TG Therapeutics' ublituximab, the sole other anti-CD20 mAb in late-stage development for RMS, lags behind ofatumumab across metrics of company awareness and credibility, and agent awareness, familiarity, and interest. By 2022, assuming a successful ublituximab approval and launch, the mAb DMT class' competitive landscape could look very different with two well-established anti-CD20 agents and biosimilar version(s) of Biogen's Tysabri. Genentech's efforts to move Ocrevus use up earlier in the RRMS treatment algorithm may also be instrumental in shifting MS treatment patterns, while also providing protection from new market entrant-related share erosion ― frequently bestowed upon preferred first-line agents. Indeed, compared to one year ago, neurologists estimate that twice as many treatment-naive RRMS patients without a concerning prognostic profile have recently been initiated on Ocrevus.