The above statement by Schechter is telling for two reasons. First, it likely establishes Bristol-Myers Squibb 's ( BMY 2.09% ) Opdivo as the superior second-line NSCLC therapy because it can treat patients regardless of PD-L1 tumor expression levels, while Keytruda is only approved to treat patients with high PD-L1 expression. Despite beating Opdivo to market, Keytruda's $249 million in Q1 sales puts it well behind Opdivo's $704 million in total first-quarter sales.