"Our commitment to bringing first of their kind therapies to rare disease indications with no existing treatment options is at the core of our work," said Shoshana Shendelman, PhD, Founder and CEO of Applied Therapeutics. "We are excited by the prospect of providing patients with SORD Deficiency with a treatment option that has the potential to slow disease progression and the consistent benefit demonstrated by govorestat." "We are thrilled by the results of this 12-month interim analysis, which demonstrate govorestat's effectiveness in reducing sorbitol levels and improving key functional measures and patient reported outcomes in SORD Deficiency, including lower limb function, upper limb function, fatigue and pain," said Riccardo Perfetti, MD, PhD, Chief Medical Officer of Applied Therapeutics. "We look forward to meeting with regulatory agencies regarding a path to potential approval based on this data, and endeavor to bring this important treatment to patients as quickly as possible."