In 2020, SIGA submitted an application for marketing authorization to the European Medicines Agency (EMA) that includes a broader label indication including the treatment of orthopox indications, including monkeypox, cowpox, and vaccinia complications in addition to smallpox. Approval is expected in late 2021 or early 2022. "As we undergo regulatory review in the EU and Canada for an expanded label for TPOXX, we continue to provide TPOXX as a compassionate use treatment for monkeypox, cowpox, and vaccinia complications," said Phil Gomez, CEO of SIGA Technologies, "It is becoming clear TPOXX will be an important tool to treat these diseases throughout the world, and we are committed to expanding our regulatory approvals and provide access for patients." Monkeypox is a contagious disease caused by infection with monkeypox virus, a virus closely related to variola virus, which causes smallpox.