Her most notable cases include the prosecutions of Goldman Sachs, two former Goldman Sachs bankers and a Malaysian financier for their participation in a multi-billion dollar bribery scheme related to 1Malaysia Development Berhad (1MDB), Malaysia's investment development fund. Her trial convictions include the conviction of Martin Shkreli for securities fraud offenses related to two hedge funds and a pharmaceutical company he had founded, and a Gambino crime family associate for murder in-aid-of racketeering and racketeering conspiracy, with predicate acts including two murders. Jacquelyn also prosecuted over 15 Genovese crime family members and associates, including three consecutive International Longshoremen's Association union presidents, for their involvement in a thirty-year extortion scheme in which longshoremen were extorted at Christmastime every year at the behest of the Genovese crime family.