An independent Data Safety Monitoring Board has continuously evaluated safety data during the trial and has not identified any safety concerns. The majority of solicited adverse events observed following VLA1553 administration were mild or moderate and resolved within three days. Importantly, the initial data suggest a favorable safety profile in seropositive participants, confirming the observations following re-vaccination of individuals in Phase 1 trial VLA1553-101 9. Juan Carlos Jaramillo M.D., Chief Medical Officer of Valneva, said, "These new data in a younger population and in individuals previously infected with the chikungunya virus confirm the robust immunity and safety profile we previously observed in adults and the elderly. Given the significant threat that chikungunya poses to individuals living in or traveling to endemic areas, it is crucial to make the vaccine accessible to all age groups. By doing so, we can enhance the protection and reduce the impact of this debilitating disease."