AXS-05 is a novel, oral, investigational non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with multimodal activity under development for treating central nervous system (CNS) disorder. Apart from the STRIDE-1 study, Axsome is conducting a phase III GEMINI study on AXS-05 for the treatment of major depressive disorder (MDD) and a phase II/III ADVANCE-1 study on agitation associated with Alzheimer's disease (AD). The company completed a phase II ASCEND study on MDD and a phase II study on smoking cessation.