"Data from the APOLLO-B exploratory endpoints, coupled with evidence of a generally consistent benefit across pre-specified patient subgroups in the 6-MWT and KCCQ-OS, reinforce our belief that TTR silencing with patisiran has the potential to address multiple aspects of ATTR amyloidosis, including cardiac manifestations of disease," said Rena N. Denoncourt, Vice President, TTR Franchise Lead at Alnylam Pharmaceuticals. "We remain steadfast in our commitment to develop impactful RNAi therapeutic options for patients living with all forms of ATTR amyloidosis as evidenced by today's data and the recent approvals of AMVUTTRA ® (vutrisiran) for adult patients with hATTR amyloidosis with polyneuropathy in the U.S., the European Union, and Japan." Alnylam plans to submit a supplemental new drug application (sNDA) for patisiran as a potential treatment for patients with ATTR amyloidosis with cardiomyopathy for review by the United States Food and Drug Administration (FDA) in late 2022.