Published: 9 April 2021 Public Health Wales supports the expert scientific advice of UK expert groups that the benefits of vaccination with all COVID-19 vaccines in use continue to outweigh the risks of COVID-19. COVID-19 has caused over 120,000 deaths in the UK, with an average of 30 deaths a day still being reported. The vaccination programme has already saved over 6,000 lives. Following reports of an extremely rare and specific blood clot after vaccination with the AstraZeneca COVID-19 vaccine, the Medicines and Healthcare Regulatory Agency (MHRA) and the Joint Committee on Vaccination and Immunisation (JCVI) confirmed on 7 April 2021 that this type of blood clot with low platelets (sticky cells) are a possible side effect of the vaccine. However, they continue to advise that the benefits of vaccination with the AstraZeneca COVID-19 vaccine continue to outweigh the risks of COVID-19 for the vast majority of adults.