Reshma Kewalramani, M.D., Chief Executive Officer and President at Vertex, said, "I'm pleased that NHS England has recognized the value of KAFTRIO, and that Vertex and NHS England have been able to work quickly, collaboratively and flexibly to expand the existing reimbursement agreement to include the triple combination therapy in advance of the medicine being licenced. This will ensure that eligible patients in England will be among the first in Europe to benefit from access to this innovative medicine upon approval." The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) recently adopted a positive opinion for KAFTRIO ® (ivacaftor/tezacaftor/elexacaftor) in a combination regimen with KALYDECO ® (ivacaftor) 150 mg to treat people with cystic fibrosis (CF) ages 12 and older with one F508del mutation and one minimal function mutation (F/MF) or two F508del mutations (F/F) in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene.