The West Virginia Democrat's daughter, Heather Bresch, is chief executive of the company, which appears to have hiked the price of the epinephrine auto-injector by 400 percent since 2007. The device, which is used to treat severe allergic reactions, now costs more than $600 per dose. This price increase has become a public relations disaster for Mylan and at least four of Manchin's Senate colleagues are either pressing the company to reduce the cost of EpiPens, asking it to explain the price increase or requesting federal regulators to investigate the matter. Manchin is not a member of the Senate Judiciary Committee, which has shown the most interest in probing Mylan's pricing practices, and so far the senator is not discussing the issue. "Right now we don't have any comment," Manchin spokesman Jon Kott said in an email Tuesday.