This is the focus of Silence's ongoing Atu027 Phase I study, and we are pleased that the product continues to be protected by this intellectual property and other patents, for example, those around AtuPLEX and the AtuRNAi sequence used in the product. Silence has exclusive licenses covering three patent families from the University of Massachusetts Medical School collectively known as the 'Zamore Design Rules'. In 2011, following an anonymous request, four of the US patents covering the Zamore Design Rules successful completed re-examination by the US Patent and Trademark Office ('USPTO') and in December 2011, we were able to report that the USPTO had issued 'Notices of Intent to Issue Re-examination Certificates'. In Europe, the patent is currently being opposed by Alnylam and other parties. Investors Relations ('IR') Strategy Silence Therapeutics maintains active communications and an investor relations' strategy to provide transparency and maximise dialogue with its stakeholders.