Advaxis can continue treating patients who are already in the trial but cannot recruit new subjects. The impact of that restriction on Advaxis' prospects is tied to the duration of the partial hold. Advaxis said it is working to address the FDA's requests for information and will respond as promptly as it can. The biotech expects to complete the 450-patient study in June 2022. Prior setbacks mean Advaxis can ill afford delays. In recent years, two earlier, now-resolved clinical holds have slowed Advaxis' progress and dragged down its stock. The company slipped deeper into penny stock territory in the back half of last year as a result of a share offering and loss of an Amgen pact. The events have left Advaxis with a market cap of $22 million. As of the end of October, Advaxis had $45 million in cash. With its annual burn rate standing at $50 million following a cost-cutting drive, a cash crunch is looming on the horizon.