The Bottom Line: In the 3 month assessments, 3 patients have tolerated the cell transplantation very well, and have no safety concerns at this point. 2 of the 3 patients have gained considerable sensory function. The gains in sensation have evolved in a progressive pattern below the level of injury and are unanticipated in spinal cord injury patients with this severity of injury, suggesting that the neural stem cells are having a beneficial clinical effect. Sensory function of all these patients was stable before transplantation, so the reappearance of sensation is rather unexpected. This is the first time a sensory change of this magnitude has been reported in patients with complete spinal cord injury following stem cell transplantation. STEM will need to collect more data to establish efficacy and is pushing ahead with the trial and plans to dose the 1st patient with an incomplete injury soon.