Neupogen (and now Zarxio) are prescribed mostly for low white-blood cell disorders, often caused by chemotherapy. It had been a billion-dollar blockbuster for Amgen, but its use has declined somewhat in recent years. (By the way, both products are temperature-controlled, requiring refrigerated storage and transportation .) The smallest-dose (300 mg) prefilled syringe will be sold at wholesale at around $275, compared to Amgen's $324. That 15% discount is less than the 30% or so that analysts have been predicting for biosimilar price savings, but the price-negotiation process is only just getting starting in the US. "Even small-molecule generics, when they first enter the market, are priced at 15-20% below the originator product," notes Larry Blandford, EVP and managing partner at Precision for Value, a New York marketing-consulting firm. "When additional small-molecule generics show up, the price drops 60% or more."