The treatment benefit of Kineret was supported by increase in the number of patients fully recovered (50.4% and 26.5%) and significantly reduction of risk of death by 55% by day 28 compared to placebo (HR: 0.45, 95% CI 0.21–0.98, P = 0.045). No new safety signals or safety concerns were observed from the use of Kineret for treatment of COVID-19.