Open Orphan PLC ( AIM:ORPH, FRA:CRO ) has secured a contract to supply consultancy services to support a Phase II trial in Onchocerciasis Disease, an infectious disease commonly known as river blindness. ADM Energy PLC ( AIM:ADME ), a West-Africa focused natural resources investor, said non-executive chairman Peter Francis will step down for personal reasons on August 2 and Oliver Andrews will take over the role. Metal Tiger PLC ( AIM:MTR ) highlighted quarterly updates from Sandfire Resources Ltd and two more of its natural resource investments.