"We are very excited to achieve this early milestone under our collaboration with Incyte as CB-1158 has demonstrated the desired pharmacologic activity in humans, with a corresponding elevation in plasma arginine levels to those achieved with efficacious doses in preclinical models of cancer. Through our collaboration with Incyte, we will continue to evaluate the role of arginase inhibition in the immuno-oncology setting with CB-1158, and we expect to present additional clinical data mid-2017," said Susan Molineaux, President and Chief Executive Officer of Calithera Biosciences. In January 2017, Calithera and Incyte established a global collaboration and license agreement for the research, development, and commercialization of Calithera's first-in-class, small molecule arginase inhibitor CB-1158 in hematology and oncology. CB-1158 is currently being studied in a monotherapy dose escalation clinical trial and also in combination with anti-PD-1 therapy.