Humira volume is rapidly eroding compared to other novel mechanisms (including Skyrizi and Rinvoq). The decline expected to be sharper in 2025 as more plans exclude branded Humira and move to exclusive biosimilar contracts.AbbVie is witnessing declining sales of Juvederm fillers in the United States and China due to challenging market conditions. The slowing growth of the U.S. facial injectables market and persistent economic headwinds, which are affecting consumer spending in China, are hurting Juvederm's sales due to its higher price point. Juvederm sales declined 14.6% in 2024.ABBV's global sales of aesthetics portfolio declined 0.6% in 2024. On the fourth-quarter conference call, AbbVie also lowered its guidance for its aesthetics franchise's long-term growth. It expects a high single-digit CAGR for this franchise through 2029.