In October 2012, Curis achieved the first two development milestones under its agreement with The Leukemia & Lymphoma Society (LLS) for the development of CUDC-907, a first-in-class orally-administered small molecule drug candidate inhibitor of phosphatidylinositol-3-kinase (PI3K) and histone deacetylase (HDAC). These milestones include a preclinical development objective, as well as Curis' recent filing of an IND application to begin Phase I clinical testing of CUDC-907 in patients. As a result, Curis earned an aggregate of $750,000 in milestone payments under the terms of its agreement with LLS. Curis is eligible to receive up to $3.3 million in additional milestone payments under this agreement, assuming the successful achievement of further clinical development objectives.