One of those reporting was drug giant Pfizer ( PFE ), whose fourth-quarter earnings fell to $1.49 billion, or 21 cents a share, from continuing operations, down from $2.6 billion, or 35 cents a share, last year. Pfizer's sales rose slightly to $12.6 billion from $12.55 billion a year earlier. Excluding certain costs, latest-quarter earnings were 43 cents a share, a penny better than estimates. The company also announced the elimination of 10,000 jobs, a move that is expected to yield savings of $1.5 billion to $2 billion by the end of 2008. Pfizer shed 27 cents, or 1%, to $26.95. Fellow Dow component American Express posted a fourth-quarter profit of $922 million, or 75 cents a share, up 24% from a year ago. Revenue jumped 13% to $7.2 billion. However, analysts expected the credit card giant to earn 76 cents on $7.33 billion of revenue. The stock dipped 3 cents, or 0.1%, at $58.06.