Both drugs have very clean safety profiles and in fact have some similar safety issues including anemia and lipid increases. Approval of the Pfizer drug will bode well for Incyte. Analysts foresee a multi-billion dollar product for Pfizer (PFE). Incyte's compound has the advantage of once-daily dosing compared to twice-a-day for tofacitinib. So far, efficacy appears similar. Analyst peg potential sales of INCB28050 at $1.8 billion; with royalties in the high 20s, this can add another $500 million to Incyte's top line.