When the pandemic first struck and lockdown orders were widespread, a handful of stocks massively benefited. It was a fascinating time to be an investor, and those who flocked to the stay-at-home type of stocks were rewarded handsomely with considerable gains. In 2022, these once seemingly unstoppable stocks have found themselves deep in the red, leaving dents in many portfolios. In its simplest form, many of the high-growth pandemic winners have been massively affected by the Fed's tightening cycle. A few big-time winners of the pandemic include Zoom Video Communications ( ZM - Free Report ), Teladoc ( TDOC - Free Report ), and Shopify ( SHOP - Free Report ). Below is a year-to-date chart of all three companies with the S&P 500 blended in as a benchmark. Image Source: Zacks Investment Research As we can see, it's undoubtedly been a tough stretch. However, some buyers have finally appeared over the last month, as illustrated in the chart below. Still, both ZM and TDOC have lagged the S&P 500 notably.