As we announced this morning, after much thoughtful consideration and planning, I've decided that this is the right time to begin a smooth transition of leadership at Alnylam. I've decided that this is the time for me to begin a new chapter in my career of yet again pushing the bounds of biomedical innovation by helping entrepreneurs and companies advance new modalities to improve the lives of patients. I couldn't be more pleased that Yvonne Greenstreet has agreed to help lead Alnylam in a planned transition that will occur at the end of this year. Of course, I am so honored to have the opportunity to build Alnylam over the last 19 years in RNAi therapeutics to patients around the world.