In March 2018, Asahi Kasei Pharma Corporation and RaQualia Pharma Inc. entered into a license agreement for a novel P2X7 receptor antagonist. Under this agreement, Asahi Kasei Pharma obtained exclusive rights for worldwide development, manufacture, and sale of P2X7 receptor antagonist, while RaQualia Pharma will receive a lump-sum payment as well as milestone payments corresponding to stages of development, and royalty payments in proportion to sales amounts. The P2X7 antagonist is AKP-23494954/RQ-00466479. In 2016, CONBA Pharmaceutical revised the synthetic route for EVT401. Furthermore, additional pre-clinical pharmacokinetics and safety studies are being conducted in order to meet the requirements of the China Food and Drug Administration prior to seeking approval for further clinical studies. In 2012, Evotec AG granted exclusive rights for EVT401 in China to CONBA Pharmaceutical.