TYME's lead CMBT candidate, SM-88, was designed to leverage innate changes in cancer metabolism that are fundamental to support the cancer's proliferation. The Warburg Effect, a process that helps most cancer cells adapt to changing conditions, is prevalent across most solid and hematological malignancies impacting energy production and the uptake of non-essential amino acids for cancer growth. SM-88 is a modified dysfunctional form of the amino acid tyrosine. Tyrosine is required for cancer cell growth and as a result, SM-88 is selectively consumed by the cancer cell, causing a disruption of protein synthesis that leads to catastrophic failure and cancer cell death.