"The strong participation and input from diverse experts was crucial in ensuring that the playbook meets the highest scientific and regulatory standards and is highly practical for immediate application in the field. We remain committed to driving collaborative innovation in this sector to improve the patient experience." The ENRICHMENT Playbook outlines the credibility assessment process based on recommendations from the recently issued FDA final guidance Assessing the Credibility of Computational Modeling and Simulation in Medical Device Submissions, and appears in the CDRH/OSEL Regulatory Science Tools Catalog. It is the result of extensive collaboration among leaders from the FDA's Office of Science and Engineering Laboratories, clinical practice, academia, the medical device industry and regulatory science. The playbook's authors are discussing outcomes and opportunities today at Dassault Systèmes' International Virtual Human Twin Experience Symposium in Paris.