Dentsply Sirona, PD Dental (IrriFlex), Kerr Endodontics, Ultradent Products, Vista Dental Products, Septodont, Coltene, Mani, Inc., Micro-Mega, Roydent Dental Products, Diadent Group International, FKG Dentaire, Medesy, Dental Hi Tec, Pac-Dent International, Komet USA, Brasseler USA, Hu-Friedy, SS White Dental, and Zipperer are the major players.