Conversely, Teva's Copaxone and Biogen's Tysabri and Avonex have all experienced significant share declines. Novartis' Gilenya, a high-efficacy oral DMT, is also showing signs of pressure, as reported share has been slowly, but consistently, declining. In this final comprehensive assessment of the 2018 Ocrevus approval and subsequent EU launches, Spherix found that Ocrevus' opportunity among patients with relapsing forms of MS (RMS) appears to be growing, even as the brand is pushed back later in the treatment algorithm. Neurologists in France and the UK are more likely to prescribe Ocrevus to patients with relapsing-remitting MS (RRMS) than primary-progressive MS (PPMS). In fact, almost half of UK neurologists select Ocrevus as one of their most preferred DMTs for the treatment of RRMS and a similar percentage of EU neurologists select the brand as a preferred DMT for active secondary progressive MS (SPMS).