The company beat Wall Street analysts' projections on profits but missed on revenue. Centene's full-year revenue in 2020 was $111.1 billion, up 49% from $74.6 billion in 2019. RELATED: Insurers' strong financial performance continues in Q3 as they brace for a potentially rocky Q4 Centene joins its peers in experiencing weaker results in the fourth quarter as the financial impacts of the COVID-19 pandemic fully come to bear. Humana also posted a loss in the fourth quarter. While it posted a fourth-quarter loss, Neidorff said in a statement that the insurer's overall performance in 2020 highlights the success of its growth strategy. "Building on our leadership position in government-sponsored healthcare, we are focused on delivering the next phase of growth through product and geographic expansion, advancing our technology strategy and further integrating our diverse capabilities," Neidorff said. "Looking ahead, we have great confidence in our ability to pursue our growth strategy in 2021 and beyond."