The Company is offering 8,840,000 of the 10,500,000 common shares in the offering. The remaining 1,660,000 common shares are being offered by certain directors, officers and employees of the Company (the " Selling Securityholders "). The Company has also granted the underwriters an over-allotment option to purchase up to an additional 1,575,000 common shares from the Company at the Offering Price, exercisable for a period of 30 days following closing of the offering. Leerink Partners LLC is acting as the sole book-running manager for the offering. Canaccord Genuity Inc. and JMP Securities LLC are acting as co-lead managers for the offering. Ladenburg Thalmann & Co. Inc. is acting as co-manager for the offering. Closing of the offering will be subject to customary closing conditions, including listing of the common shares on the TSX and NASDAQ and any required approvals of the TSX, and is expected to occur on or about February 3, 2015.