Cephalon ( CEPH) upgraded at Jefferies from Hold to Buy. $63 price target. Stock is already pricing in negative news and there's upside potential for Treanda sales. Ciena ( CIEN ) target boosted at Citigroup. Shares of CIEN now seen reaching $18.50. Still believe the Nortel deal makes strategic sense. Buy rating. Ciena ( CIEN ) downgraded at Jefferies from Hold to Underperform. $12 price target. See several risks surrounding the Nortel acquisition. Lexicon Pharmaceuticals ( LXRX ) initiated at Thomas Weisel with and Overweight rating and $2.50 price target. 2009 and 2010 EPS estimates set at -$0.55 and -$0.54, respectively. Prudential Financial ( PRU ) upgraded at Wells from Market Perform to Outperform. Company is emerging from the financial crisis in a relatively strong position. Reliance Steel ( RS ) upgraded at UBS from Neutral to Buy. Company should see more M&A opportunities materialize. $50 price target. St.