The first in-human Phase 2 dose escalation trial evaluates the safety and efficacy of Claudin-6 CAR-T cell monotherapy, and in combination with CARVac in patients with Claudin-6-positive relapsed or refractory advanced solid tumor. Part 1 comprised Claudin-6 CAR-T monotherapy dose escalation cohorts, and Part 2 is a dose escalation of CAR-T combined with a fixed dose of CARVac. There are three dose level cohorts for each part. The subsequent dose expansion will focus on ovarian, testicular, and endometrial cancers, as well as other Claudin-6-positive cancers.