The man, 71, was injured at about 21:25 BST outside Earl's Court Tube station on Friday night. He died in hospital.
Met Police said the driver did not stop at the scene and it is not known if the individual was aware of the collision.
Officers have urged the driver of the large, white, articulated lorry, to contact them.
A lorry driver is being sought by police following the death of a pedestrian who was hit by a vehicle in central London.