In 2018, many OCM practices adopted a DR program for biologic agents as a strategy to reduce drug waste and TCOC; however, whether the strategy worked remained to be seen. The investigators assessed claims data for 14 practices in The US Oncology Network participating in the OCM. The data included drug administration data for reference bevacizumab and bevacizumab biosimilars (Vegzelma, Mvasi, Zirabev, and Alymsys) to evaluate drug waste, total dose, TCOC, DR, and the financial impact of drug waste reduction on TCOC from 2017 to 2021.