Currently, ZYNRELEF is reimbursed by CMS through a special payment policy referred to as pass-through payment status. This pass-through payment status will expire on March 31, 2025. The Proposed Rule's April 1, 2025 effective date for ZYNRELEF is expected to allow ZYNRELEF to continue to maintain separate reimbursement in the HOPD and ASC settings without disruption. Additionally, for calendar year 2025, CMS proposed that payments for qualifying drugs, like ZYNRELEF, will not be reduced by an offset which means Medicare payments will remain at average sales price plus six percent. Given the significant influence of CMS policy on other payer policies, Heron expects that most commercial payers will follow suit. "We applaud the efforts of CMS to expand access to non-opioid postsurgical pain management options.