Because symptoms often develop slowly, diagnosis may be delayed by years or decades, making it difficult to determine the total number of people with the disease. About Chiasma Chiasma is dedicated to improving the lives of patients who face challenges associated with their existing treatments for rare and serious chronic diseases. The company is headquartered in the United States with a wholly-owned subsidiary in Israel. Chiasma, the Chiasma logo, and MPOWERED are trademarks of Chiasma.