Ampio was recently awarded multiple patents worldwide for combinations of Zertane™ with any PDE5 inhibitors and for reduction of side effects of Tramadol. These recently awarded patents will benefit from a full patent life and are important for negotiations with potential partners whose PDE5 inhibitors patent protection has expired or are about to expire which could be greatly extended by Ampio's patents." Mr. Macaluso continued "As a first step for the clinical study of Zertane-ED ™, Ampio entered into an agreement with Syngene ( Bangalore, India ) to begin manufacturing (in compliance with FDA standards) the combo product for the conduct of a phase III trial for these co-morbid conditions in South Korea by our partner Daewoong Co. Ltd. By previous contractual agreement Daewoong will finance and conduct the South Korean phase III trial according to FDA standards/guidelines and the data generated will be used both for approval in South Korea and to support an FDA submission.