Presenters: Sheila Hegde, 1 Sara Saberi 2 1. Brigham and Women's Hospital, Boston, Massachusetts, USA 2. University of Michigan Medical School, Ann Arbor, Michigan, USA Disclosure: Dr Hegde has received an institutional grant from MyoKardia. Dr Saberi has received consulting fees from MyoKardia. Acknowledgements: Writing assistance was provided by Amanda Barrell, Brighton, UK. Support: The writing and publication of this article was funded by MyoKardia, Inc., a wholly owned subsidiary of Bristol Myers Squibb TM. The EXPLORER-HCM study was funded by MyoKardia, Inc., a wholly owned subsidiary of Bristol Myers Squibb TM. Citation: EMJ Cardiol. 2021;9[Suppl 1]:2-6.