AstraZeneca PLC (NASDAQ:AZN) has upgraded its full-year guidance, now expecting total revenue and core EPS to grow by high-teen percent. The pharma giant reported strong global revenue distribution in the first nine months, with 43% from the US, 21% from Europe, 13% from China, and 14% from emerging markets outside China, which have outpaced China's contribution. To drive further US growth as part of its 2030 ambition, AZN announced a $3.5 billion investment in US manufacturing and R&D.