Bortezomib (Velcade), a targeted therapy medication, is frequently used during induction. It may also be used as part of combination therapy with the immunomodulator lenalidomide (Revlimid ) and the steroid dexamethasone. Typically, autologous stem cell transplants are employed. Prior to the transplant, healthy stem cells are extracted from the patient's body rather than from a donor. A large dose of chemotherapy is given prior to a stem cell transplant to kill the cells in the bone marrow. This kills both normal and malignant cells. The previously obtained stem cells are then infused. The goal is for these cells to colonize the body and establish healthy bone marrow. A simultaneous stem cell transplant may also be advised. This entails receiving two autologous stem cell transplants in quick succession. Receiving a tandem stem cell transplant may aid in overall survival. Following a stem cell transplant, maintenance therapy is administered.