeable through the membrane separating circulating blood and extracellular brain fluid.
User: Is the molecule with the {SMILES__description} {SMILES#} {p_np__names__adjective}?
Assistant: {p_np#No&Yes}, it is {p_np#not &NULL}{p_np__names__adjective}.
COC(=O)N1CCN(C(=O)Cc2ccc(Cl)c(Cl)c2)[C@@H](CN2CCCC2)C1
COC(=O)N1CCN(C(=O)Cc2ccc(Cl)c(Cl)c2)[C@@H](CN2CCCC2)C1
methyl(3S)-4-[2-(3,4-dichlorophenyl)acetyl]-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate