"Linzess faces competition from Sucampo/Takeda/Abbott's Amitiza and the potential introduction of two additional IBS-C products, namely Synergy's plecanatide and AstraZeneca/Ardelyx's tenapanor, during the forecast period. However, we still expect the drug's uptake to rise by 2023, due to increased physician experience with its use and continued marketing efforts by Ironwood, Actavis, Almirall, and Astellas in their respective markets." Among the late-stage IBS pipeline therapies, GlobalData believes that Furiex's (Actavis') eluxadoline will generate the highest sales by 2023, with expected revenues of around $236.9 million following its anticipated launch in the US, 5EU, and Japan in 2015, 2016, and 2018, respectively. The analyst comments, "Eluxadoline could become the first treatment for both male and female diarrhea-predominant IBS (IBS-D) patients in the US without prescribing restrictions, and the first product indicated for IBS-D in the 5EU.