Biggest losers included Eisai Co., Ltd. (TYO: 4523 ), which lost 6.22% or 596.00 points to trade at 8,988.00 in late trade. Alps Electric Co., Ltd. (TYO: 6770 ) declined 3.27% or 44.00 points to end at 1,303.00 and Taiyo Yuden Co., Ltd. (TYO: 6976 ) shed 2.68% or 120.00 points to 4,355.00. Declining stocks outnumbered rising ones by 2207 to 1305 and 284 ended unchanged on the Tokyo Stock Exchange. The Nikkei Volatility, which measures the implied volatility of Nikkei 225 options, was up 5.95% to 18.53.