Organovo Holdings (ONVO) had the worst year ever in 2015, the stock lost most of its value and is trading below the $3 mark. Despite the fact that the company finally released its first product, presented impressive results, tied in projects with clients, and even reported revenue during the year. All this did not help Organovo's case, why because firstly, the investors had substantially high hopes for the stock, second, the company took one stock offering after another during the year to accumulate cash, and thirdly, the short interest in the company was and still is substantial. However, the short interest has been on a decreasing trend, with almost 2% decrease recently and bringing the interest to 15.27% of the float.