Second Half begins Manchester United 2, Reading 0.
Substitution, Reading. Jordan Obita replaces Tyler Blackett.
First Half ends, Manchester United 2, Reading 0.
Attempt missed. Anthony Martial (Manchester United) right footed shot from the centre of the box is high and wide to the right. Assisted by Marcus Rashford.
Attempt missed. Juan Mata (Manchester United) left footed shot from outside the box is too high. Assisted by Anthony Martial.
Attempt blocked. Juan Mata (Manchester United) left footed shot from the centre of the box is blocked. Assisted by Ashley Young.
Offside, Manchester United. Ashley Young tries a through ball, but Juan Mata is caught offside.
Foul by Marouane Fellaini (Manchester United).
Liam Moore (Reading) wins a free kick in the defensive half.
Attempt missed. Juan Mata (Manchester United) left footed shot from outside the box misses to the left following a set piece situation.
Attempt blocked. Juan Mata (Manchester United) left footed shot from outside the box is blocked.
Ashley Young (Manchester United) wins a free kick in the attacking half.
Foul by Roy Beerens (Reading).
Corner,  Manchester United. Conceded by Yann Kermorgant.
Corner,  Manchester United. Conceded by Joey van den Berg.
Attempt blocked. Chris Smalling (Manchester United) right footed shot from the centre of the box is blocked. Assisted by Wayne Rooney with a cross.
Corner,  Manchester United. Conceded by Ali Al Habsi.
Attempt saved. Marcus Rashford (Manchester United) right footed shot from the right side of the box is saved in the centre of the goal. Assisted by Wayne Rooney with a through ball.
Foul by Marcus Rashford (Manchester United).
Joey van den Berg (Reading) wins a free kick in the defensive half.
Attempt missed. Wayne Rooney (Manchester United) right footed shot from outside the box is too high.
Attempt missed. Marcus Rashford (Manchester United) right footed shot from outside the box misses to the right. Assisted by Anthony Martial.
Attempt missed. Marcus Rashford (Manchester United) right footed shot from a difficult angle on the right is close, but misses to the right. Assisted by Chris Smalling with a through ball.
Attempt missed. Liam Moore (Reading) right footed shot from the centre of the box misses to the right. Assisted by Joey van den Berg following a corner.
Attempt missed. Joey van den Berg (Reading) left footed shot from the left side of the box misses to the right. Assisted by Liam Kelly with a cross following a corner.
Corner,  Reading. Conceded by Phil Jones.
Attempt saved. Anthony Martial (Manchester United) left footed shot from the left side of the box is saved in the centre of the goal. Assisted by Juan Mata.
Corner,  Reading. Conceded by Michael Carrick.
Marouane Fellaini (Manchester United) wins a free kick in the defensive half.
Foul by Danny Williams (Reading).
Delay over. They are ready to continue.
Substitution, Manchester United. Phil Jones replaces Marcos Rojo because of an injury.
Delay in match Marcos Rojo (Manchester United) because of an injury.
Offside, Manchester United. Sergio Romero tries a through ball, but Wayne Rooney is caught offside.
Marcus Rashford (Manchester United) wins a free kick on the left wing.
Foul by George Evans (Reading).
Goal!  Manchester United 2, Reading 0. Anthony Martial (Manchester United) right footed shot from the left side of the box to the bottom right corner. Assisted by Wayne Rooney.
Attempt saved. Anthony Martial (Manchester United) right footed shot from the left side of the box is saved in the top right corner. Assisted by Juan Mata.
Attempt missed. Juan Mata (Manchester United) left footed shot from outside the box is high and wide to the left following a corner.
Corner,  Manchester United. Conceded by Danny Williams.
Argentine goalkeeper Sergio Romero will also start instead of David de Gea.
Morgan Schneiderlin and Memphis Depay will not be considered while their futures remain unresolved.
Reading midfielder Callum Harriott (hamstring) will miss the Old Trafford trip, while Stephen Quinn and Anssi Jaakkola (both knee injuries) are out.
Striker Deniss Rakels is nearing a return from a broken ankle but is not expected to be included in the squad this weekend.
England and Manchester United captain Rooney, 31, needs one goal to equal Sir Bobby Charlton's all-time club record of 249 and returns after missing three games with a thigh problem.
United, who are sixth in the Premier League, are aiming for their eighth successive win in all competitions.
The Championship visitors are managed by former Red Devils defender Jaap Stam, who has led them to third place in the second tier.
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Manchester United manager Jose Mourinho:
"We don't need to go to Reading for a replay. It would be even worse if we were out of the competition in the first game. We have to try and win.
"We need points in the Premier League and got 18 in a short period of time. Now it is Reading and Hull in the EFL Cup semi [on Tuesday], which is very important. A busy time for us. We are in good situation with everyone available."
Reading manager Jaap Stam told BBC South Today:
"We know it's going to be a tough game, but we've got confidence in ourselves, we believe in what we can do.
"Of course it doesn't make it easier for you if you've got to play Manchester United. But we're looking forward to this game. You want to go to places like Old Trafford and show what you can do.
"It's always nice for a manager to have a game like this, but also for the players and for the squad to have an opportunity to face quality players."
BBC Radio Berkshire's Tim Dellor:
One Portuguese manager who has at times endured a tricky start to his new club this season, and never hides in the shadows, who has won so many trophies in his career, up against a Dutchman who has had the dream start to life at his new club, seems keen to avoid the limelight, and has not yet won anything in his management career.
Of course all the pre-match hype will be around Stam's departure from Old Trafford as a player, but equally the contrasting characters. Mourinho's difficult relationship with Reading (stemming from Chelsea goalkeeper Petr Cech's accident at the Madejski Stadium 10 years ago), or Reading's impressive recent cup exploits could dominate the build-up.
Two years ago, Reading reached the FA Cup semi-finals for the first time since 1927. Ninety years ago, they beat Manchester United 2-1 during the run, but haven't repeated the trick since.
They've won both their most recent away games in the Championship 3-2, so they should not be low on confidence.
Manchester United captain Wayne Rooney will start Saturday's FA Cup third-round tie against Reading, says Red Devils manager Jose Mourinho.