The incident happened at about 13:00 near the junction at Torness Power Station.
Police said the man, who was driving a black Ford Focus, suffered serious injuries. He was taken to hospital in Edinburgh but died a short time later.
The 51-year-old man driving the lorry was uninjured. An investigation into the cause of the crash is ongoing.
Witnesses to the collision are asked to contact police.
A 70-year-old man has died after his car was in collision with a lorry on the A1 in East Lothian.