The simplest way to benefit from a rising market is to buy an index fund. Active investors aim to buy stocks that vastly outperform the market - but in the process, they risk under-performance. Unfortunately the Crinetics Pharmaceuticals, Inc. ( NASDAQ:CRNX ) share price slid 38% over twelve months. That's well below the market decline of 24%. Longer term shareholders haven't suffered as badly, since the stock is down a comparatively less painful 9.8% in three years. The falls have accelerated recently, with the share price down 18% in the last three months. But this could be related to the weak market, which is down 8.7% in the same period.